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Chapter 16 - Treatment of Ovarian Hyperstimulation Syndrome

from Section 3 - Difficulties and Complications of Ovarian Stimulation and Implantation

Published online by Cambridge University Press:  14 April 2022

By
Mohamed Youssef ,
Abdel-Maguid Ramzy  and
Botros Rizk
Edited by
Mohamed Aboulghar  and
Botros Rizk
Mohamed Aboulghar
Affiliation:
University of Cairo IVF Centre
Botros Rizk
Affiliation:
University of South Alabama
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Summary

Although, ovarian hyperstimulation syndrome (OHSS) is the most serious iatrogenic complication of ovarian stimulation, the condition usually resolves within 14 days in women who are subjected to freeze-all embryos policy; meanwhile symptoms may extend through the first trimester in women who do become pregnant as endogenous human chorionic gonadotropin (hCG) levels continue to stimulate the ovaries. The exact pathophysiology and etiology of OHSS remains unknown, but increased capillary permeability with the resulting loss of fluid into the third space is common to the syndrome [1]. Administration of hCG for final follicle maturation and triggering of ovulation appears to be the pivotal stimulus in a susceptible patient, by releasing vasoactive–angiogenic substances such as vascular endothelial growth factor from the ovaries hyperstimulated with gonadotropins [2].

Type
Chapter
Information
Ovarian Stimulation , pp. 158 - 165
Publisher: Cambridge University Press
Print publication year: 2022

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References

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