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Drug Resistance in the Treatment of Cancer

Drug Resistance in the Treatment of Cancer

$229.99 (Z)

Part of Cancer: Clinical Science in Practice

Erdem Göker, Richard Gorlick, Joseph R. Bertino, Beverly A. Teicher, Emil Frei III, Lyn Mickley, Antonio Tito Fojo, Giuseppe Giaccone, John A. Hickman, Henk M. W. Verheul, Herbert M. Pinedo, William S Dalton, David Fennelly, George Raptis, John P. A. Crown, Larry Norton, Elisabeth G. E. de Vries, Wil Dolsma, Geke A. P. Hospers, Nanno H. Mulder, Karol Sikora
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  • Date Published: March 1998
  • availability: Available
  • format: Hardback
  • isbn: 9780521473217

$229.99 (Z)
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About the Authors
  • The development of drug-resistant cancers is considered to be the most significant obstacle to the cure of cancer today. Nearly half of all patients with cancer suffer from tumors that are intrinsically resistant to chemotherapy, and most of the remaining half develop drug resistance during the course of their treatment. This book reviews the mechanisms and clinical implications of drug resistance in cancer with unrivaled authority. The authors, who are among the leading clinicians and investigators in the field, cover topics of current clinical concern, including multiple drug resistance and its reversal, topoisomerase drugs, apoptosis, dose intensity and escalation, gene therapy and hematopoietic support.

    • Topic of major concern to all clinicians treating cancer
    • Covers more recent developments, including gene therapy
    • Contributors are leading scientific and clinical authorities
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    Product details

    • Date Published: March 1998
    • format: Hardback
    • isbn: 9780521473217
    • length: 340 pages
    • dimensions: 229 x 152 x 22 mm
    • weight: 0.67kg
    • contains: 35 b/w illus. 32 tables
    • availability: Available
  • Table of Contents

    List of contributors
    Series editor's preface
    Abbreviations
    1. Resistance mechanisms to antimetabolites Erdem Göker, Richard Gorlick and Joseph R. Bertino
    2. Resistance to antitumor alkylating agents and cisplatin Beverly A. Teicher and Emil Frei III
    3. The MDR genes Lyn Mickley and Antonio Tito Fojo
    4. Topoisomerase genes and resistance to topoisomerase inhibitors Giuseppe Giaccone
    5. Genes that modulate apoptosis: major determinants of drug resistance John A. Hickman
    6. Clinical implications of drug resistance Henk M. W. Verheul and Herbert M. Pinedo
    7. The reversal of multidrug resistance William S. Dalton
    8. Effect of dose and schedule on chemotherapeutic drug resistance David Fennelly, George Raptis, John P. A. Crown and Larry Norton
    9. Circumvention of drug resistance by high-dose chemotherapy in solid tumors Elisabeth G. E. de Vries, Wil Dolsma, Geke A. P. Hospers and Nanno H. Mulder
    10. Enhancing drug effectiveness by gene transfer Karol Sikora
    Index.

  • Authors

    Herbert M. Pinedo, Vrije Universiteit, Amsterdam

    Giuseppe Giaccone, Vrije Universiteit, Amsterdam

    Foreword

    Karol Sikora

    Contributors

    Erdem Göker, Richard Gorlick, Joseph R. Bertino, Beverly A. Teicher, Emil Frei III, Lyn Mickley, Antonio Tito Fojo, Giuseppe Giaccone, John A. Hickman, Henk M. W. Verheul, Herbert M. Pinedo, William S Dalton, David Fennelly, George Raptis, John P. A. Crown, Larry Norton, Elisabeth G. E. de Vries, Wil Dolsma, Geke A. P. Hospers, Nanno H. Mulder, Karol Sikora

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