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Optogenetics
From Neuronal Function to Mapping and Disease Biology

£125.00

Georg Nagel, Krishnarao Appasani, Raghu K. Appasani, Boris V. Zemelman, Koutarou D. Kimura, Karl Emanuel Busch, Jatin Nagpal, Dany Adams Ai-Sun Tseng, Michael Levin, Vitaly Shevchenko, Ivan Gushchin, Vitaly Polovinkin, Kirill Kovalev, Taras Balandin, Valentin Borshchevskiy, Valentin Gordeliy, Yonatan Katz, Ilan Lampl, Olga Malyshevskaya, Nobuhiko Yamamoto, Christian Renicke, Christof Taxis, Marc Folcher, Ute Hochgeschwender, William F. Kaemmerer, Anja G. Teschemacher, Sergey Kasparov, Yan Tang, Jérôme Wahis, Meggane Melchior, Valery Grinevich, Alexandre Charlet, Alexander M. Herman, Jay M. Patel, Benjamin R. Arenkiel, Michael Kohl, Dennis Kaetzel, Andrea L. Gutman, Ryan T. LaLumiere, Barbara Juarez, Allyson K. Friedman, Ming-Hu Han, Adam C. G. Crego, Stephen E. Chang, William N. Butler, Kyle S. Smith, Jan Tonnensen, Marco Ledri, Merab Kokaia, J. Barney Bryson, Linda Greensmith, Dasha Nelidova, Federico Esposti, Sonja Kleinlogel, Grégory Gauvain, Antoine Chaffiol, Jens Duebel, Serge A. Picaud, Adi Schejter Bar-Noam, Inna Gefen, Shy Shoham, Hiroshi Tomita, Eriko Sugano, Priyamvada Rajasethupathy, Charles-Francois Vincent Latchoumane, Hee-Sup Shin, Jenny X. Chen, Elliott Kozin, Christian Brown, Daniel J. Lee, Victor Hugo Hernandez Gonzalez, Tobias Moser, Joan Fallon, Sabine Müller, Henrik Walter
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  • Date Published: April 2017
  • availability: In stock
  • format: Hardback
  • isbn: 9781107053014

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  • Discovered little more than a decade ago, optogenetics - a revolutionary technique combining genetic and optical methods to observe and control the function of neurons - is now a widely used research tool. Optogenetics-driven research has led to insights into Parkinson's disease and other neurological and psychiatric disorders. With contributions from leaders and innovators from both academia and industry, this volume explores the discovery and application of optogenetics, from the basic science to its potential clinical use. Chapters cover a range of optogenetics applications, including for brain circuits, plasticity, memory, learning, sleep, vision and neurodegenerative and neuropsychiatric diseases. Providing authoritative coverage of the huge potential that optogenetics research carries, this is an ideal resource for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries and in a clinical setting.

    • The first text to examine in full the discovery and application of optogenetics techniques, from the basic science to potential clinical use
    • Features contributions from experts from both academia and industry, covering the use of optogenetics in model organisms, opsin biological tools, and applications in neurobiology and neurodegenerative diseases
    • Places special emphasis on the development of a new generation of tools for the in vivo imaging of learning, neuro-psychiatric diseases and behavior
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    Reviews & endorsements

    'Optogenetics has transformed neuroscience and has become a key element of the toolkit used by thousands of labs worldwide. If anyone needs convincing that the field of optogenetics has come of age, this book provides compelling evidence. Written by leading experts in the field and covering the gamut of optogenetics research from tool development and use in basic research through to translational applications, Optogenetics exemplifies how this technique now illuminates all areas of neuroscience research.' Michael Hausser, University College London,

    ''Let there be light'. Or more precisely, deliver the needed wavelength at appropriate power, with high temporal and spatial resolution if you want to figure out how brain circuits work. This volume has many excellent chapters and the right toolbox for the job.' György Buzsáki, Neuroscience Institute and Langone Medical Center, New York University

    'Optogenetics is a unique compilation of articles by some of the key experts in the field covering the entire breadth of topics from molecular mechanisms, via hands-on application tips all the way to clinical use and ethical implications as well as a detailed and accurate historical perspective. For this still rapidly developing field it will become a must-read and core reference for novices and experts alike.' Andreas Schaefer, he Francis Crick Institute, London

    'Both the expert and novice, alike, will find this to be a valuable resource that covers multiple aspects of the Optogenetics field, from its history through to current scientific and potential clinical applications.' Michelle M. Sidor, Novartis Institutes for Biomedical Research, Massachusetts

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    Product details

    • Date Published: April 2017
    • format: Hardback
    • isbn: 9781107053014
    • length: 502 pages
    • dimensions: 253 x 179 x 29 mm
    • weight: 1.2kg
    • contains: 65 b/w illus. 37 colour illus. 6 tables
    • availability: In stock
  • Table of Contents

