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Section V - Iatrogenic hemorrhagic strokes: intracranial bleeding

Published online by Cambridge University Press:  20 October 2016

Edited by
Alexander Tsiskaridze ,
Arne Lindgren  and
Adnan I. Qureshi
Alexander Tsiskaridze
Affiliation:
Sarajishvili Institute of Neurology, Tblisi State University, Georgia
Arne Lindgren
Affiliation:
Department of Neurology, University Hospital Lund, Sweden
Adnan I. Qureshi
Affiliation:
Department of Neurology, University of Minnesota
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Treatment-Related Stroke
Including Iatrogenic and In-Hospital Strokes
 , pp. 169 - 184
Publisher: Cambridge University Press
Print publication year: 2016

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References

Qureshi, A I, Mendelow, A D, Hanley, D F. Intracerebral haemorrhage. Lancet. 2009; 373:1632–44.CrossRefGoogle ScholarPubMed
Trialists’ Collaboration. A collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. British Medical Journal. 2002; 324:71–86.CrossRefGoogle Scholar
Sudlow, C L M, Warlow, C P; International Stroke Incidence C. Comparable studies of the incidence of stroke and its pathological types: Results from an international collaboration. Stroke. 1997; 28:491–9.CrossRefGoogle ScholarPubMed
Carolei, A, Marini, C, Di Napoli, M, et al. High stroke incidence in the prospective community-based l’Aquila registry (1994–1998): First year’s results. Stroke. 1997; 28:2500–6.CrossRefGoogle ScholarPubMed
Dennis, M S. Outcome after brain haemorrhage. Cerebrovascular Diseases. 2003; 16(suppl 1):9–13.CrossRefGoogle ScholarPubMed
Kothari, R U, Brott, T, Broderick, J P, et al. The ABCs of measuring intracerebral hemorrhage volumes. Stroke. 1996; 27:1304–5.CrossRefGoogle ScholarPubMed
Broderick, J P, Brott, T G, Duldner, J E, Tomsick, T, Huster, G. Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality. Stroke. 1993; 24:987–93.CrossRefGoogle ScholarPubMed
Palareti, G, Leali, N, Coccheri, S, et al. Bleeding complications of oral anticoagulant treatment: An inception-cohort, prospective collaborative study (ISCOAT). Lancet. 1996; 348:423–8.CrossRefGoogle ScholarPubMed
Nicolini, A, Ghirarduzzi, A, Iorio, A, et al. Intracranial bleeding: Epidemiology and relationships with antithrombotic treatment in 241 cerebral hemorrhages in Reggio Emilia. Haematologica. 2002; 87:948–56.Google ScholarPubMed
Rosand, J, Eckman, M H, Knudsen, K A, Singer, D E, Greenberg, S M. The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Archives of Internal Medicine. 2004; 164:880–4.CrossRefGoogle ScholarPubMed
Campbell, P G, Sen, A, Yadla, S, Jabbour, P, Jallo, J. Emergency reversal of antiplatelet agents in patients presenting with an intracranial hemorrhage: A clinical review. World Neurosurgery. 2010; 74:279–85.CrossRefGoogle ScholarPubMed
Cantalapiedra, A, Gutierrez, O, Tortosa, J I, et al. Oral anticoagulant treatment: Risk factors involved in 500 intracranial hemorrhages. Journal of Thrombosis and Thrombolysis. 2006; 22:113–20.CrossRefGoogle ScholarPubMed
Caso, V, Paciaroni, M, Venti, M, et al. Effect of on-admission antiplatelet treatment on patients with cerebral hemorrhage. Cerebrovascular Diseases. 2007; 24:215–18.CrossRefGoogle ScholarPubMed
Foerch, C, Sitzer, M, Steinmetz, H, Neumann-Haefelin, T. Pretreatment with antiplatelet agents is not independently associated with unfavorable outcome in intracerebral hemorrhage. Stroke. 2006; 37:2165–7.CrossRefGoogle Scholar
