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Childhood Leukemias

3rd Edition

$284.00 (P)

Paul Gaynon, Toska Zomorodian, Donald Pinkel, Mihaela Onciu, Ching-Hon Pui, Logan Spector, Bridget Charbonneau, Leslie L. Robison, Fred G. Behm, Jacques J. M. van Dongen, Anton W. Langerak, Susana C. Raimondi, Charles Mullighan, Tanja A. Gruber, James R. Downing, William Stevenson, Guillermo Garcia-Manero, Monique L. den Boer, Rob Pieters, Doan Le, Kevin Shannon, Beverly J. Lange, Stephen W. Paugh, Mary V. Relling, Williams E. Evans, Günter Henze, Arend von Stackelberg, John T. Sandlund, Jeffrey E. Rubnitz, Hiroto Inaba, Raul Ribeiro, Ursula Creutzig, Henrik Hasle, Charlotte M. Niemeyer, Franco Locatelli, Jeffrey W. Taub, April Sorrell, James A. Whitlock, James Nachman, Wing Leung, Michael A. Pulsipher, Scott C. Howard, Alan S. Wayne, Hyoung Jin Kang, Cliona M. Rooney, Helen Heslop, Ulrike Gerdemann, Martin Pulé, Malcolm K. Brenner, Sima Jeha, Dario Campana, Andrea Biondi, Melissa Hudson, Carolyn A. Felix, Hana Hakim, Patricia M. Flynn, Fariba Navid, Victor M. Santana, Doralina L. Anghelescu, Roland Kaddoum, Sean Phipps, Vida L. Tyc, Heather Conklin, Kevin Krull, Jami S. Gattuso, Martha May, Michele Pritchard
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  • Date Published: July 2012
  • availability: In stock
  • format: Hardback
  • isbn: 9780521196611

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  • New insights into the molecular biology of childhood leukemias have stimulated numerous advances in diagnostic methods, strategies for risk assessment and the development of novel therapy for genetic subtypes of the diseases. Fully revised and updated, this new edition of Childhood Leukemias provides the most comprehensive, clinically-oriented and authoritative reference dedicated to these diseases. Beginning with an overview of history, cell biology, and pathology, subsequent chapters review approaches in the evaluation and management of specific leukemias, new therapeutic development and the unique pharmacodynamics and pharmacogenetics of individual patients. New chapters include epigenetics of leukemias, leukemias in patients with Down syndrome and leukemia in adolescents and young adults. The final section covers the complications associated with the disease or its treatment and supportive care during and after treatment. Authored by leading experts, this is a 'must-have' for any physician or investigator who deals with leukemias in childhood.

    • Includes comprehensive diagnosis, risk assessment and treatment of all subtypes of childhood leukemias, aiding accurate management of children with leukemia
    • Contains numerous high-quality figures and tables, enabling quick learning
    • Describes the most up-to-date clinical, translational and basic research in leukemia, and addresses future directions
    Read more

    Reviews & endorsements

    Review of the previous editions: '… comprehensively referenced and the indexing is simple to use … informative and relevant … I would commend the book to anyone looking for an up-to-date and comprehensive reference monograph on childhood leukaemia.' The Bulletin of The Royal College of Pathologists

    'This is an exceptional book that's highly extensive in coverage of the very complex field of leukemias among children and to some extent, adolescents. The information in it is presented well, and written very clearly. The fact that it is in its third edition speaks for itself. The first and second editions had to have been successful by providing great value in terms of not just the knowledge but also its ease of use.' Nano Khilnani, Biz India Online News (www.bizindia.net)

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    Product details

    • Edition: 3rd Edition
    • Date Published: July 2012
    • format: Hardback
    • isbn: 9780521196611
    • length: 892 pages
    • dimensions: 283 x 224 x 44 mm
    • weight: 2.7kg
    • contains: 158 b/w illus. 51 colour illus. 120 tables
    • availability: In stock
  • Table of Contents

