Skip to main content Accessibility help
×
Hostname: page-component-8448b6f56d-c4f8m Total loading time: 0 Render date: 2024-04-24T17:09:17.464Z Has data issue: false hasContentIssue false

Chapter 14 - Time-Resolved Fluorescence Resonance Energy Transfer Technologies in HTS

from Section Four - Chemical Genomics Assays and Screens

Published online by Cambridge University Press:  05 June 2012

Haian Fu
Affiliation:
Emory University, Atlanta
Get access

Summary

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Chemical Genomics , pp. 198 - 214
Publisher: Cambridge University Press
Print publication year: 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Centonze, V.E.Sun, M.Masuda, A.Gerritsen, H.Herman, B. 2003 Fluorescence resonance energy transfer imaging microscopyMethods Enzymol 360 542Google Scholar
Truong, KIkura, M 2001 The use of FRET imaging microscopy to detect protein-protein interactions and protein conformational changes in vivoCurr Opin Struct Biol 11 573Google Scholar
Wu, P.Brand, L. 1994 Resonance energy transfer: methods and applicationsAnal Biochem 218 1Google Scholar
Bazin, HPreaudat, MTrinquet, EMathis, G 2001 Homogeneous time resolved fluorescence resonance energy transfer using rare earth cryptates as a tool for probing molecular interactions in biologySpectrochim Acta A Mol Biomol Spectrosc 57 2197Google Scholar
Hemmila, ILaitala, V 2005 Progress in lanthanides as luminescent probesJ Fluoresc 15 529Google Scholar
Morrison, L.E 1988 Time-resolved detection of energy transfer: theory and application to immunoassaysAnal Biochem 174 101Google Scholar
Degorce, FCard, ASoh, STrinquet, EKnapik, G.PXie, B 2009 HTRF: A technology tailored for drug discovery – a review of theoretical aspects and recent applicationsCurr Chem Genomics 3 22Google Scholar
Mathis, G 1995 Probing molecular interactions with homogeneous techniques based on rare earth cryptates and fluorescence energy transferClin Chem 41 1391Google Scholar
Gingras, A.CRaught, BSonenberg, N 2001 Regulation of translation initiation by FRAP/mTORGenes Dev 15 807Google Scholar
Cencic, RYan, YPelletier, J 2007 Homogenous time resolved fluorescence assay to identify modulators of cap-dependent translation initiationComb Chem High Throughput Screen 10 181Google Scholar
Nakamura, KZawistowski, J.SHughes, M.ASexton, J.ZYeh, L.AJohnson, G.LScott, J.E 2008 Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of Phox/Bem1p (PB1) domain heterodimerizationJ Biomol Screen 13 396Google Scholar
Whitfield, JHarada, KBardelle, CStaddon, J.M 2003 High-throughput methods to detect dimerization of Bcl-2 family proteinsAnal Biochem 322 170Google Scholar
Kota, SScampavia, LSpicer, TBeeler, A.BTakahashi, VSnyder, J.KPorco, J.AHodder, PStrosberg, A.DA time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerizationAssay Drug Dev Technol 8 96
Milligan, GWilson, SLopez-Gimenez, J.F 2005 The specificity and molecular basis of alpha1-adrenoceptor and CXCR chemokine receptor dimerizationJ Mol Neurosci 26 161Google Scholar
Neckers, LIvy, S.P 2003 Heat shock protein 90Curr Opin Oncol 15 419Google Scholar
Workman, P 2003 Overview: translating Hsp90 biology into Hsp90 drugsCurr Cancer Drug Targets 3 297Google Scholar
Whitesell, LBagatell, RFalsey, R 2003 The stress response: implications for the clinical development of hsp90 inhibitorsCurr Cancer Drug Targets 3 349Google Scholar
Zhou, VHan, SBrinker, AKlock, HCaldwell, JGu, X.J 2004 A time-resolved fluorescence resonance energy transfer-based HTS assay and a surface plasmon resonance-based binding assay for heat shock protein 90 inhibitorsAnal Biochem 331 349Google Scholar
Sharif, OHu, HKlock, HHampton, E.NNigoghossian, EKnuth, M.WMatzen, JAnderson, PTrager, RUno, TGlynne, R.JAzarian, S.MCaldwell, J.SBrinker, A 2009 Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4Anal Biochem 392 162Google Scholar
Moore, K.JTurconi, SMiles-Williams, ADjaballah, HHurskainen, PHarrop, JMurray, K.JPope, A.J 1999 A homogenous 384-well high throughput screen for novel tumor necrosis factor receptor: ligand interactions using time resolved energy transferJ Biomol Screen 4 205Google Scholar
Hu, L.AZhou, THamman, B.DLiu, Q 2008 A homogeneous G protein-coupled receptor ligand binding assay based on time-resolved fluorescence resonance energy transferAssay Drug Dev Technol 6 543Google Scholar