Roquer, J, Campello, A R, Gomis, M, et al. Previous antiplatelet therapy is an independent predictor of 30-day mortality after spontaneous supratentorial intracerebral hemorrhage. Journal of Neurology. 2005; 252:412–16.CrossRefGoogle ScholarPubMed
Sansing, L H, Messe, S R, Cucchiara, B L, et al. Prior antiplatelet use does not affect hemorrhage growth or outcome after ICH. Neurology. 2009; 72:1397–402.CrossRefGoogle ScholarPubMed
Toyada, K, Okada, Y, Minematsu, K, et al. Antiplatelet therapy contributes to acute deterioration of intracerebral hemorrhage. Neurology. 2005; 65:1000–4.Google Scholar
Akbari, S H, Reynolds, M R, Kadkhodayan, Y, Cross, D T, Moran, C J. Hemorrhagic complications after prasugrel (Effient) therapy for vascular neurointerventional procedures. Journal of Neurointerventional Surgery. 2012.CrossRefGoogle Scholar
Broderick, J P, Diringer, M N, Hill, M D, et al. Determinants of intracerebral hemorrhage growth: an exploratory analysis. Stroke. 2007; 38:1072–5.CrossRefGoogle ScholarPubMed
Lacut, K, Le Gal, G, Seizeur, R, et al. Antiplatelet drug use preceding the onset of intracerebral hemorrhage is associated with increased mortality. Fundamental & Clinical Pharmacology. 2007; 21:327–33.CrossRefGoogle ScholarPubMed
Roquer, J. Previous antiplatelet treatment and mortality in patients with intracerebral hemorrhage. Stroke. 2007; 38:863.CrossRefGoogle ScholarPubMed
Sorimachi, T, Fujii, Y, Morita, K, Tanaka, R. Predictors of hematoma enlargement in patients with intracerebral hemorrhage treated with rapid administration of antifibrinolytic agents and strict blood pressure control. Journal of Neurosurgery. 2007; 106:250–4.CrossRefGoogle ScholarPubMed
Thrift, A G, McNeil, J J, Forbes, A, Donnan, G A. Risk of primary intracerebral haemorrhage associated with aspirin and non-steroidal anti-inflammatory drugs: Case-control study. British Medical Journal. 1999; 318:759–64.CrossRefGoogle ScholarPubMed
Hart, R G, Tonarelli, S B, Pearce, L A. Avoiding central nervous system bleeding during antithrombotic therapy: recent data and ideas. Stroke. 2005; 36:1588–93.CrossRefGoogle ScholarPubMed
Hennekens, C. Final report on the aspirin component of the ongoing physicians health study. New England Journal of Medicine. 1989; 321:129–35.Google Scholar
The SALT Collaborative Group. Swedish Aspirin Low-dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. Lancet. 1991; 338:1345–19.Google Scholar
He, J, Whelton, P, Vu, B, Klag, M. Aspirin and risk of hemorrhagic stroke. Journal of the American Medical Association. 1998; 280:1930–5.Google ScholarPubMed
Sudlow, C. Antithrombotic Treatment: Clinical Evidence. London: BMJ Publishing Group; 2001.Google Scholar
Thrift, A G, McNeil, J J, Forbes, A, Donnan, G A. Risk of primary intracerebral haemorrhage associated with aspirin and non-steroidal anti-inflammatory drugs: Case-control study. British Medical Journal. 1999; 318:759.CrossRefGoogle ScholarPubMed
Baldi, G, Altomonte, F, Altomonte, M, et al. Intracranial haemorrhage in patients on antithrombotics: Clinical presentation and determinants of outcome in a prospective multicentric study in Italian emergency departments. Cerebrovascular Diseases. 2006; 22:286–93.CrossRefGoogle Scholar
Connolly, B J, Pearce, L A, Kurth, T, Kase, C S, Hart, R G. Aspirin therapy and risk of subdural hematoma: Meta-analysis of randomized clinical trials. Journal of Stroke and Cerebrovascular Diseases. 2013.CrossRefGoogle Scholar
Hass, W K, Easton, J D, Adams, H P Jr, et al. Ticlopidine Aspirin Stroke Study Group. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. New England Journal of Medicine. 1989; 321:501–7.CrossRefGoogle ScholarPubMed
