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The Newborn Brain
Neuroscience and Clinical Applications

2nd Edition

$189.00 (P)

Jean-Pierre Changeux, Ola Hermanson, Urban Lendahl, Verne S. Caviness Jr, Pradeep G. Bhide, Richard S. Nowakowski, Sandrine Passemard, Angela M. Kaindl, Virginia Leverche, Pascal Dournaud, Pierre Gressens, Jean-Pierre Bourgeois, Thomas Ringstedt, Eric Herlenius, Hugo Lagercrantz, Arne Schousboe, Helle S. Waagepetersen, Sandra Rees, David Walker, Ernest Jennings, Anna A. Penn, Carla J. Shatz, S. Allen Counter, Elena V. Kushnerenko, Mark H. Johnson, Mary A. Rutherford, Lena Hellström-Westas, Ingemar Rosén, Sampsa Vanhatalo, Kai Kaila, Donald Peebles, Deanna L. Taylor, Grisha Pirianov, A. David Edwards, Henrik Hagberg, Andrew Whitelaw, Marianne Thoresen, Michael Weindling, Koray Özduman, Laura R. Ment, Mijna Hadders-Algra, Hans Forssberg, Stephen G. Matthews, Amita Kapoor, Hugo Lagercrantz
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  • Date Published: February 2010
  • availability: In stock
  • format: Hardback
  • isbn: 9780521889759

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About the Authors
  • Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child's future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant.

    • Describes the milestones of brain development in the fetus and the newborn – correlated with neuroimaging studies
    • Describes in depth all the common disturbances and diseases of the newborn brain – clinical disorders and management highlighted
    • Describes in detail the main neurological complications seen in preterm infants – relevant to critical care practice
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    Reviews & endorsements

    '… wonderful book … The editors smoothly transition from the bench to the bedside by examining techniques the clinician can use to evaluate the state of brain development and injury … At a time when there is rapidly improving understanding of brain development and neonatal brain injury, this book should be of interest to scientists and clinicians alike.' Pediatrics Adolescent Medicine

    'Because of the quality and breath of materials, it remains that this book will prove relevant and useful to the broad readership of this journal. Readers may wish a copy for their own bookshelf, but they should at least request that one is stored by their institution's library.' Psychological Medicine

    'The book is elegantly written and well referenced … As a comprehensive review of the most recent research results on brain development and its clinical application, this book is strongly recommended …' European Journal of Paediatric Neurology

    '… a fantastically rich collection of studies and essays … comprehensive and accessible … a fascinating text and an extremely useful resource …' The Psychologist

    '… unique … combines neuroscience and developmental biology with clinical aspects of fetal-neonatal brain development … the second edition adds some new chapters and information.' Doody's Notes

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    Product details

    • Edition: 2nd Edition
    • Date Published: February 2010
    • format: Hardback
    • isbn: 9780521889759
    • length: 426 pages
    • dimensions: 253 x 198 x 25 mm
    • weight: 1.09kg
    • contains: 96 b/w illus. 4 colour illus. 13 tables
    • availability: In stock
  • Table of Contents

