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Bioengineering
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C. Ross Ethier, University of Toronto
Craig A. Simmons, University of Toronto
Introductory Biomechanics is a new, integrated text written specifically for engineering students. It provides a broad overview of this important branch of the rapidly growing field of bioengineering. A wide selection of topics is presented, ranging from the mechanics of single cells to the dynamics of human movement. No prior biological knowledge is assumed and in each chapter, the relevant anatomy and physiology are first described. The biological system is then analyzed from a mechanical viewpoint by reducing it to its essential elements, using the laws of mechanics and then tying mechanical insights back to biological function. This integrated approach provides students with a deeper understanding of both the mechanics and the biology than from qualitative study alone. The text is supported by a wealth of illustrations, tables and examples, a large selection of suitable problems and hundreds of current references, making it an essential textbook for any biomechanics course. C. Ross Ethier is a professor of Mechanical and Industrial Engineering, the Canada Research Chair in Computational Mechanics, and the Director of the Institute of Biomaterials and Biomedical Engineering at the University of Toronto, with cross-appointment to the Department of Ophthalmology & Vision Sciences. His research focuses on biomechanical factors in glaucoma and blood flow and mass transfer in the large arteries. He has taught biomechanics for over ten years. Craig A. Simmons is the Canada Research Chair in Mechanobiology and an assistant professor of Mechanical and Industrial Engineering at the University of Toronto, with cross-appointments to the Institute of Biomaterials and Biomedical Engineering and the Faculty of Dentistry. His research interests include cell and tissue biomechanics and cell mechanobiology, particularly as it relates to tissue engineering and heart valve disease.
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Daniel A. Beard
Hong Qian, University of Washington
Chemical Biophysics provides an engineering-based approach to biochemical system analysis for graduate level courses on systems biology, computational bioengineering and molecular biophysics. It is the first textbook to apply rigorous physical chemistry principles to mathematical and computational modeling of biochemical systems for an interdisciplinary audience. The book is structured to show the student the basic biophysical concepts before applying this theory to computational modeling and analysis, building up to advanced topics and current research. Topics explored include the kinetics of nonequilibrium open biological systems, enzyme mediated reactions, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems. End-of-chapter exercises range from confidence-building calculations to computational simulation projects.
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Shreefal S. Mehta
Successful product design and development requires the ability to take a concept and translate the technology into useful, patentable, commercial products. This book guides the reader through the practical aspects of the commercialization process of drug, diagnostic and device biomedical technology including market analysis, product development, intellectual property and regulatory constraints. Key issues are highlighted at each stage in the process, and case studies are used to provide practical examples. The book will provide a sound road map for those involved in the biotechnology industry to effectively plan the commercialization of profitable regulated medical products. It will also be suitable for a capstone design course in engineering and biotechnology, providing the student with the business acumen skills involved in product development.
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Edward Cussler, University of Minnesota
This overview of diffusion and separation processes brings unsurpassed, engaging clarity to this complex topic. Diffusion is a key part of the undergraduate chemical engineering curriculum and at the core of understanding chemical purification and reaction engineering. This spontaneous mixing process is also central to our daily lives, with importance in phenomena as diverse as the dispersal of pollutants to digestion in the small intestine. For students, Diffusion goes from the basics of mass transfer and diffusion itself, with strong support through worked examples and a range of student questions. It also takes the reader right through to the cutting edge of our understanding, and the new examples in this third edition will appeal to professional scientists and engineers. Retaining the trademark enthusiastic style, the broad coverage now extends to biology and medicine.
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Donald T. Haynie, Central Michigan University
This inter-disciplinary guide to the thermodynamics of living organisms has been thoroughly revised and updated to provide a uniquely integrated overview of the subject. Retaining its highly readable style, it will serve as an introduction to the study of energy transformation in the life sciences and particularly as an accessible means for biology, biochemistry and bioengineering undergraduate students to acquaint themselves with the physical dimension of their subject. The emphasis throughout the text is on understanding basic concepts and developing problem-solving skills. The mathematical difficulty increases gradually by chapter, but no calculus is required. Topics covered include energy and its transformation, the First Law of Thermodynamics, Gibbs free energy, statistical thermodynamics, binding equilibria and reaction kinetics. Each chapter comprises numerous illustrative examples taken from different areas of biochemistry, as well as a broad range of exercises and references for further study.
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Bernhard O. Palsson, University of California, San Diego
Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The new discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook describes how to model networks, determine their properties, and relate these to phenotypic functions. Some knowledge of linear algebra and biochemistry is required, since the book reflects the irreversible trend of increasing mathematical content in biology education.
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Igor N. Serdyuk, Institue of Protein Research, Moscow
Nathan R. Zaccai, University of Bristol
Joseph Zaccai, Institut de Biologie Structurale, Grenoble
Our knowledge of biological macromolecules and their interactions is based on the application of physical methods, ranging from classical thermodynamics to recently developed techniques for the detection and manipulation of single molecules. These methods, which include mass spectrometry, hydrodynamics, microscopy, diffraction and crystallography, electron microscopy, molecular dynamics simulations, and nuclear magnetic resonance, are complementary; each has its specific advantages and limitations. Organised by method, this textbook provides descriptions and examples of applications for the key physical methods in modern biology. It is an invaluable resource for undergraduate and graduate students of molecular biophysics in science and medical schools, as well as research scientists looking for an introduction to techniques beyond their specialty. As appropriate for this interdisciplinary field, the book includes short asides to explain physics aspects to biologists and biology aspects to physicists.
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Meyer B. Jackson
Providing advanced undergraduate and graduate students with a foundation in the basic concepts of biophysics, students who have taken physical chemistry and calculus courses will find this book an accessible and valuable aid in learning how these concepts can be used in biological research. The text provides a rigorous treatment of the fundamental theories in biophysics and illustrates their application with examples including protein folding, enzyme catalysis and ion channel permeation. Through these examples, students will gain an understanding of the general importance and broad applicability of biophysical principles to biological problems.
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David Boal, Simon Fraser University, British Columbia
Biological physics, the application of physics to provide an understanding of biological phenomenas, is a burgeoning, new inter-disciplinary subject. This text explores the physics behind the architecture of a cell's envelope and internal scaffolding, as well as the properties of its soft components. The analysis is performed within a consistent mathematical framework, although readers can navigate from the introductory material to biological applications without working through the intervening mathematics. The book includes applications and extensions handled through problems at the end of each chapter. This text is aimed at senior undergraduates and graduate students in science and biomedical engineering.
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Colin Ratledge, University of Hull
Bjorn Kristiansen, EU Biotech Consulting, Norway
Biotechnology's wide-ranging, multi-disciplinary activities include recombinant DNA techniques, cloning, and the application of microbiology to the production of goods from bread to antibiotics. In this new edition, biology and bioprocessing topics are uniquely combined to provide a complete overview of biotechnology. A distinctive feature of the text is the discussions of the public perception of biotechnology and the business of biotechnology, which set the science in a broader context. This comprehensive textbook is essential reading for all students of biotechnology and applied microbiology, and for researchers in biotechnology industries.
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