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Chapter 25 - Male Oncofertility – Considerations for Fertility Preservation and Restoration

from Section 4 - Treatment of Male Infertility

Published online by Cambridge University Press:  08 July 2023

By
Darshan P. Patel ,
Alexander W. Pastuszak  and
James M. Hotaling
Edited by
Larry I. Lipshultz ,
Stuart S. Howards ,
Craig S. Niederberger  and
Dolores J. Lamb
Larry I. Lipshultz
Affiliation:
Baylor College of Medicine, Texas
Stuart S. Howards
Affiliation:
University of Virginia
Craig S. Niederberger
Affiliation:
University of Illinois, Chicago
Dolores J. Lamb
Affiliation:
Weill Cornell Medical College, New York
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Summary

Over the last few decades, cancer incidence has increased in the United States. Many patients diagnosed with cancer are young, with nearly 10 percent below the age of 45 years and 1 percent below the age of 20 years [1]. Specifically for males aged between 15 and 19 years, cancer incidence has increased annually by 0.67 percent, resulting in >25 percent increase over 40 years [2]. Despite, the rise in cancer incidence, cancer survival has also dramatically improved, largely due to earlier detection and better treatments. With a growing number of chronic cancer survivors, there is focus on a concept termed cancer survivorship. Cancer survivorship focuses on maintaining and enhancing wellness in cancer survivors and on optimizing management of long-term side effects of their cancer and cancer treatments [3, 4].

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Infertility in the Male , pp. 461 - 476
Publisher: Cambridge University Press
Print publication year: 2023

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References

Further Reading

Del Vento, F, Vermeulen, M, de Michele, F, et al. Tissue engineering to improve immature testicular tissue and cell transplantation outcomes: one step closer to fertility restoration for prepubertal boys exposed to gonadotoxic treatments. Int J Mol Sci 2018;19:286.Google Scholar
Halpern, JA, Hill, R, Brannigan, RE. Guideline based approach to male fertility preservation. Urol Oncol 2020;38:31–5.Google Scholar
Oktay, K, Harvey, BE, Partridge, AH, et al. Fertility preservation in patients with cancer: ASCO Clinical Practice Guideline Update. J Clin Oncol 2018;36:1994–2001.Google Scholar
Onofre, J, Baert, Y, Faes, K, Goossens, E. Cryopreservation of testicular tissue or testicular cell suspensions: a pivotal step in fertility preservation. Hum Reprod Update 2016;22:744–61.Google Scholar

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