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Demyelinating Disorders of the Central Nervous System in Childhood

$127.00 (M)

Deborah Hertz, Anita L. Belman, Folker Hanefeld, Dorothée Chabas, Lauren B. Krupp, Marc Tardieu, Martino Ruggieri, Immacolata Plasmati, Isabella Simone, Angelo Ghezzi, Brenda Banwell, Bruno P. Soares, Max Wintermark, Nancy L. Kuntz, Jonathan Strober, Christel Renoux, Emmanuelle L. Waubant, Khurram Bashir, Gregory S. Aaen, E. Ann Yeh, Moses Rodriguez, Daniela Pohl, Sunita Venkateswaran, Susan Bennet, Jayne Ness, Laura J. Julian, Maria Trojano, Maria Pia Amato, Sunny Im-Wang, Maria Milazzo, Ellen M. Mowry, Tanuja Chitnis, Amit Bar-Or, A. D. Sadovnick, R. Q. Hintzen, Jin S. Hahn, Silvia Tenembaum, Russell C. Dale, Esther Tantsis, Amy T. Waldman, Laura J. Balcer, Bianca Weinstock-Guttman, Grant T. Liu, Frank S. Pidcock, Guillaume Sébire, Andrew McKeon, Timothy Lotze
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  • Date Published: April 2011
  • availability: In stock
  • format: Hardback
  • isbn: 9780521763493

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  • Although multiple sclerosis and other disorders of myelin formation and repair are most commonly associated with adults, they can also occur in infants, children and adolescents. Up to 5 percent of those with MS experience symptoms before the age of 18, and the number of cases diagnosed is rising. There is a lack of awareness about these diseases in childhood, however, even amongst pediatric neurologists and MS specialists. Demyelinating Disorders of the Central Nervous System in Childhood provides comprehensive coverage of these diseases, highlighting throughout the differences between management in childhood and in adults. With sections dedicated to the diagnosis, course, treatment and biology of pediatric MS, detailed chapters on other childhood demyelinating diseases, including acute disseminated encephomyelitis, optic neuritis, acute complete transverse myelitis and neuromyelitis optica, are also provided. Essential reading for pediatric neurologists and MS specialists, this book will also be valuable reading for adult neurologists and pediatricians.

    • Authoritative guidance on a poorly understood and under-diagnosed clinical entity
    • Highlights differences between MS in children and adults to optimize management of pediatric patients
    • Contains enough basic science to inform clinical practice and covers diseases that mimic MS in children, with details on differential diagnosis
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    Product details

    • Date Published: April 2011
    • format: Hardback
    • isbn: 9780521763493
    • length: 292 pages
    • dimensions: 252 x 195 x 11 mm
    • weight: 0.79kg
    • contains: 35 b/w illus. 7 colour illus. 46 tables
    • availability: In stock
  • Table of Contents

    Preface
    1. Introduction: historical perspective of pediatric Multiple Sclerosis and related disorders Deborah Hertz, Anita L. Belman and Folker Hanefeld
    2. Controversies around the current operational definitions of pediatric MS, ADEM and related diseases Dorothée Chabas, Lauren B. Krupp and Marc Tardieu
    Part I. Pediatric MS Diagnosis:
    3. Epidemiology of pediatric MS: incidence, prevalence and susceptibility risk factors Martino Ruggieri, Immacolata Plasmati and Isabella Simone
    4. Clinical presentation of Multiple Sclerosis in children Angelo Ghezzi and Brenda Banwell
    5. Conventional MRI features of pediatric Multiple Sclerosis Bruno P. Soares, Dorothée Chabas and Max Wintermark
    6. Differential diagnosis of Multiple Sclerosis and acquired central nervous system demyelinating disorders in children and adolescents Nancy L. Kuntz and Jonathan Strober
    Part II. Pediatric MS Course and Treatment:
    7. Pediatric MS course (including predictive factors) Christel Renoux and Emmanuelle L. Waubant
    8. Plasma exchange and IV immunoglobulin for acute demyelinating relapses Khurram Bashir
    9. Corticosteroids in pediatric Multiple Sclerosis relapses Gregory S. Aaen
    10. Disease modifying therapy and response to first-line treatment in pediatric multiple sclerosis E. Ann Yeh and Moses Rodriguez
    11. Treatment of breakthrough disease Daniela Pohl and Emmanuelle L. Waubant
    12. Symptomatic therapy in pediatric Multiple Sclerosis Sunita Venkateswaran, Susan Bennet and Jayne Ness
    13. Cognitive dysfunction in pediatric onset Multiple Sclerosis Laura J. Julian, Maria Trojano, Maria Pia Amato and Lauren B. Krupp
    14. Living with pediatric Multiple Sclerosis: patient well-being Sunny Im-Wang, Maria Milazzo and Ellen M. Mowry
    Part III. Pediatric MS Biology:
    15. Pediatric MS: biological presentation and research update Tanuja Chitnis and Amit Bar-Or
    16. Genetics of pediatric Multiple Sclerosis A. D. Sadovnick and R. Q. Hintzen
    Part IV. ADEM:
    17. Clinical and biological features of Acute Disseminated Encephalomyelitis Jin S. Hahn and Silvia Tenembaum
    18. Magnetic Resonance Imaging of Acute Disseminated Encephalomyelitis Russell C. Dale and Esther Tantsis
    19. Treatment and prognosis of ADEM Marc Tardieu and Amy T. Waldman
    Part V. Optic Neuritis in Children:
    20. Pediatric optic neuritis Amy T. Waldman and Laura J. Balcer
    21. Recurrent isolated optic neuritis in the pediatric population Bianca Weinstock-Guttman and Grant T. Liu
    Part VI. Acute Complete Transverse Myelitis in Children:
    22. What is acute transverse myelitis (ATM) in children? Frank S. Pidcock and Guillaume Sébire
    Part VII. Neuromyelitis in Children:
    23. Neuromyelitis optica in children Andrew McKeon and Timothy Lotze
    Index.

  • Editors

    Dorothée Chabas, University of California, San Francisco
    Dorothée Chabas is Assistant Professor of Neurology at the University of California, San Francisco, USA.

    Emmanuelle L. Waubant, University of California, San Francisco
    Emmanuelle Waubant is Associate Professor in Neurology at the UCSF MS Center. She is also the Nancy Davis Medical Director, and heads a collaboration between six American MS centers recognized as Centers of Excellence.

    Contributors

    Deborah Hertz, Anita L. Belman, Folker Hanefeld, Dorothée Chabas, Lauren B. Krupp, Marc Tardieu, Martino Ruggieri, Immacolata Plasmati, Isabella Simone, Angelo Ghezzi, Brenda Banwell, Bruno P. Soares, Max Wintermark, Nancy L. Kuntz, Jonathan Strober, Christel Renoux, Emmanuelle L. Waubant, Khurram Bashir, Gregory S. Aaen, E. Ann Yeh, Moses Rodriguez, Daniela Pohl, Sunita Venkateswaran, Susan Bennet, Jayne Ness, Laura J. Julian, Maria Trojano, Maria Pia Amato, Sunny Im-Wang, Maria Milazzo, Ellen M. Mowry, Tanuja Chitnis, Amit Bar-Or, A. D. Sadovnick, R. Q. Hintzen, Jin S. Hahn, Silvia Tenembaum, Russell C. Dale, Esther Tantsis, Amy T. Waldman, Laura J. Balcer, Bianca Weinstock-Guttman, Grant T. Liu, Frank S. Pidcock, Guillaume Sébire, Andrew McKeon, Timothy Lotze

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