Gent, M, Donald Easton, J, Hachinski, V, et al. The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet. 1989; 333:1215–20.CrossRefGoogle Scholar
Montalescot, G, Wiviott, S D, Braunwald, E, et al. Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (triton-timi 38): Double-blind, randomised controlled trial. Lancet. 2009; 373:723–31.CrossRefGoogle ScholarPubMed
Becker, R C, Bassand, J P, Budaj, A, et al. Bleeding complications with the p2y12 receptor antagonists clopidogrel and ticagrelor in the Platelet Inhibition and Patient Outcomes (PLATO) trial. European Heart Journal. 2011; ehr422.CrossRefGoogle Scholar
Cordina, S M, Hassan, A E, Ezzeddine, M A. Prevalence and clinical characteristics of intracerebral hemorrhages associated with clopidogrel. Journal of Vascular and Interventional Neurology. 2009; 2:136.Google ScholarPubMed
Weber, A A, Braun, M, Hohlfeld, T, et al. Recovery of platelet function after discontinuation of clopidogrel treatment in healthy volunteers. British Journal of Clinical Pharmacology. 2001; 52:333–6.CrossRefGoogle ScholarPubMed
Gent, M, Beaumont, D, Blanchard, J, et al. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet. 1996; 348:1329–39.Google Scholar
Diener, H-C, Sacco, R L, Yusuf, S, et al. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the prevention regimen for effectively avoiding second strokes (PROFESS) trial: A double-blind, active and placebo-controlled study. Lancet Neurology. 2008; 7:875–84.CrossRefGoogle Scholar
Sacco, R L, Diener, H-C, Yusuf, S, et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. New England Journal of Medicine. 2008; 359:1238–51.CrossRefGoogle ScholarPubMed
Campbell, P G, Yadla, S, Sen, A N, Jallo, J, Jabbour, P. Emergency reversal of clopidogrel in the setting of spontaneous intracerebral hemorrhage. World Neurosurgery. 2011; 76:100–4.CrossRefGoogle ScholarPubMed
Naidech, A M, Bendok, B R, Garg, R K, et al. Reduced platelet activity is associated with more intraventricular hemorrhage. Neurosurgery. 2009; 65:684–8.CrossRefGoogle ScholarPubMed
Naidech, A M, Bernstein, R A, Levasseur, K, et al. Platelet activity and outcome after intracerebral hemorrhage. Annals of Neurology. 2009; 65:352–6.CrossRefGoogle ScholarPubMed
Naidech, A M, Jovanovic, B, Liebling, S, et al. Reduced platelet activity is associated with early clot growth and worse 3-month outcome after intracerebral hemorrhage. Stroke. 2009; 40:2398–401.CrossRefGoogle ScholarPubMed
Berger, P B, Bhatt, D L, Fuster, V, et al. Bleeding complications with dual antiplatelet therapy among patients with stable vascular disease or risk factors for vascular disease: results from the clopidogrel for high atherothrombotic risk and ischemic stabilization, management, and avoidance (CHARISMA) trial. Circulation. 2010; 121:2575–83.CrossRefGoogle ScholarPubMed
Diener, H-C, Bogousslavsky, J, Brass, L M, et al. Aspirin and Clopidogrel Compared with Clopidogrel Alone after Recent Ischaemic Stroke or Transient Ischaemic Attack in High-risk Patients (MATCH): Randomised, double-blind, placebo-controlled trial. Lancet. 2004; 364:331–7.CrossRefGoogle ScholarPubMed
Kennedy, J, Hill, M D, Ryckborst, K J, et al. Fast Assessment of Stroke and Transient Ischaemic Attack to Prevent Early Recurrence (FASTER): A randomised controlled pilot trial. Lancet Neurology. 2007; 6:961–9.CrossRefGoogle ScholarPubMed
Wang, Y, Wang, Y, Zhao, X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. New England Journal of Medicine. 2013; 369:11–19.CrossRefGoogle ScholarPubMed
