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    Seddon, Jennifer L. Birchwood, Max Copello, Alex Everard, Linda Jones, Peter B. Fowler, David Amos, Tim Freemantle, Nick Sharma, Vimal Marshall, Max and Singh, Swaran P. 2016. Cannabis Use Is Associated With Increased Psychotic Symptoms and Poorer Psychosocial Functioning in First-Episode Psychosis: A Report From the UK National EDEN Study. Schizophrenia Bulletin, Vol. 42, Issue. 3, p. 619.

    CASTLE, DAVID 2008. Letter to the Editor: Drawing conclusions about cannabis and psychosis. Psychological Medicine, Vol. 38, Issue. 03,

    Hinton, Mark Edwards, Jane Elkins, Kathryn Harrigan, Susy M. Donovan, Kerri Purcell, Rosemary and McGorry, Patrick D. 2007. Reductions in cannabis and other illicit substance use between treatment entry and early recovery in patients with first-episode psychosis. Early Intervention in Psychiatry, Vol. 1, Issue. 3, p. 259.

  • Print publication year: 2004
  • Online publication date: December 2009

8 - Cannabis abuse and the course of schizophrenia


As detailed elsewhere in this book (Chapter 3), cannabis has been used for centuries to produce euphoria and relaxation as desired mental effects. However, adverse effects of intoxication with cannabis include anxiety and panic (Thomas, 1996; Reilly et al., 1998), depression (Bovasso, 2001; Patton et al., 2002: see Chapter 4), and impairment in certain domains of cognitive function (see Chapters 3 and 13). Psychosis, including paranoid delusions and hallucinations, has been found to be an effect of cannabis use in cohort studies from New Zealand (Thomas, 1996), Vietnam (Talbott and Teague, 1969), India (Chopra and Smith, 1974) and Pakistan (Chaudry et al., 1991) (Chapter 6). This work suggests that cannabis, especially in high doses, can produce a toxic psychosis in people without mental disorders. Evidence for cannabis (and especially heavy abuse) as a causal risk factor for psychotic disorders comes from epidemiological studies of Swedish conscripts (Andreasson et al., 1987; Zammit et al., 2002), from the Dunedin study from New Zealand (Arsenault et al., 2002), from a Dutch sample (Van Os et al., 2002) and from a study of Israeli conscripts (Weiser et al., 2001) (see Chapter 7).

Schizophrenia and related psychotic disorders are clinical syndromes with a wide variation in symptoms between individuals (Thaker and Carpenter, 2001). Factor-analytic studies of schizophrenia have revealed that the symptoms are best described by three dimensions or syndromes: reality distortion (hallucinations and delusions), psychomotor poverty (restriction of affect, loss of motivation and restricted emotional experience) and disorganization (disorganized thought, incongruity of affect and bizarre behaviour) (Liddle, 1987).

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