Zhou, G.Cummings, R.Hermes, J.Moller, D.E. 2001 Use of homogeneous time-resolved fluorescence energy transfer in the measurement of nuclear receptor activationMethods 25 54Google Scholar
Gowda, KMarks, B.DZielinski, T.KOzers, M.S 2006 Development of a coactivator displacement assay for the orphan receptor estrogen-related receptor-gamma using time-resolved fluorescence resonance energy transferAnal Biochem 357 105Google Scholar
Gunther, J.R.Du, Y.Rhoden, E.Lewis, I.Revennaugh, B.Moore, T.W.Kim, S.H.Dingledine, R.Fu, H.Katzenellenbogen, J.A. 2009 A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator bindingJ Biomol Screen 14 181Google Scholar
Enomoto, KOkamoto, HNumata, YTakemoto, H 2006 A simple and rapid assay for heparanase activity using homogeneous time-resolved fluorescenceJ Pharm Biomed Anal 41 912Google Scholar
Ferrer, MZuck, PKolodin, GMao, S.SPeltier, R.RBailey, CGardell, S.JStrulovici, BInglese, J 2003 Miniaturizable homogenous time-resolved fluorescence assay for carboxypeptidase B activityAnal Biochem 317 94Google Scholar
Karvinen, JHurskainen, PGopalakrishnan, SBurns, DWarrior, UHemmila, I 2002 Homogeneous time-resolved fluorescence quenching assay (LANCE) for caspase-3J Biomol Screen 7 223Google Scholar
Manning, GWhyte, D.BMartinez, RHunter, TSudarsanam, S 2002 The protein kinase complement of the human genomeScience 298 1912Google Scholar
Hunter, T 2000 Signaling – 2000 and beyondCell 100 113Google Scholar
Blume-Jensen, P.Hunter, T. 2001 Oncogenic kinase signallingNature 411 355Google Scholar
Fantl, W.JJohnson, D.EWilliams, L.T 1993 Signalling by receptor tyrosine kinasesAnnu Rev Biochem 62 453Google Scholar
Jia, YQuinn, C.MGagnon, A.ITalanian, R 2006 Homogeneous time-resolved fluorescence and its applications for kinase assays in drug discoveryAnal Biochem 356 273Google Scholar
Xu, KStern, A.SLevin, WChua, AVassilev, L.T 2003 A generic time-resolved fluorescence assay for serine/threonine kinase activity: application to Cdc7/Dbf4J Biochem Mol Biol 36 421Google Scholar
Wang, YMalkowski, MHailey, JTurek-Etienne, TTripodi, TPachter, J.A 2004 Screening for small molecule inhibitors of insulin-like growth factor receptor (IGF-1R) kinase: comparison of homogeneous time-resolved fluorescence and 33P-ATP plate assay formatsJ Exp Ther Oncol 4 111Google Scholar
Patnaik, DJun, XGlicksman, M.ACuny, G.DStein, R.LHiggins, J.M 2008 Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assayJ Biomol Screen 13 1025Google Scholar
Schroter, T.Minond, D.Weiser, A.Dao, C.Habel, J.Spicer, T.Chase, P.Baillargeon, P.Scampavia, L.Schurer, S.Chung, C.Mader, C.Southern, M.Tsinoremas, N.LoGrasso, P.Hodder, P. 2008 Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II)J Biomol Screen 13 17Google Scholar
Sharlow, E.RLeimgruber, SShun, T.YLazo, J.S 2007 Development and implementation of a miniaturized high-throughput time-resolved fluorescence energy transfer assay to identify small molecule inhibitors of polo-like kinase 1Assay Drug Dev Technol 5 723Google Scholar
Zhang, W.X.Wang, R.Wisniewski, D.Marcy, A.I.LoGrasso, P.Lisnock, J.M.Cummings, R.T.Thompson, J.E. 2005 Time-resolved Forster resonance energy transfer assays for the binding of nucleotide and protein substrates to p38alpha protein kinaseAnal Biochem 343 76Google Scholar
Bader, B.Butt, E.Palmetshofer, A.Walter, U.Jarchau, T.Drueckes, P. 2001 A cGMP-dependent protein kinase assay for high throughput screening based on time-resolved fluorescence resonance energy transferJ Biomol Screen 6 255Google Scholar
Ohmi, NWingfield, J.MYazawa, HInagaki, O 2000 Development of a homogeneous time-resolved fluorescence assay for high throughput screening to identify Lck inhibitors: comparison with scintillation proximity assay and streptavidin-coated plate assayJ Biomol Screen 5 463Google Scholar
Biazzo-Ashnault, D.EPark, Y.WCummings, R.TDing, VMoller, D.EZhang, B.BQureshi, S.A 2001 Detection of insulin receptor tyrosine kinase activity using time-resolved fluorescence energy transfer technologyAnal Biochem 291 155Google Scholar
Braunwalder, A.F.Yarwood, D.R.Sills, M.A.Lipson, K.E. 1996 Measurement of the protein tyrosine kinase activity of c-src using time-resolved fluorometry of europium chelatesAnal Biochem 238 159Google Scholar