Johnston, S C, Easton, J D, Farrant, M, et al. Platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trial: rationale and design. International Journal of Stroke. 2013; 8:479–83.CrossRefGoogle ScholarPubMed
Benavente, O R, White, C L, Pearce, L, et al. The Secondary Prevention of Small Subcortical Strokes (SPS3) study. International Journal of Stroke. 2011; 6:164–75.CrossRefGoogle ScholarPubMed
Chimowitz, M I, Lynn, M J, Derdeyn, C P, et al. Stenting versus aggressive medical therapy for intracranial arterial stenosis. New England Journal of Medicine. 2011; 365:993–1003.CrossRefGoogle ScholarPubMed
Wong, K S L, Chen, C, Fu, J, et al. Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): A randomised, open-label, blinded-endpoint trial. Lancet Neurology. 2010; 9:489–97.CrossRefGoogle ScholarPubMed
Wang, Y, Wang, Y, Zhao, X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. New England Journal of Medicine. 2013; 369:11–19.CrossRefGoogle ScholarPubMed
Geeganage, C M, Diener, H-C, Algra, A, et al. Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: systematic review and meta-analysis of randomized controlled trials. Stroke. 2012; 43:1058–66.CrossRefGoogle ScholarPubMed
Markus, H S, Droste, D W, Kaps, M, et al. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using Doppler embolic signal detection: the clopidogrel and aspirin for reduction of emboli in symptomatic carotid stenosis (CARESS) trial. Circulation. 2005; 111:2233–40.CrossRefGoogle ScholarPubMed
Connolly, S J, Pogue, J, Hart, R G, et al. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. New England Journal of Medicine. 2009; 360:2066–78.Google ScholarPubMed
Connolly, S, Pogue, J, Hart, R, et al. Active writing group of the active investigators. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (Active W): A randomised controlled trial. Lancet. 2006; 367:1903–12.Google Scholar
Nurden, A T, Poujol, C, Durrieu-Jais, C, Nurden, P. Platelet glycoprotein IIb/IIIa inhibitors: basic and clinical aspects. Arteriosclerosis, Thrombosis, and Vascular Biology. 1999; 19:2835–40.CrossRefGoogle ScholarPubMed
The Epic I. Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. New England Journal of Medicine. 1994; 330:956–61.Google Scholar
The EPILOG Investigators. Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization. New England Journal of Medicine. 1997; 336:1689–97.Google Scholar
Lincoff, A M, Califf, R M, Anderson, K M, et al. Evidence for prevention of death and myocardial infarction with platelet membrane glycoprotein IIb/IIIa receptor blockade by abciximab (c7e3 Fab) among patients with unstable angina undergoing percutaneous coronary revascularization. Journal of the American College of Cardiology. 1997; 30:149–56.CrossRefGoogle ScholarPubMed
Qureshi, A I. Adjunctive use of platelet glycoprotein IIb/IIIa inhibitors for carotid angioplasty and stent placement: Time to say good bye? Journal of Endovascular Therapy. 2003; 10:42–4.CrossRefGoogle ScholarPubMed
Velat, G J, Burry, M V, Eskioglu, E, et al. The use of abciximab in the treatment of acute cerebral thromboembolic events during neuroendovascular procedures. Surgical Neurology. 2006; 65:352–8.CrossRefGoogle ScholarPubMed
Deshmukh, V R, Fiorella, D J, Albuquerque, F C, et al. Intra-arterial thrombolysis for acute ischemic stroke: Preliminary experience with platelet glycoprotein IIb/IIIa inhibitors as adjunctive therapy. Neurosurgery. 2005; 56.CrossRefGoogle ScholarPubMed
