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Biochemistry and Physiology of the Neutrophil

Biochemistry and Physiology of the Neutrophil

$133.00

  • Date Published: March 1994
  • availability: In stock
  • format: Hardback
  • isbn: 9780521416986

$133.00
Hardback

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About the Authors
  • This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of this cell, highlighting the mechanisms by which they seek out and destroy pathogenic microorganisms. The development of these cells during haematopoiesis is described and the mechanisms that lead to the production of reactive oxidants and the intracellular signal transduction systems that lead to the cell's activation are reviewed. The book also discusses recent discoveries concerning the role of cytokines in the regulation of neutrophil function together with the importance of the neutrophil as a generator of inflammatory cytokines. Finally, there is a description of the biochemical defects that give rise to some of the neutrophil-associated human diseases.

    •  An up-to-date review of the role of the neutrophil in infection
    • Neutrophils are important to us as they represent our first line of defence against invading bacterial and fungal pathogens
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    Reviews & endorsements

    "...a useful basic reference and I would recommend it to immunologists, microbiologists, biochemists, physiologists, infectious disease specialists, hematologists, or to anyone whose interest lies in immunology or microbiology." John O. Naim, Immunological Investigations

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    Product details

    • Date Published: March 1994
    • format: Hardback
    • isbn: 9780521416986
    • length: 319 pages
    • dimensions: 237 x 158 x 22 mm
    • weight: 0.591kg
    • contains: 97 b/w illus. 7 tables
    • availability: In stock
  • Table of Contents

    1. Neutrophils and host defence: the fight against infection
    2. The development and structure of neutrophils
    3. The generation and recognition of neutrophil-activating factors: structure and function of neutrophil receptors
    4. The cytoskeleton: the molecular framework regulating cell shape and the traffic of intracellular components
    5. The respiratory burst: the generation of reactive oxygen metabolites and their role in microbial killing
    6. Neutrophil activation: the production of intracellular signalling molecules
    7. Neutrophil priming: regulation of neutrophil function during inflammatory activation
    8. Disorders of neutrophil function
    Index.

  • Author

    Steven W. Edwards, University of Liverpool

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