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Cytoskeletal Mechanics
Models and Measurements in Cell Mechanics

$61.00

Part of Cambridge Texts in Biomedical Engineering

Mohammad R. K. Mofrad, Roger Kamm, Paul Janmey, Christoph Schmidt, Jeffrey Fredberg, Ben Fabry, Helene Karcher, Farshid Guilak, Mansoor A. Haider, Lori A. Setton, Tod A. Laursen, Frank P. T. Baaijens, Dimitrije Stamenovic, Gerald H. Pollack, F. C. MacKintosh, James L. McGrath, C. Forbes Dewey, Jr, Marc Herant, Micah Dembo
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  • Date Published: June 2011
  • availability: Available
  • format: Paperback
  • isbn: 9781107648289

$61.00
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About the Authors
  • This book presents a full spectrum of views on current approaches to modeling cell mechanics. The authors of this book come from the biophysics, bioengineering, and physical chemistry communities and each joins the discussion with a unique perspective on biological systems. Consequently, the approaches range from finite element methods commonly used in continuum mechanics to models of the cytoskeleton as a cross-linked polymer network to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure, as well as its dynamic nature due to polymerization and the full array of biological processes. While it is unlikely that a single unifying approach will evolve from this diversity, it is our hope that a better appreciation of the various perspectives will lead to a highly coordinated approach to exploring the essential problems and better discussions among investigators with differing views.

    • Contributors are the most recognized names in the field
    • Covers the full range of opinions on the structure of cells
    • Interdisciplinary approach
    • Accessible to the non-specialist
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    Product details

    • Date Published: June 2011
    • format: Paperback
    • isbn: 9781107648289
    • length: 256 pages
    • dimensions: 254 x 178 x 14 mm
    • weight: 0.45kg
    • availability: Available
  • Table of Contents

    1. Introduction and the biological basis for cell mechanics Mohammad R. K. Mofrad and Roger Kamm
    2. Experimental measurements of intracellular mechanics Paul Janmey and Christoph Schmidt
    3. The cytoskeleton as a soft glassy material Jeffrey Fredberg and Ben Fabry
    4. Continuum elastic or viscoelastic models for the cell Mohammad R. K. Mofrad, Helene Karcher and Roger Kamm
    5. Multiphasic models of cell mechanics Farshid Guuilak, Mansoor A. Haider, Lori A. Setton, Tod A. Laursen and Frank P. T. Baaijens
    6. Models of cytoskeletal mechanics based on tensegrity Dimitrije Stamenovic
    7. Cells, gels and mechanics Gerald H. Pollack
    8. Polymer-based models of cytoskeletal networks F. C. MacKintosh
    9. Cell dynamics and the actin cytoskeleton James L. McGrath and C. Forbes Dewey, Jr
    10. Active cellular motion: continuum theories and models Marc Herant and Micah Dembo
    11. Summary Mohammad R. K. Mofrad and Roger Kamm.

  • Editors

    Mohammad R. K. Mofrad, University of California, Berkeley
    Dr Mohammad Reza Kaazempur Mofrad is an Assistant Professor at the University of California, Berkeley's Department of Bioengineering. His research at the Mofrad Laboratory is focused around understanding the principles underlying cellular mechanics, rheology and mechanotransduction, as well as the multiscale biomechanical processes underlying cardiovascular tissue mechanotransduction involved in diseases like aortic valve calcification and arterial atherosclerosis. Before joining the faculty at Berkeley, Dr Mofrad was a Principal Research Scientist at MIT for nearly two years. He is the recipient of the Partner in Excellence Award from Partners HealthCare System, Massachusetts General Hospital. He is also the co-editor of Cellular Mechanotransduction.

    Roger D. Kamm, Massachusetts Institute of Technology
    Roger D. Kamm has been on the faculty at MIT since receiving his Ph.D. in 1977 and now holds a joint appointment in the Biological Engineering and Mechanical Engineering Departments. Current research activities in the Kamm Laboratory at MIT include tissue engineering and microfluidics, cellular rheology and molecular mechanics. He is currently the Chair of the U.S. National Committee on Biomechanics and the World Council on Biomechanics and he is Director of the Global Enterprise for MicroMechanics and Molecular Medicine. Kamm has a long-standing interest in bioengineering education, directs a NIH-funded biomechanics training program, co-chaired the committee to form MIT's new undergraduate major in biological engineering and helped to develop MIT's course on molecular, cellular and tissue biomechanics.

    Contributors

    Mohammad R. K. Mofrad, Roger Kamm, Paul Janmey, Christoph Schmidt, Jeffrey Fredberg, Ben Fabry, Helene Karcher, Farshid Guilak, Mansoor A. Haider, Lori A. Setton, Tod A. Laursen, Frank P. T. Baaijens, Dimitrije Stamenovic, Gerald H. Pollack, F. C. MacKintosh, James L. McGrath, C. Forbes Dewey, Jr, Marc Herant, Micah Dembo

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