    Preface
    Part I. History and General Issues:
    1. History of leukemia Paul Gaynon, Toska Zomorodian and Donald Pinkel
    2. Diagnosis and classification Mihaela Onciu and Ching-Hon Pui
    3. Epidemiology and etiology Logan Spector, Bridget Charbonneau and Leslie L. Robison
    Part II. Cell Biology and Pathobiology:
    4. Immunophenotyping Fred G. Behm
    5. Immunoglobulin and T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W. Langerak
    6. Cytogenetics of acute leukemias Susana C. Raimondi
    7. Molecular genetics of acute lymphoblastic leukemias Charles Mullighan
    8. Molecular genetics of acute myeloid leukemia Tanja A. Gruber and James R. Downing
    9. Epigenetics of leukemias William Stevenson and Guillermo Garcia-Manero
    10. Genetics and cellular drug resistance in acute leukemia Monique L. den Boer and Rob Pieters
    11. Heritable predispositions to childhood hematologic malignancies Doan Le, Kevin Shannon and Beverly J. Lange
    Part III. Evaluation and Treatment:
    12. Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations Stephen W. Paugh, Mary V. Relling and Williams E. Evans
    13. Acute lymphoblastic leukemia Ching-Hon Pui
    14. Relapsed acute lymphoblastic leukemia Günter Henze and Arend von Stackelberg
    15. B-cell acute lymphoblastic leukemia and Burkitt lymphoma John T. Sandlund and Mihaela Onciu
    16. Acute myeloid leukemia Jeffrey E. Rubnitz, Hiroto Inaba and Raul Ribeiro
    17. Relapsed acute myeloid leukemia Ursula Creutzig
    18. Myelodysplastic syndromes Henrik Hasle
    19. Chronic myeloproliferative disorders Charlotte M. Niemeyer and Franco Locatelli
    20. Leukemias in patients with Down syndrome Jeffrey W. Taub, April Sorrell and James A. Whitlock
    21. Treatment of adolescents and young adults with acute lymphoblastic leukemia James Nachman
    22. Hematopoietic stem cell and natural killer cell transplantation Wing Leung and Michael A. Pulsipher
    23. Treatment in the underprivileged countries Raul Ribeiro, Scott C. Howard and Ching-Hon Pui
    24. Antibody-targeted therapy Alan S. Wayne
    25. Adoptive cellular immunotherapy Hyoung Jin Kang, Cliona M. Rooney and Helen Heslop
    26. Gene therapy: methods and applications Ulrike Gerdemann, Martin Pulé and Malcolm K. Brenner
    27. Development therapeutics Sima Jeha
    28. Minimal residual disease Dario Campana, Andrea Biondi and Jacques J. M. van Dongen
    Part IV. Complications and Supportive Care:
    29. Acute complications Scott C. Howard, Raul Ribeiro and Ching-Hon Pui
    30. Late complications after leukemia therapy Melissa Hudson
    31. Therapy-related leukemias Carolyn A. Felix
    32. Infectious complications Hana Hakim and Patricia M. Flynn
    33. Hematologic supportive care Fariba Navid and Victor M. Santana
    34. Pain management Doralina L. Anghelescu and Roland Kaddoum
    35. Psychosocial issues Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull
    36. Nursing care Jami S. Gattuso, Martha May and Michele Pritchard
    Index.

  • Editor

    Ching-Hon Pui, St Jude's Children's Research Hospital
    Ching-Hon Pui is Chair of the Department of Oncology, Fahad Nassar Al-Rashid Chair of Leukemia Research and co-Director of the Hematological Malignancies Program at St Jude's Children's Research Hospital, Memphis, TN, USA.

    Contributors

    Paul Gaynon, Toska Zomorodian, Donald Pinkel, Mihaela Onciu, Ching-Hon Pui, Logan Spector, Bridget Charbonneau, Leslie L. Robison, Fred G. Behm, Jacques J. M. van Dongen, Anton W. Langerak, Susana C. Raimondi, Charles Mullighan, Tanja A. Gruber, James R. Downing, William Stevenson, Guillermo Garcia-Manero, Monique L. den Boer, Rob Pieters, Doan Le, Kevin Shannon, Beverly J. Lange, Stephen W. Paugh, Mary V. Relling, Williams E. Evans, Günter Henze, Arend von Stackelberg, John T. Sandlund, Jeffrey E. Rubnitz, Hiroto Inaba, Raul Ribeiro, Ursula Creutzig, Henrik Hasle, Charlotte M. Niemeyer, Franco Locatelli, Jeffrey W. Taub, April Sorrell, James A. Whitlock, James Nachman, Wing Leung, Michael A. Pulsipher, Scott C. Howard, Alan S. Wayne, Hyoung Jin Kang, Cliona M. Rooney, Helen Heslop, Ulrike Gerdemann, Martin Pulé, Malcolm K. Brenner, Sima Jeha, Dario Campana, Andrea Biondi, Melissa Hudson, Carolyn A. Felix, Hana Hakim, Patricia M. Flynn, Fariba Navid, Victor M. Santana, Doralina L. Anghelescu, Roland Kaddoum, Sean Phipps, Vida L. Tyc, Heather Conklin, Kevin Krull, Jami S. Gattuso, Martha May, Michele Pritchard

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