This chapter offers a practical guide to the medication management of attention-deficit hyperactivity disorder (ADHD) in adults from a clinical point of view. It discusses the opinions and fears about medication, and the impact of not treating ADHD with medication. The chapter also talks about psychoeducation and the motivational approach, the order of treatment, and available medications. It focuses on combining stimulants and other medications, set-up with stimulants atomoxetine, and bupropion XL. The chapter further talks about appropriate dosing, measuring efficacy, the frequency of control visits, and driving and stimulant use. Patients have to record their intake of substances before the start of and during medication treatment, until the physician and the patient agree on the data. Medication studies in adults with ADHD for the purpose of registration are ongoing, leading to more treatment options for adults with ADHD in other countries around the world.