Qureshi, A I, Siddiqui, A M, Hanel, R A, et al. Safety of high-dose intravenous eptifibatide as an adjunct to internal carotid artery angioplasty and stent placement: A prospective registry. Neurosurgery. 2004; 54.CrossRefGoogle Scholar
Qureshi, A I, Saad, M, Zaidat, O O, et al. Intracerebral hemorrhages associated with neurointerventional procedures using a combination of antithrombotic agents including abciximab. Stroke. 2002; 33:1916–19.CrossRefGoogle ScholarPubMed
Kellert, L, Hametner, C, Rohde, S, et al. Endovascular stroke therapy tirofiban is associated with risk of fatal intracerebral hemorrhage and poor outcome. Stroke. 2013; 44:1453–5.Google ScholarPubMed
Gotoh, F, Tohgi, H, Hirai, S, et al. Cilostazol stroke prevention study: A placebo-controlled double-blind trial for secondary prevention of cerebral infarction. Journal of Stroke and Cerebrovascular Diseases. 2000; 9:147–57.CrossRefGoogle ScholarPubMed
Goto, S. Cilostazol: Potential mechanism of action for antithrombotic effects accompanied by a low rate of bleeding. Atherosclerosis Supplements. 2005; 6:3–11.CrossRefGoogle ScholarPubMed
Gorter, J. Major bleeding during anticoagulation after cerebral ischemia patterns and risk factors. Neurology. 1999; 53:1319.CrossRefGoogle ScholarPubMed
Smith, E, Rosand, J, Knudsen, K, Hylek, E, Greenberg, S. Leukoaraiosis is associated with warfarin-related hemorrhage following ischemic stroke. Neurology. 2002; 59:193–7.CrossRefGoogle ScholarPubMed
Werring, D, Coward, L, Losseff, N, Jäger, H, Brown, M. Cerebral microbleeds are common in ischemic stroke but rare in TIA. Neurology. 2005; 65:1914–18.CrossRefGoogle ScholarPubMed
Vernooij, M, Van Der Lugt, A, Ikram, M, et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology. 2008; 70:1208–14.CrossRefGoogle ScholarPubMed
Greenberg, S M, Eng, J A, Ning, M, Smith, E E, Rosand, J. Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke. 2004; 35:1415–20.CrossRefGoogle ScholarPubMed
Jeon, S-B, Kang, D-W, Lee, E-M, et al. Initial microbleeds at MR imaging can predict recurrent intracerebral hemorrhage. Journal of Neurology. 2007; 254:508–12.CrossRefGoogle ScholarPubMed
Vernooij, M W, Haag, M D, van der Lugt, A, et al. Use of antithrombotic drugs and the presence of cerebral microbleeds: The Rotterdam scan study. Archives of Neurology. 2009.CrossRefGoogle Scholar
Soo, Y O, Yang, S R, Lam, W W, et al. Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds. Journal of Neurology. 2008; 255:1679–86.CrossRefGoogle ScholarPubMed
Wintzen, A, De Jonge, H, Loeliger, E, Bots, G. The risk of intracerebral hemorrhage during oral anticoagulant treatment: A population study. Annals of Neurology. 1984; 16:553–8.CrossRefGoogle ScholarPubMed
Greenberg, S M. Cerebral amyloid angiopathy: prospects for clinical diagnosis and treatment. Neurology. 1998; 51:690–4.CrossRefGoogle ScholarPubMed
Rosand, J, Hylek, E M, O’Donnell, H C, Greenberg, S M. Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study. Neurology. 2000; 55:947–51.CrossRefGoogle ScholarPubMed
Wong, K, Mok, V, Lam, W, et al. Aspirin-associated intracerebral hemorrhage: clinical and radiologic features. Neurology. 2000; 54:2298–301.CrossRefGoogle ScholarPubMed
Gregoire, S M, Jäger, H, Yousry, T A, et al. Brain microbleeds as a potential risk factor for antiplatelet-related intracerebral haemorrhage: Hospital-based, case-control study. Journal of Neurology, Neurosurgery & Psychiatry. 2010; 81:679–84.CrossRefGoogle ScholarPubMed
Buresly, K, Eisenberg, M J, Zhang, X, Pilote, L. Bleeding complications associated with combinations of aspirin, thienopyridine derivatives, and warfarin in elderly patients following acute myocardial infarction. Archives of Internal Medicine. 2005; 165:784.CrossRefGoogle ScholarPubMed
