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Rheumatic Diseases

Rheumatic Diseases
Immunological Mechanisms and Prospects for New Therapies

$194.00 (Z)

R. J. Moots, K. W. Wucherpfennig, J. H. Buckner, G. T. Nepom, A. Rahman, F. K. Stevenson, D. A. Isenberg, P. Lane, D. M. Samson, L. S. K. Walker, D. R. Alexander, C. Pitzalis, J. McNally, A. K. Vaishnaw, K. B. Elkon, W. B. van den Berg, F. J. J. van de Loo, F. Ramirez, B. Seddon, D. Mason, J. M. Ahearn, A. M. Rosengard
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  • Date Published: July 1999
  • availability: Temporarily unavailable - no date available
  • format: Hardback
  • isbn: 9780521593274

$194.00 (Z)
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About the Authors
  • This authoritative volume provides a wide-ranging account of the immunological mechanisms that underlie many rheumatic diseases. Advances in our understanding of the immunopathology of diseases such as rheumatoid arthritis, ankylosing spondylitis and SLE, are paving the way for the development of effective and rational new therapies. This exciting prospect is an important influence for ground-breaking research into these diseases and the investigation of new therapeutic options. As the first book to focus exclusively on this burgeoning area of clinical research, this is an invaluable and current resource for all rheumatologists, clinical immunologists, and those seeking to develop effective new therapies to combat rheumatic diseases.

    • Deals with the immunopathology of common rheumatic diseases such as rheumatoid arthritis, ankylosing spondylitis and SLE
    • Provides a rational approach to the development of new therapies
    • First book to focus exclusively on the interface of rheumatology and immunology
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    Reviews & endorsements

    "The introductory chapter provides an excellent overview of the implications of advances in immunology for understanding the pathogenesis and treatment of rheumatic diseases...The list of authors includes important names in the field...an excellent resource in a single volume for those with clinical or scientific interests in the rheumatic diseases. For the clinician it provides a starting point for understanding the rationale behind current therapeutic approaches in rheumatology and will foster a better understanding of new research in immunology and its application to the treatment of the rheumatic diseases." Journal of Rheumatology

    "...a good read..." Rheumatology

    "This is an outstanding contribution. The frequent attempts to show the relevance of immunological principles to disease distinguish this volume from basic immunology and clinical rheumatology books. Indeed, this is an outstanding bridge between perspectives usually provided in both types of books." Doody's Health Sciences Book Review Journal

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    Product details

    • Date Published: July 1999
    • format: Hardback
    • isbn: 9780521593274
    • length: 296 pages
    • dimensions: 255 x 178 x 23 mm
    • weight: 0.725kg
    • contains: 36 b/w illus.
    • availability: Temporarily unavailable - no date available
  • Table of Contents

    Implications of advances in immunology for understanding the pathogenesis and treatment of rheumatic disease J. S. Hill Gaston
    1. The role of T cells in autoimmune disease R. J. Moots and K. W. Wucherpfennig
    2. The role of MHC antigens in autoimmunity J. H. Buckner and G. T. Nepom
    3. B cells - formation and structure of autoantibodies A. Rahman, F. K. Stevenson and D. A. Isenberg
    4. Role of CD40 in immune responses P. Lane
    5. Manipulation of the T cell immune system via CD28 and CTLA-4 D. M. Samson and L. S. K. Walker
    6. Lymphocyte antigen receptor signal transduction D. R. Alexander
    7. Role of adhesion mechanisms in inflammation C. Pitzalis
    8. Regulation of apoptosis in rheumatic disorders J. McNally, A. K. Vaishnaw and K. B. Elkon
    9. The role of monokines in arthritisW. B. van den Berg and F. J. J. van de Loo
    10. T lymphocyte sub sets in relation to autoimuune disease F. Ramirez, B. Seddon and D. Mason
    11. Complement receptors J. M. Ahearn and A. M. Rosengard
    Index.

  • Editor

    J. S. H. Gaston, University of Cambridge

    Contributors

    R. J. Moots, K. W. Wucherpfennig, J. H. Buckner, G. T. Nepom, A. Rahman, F. K. Stevenson, D. A. Isenberg, P. Lane, D. M. Samson, L. S. K. Walker, D. R. Alexander, C. Pitzalis, J. McNally, A. K. Vaishnaw, K. B. Elkon, W. B. van den Berg, F. J. J. van de Loo, F. Ramirez, B. Seddon, D. Mason, J. M. Ahearn, A. M. Rosengard

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