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Chemical Genomics

Chemical Genomics

  • Editor: Haian Fu, Emory University, Atlanta
Cheryl L. Meyerkord, Haian Fu, Nicholas Aberle, Craig M. Crews, Akihisa Matsuyama, Yoko Yashiroda, Minoru Yoshida, Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell, David R. Spring, Gregory P. Tochtrop, Ryan E. Looper, Sandra Bartoli, Antonella Squarcia, Daniela Fattori, Ronald J. Quinn, Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday, Caroline E. Shamu, Paul A. Johnston, Grant N. Wheeler, Robert A. Field, Matthew L. Tomlinson, Lestyn Lewis, Eduard Sergienko, Douglas S. Auld, Natasha Thorne, Yuhong Du, Jonathan Havel, Thomas Mayer, Stephan Schürer, Jaeki Min, Brenda Bondesen, Brian Revennaugh, Peter Eimon, Ray Dingledine, Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena Ivnitski-Steele, Bruce S. Edwards, Larry A. Sklar, Chao-Yie Yang, Denzil Bernard, Shaomeng Wang, Honglin Li, Mingyue Zheng, Xiaofeng Liu, Hualiang Jiang, Arron Xu, Mark M. Bouzyk, Weining Tang, Brian Leyland-Jones, Rafael Rosell, Teresa Moran, Miguel Taron, Andreas Russ
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  • Date Published: February 2012
  • availability: In stock
  • format: Hardback
  • isbn: 9780521889483

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  • Advances in chemistry, biology, and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text with contributions from experts in the field discusses evolving concepts, essential techniques, and a wide range of applications to help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small molecule chemicals, the basics of high-throughput screening technologies, various bioassays for biochemical-, cellular-, and organism-based screens, and computational approaches. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. In selected chapters, a resource section is included for further information. This book provides an introduction to the principles of chemical genomics, serves as a resource for the associated technologies, and gives readers general concepts, useful vocabulary, practical techniques, and broad, forward-thinking perspectives. This book will be valuable to researchers, professionals, and students in many fields besides chemical genomics, including biology, biomedicine, chemistry, and drug discovery.

    • Discusses how chemical genomics is essential in many fields including biology, chemistry and biomedicine
    • Includes contributions from expert researchers and scientists
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    Reviews & endorsements

    "Author Haian Fu has effectively assembled his textbook, Chemical Genomics, in a manner that is easy to comprehend and builds a basic understanding of chemical genomics."
    Danielle Gerhard, Yale Journal of Biology and Medicine

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    Product details

    • Date Published: February 2012
    • format: Hardback
    • isbn: 9780521889483
    • length: 344 pages
    • dimensions: 285 x 221 x 21 mm
    • weight: 1.25kg
    • contains: 27 b/w illus. 142 colour illus. 21 tables
    • availability: In stock
  • Table of Contents

