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Gene Therapy in the Treatment of Cancer

Gene Therapy in the Treatment of Cancer
Progress and Prospects

$164.99 (Z)

Part of Cancer: Clinical Science in Practice

  • Editors:
  • Brian E. Huber, Glaxo Wellcome Research Institute, North Carolina
  • Ian Magrath, National Cancer Institute, Bethesda, Maryland
Brian E. Huber, Ian Magrath, Kishor Bhatia, Prem Seth, Jack A. Roth, John C. Krauss, Suyu Shu, Alfred E. Chang, Patrick J. Geraghty, James J. Mulé, Leonard M. Neckers, Kanak Iyer, Cynthia A. Richards, J. Patrick Condreay
View all contributors
  • Date Published: January 1999
  • availability: Available
  • format: Hardback
  • isbn: 9780521444361

$164.99 (Z)
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About the Authors
  • The clinical applications of human gene therapy have been particularly fruitful in oncology, and in the past two decades there has been explosive growth in understanding of the genetic lesions leading to neoplasia. This volume in the series Cancer: Clinical Science in Practice reviews progress in the basic and clinical science of gene therapy in oncology, and looks toward future developments. It considers what has worked and what has not in the fast-evolving field of gene therapy, drawing on laboratory studies and clinical trials, including the ground-breaking work of the contributors themselves. Up to date and authoritative, the volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.

    • Cancer is the biggest target worldwide for gene therapy, an interesting, far-reaching treatment approach
    • Documents preclinical and clinical progress
    • Covers biological principles and practical concerns, including safety
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    Product details

    • Date Published: January 1999
    • format: Hardback
    • isbn: 9780521444361
    • length: 230 pages
    • dimensions: 229 x 152 x 14 mm
    • weight: 0.48kg
    • contains: 18 b/w illus. 23 tables
    • availability: Available
  • Table of Contents

    Contributors
    Preface
    1. Introduction: gene therapy approaches to cancer Brian E. Huber
    2. Principles of transformation-directed cancer therapy Ian Magrath and Kishor Bhatia
    3. Vectors for cancer gene therapy Prem Seth
    4. Genetically engineering drug sensitivity and drug resistance for the treatment of cancer Brian E. Huber
    5. Oncogene inactivation and replacement strategies for cancer Jack A. Roth
    6. Genetically modified tumor cells as tumor vaccines John C. Krauss, Suyu Shu and Alfred E. Chang
    7. Genetically modified lymphocytes and hematopoietic stem cells as therapeutic vehicles Patrick J. Geraghty and James J. Mulé
    8. Pharmacologic effects of oligonucleotides and some clinical applications Leonard M. Neckers and Kanak Iyer
    9. Current status of gene marking and gene therapy in oncology clinical trials Cynthia A. Richards
    10. Safety testing for gene therapy products J. Patrick Condreay
    Index.

  • Editors

    Brian E. Huber, Glaxo Wellcome Research Institute, North Carolina

    Ian Magrath, National Cancer Institute, Bethesda, Maryland

    Contributors

    Brian E. Huber, Ian Magrath, Kishor Bhatia, Prem Seth, Jack A. Roth, John C. Krauss, Suyu Shu, Alfred E. Chang, Patrick J. Geraghty, James J. Mulé, Leonard M. Neckers, Kanak Iyer, Cynthia A. Richards, J. Patrick Condreay

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