Skip to main content Accessibility help
×
Home
Hostname: page-component-66d7dfc8f5-g2shf Total loading time: 6.448 Render date: 2023-02-08T15:56:12.835Z Has data issue: true Feature Flags: { "useRatesEcommerce": false } hasContentIssue true

Chapter 27 - Genetics of recurrent hypersomnia

from Section 5 - Narcolepsyand hypersomnias

Published online by Cambridge University Press:  05 November 2013

Paul Shaw
Affiliation:
University of Washington, St Louis
Mehdi Tafti
Affiliation:
University of Lausanne
Michael J. Thorpy
Affiliation:
Sleep-Wake Disorders Center, Albert Einstein College of Medicine, New York
Get access

Summary

This chapter reviews the genetics of Kleine-Levin syndrome (KLS) and menstrual-related hypersomnia (MRH). Up to now, two cases of monozygotic twins affected with KLS have been published. In the first case, the first-born twin showed a less typical form, in which there was no compulsive eating, but instead decreased eating. In the second case there was not such a difference as neither of the twins showed compulsive eating. Based on the recurrence of hypersomniac episodes, the frequent infectious precipitating factors at onset, the generally young age at onset and a marginally significant association with HLADQB1, an autoimmune etiology has been suggested. The autoimmune hypothesis, suggested by an initial human leukocyte antigen (HLA) association, does not seem to be replicated in larger population. Nevertheless, potential association between KLS and other autoimmune disorders might help a better understanding of implication of immune-related processes in the pathophysiology of KLS.
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)
1
Cited by

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×