Dale, J, Myhre, E, Storstein, O, Stormorken, H, Efskind, L. Prevention of arterial thromboembolism with acetylsalicylic acid: A controlled clinical study in patients with aortic ball valves. American Heart Journal. 1977; 94:101–11.CrossRefGoogle ScholarPubMed
Hansen, M L, Sorensen, R, Clausen, M T, et al. Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. Archives of Internal Medicine. 2010; 170:1433.CrossRefGoogle ScholarPubMed
Rodgers, R P, Levin, J. A critical reappraisal of the bleeding time. Semin Thromb Hemost. 1990; 16:1–20.CrossRefGoogle ScholarPubMed
Yardumian, D A, Mackie, I J, Machin, S J. Laboratory investigation of platelet function: A review of methodology. Journal of Clinical Pathology. 1986; 39:701–12.CrossRefGoogle ScholarPubMed
Davidson, J F, Colvin, B T, Barrowcliffe, T W, et al. The British Society for Haematology Hemostasis and Thrombosis Task-force. Guidelines on platelet-function testing. Journal of Clinical Pathology. 1988; 41:1322–30.Google Scholar
Seidel, H, Rahman, M M, Scharf, R E. Monitoring of antiplatelet therapy. Current limitations, challenges, and perspectives. Hamostaseologie. 2011; 31:41–51.CrossRefGoogle ScholarPubMed
Breet, N J, van Werkum, J W, Bouman, H J, et al. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. Journal of the American Medical Association. 2010; 303:754–62.Google ScholarPubMed
Sibbing, D, Schulz, S, Braun, S, et al. Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement. Journal of Thrombosis and Haemostasis. 2010; 8:250–6.CrossRefGoogle ScholarPubMed
Godino, C, Mendolicchio, L, Figini, F, et al. Comparison of Verifynow-p2y. Thrombosis Journal. 2009; 7:4.CrossRefGoogle Scholar
Jakubowski, J A, Li, Y G, Small, D S, et al. A comparison of the Verifynow p2y12 point-of-care device and light transmission aggregometry to monitor platelet function with prasugrel and clopidogrel: An integrated analysis. Journal of Cardiovascular Pharmacology. 2010; 56:29–37.CrossRefGoogle ScholarPubMed
Mangiacapra, F, Patti, G, Peace, A, et al. Comparison of platelet reactivity and periprocedural outcomes in patients with versus without diabetes mellitus and treated with clopidogrel and percutaneous coronary intervention. American Journal of Cardiology. 2010; 106:619–23.CrossRefGoogle ScholarPubMed
Ozben, S, Ozben, B, Tanrikulu, A M, Ozer, F, Ozben, T. Aspirin resistance in patients with acute ischemic stroke. Journal of Neurology. 2011; 258:1979–86.CrossRefGoogle ScholarPubMed
Paniccia, R, Antonucci, E, Gori, A M, et al. Different methodologies for evaluating the effect of clopidogrel on platelet function in high‐risk coronary artery disease patients. Journal of Thrombosis and Haemostasis. 2007; 5:1839–47.CrossRefGoogle ScholarPubMed
Paniccia, R, Antonucci, E, Maggini, N, et al. Comparison of methods for monitoring residual platelet reactivity after clopidogrel by point-of-care tests on whole blood in high-risk patients. Thrombosis & Haemostasis. 2010; 104:287.Google ScholarPubMed
Altman, R, Scazziota, A, De Lourdes Herrera, M, Gonzalez, C. Recombinant factor VIIa reverses the inhibitory effect of aspirin or aspirin plus clopidogrel on in vitro thrombin generation. Journal of Thrombosis and Haemostasis. 2006; 4:2022–7.CrossRefGoogle ScholarPubMed
Flordal, P A, Sahlin, S. Use of desmopressin to prevent bleeding complications in patients treated with aspirin. British Journal of Surgery. 1993; 80:723–4.CrossRefGoogle ScholarPubMed
