Skip to main content

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
Cancel
×
×
Home
  • Home
Chapter
  • Get access
    Buy the print book
    Check if you have access via personal or institutional login
    Log in Register Recommend to librarian
  • Cited by 2
  • Cited by
    Crossref Citations
    Crossref logo
    This (lowercase (translateProductType product.productType)) has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Pöhlmann, Stefan Krüger, Astrid Hafezi, Wali Schneider, Stefan Gruber, Jens Winkler, Michael and Kaul, Artur 2017. Detection systems for antibody responses against herpes B virus. Primate Biology, Vol. 4, Issue. 1, p. 9.
    Johnson, Barbara 2012. Animal Bytes. Applied Biosafety, Vol. 17, Issue. 2, p. 89.
    ×
  • Print publication year: 2007
  • Online publication date: December 2009

57 - Monkey B virus

from Part IV - Non-human primate herpesviruses
Export citation
Summary

Introduction

B virus (Cercopithecine herpesvirus 1, herpesviridae), an alphaherpesvirus endemic in macaque monkeys, has the unique distinction of being the only one of nearly 35 identified non-human primate herpesviruses that is highly pathogenic in humans. B virus has been positively linked with more than two dozen human deaths since the first report describing it in 1933, five of those in the last 12 years, following exposures involving macaques in during acute B virus infection. B virus, unique among the non-human herpesviruses, is included in this volume because it is distinctively neurotropic and neurovirulent in the foreign human host inadvertently exposed by handling macaque monkeys generally used in biomedical research. Untreated B virus infections in humans result in an extremely high mortality rate (∼80%) and, consequently, present unique and potentially lethal challenges for individuals handling macaque monkeys or macaque cells and tissues. Infection in humans is associated with breach of primary skin or mucosal defenses and subsequent contamination of the site with virus from a macaque or cells or tissues harvested from this animal. Fomites, contaminated particulates or surfaces, can serve as source of virus as well. In one case, human-to-human transmission was reported and attributed to a shared tube of medication which resulted in contamination at a broken skin site with cream used to treat another patient's bite wound. Later, the same patient autoincoculated one eye during manipulation of a contact lens.

Recommend this book

Email your librarian or administrator to recommend adding this book to your organisation's collection.

Human Herpesviruses
  • Online ISBN: 9780511545313
  • Book DOI: https://doi.org/10.1017/CBO9780511545313
Please enter your name
Please enter a valid email address
Who would you like to send this to *