Gratz, AGotz, CJose, JA FRET-based microplate assay for human protein kinase CK2, a target in neoplastic diseaseJ Enzyme Inhib Med Chem 25 234
Dominguez, D.IDe Strooper, B 2002 Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's diseaseTrends Pharmacol Sci 23 324Google Scholar
Albrecht, HZbinden, PRizzi, AVilletti, GRiccardi, BPuccini, PCatinella, SImbimbo, B.P 2004 High throughput screening of beta-amyloid secretion inhibitors using homogenous time-resolved fluorescenceComb Chem High Throughput Screen 7 745Google Scholar
Haugabook, S.JYager, D.MEckman, E.AGolde, T.EYounkin, S.GEckman, C.B 2001 High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta)J Neurosci Methods 108 171Google Scholar
Pennanen, N.Lapinjoki, S.Palander, A.Urtti, A.Monkkonen, J. 1995 Macrophage-like RAW 264 cell line and time-resolved fluoroimmunoassay (TRFIA) as tools in screening drug effects on cytokine secretionInt J Immunopharmacol 17 475Google Scholar
Ruedl, CWick, GWolf, H 1994 A novel and sensitive method for the detection of secreted cell products using time-resolved fluorescenceJ Immunol Methods 168 61Google Scholar
Martikkala, ELehmusto, MLilja, MRozwandowicz-Jansen, ALunden, JTomohiro, THanninen, PPetaja-Repo, UHarma, H 2009 Cell-based beta2-adrenergic receptor-ligand binding assay using synthesized europium-labeled ligands and time-resolved fluorescenceAnal Biochem 392 103Google Scholar
Harma, HRozwandowicz-Jansen, AMartikkala, EFrang, HHemmila, ISahlberg, NFey, VPerala, MHanninen, P 2009 A new simple cell-based homogeneous time-resolved fluorescence QRET technique for receptor-ligand interaction screeningJ Biomol Screen 14 936Google Scholar
Lundin, K.Blomberg, K.Nordstrom, T.Lindqvist, C. 2001 Development of a time-resolved fluorescence resonance energy transfer assay (cell TR-FRET) for protein detection on intact cellsAnal Biochem 299 92Google Scholar
Maurel, DComps-Agrar, LBrock, CRives, M.LBourrier, EAyoub, M.ABazin, HTinel, NDurroux, TPrezeau, LTrinquet, EPin, J.P 2008 Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerizationNat Methods 5 561Google Scholar
Maurel, DKniazeff, JMathis, GTrinquet, EPin, J.PAnsanay, H 2004 Cell surface detection of membrane protein interaction with homogeneous time-resolved fluorescence resonance energy transfer technologyAnal Biochem 329 253Google Scholar
Adams, D.GWang, YMak, P.AChyba, JShalizi, OMatzen, JAnderson, PSmith, T.RGarcia, MWelch, G.LClaret, E.JFink, MOrth, A.PCaldwell, J.SBrinker, A 2008 Cellular Ser/Thr-kinase assays using generic peptide substratesCurr Chem Genomics 1 54Google Scholar
Carlson, C.BRobers, M.BVogel, K.WMachleidt, T 2009 Development of LanthaScreen cellular assays for key components within the PI3K/AKT/mTOR pathwayJ Biomol Screen 14 121Google Scholar
Robers, M.BHorton, R.ABercher, M.RVogel, K.WMachleidt, T 2008 High-throughput cellular assays for regulated posttranslational modificationsAnal Biochem 372 189Google Scholar
Ding, Q.Gros, R.Gray, I.D.Taussig, R.Ferguson, S.S.Feldman, R.D. 2004 Raf kinase activation of adenylyl cyclases: isoform-selective regulationMol Pharmacol 66 921Google Scholar
Feldman, R.DGros, R 2007 New insights into the regulation of cAMP synthesis beyond GPCR/G protein activation: implications in cardiovascular regulationLife Sci 81 267Google Scholar
Jiang, JGanesh, TDu, YThepchatri, PRojas, ALewis, IKurtkaya, SLi, LQui, MSerrano, GShaw, RSun, ADingledine, RNeuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptorProc Natl Acad Sci U S A 107 2307
Katzenellenbogen, B.S. 1996 Estrogen receptors: bioactivities and interactions with cell signaling pathwaysBiol Reprod 54 287Google Scholar
Schiff, R.Massarweh, S.A.Shou, J.Bharwani, L.Arpino, G.Rimawi, M.Osborne, C.K. 2005 Advanced concepts in estrogen receptor biology and breast cancer endocrine resistance: implicated role of growth factor signaling and estrogen receptor coregulatorsCancer Chemother Pharmacol 56 10Google Scholar
Zhang, J.HChung, T.DOldenburg, K.R 1999 A simple statistical parameter for use in evaluation and validation of high throughput screening assaysJ Biomol Screen 4 67Google Scholar
Alvarez-Curto, EWard, R.JPediani, J.DMilligan, G 2010 Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRETJ Biol Chem 285 23318Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×