    List of contributors
    Foreword
    Preface
    List of abbreviations
    Part I. Optogenetics in Model Organisms:
    1. Introduction to optogenetics: from neuronal function to mapping and disease biology
    2. Uncovering key neurons for manipulation in mammals
    3. From connectome to function: using optogenetics to shed light on the Caenorhabditis elegans nervous system
    4. From synapse to behaviour: optogenetic tools for investigation of the Caenorhabditis elegans nervous system
    5. Using optogenetics in vivo to stimulate regeneration in Xenopus laevis
    Part II. Opsin Biology, Tools and Technology Platform:
    6. Sodium and engineered potassium light-driven pumps
    7. Simultaneous electrophysiology and optogenetic stimulation methods
    8. Role of electrical activity in horizontal axon growth in the developing cortex: a time-lapse study using optogenetic stimulation
    9. Development of an optogenetic tool to regulate protein stability in vivo
    10. Photo-activatable nucleotide cyclases for synthetic photobiology applications
    11. Bioluminescence activation of light-sensing molecules
    Part III. Optogenetics in Neurobiology, Brain Circuits and Plasticity:
    12. Optogenetics for neurological disorders: what is a path to the clinic?
    13. Optogenetic control of astroglia
    14. Optogenetics for neurohormones and neuropeptides: focus on oxytocin
    15. Optogenetic approaches to investigate brain circuits
    16. Optogenetic mapping of neuronal connections and their plasticity
    Part IV. Optogenetics in Learning, Neuro-psychiatric Diseases and Behavior:
    17. Optogenetics to study reward learning and addiction
    18. Optogenetics and the dissection of neural circuits underlying depression and substance-use disorders
    19. Optogenetics research in behavioral neuroscience: insights into the brain basis of reward learning and goal-directed behavior
    20. An optogenetic approach to treat epilepsy
    21. Using optogenetics and stem cells-derived neural engraftment techniques to restore lost motor function
    Part V. Optogenetics in Vision Restoration and Memory:
    22. Optogenetics in treating retinal disease
    23. Optogenetics for vision recovery: from traditional to designer optogenetic tools
    24. A promise of vision restoration
    25. Holographic Optical Neural Interfacing (HONI) with retinal neurons
    26. Strategies for restoring vision by transducing a channelrhodopsin gene into retinal ganglion cells
    27. Optogenetic dissection of a top-down prefrontal-to-hippocampus memory circuit
    Part VI. Optogenetics in Sleep, Prosthetics and Epigenetics of Neurodegenerative Diseases:
    28. Optogenetic dissection of sleep-wake control: evidence for a thalamic control of sleep architecture
    29. Optogenetics and auditory implants
    30. Optogenetic stimulation for cochlear prosthetics
    31. The role of amino acids in neurodegenerative and addictive diseases
    32. Applications of combinations of deep brain stimulation and optogenetics: ethical considerations: an epilogue.

  • Editor

    Krishnarao Appasani, GeneExpression Systems, Inc., Massachusetts
    Krishnarao Appasani is the Founder and Chief Executive Officer of GeneExpression Systems, a global conference-producing organization focusing on biomedical and physical sciences. He is an award-winning scientist, Fellow of the Royal Society of Biology and the editor of Genome-Wide Association Studies: From Polymorphism to Personalized Medicine (2016), Epigenomics: From Chromatin Biology to Therapeutics (2012), MicroRNAs: From Basic Science to Disease Biology (2007) and RNA Interference: From Basic Science to Drug Development (2005), all published by Cambridge University Press.

    Contributors

    Georg Nagel, Krishnarao Appasani, Raghu K. Appasani, Boris V. Zemelman, Koutarou D. Kimura, Karl Emanuel Busch, Jatin Nagpal, Dany Adams Ai-Sun Tseng, Michael Levin, Vitaly Shevchenko, Ivan Gushchin, Vitaly Polovinkin, Kirill Kovalev, Taras Balandin, Valentin Borshchevskiy, Valentin Gordeliy, Yonatan Katz, Ilan Lampl, Olga Malyshevskaya, Nobuhiko Yamamoto, Christian Renicke, Christof Taxis, Marc Folcher, Ute Hochgeschwender, William F. Kaemmerer, Anja G. Teschemacher, Sergey Kasparov, Yan Tang, Jérôme Wahis, Meggane Melchior, Valery Grinevich, Alexandre Charlet, Alexander M. Herman, Jay M. Patel, Benjamin R. Arenkiel, Michael Kohl, Dennis Kaetzel, Andrea L. Gutman, Ryan T. LaLumiere, Barbara Juarez, Allyson K. Friedman, Ming-Hu Han, Adam C. G. Crego, Stephen E. Chang, William N. Butler, Kyle S. Smith, Jan Tonnensen, Marco Ledri, Merab Kokaia, J. Barney Bryson, Linda Greensmith, Dasha Nelidova, Federico Esposti, Sonja Kleinlogel, Grégory Gauvain, Antoine Chaffiol, Jens Duebel, Serge A. Picaud, Adi Schejter Bar-Noam, Inna Gefen, Shy Shoham, Hiroshi Tomita, Eriko Sugano, Priyamvada Rajasethupathy, Charles-Francois Vincent Latchoumane, Hee-Sup Shin, Jenny X. Chen, Elliott Kozin, Christian Brown, Daniel J. Lee, Victor Hugo Hernandez Gonzalez, Tobias Moser, Joan Fallon, Sabine Müller, Henrik Walter

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