CAPTCHA *

Skip to the audio challenge
×
References
Anon. (1987). B-virus infection in humans–Pensacola, Florida. Morb. Mortal. Wkly Rep., 36(19), 289–290, 295–296.
Anon. (1987). Leads from the MMWR. B-virus infection in humans–Pensacola, Florida. J. Am. Med. Assoc., 257(23), 3192–3193, 3198.
Anon. (1989). B virus infections in humans – Michigan. Morb. Mortal. Wkly Rep., 38(26), 453–454.
Artenstein, A. W., Hicks, C. B., Goodwin, B. S. Jr.et al. (1991). Human infection with B virus following a needlestick injury. Rev. Infect. Dis., 13(2), 288–291.
Bennett, A. M., Harrington, L., and Kelly, D. C.et al. (1992). Nucleotide sequence analysis of genes encoding glycoproteins D and J in simian herpes B virus. J. Gen. Virol., 73(11), 2963–2967.
Benson, P. M., Malane, S. L., Banks, R.et al. (1989). B virus (Herpesvirus simiae) and human infection. Arch. Dermatol., 125(9), 1247–1248.
Boulter, E. A. (1975). The isolation of monkey B virus (Herpesvirus simiae) from the trigeminal ganglia of a healthy seropositive rhesus monkey. J. Biol. Stand., 3(3), 279–280.
Chellman, G. J., Lukas, V. S., Eugui, E. M.et al. (1992). Activation of B virus (Herpesvirus simiae) in chronically immunosuppressed cynomolgus monkeys. Lab. Anim. Sci., 42(2), 146–151.
DiGiacomo, R. F. and Shah, K. V. (1972). Virtual absence of infection with Herpesvirus simiae in colony-reared rhesus monkeys (Macaca mulatta), with a literature review on antibody prevalence in natural and laboratory rhesus populations. Lab. Anim. Sci., 22(1), 61–67.
Eberle, R., Black, D., and Hilliard, J. K. (1989). Relatedness of glycoproteins expressed on the surface of simian herpes-virus virions and infected cells to specific HSV glycoproteins. Arch. Virol., 109(3–4), 233–252.
Eberle, R., Black, D. H., Lipper, S.et al. (1995). Herpesvirus papio 2, an SA8-like alpha-herpesvirus of baboons. Arch. Virol., 140(3), 529–545.
Freifeld, A. G., Hilliard, J., Southers, J.et al. (1995). A controlled seroprevalence survey of primate handlers for evidence of asymptomatic herpes B virus infection. J. Infect. Dis., 171(4), 1031–1034.
Gay, F. P. and Holden, M. (1933). Isolation of herpes virus from several cases of epidemic encephalitis. Proc. Soc. Exp. Biol. Med., 30, 1051–1053.
Harrington, L., Wall, L. V., and Kelly, D. C.et al. (1992). Molecular cloning and physical mapping of the genome of simian herpes B virus and comparison of genome organization with that of herpes simplex virus type 1. J. Gen. Virol., 73(5), 1217–1226.
Hilliard, J. K., Eberle, R., Lipper, S. L.et al. (1987). Herpesvirus simiae (B virus): replication of the virus and identification of viral polypeptides in infected cells. Arch. Virol., 93(3–4), 185–198.
Hilliard, J. K., Black, D., and Eberle, R. (1989). Simian alphaherpesviruses and their relation to the human herpes simplex viruses. Arch. Virol., 109(1–2), 83–102.
Keeble, S. A. (1960). B virus infection in monkeys. Ann. NY Acad. Sci., 85, 960–969.
Keeble, S. A., Christofinis, G. J., and wood, W. et al. (1958). Natural B virus infection in rhesus monkeys. J. Path. Bacteriol., 76, 189–199.
Kessler, M. J. and Hilliard, J. K. (1990). Seroprevalence of B virus (Herpesvirus simiae) antibodies in a naturally formed group of rhesus macaques. J. Med. Primatol., 19(2), 155–160.
Killeen, A. M., Harrington, L., Wall, L. V.et al. (1992). Nucleotide sequence analysis of a homologue of herpes simplex virus type 1 gene US9 found in the genome of simian herpes B virus. J. Gen. Virol., 73(1), 195–199.
Loomis, M. R., O'Neill, T., Bush, M.et al. (1981). Fatal herpesvirus infection in patas monkeys and a black and white colobus monkey. J. Am. Vet. Med. Assoc., 179, 1236–1239.
Palmer, A. E. (1987). B virus, Herpesvirus simiae: historical perspective. J. Med. Primatol., 16(2), 99–130.
Perelygina, L., Zhu, L., Zurkuhlen, H.et al. (2003). Complete sequence and comparative analysis of the genome of herpes B virus (cercopithicine herepsvirus 1) from a rhesus monkey. J. Virol., 77(11), 6167–6177.
Ruebner, B. H., Kevereux, D., Rorvik, M.et al. (1975). Ultrastructure of Herpesvirus simiae (Herpes B ivurs). Exp. Mol. Pathol., 22(3), 317–325.
Sabin, A. B. (1934). Studies on the B virus. II. Properties of the virus and pathogenesis of the experimental disease in rabbits. Br. J. Exp. Pathol., 15, 268–279.
Sato, H., Arikawa, J., Fururya, M.et al. (1998). Prevalence of herpes B virus antibody in nonhuman primates reared at the National University of Japan. Exp. Anim., 47(3), 199–202.
Shah, K. V. and Southwick, C. H. (1965). Prevalence of antibodies to certain viruses in sera of free-living rhesus and of captive monkeys. Ind. J. Med. Res., 53, 488–500.
Slomka, M. J., Harrington, L., Arnold, C.et al. (1995). Complete nucleotide sequence of the herpesvirus simiae glycoprotein G gene and its expression as an immunogenic fusion protein in bacteria. J. Gen. Virol., 76(9), 2161–2168.
Vizoso, A. D. (1975). Recovery of herpes simiae (B virus) from both primary and latent infections in rhesus monkeys. Br. J. Exp. Pathol., 56(6), 485–488.
Weigler, B. J. (1992). Biology of B virus in macaque and human hosts: a review. Clin. Infect. Dis., 14(2), 555–567.
Weigler, B. J., Hird, D. W., Hilliard, J. K.et al. (1993). Epidemiology of cercopithecine herpesvirus 1 (B virus) infection and shedding in a large breeding cohort of rhesus macaques. J. Infect. Dis., 167(2), 257–263.
Weigler, B. J., Scinicariello, F., and Hilliard, J. K. (1995). Risk of venereal B virus (cercopithecine herpesvirus 1) transmission in rhesus monkeys using molecular epidemiology. J. Infect. Dis., 171(5), 1139–1143.
Wilson, R. B., Holscher, M. A., Chang, T.et al. (1990). Fatal herpesvirus simiae (B virus) infection in a patas monkey (Erythrocebus patas). J. Vet. Diagn. Invest., 2(3), 242–244.
Cancel
Confirm
×