Gratz, I, Koehler, J, Olsen, D, et al. The effect of desmopressin acetate on postoperative hemorrhage in patients receiving aspirin therapy before coronary artery bypass operations. Journal of Thoracic and Cardiovascular Surgery. 1992; 104:1417–22.CrossRefGoogle ScholarPubMed
James, R F, Palys, V, Lomboy, J R, Lamm, J R Jr, Simon, S D. The role of anticoagulants, antiplatelet agents, and their reversal strategies in the management of intracerebral hemorrhage. Neurosurgical Focus. 2013; 34:E6.CrossRefGoogle ScholarPubMed
Gayle, J A, Kaye, A D, Kaye, A M, Shah, R. Anticoagulants: Newer ones, mechanisms, and perioperative updates. Anesthesiology Clinics. 2010; 28:667–79.CrossRefGoogle ScholarPubMed
Horwitz, P A, Berlin, J A, Sauer, W H, et al. Bleeding risk of platelet glycoprotein IIb/IIIa receptor antagonists in broad-based practice (results from the Society for Cardiac Angiography and Interventions Registry). American Journal of Cardiology. 2003; 91:803–6.CrossRefGoogle Scholar
Ducruet, A F, Hickman, Z L, Zacharia, B E, et al. Impact of platelet transfusion on hematoma expansion in patients receiving antiplatelet agents before intracerebral hemorrhage. Neurological Research. 2010; 32:706–10.CrossRefGoogle ScholarPubMed
Nishijima, D K, Zehtabchi, S, Berrong, J, Legome, E. Utility of platelet transfusion in adult patients with traumatic intracranial hemorrhage and preinjury antiplatelet use: A systematic review. Journal of Trauma and Acute Care Surgery. 2012; 72.CrossRefGoogle ScholarPubMed
Batchelor, J S, Grayson, A. A meta-analysis to determine the effect on survival of platelet transfusions in patients with either spontaneous or traumatic antiplatelet medication-associated intracranial haemorrhage. BMJ Open. 2012; 2.CrossRefGoogle ScholarPubMed
de Gans, K, de Haan, R J, Majoie, C B, et al. PATCH: Platelet Transfusion in Cerebral Haemorrhage: Study protocol for a multicentre, randomised, controlled trial. BMC Neurology. 2010; 10:19.CrossRefGoogle ScholarPubMed
Qureshi, A I. Intracerebral hemorrhage specific intensity of care quality metrics. Neurocritical Care. 2011; 14:291–317.CrossRefGoogle ScholarPubMed
Baker, R I, Coughlin, P B, Gallus, A S, et al. Warfarin reversal: Consensus guidelines on behalf of the Australasian Society of Thrombosis and Haemostasis. Medical Journal of Australia. 2004; 181:492–7.CrossRefGoogle Scholar
Jr. Pollack, C V, Reilly, P A, Eikelboom, J, et al. Idamcizumab for dabigatran reversal. New England Journal of Medicine. 2015; 373:511–20.CrossRefGoogle ScholarPubMed
Kazui, S, Minematsu, K, Yamamoto, H, Sawada, T, Yamaguchi, T. Predisposing factors to enlargement of spontaneous intracerebral hematoma. Stroke. 1997; 28:2370–5.CrossRefGoogle ScholarPubMed
Dandapani, B K, Suzuki, S, Kelley, R E, Reyes-Iglesias, Y, Duncan, R C. Relation between blood pressure and outcome in intracerebral hemorrhage. Stroke. 1995; 26:21–4.CrossRefGoogle ScholarPubMed
Vemmos, K N, Tsivgoulis, G, Spengos, K, et al. Association between 24-h blood pressure monitoring variables and brain oedema in patients with hyperacute stroke. Journal of Hypertension. 2003; 21:2167–73.CrossRefGoogle ScholarPubMed
Anderson, C S, Huang, Y, Wang, J G, et al. Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT): A randomised pilot trial. Lancet Neurology. 2008; 7:391–9.CrossRefGoogle ScholarPubMed
Qureshi, A I. Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH). Neurocritical Care. 2007; 6:56–66.CrossRefGoogle ScholarPubMed
Butcher, K S, Jeerakathil, T, Hill, M, et al. The intracerebral hemorrhage acutely decreasing arterial pressure trial. Stroke. 2013; 44:620–6.CrossRefGoogle ScholarPubMed