    Part I. Overviews:
    1. Harnessing the power of chemistry for biology and medicine Cheryl L. Meyerkord and Haian Fu
    2. Chemical genomics: exploring biology with small organic molecules Nicholas Aberle and Craig M. Crews
    3. Chemical proteomics Akihisa Matsuyama, Yoko Yashiroda and Minoru Yoshida
    Part II. Molecules for Chemical Genomics:
    4. Diversity-oriented synthesis Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell and David R. Spring
    5. Targeted chemical libraries Gregory P. Tochtrop and Ryan E. Looper
    6. Fragment-based ligand discovery Sandra Bartoli, Antonella Squarcia and Daniela Fattori
    7. Basics and principles for building natural product-based libraries for HTS Ronald J. Quinn
    Part III. Basics of High Throughput Screening:
    8. Essentials for high throughput screening operations Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday and Caroline E. Shamu
    9. High content analysis and screening: basics, instrumentation and applications Paul A. Johnston
    10. Phenotypic screens with model organisms Grant N. Wheeler, Robert A. Field and Matthew L. Tomlinson
    11. Screening informatics and ChemInformatics Lestyn Lewis
    Part IV. Chemical Genomics Assays and Screens:
    12. Basics on HTS assay design and optimization Eduard Sergienko
    13. Molecular sensors for transcriptional and post-transcriptional assays Douglas S. Auld and Natasha Thorne
    14. Fluorescence-based platforms for HTS assays – FP and TR-FRET Yuhong Du and Jonathan Havel
    15. Compound profiling with high content screening methodology Thomas Mayer and Stephan Schürer
    16. Use of transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors Jaeki Min, Yuhong Du, Brenda Bondesen, Brian Revennaugh, Peter Eimon and Ray Dingledine
    17. Flow cytometry multiplexed screening methodologies Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena Ivnitski-Steele, Bruce S. Edwards and Larry A. Sklar
    18. Basic principles and practices of computer-aided screening and drug design Chao-Yie Yang, Denzil Bernard and Shaomeng Wang
    19. Computational approach for drug target identification Honglin Li, Mingyue Zheng, Xiaofeng Liu and Hualiang Jiang
    20. Label-free biosensor technologies for assay development and HTS Yuhong Du and Arron Xu
    Part V. Chemical Genomics and Medicine:
    21. Pharmacogenomics to link genetic background with therapeutic efficacy and safety Mark M. Bouzyk, Weining Tang and Brian Leyland-Jones
    22. Drugs, genomic response signatures, and customized cancer therapy Rafael Rosell, Teresa Moran and Miguel Taron
    Appendix. Current drug targets and the druggable genome Andreas Russ.

  • Editor

    Haian Fu, Emory University, Atlanta
    Haian Fu is a Professor of Pathology, Hematology, and Medical Oncology at Emory University School of Medicine. He also serves as director of the Chemical Biology Discovery Center and co-director of the Discovery and Developmental Therapeutics Program at the Winship Cancer Institute at Emory University. His research focuses on protein-protein interactions in signal transduction pathways that control cell survival and death in normal and cancer cells. He serves on the editorial board of several scientific journals, including Current Chemical Genomics. He edited Protein-Protein Interactions: Methods and Applications (2004). Dr Fu has been recognized by various honors including the PhRMA Faculty Development Award, the Burroughs Wellcome Fund New Investigator Award, the GRA Distinguished Investigator Award and the Georgia Cancer Coalition Distinguished Cancer Scholar. He is also a recipient of the Award for Excellence in Mentorship by the Emory Graduate Division of Biological and Biomedical Sciences (2000) and the Emory Pharmacology Teaching Excellence Award (2006).

    Contributors

    Cheryl L. Meyerkord, Haian Fu, Nicholas Aberle, Craig M. Crews, Akihisa Matsuyama, Yoko Yashiroda, Minoru Yoshida, Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell, David R. Spring, Gregory P. Tochtrop, Ryan E. Looper, Sandra Bartoli, Antonella Squarcia, Daniela Fattori, Ronald J. Quinn, Stewart P. Rudnicki, James V. Follen, Nicola J. Tolliday, Caroline E. Shamu, Paul A. Johnston, Grant N. Wheeler, Robert A. Field, Matthew L. Tomlinson, Lestyn Lewis, Eduard Sergienko, Douglas S. Auld, Natasha Thorne, Yuhong Du, Jonathan Havel, Thomas Mayer, Stephan Schürer, Jaeki Min, Brenda Bondesen, Brian Revennaugh, Peter Eimon, Ray Dingledine, Virginia M. Salas, J. Jacob Strouse, Zurab Surviladze, Irena Ivnitski-Steele, Bruce S. Edwards, Larry A. Sklar, Chao-Yie Yang, Denzil Bernard, Shaomeng Wang, Honglin Li, Mingyue Zheng, Xiaofeng Liu, Hualiang Jiang, Arron Xu, Mark M. Bouzyk, Weining Tang, Brian Leyland-Jones, Rafael Rosell, Teresa Moran, Miguel Taron, Andreas Russ

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