    List of contributors
    1. Reflections on the origins of the human brain Jean-Pierre Changeux
    Part I. Making of the Brain:
    2. The molecular basis of central nervous system development Ola Hermanson and Urban Lendahl
    Historical box 1
    3. Holoprosencephaly and microcephaly vera: perturbations of proliferations Verne S. Caviness Jr, Pradeep G. Bhide and Richard S. Nowakowski
    Historical box 2
    4. Neuronal migration Sandrine Passemard, Angela M. Kaindl, Virginia Leverche, Pascal Dournaud and Pierre Gressens
    5. Synaptogenesis in the neocortex of the newborn: the ultimate frontier for individuation? Jean-Pierre Bourgeois
    6. Neurotrophic factors in brain development Thomas Ringstedt
    Historical box 3
    7. Neurotransmitters and neuromodulators Eric Herlenius and Hugo Lagercrantz
    Historical box 4
    8. Glial cell biology Arne Schousboe and Helle S. Waagepetersen
    Part II. Sensory Systems and Behavior:
    9. Development of the somatosensory system Sandra Rees, David Walker and Ernest Jennings
    10. Principles of endogenous and sensory activity-dependent brain development: the visual system Anna A. Penn and Carla J. Shatz
    Historical box 5
    11. Fetal and neonatal development of the auditory system S. Allen Counter
    12. Newborn behaviour and perception Elena V. Kushnerenko and Mark H. Johnson
    Part III. Radiological and Neurophysiological Investigation:
    13. Imaging the infant brain Mary A. Rutherford
    14. Electroencephalography and amplitude-integrated EEG Lena Hellström-Westas and Ingemar Rosén
    15. Emergence of spontaneous and evoked EEG activity in the human brain Sampsa Vanhatalo and Kai Kaila
    Part IV. Clinical Aspects:
    16. Perinatal infections and brain injuries Donald Peebles
    17. Hypoxic-ischemic encephalopathy Deanna L. Taylor, Grisha Pirianov, A. David Edwards and Henrik Hagberg
    18. Clinical assessment and therapeutic interventions for hypoxic-ischemic encephalopathy in the full-term infant Andrew Whitelaw and Marianne Thoresen
    19. Clinical aspects of brain injury in the preterm infant Michael Weindling
    Part V. Follow-Up:
    20. Injury and recovery in the developing brain Koray Özduman and Laura R. Ment
    21. Development of motor functions in health and disease Mijna Hadders-Algra and Hans Forssberg
    22. Antenatal glucocorticoids and programming of neuroendocrine function and behavior Stephen G. Matthews and Amita Kapoor
    Part VI. Consciousness:
    23. On the emergence of consciousness Hugo Lagercrantz and Jean-Pierre Changeux
    Index.

  • Editors

    Hugo Lagercrantz, Karolinska Institutet, Stockholm
    Hugo Lagercrantz is Professor of Pediatrics at the Karolinska Institute and Clinical Consultant at the Astrid Lindgren Children's Hospital, Stockholm, Sweden.

    M. A. Hanson, Southampton General Hospital
    M. A. Hanson is Director of the Institute of Developmental Sciences, Director of the Developmental Origins of Health and Disease Division and the British Heart Foundation Professor of Cardiovascular Science at the University of Southampton, UK.

    Laura R. Ment, Yale University, Connecticut
    Laura R. Ment is Professor of Pediatrics and Neurology at Yale University School of Medicine, New Haven, CT, USA.

    Donald M. Peebles, University College London
    Donald M. Peebles is Professor of Obstetrics at the Department of Obstetrics and Gynaecology, University College London School of Medicine, London, UK.

    Contributors

    Jean-Pierre Changeux, Ola Hermanson, Urban Lendahl, Verne S. Caviness Jr, Pradeep G. Bhide, Richard S. Nowakowski, Sandrine Passemard, Angela M. Kaindl, Virginia Leverche, Pascal Dournaud, Pierre Gressens, Jean-Pierre Bourgeois, Thomas Ringstedt, Eric Herlenius, Hugo Lagercrantz, Arne Schousboe, Helle S. Waagepetersen, Sandra Rees, David Walker, Ernest Jennings, Anna A. Penn, Carla J. Shatz, S. Allen Counter, Elena V. Kushnerenko, Mark H. Johnson, Mary A. Rutherford, Lena Hellström-Westas, Ingemar Rosén, Sampsa Vanhatalo, Kai Kaila, Donald Peebles, Deanna L. Taylor, Grisha Pirianov, A. David Edwards, Henrik Hagberg, Andrew Whitelaw, Marianne Thoresen, Michael Weindling, Koray Özduman, Laura R. Ment, Mijna Hadders-Algra, Hans Forssberg, Stephen G. Matthews, Amita Kapoor, Hugo Lagercrantz

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