Ropper, A H. Lateral displacement of the brain and level of consciousness in patients with an acute hemispheral mass. New England Journal of Medicine. 1986; 314:953–8.CrossRefGoogle ScholarPubMed
Vespa, P M, O’Phelan, K, Shah, M, et al. Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology. 2003; 60:1441–6.CrossRefGoogle ScholarPubMed
Qureshi, A I. Acute hypertensive response in patients with stroke pathophysiology and management. Circulation. 2008; 118:176–87.CrossRefGoogle ScholarPubMed
Lee, S H, Kim, B J, Bae, H J, et al. Effects of glucose level on early and long-term mortality after intracerebral haemorrhage: The acute brain bleeding analysis study. Diabetologia. 2010; 53:429–34.CrossRefGoogle ScholarPubMed
Reith, J, Jorgensen, H S, Pedersen, P M, et al. Body temperature in acute stroke: Relation to stroke severity, infarct size, mortality, and outcome. Lancet. 1996; 347:422–5.CrossRefGoogle ScholarPubMed
Chastre, J, Wolff, M, Fagon, J-Y, et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: A randomized trial. Journal of the American Medical Association. 2003; 290:2588–98.Google ScholarPubMed
Ogata, T, Yasaka, M, Wakugawa, Y, et al. Deep venous thrombosis after acute intracerebral hemorrhage. Journal of the Neurological Sciences. 2008; 272:83–6.CrossRefGoogle ScholarPubMed
Boeer, A, Voth, E, Henze, T H, Prange, H W. Early heparin therapy in patients with spontaneous intracerebral haemorrhage. Journal of Neurology, Neurosurgery & Psychiatry. 1991; 54:466–7.CrossRefGoogle ScholarPubMed
Tetri, S, Hakala, J, Juvela, S, et al. Safety of low-dose subcutaneous enoxaparin for the prevention of venous thromboembolism after primary intracerebral haemorrhage. Thrombosis Research. 2008; 123:206–12.CrossRefGoogle ScholarPubMed
Misra, U K, Kalita, J, Pandey, S, Mandal, S K, Srivastava, M. A randomized placebo controlled trial of ranitidine versus sucralfate in patients with spontaneous intracerebral hemorrhage for prevention of gastric hemorrhage. Journal of the Neurological Sciences. 2005; 239:5–10.CrossRefGoogle ScholarPubMed
Eddleston, J M, Pearson, R C, Holland, J, et al. Prospective endoscopic study of stress erosions and ulcers in critically ill adult patients treated with either sucralfate or placebo. Critical Care Medicine. 1994; 22:1949–54.CrossRefGoogle ScholarPubMed
Finestone, H M, Greene-Finestone, L S, Wilson, E S, Teasell, R W. Prolonged length of stay and reduced functional improvement rate in malnourished stroke rehabilitation patients. Archives of Physical Medicine and Rehabilitation. 1996; 77:340–5.CrossRefGoogle ScholarPubMed
Qureshi, A I, Suarez, J I, Parekh, P D, Bhardwaj, A. Prediction and timing of tracheostomy in patients with infratentorial lesions requiring mechanical ventilatory support. Critical Care Medicine. 2000; 28:1383–7.CrossRefGoogle ScholarPubMed
Griffiths, J, Barber, V S, Morgan, L, Young, J D. Systematic review and meta-analysis of studies of the timing of tracheostomy in adult patients undergoing artificial ventilation. British Medical Journal. 2005; 330:1243.CrossRefGoogle ScholarPubMed
Dennis, M S, Lewis, S C, Warlow, C. Routine oral nutritional supplementation for stroke patients in hospital (food): A multicentre randomised controlled trial. Lancet. 2005; 365:755–63.Google ScholarPubMed
Hemphill, J C 3rd, White, D B. Clinical nihilism in neuroemergencies. Emergency Medicine Clinics of North America. 2009; 27:27–37.CrossRefGoogle ScholarPubMed

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