Programmed cell death or apoptosis is centrally involved in the pathogenesis of many significant human illnesses and injury states, including cancer, autoimmune disease, psoriasis, and other degenerative conditions. This 2005 book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies.
Preface; 1. Apoptosis in health, disease and therapy: overview and methodology Eric C. LaCasse, Martin Holcik, Robert G. Korneluk and Alex E. MacKenzie; 2. Developmental apoptosis Hyung Don Ryoo and Hermann Steller; 3. Apoptosis and cancer Erinn L. Soucie, Gerard Evan and Linda Z. Penn; 4. Neuronal cell death in human neurodegenerative diseases and their animal/cell models Lee J. Martin, Zhiping Liu, Juan Troncoso and Donald L. Price; 5. Apoptosis in the cardiovascular system: incidence, regulation and therapeutic options Martin R. Bennett; 6. Cytotoxic lymphocytes, apoptosis and autoimmunity Pere Santamaria and R. Chris Bleackley; 7. Pro- and anti-apoptotic strategies of viruses Helmut Fickenscher, Bernhard Fleckenstein and Armin Ensser.
"an interesting introduction to the field" - David R. Bell, University of Nottingham, UK