Brain Drug Targeting: The Future of Brain Drug Development

William M. Pardridge

doi:10.1017/CBO9780511549571

The thesis of this innovative and challenging book, first published in 2001, is that brain drug development has been restricted by the failure of adequate brain drug targeting, and that this is an increasingly urgent problem as developments in genomics lead to new generations of therapeutic macromolecules. The author, a world leader in the study of the blood-brain barrier and its clinical implications, reviews the field of neurotherapeutics from the point of view of drug targeting. He surveys the scientific and clinical basis of drug delivery across biological membranes, including topics such as genetically engineered trojan horses for drug targeting, antisense neurotherapeutics, and gene therapy of brain disorders. At a time when there are few significant new drug treatments in prospect for common neurological diseases, this authoritative review will encourage a wide range of clinicians and neuroscientists to reexamine the development and use of drugs in treating disorders of the central nervous system.

Review of the hardback:‘… a book that will become a standard on drug targeting to the brain … a must for everybody who works in the field of brain drug delivery in academia as well as in the pharmaceutical industry.’

W. Kamphorst - www.bmjbookshop.com

Review of the hardback:‘This book provides an extensive review of brain drug targeting of large molecules and will be a valuable reference to those interested in completing research in this field.’

Tejal Patel Source: Doody’s Health Sciences Book Review Journal

Review of the hardback:‘This is an excellent book to be expected from a major researcher in the field. The lucid text is illuminated by an eclectic mix of diagrams and plates that will have a broad appeal to a wide audience.’

A. Davenport Source: British Journal of Neurosurgery

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Brain Drug Targeting

The Future of Brain Drug Development

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Contents

Frontmatter
pp i-vi

Contents
pp vii-viii

Preface
pp ix-x

List of abbreviations
pp xi-xviii

1 - Drug targeting, drug discovery, and brain drug development
pp 1-12

2 - Invasive brain drug delivery
pp 13-35

3 - Lipid-mediated transport and carrier-mediated transport of small molecules
pp 36-81

4 - Receptor-mediated transcytosis of peptides
pp 82-125

5 - Vector discovery: genetically engineered Trojan horses for drug targeting
pp 126-154

6 - Linker strategies: the engineering of multifunctional drug formulations
pp 155-185

7 - Protein neurotherapeutics and peptide radiopharmaceuticals
pp 186-220

8 - Antisense neurotherapeutics and imaging gene expression in vivo
pp 221-250

9 - Gene therapy of the brain
pp 251-274

10 - Blood–brain barrier genomics
pp 275-300

References
pp 301-346

Index
pp 347-353

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The Future of Brain Drug Development

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