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Chapter 4 - Management of Disorders of Consciousness in Neurorehabilitation

Published online by Cambridge University Press:  13 October 2018

Krishnan Padmakumari Sivaraman Nair
Affiliation:
Royal Hallamshire Hospital, Sheffield
Marlís González-Fernández
Affiliation:
Johns Hopkins University Hospital, Baltimore, MD
Jalesh N. Panicker
Affiliation:
National Hospital for Neurology & Neurosurgery, London
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Publisher: Cambridge University Press
Print publication year: 2018

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References

Royal College of Physicians. Prolonged disorders of consciousness: National clinical guidelines. London, UK: Royal College of Physicians, 2013.Google Scholar
Giacino, JT, Fins, JJ, Laureys, S, et al. Disorders of consciousness after acquired brain injury: The state of the science. Nat. Rev. Neurol. 2014; 10: 99114.Google Scholar
Jennett, B, Teasdale, G. Aspects of coma after severe head injury. Lancet 1977; 1: 878–81.Google ScholarPubMed
Laureys, S, Celesia, GG, Cohadon, F, et al. Unresponsive wakefulness syndrome: A new name for the vegetative state or apallic syndrome. BMC Med 2010; 8: 68.Google Scholar
Giacino, JT, Ashwal, S, Childs, N, et al. The minimally conscious state: Definition and diagnostic criteria. Neurology 2002; 58: 349–53.Google Scholar
Gosseries, O, Bruno, MA, Chatelle, C, et al. Disorders of consciousness: What’s in a name? NeuroRehabilitation 2011; 28: 314.Google Scholar
Van Erp, WS, Lavrijsen, JC, Vos, PE, et al. The vegetative state: Prevalence, misdiagnosis, and treatment limitations. J. Am. Med. Dir. Assoc. 2015; 16: 85 e985 e14.Google Scholar
Giacino, JT, Schnakers, C, Rodriguez-Moreno, D, et al. Behavioral assessment in patients with disorders of consciousness: Gold standard or fool’s gold? Prog. Brain Res. 2009; 177: 3348.CrossRefGoogle ScholarPubMed
Seel, RT, Sherer, M, Whyte, J, et al. Assessment scales for disorders of consciousness: Evidence-based recommendations for clinical practice and research. Archives of Physical Medicine and Rehabilitation 2010; 91: 1795–813.CrossRefGoogle ScholarPubMed
Di, H, Nie, Y, Hu, X, et al. Assessment of visual fixation in vegetative and minimally conscious states. BMC Neurol. 2014; 14: 147.Google Scholar
Bender, A, Jox, RJ, Grill, E, et al. Persistent vegetative state and minimally conscious state: A systematic review and meta-analysis of diagnostic procedures. Dtsch. Arztebl. Int. 2015; 112: 235–42.Google Scholar
Monti, MM, Vanhaudenhuyse, A, Coleman, MR, et al. Willful modulation of brain activity in disorders of consciousness. New England Journal of Medicine 2010; 362: 579–89.Google Scholar
Stender, J, Gosseries, O, Bruno, MA, et al. Diagnostic precision of PET imaging and functional MRI in disorders of consciousness: A clinical validation study. Lancet 2014; 384: 514–22.Google Scholar
Young, GB. Coma. Ann. N. Y. Acad. Sci. 2009; 1157: 3247.Google Scholar
Di Perri, C, Bahri, MA, Amico, E, et al. Neural correlates of consciousness in patients who have emerged from a minimally conscious state: A cross-sectional multimodal imaging study. Lancet Neurol. 2016; 15: 830–42.Google Scholar
Meyer, MJ, Megyesi, J, Meythaler, J, et al. Acute management of acquired brain injury Part III: An evidence-based review of interventions used to promote arousal from coma. Brain Injury 2010; 24: 722–9.Google Scholar
Oliveira, L, Fregni, F. Pharmacological and electrical stimulation in chronic disorders of consciousness: New insights and future directions. Brain Injury 2011; 25: 315–27.Google Scholar
Frazzitta, G, Zivi, I, Valsecchi, R, et al. Effectiveness of a very early stepping verticalization protocol in severe acquired brain injured patients: A randomized pilot study in ICU. PLoS One 2016; 11: e0158030.CrossRefGoogle ScholarPubMed
Krewer, C, Luther, M, Koenig, E, et al. Tilt table therapies for patients with severe disorders of consciousness: A randomized, controlled trial. PLoS One 2015; 10: e0143180.Google Scholar
Riberholt, CG, Thorlund, JB, Mehlsen, J, et al. Patients with severe acquired brain injury show increased arousal in tilt-table training. Dan. Med. J. 2013; 60: A4739.Google Scholar
Tolle, P, Reimer, M. Do we need stimulation programs as a part of nursing care for patients in ‘persistent vegetative state’? A conceptual analysis. Axone 2003; 25: 20–6.Google Scholar
Padilla, R, Domina, A. Effectiveness of sensory stimulation to improve arousal and alertness of people in a coma or persistent vegetative state after traumatic brain injury: A systematic review. Am. J. Occup. Ther. 2016; 70: 7003180030: pp. 18.Google Scholar
Schnakers, C, Magee, WL, Harris, B. Sensory stimulation and music therapy programs for treating disorders of consciousness. Front Psychol. 2016; 7: 297.CrossRefGoogle ScholarPubMed
Magee, WL, O’Kelly, J. Music therapy with disorders of consciousness: Current evidence and emergent evidence-based practice. Ann. N. Y. Acad. Sci. 2015; 1337: 256–62.Google ScholarPubMed
Vanhaudenhuyse, A, Noirhomme, Q, Tshibanda, LT, et al. Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 2010; 133: 161–71.Google Scholar
O’Kelly, J, James, L, Palaniappan, R, et al. Neurophysiological and behavioral responses to music therapy in vegetative and minimally conscious states. Front. Hum. Neurosci. 2013; 7: 884.Google Scholar
Lombardi, F, Taricco, M, De Tanti, A, et al. Sensory stimulation of brain-injured individuals in coma or vegetative state: Results of a Cochrane systematic review. Clin. Rehabil. 2002; 16: 464–72.CrossRefGoogle ScholarPubMed
Pape, TL, Rosenow, JM, Steiner, M, et al. Placebo-controlled trial of familiar auditory sensory training for acute severe traumatic brain injury: A preliminary report. Neurorehabil. Neural. Repair 2015; 29: 537–47.CrossRefGoogle ScholarPubMed
Megha, M, Harpreet, S, Nayeem, Z. Effect of frequency of multimodal coma stimulation on the consciousness levels of traumatic brain injury comatose patients. Brain Injury 2013; 27: 570–7.Google Scholar
Binzer, I, Schmidt, HU, Timmermann, T, et al. Immediate responses to individual dialogic music therapy in patients in low awareness states. Brain Injury 2016; 30(7): 17.Google Scholar
Thibaut, A, Bruno, MA, Ledoux, D, et al. tDCS in patients with disorders of consciousness: Sham-controlled randomized double-blind study. Neurology 2014; 82: 1112–18.Google Scholar
Kessler, SK, Turkeltaub, PE, Benson, JG, et al. Differences in the experience of active and sham transcranial direct current stimulation. Brain Stimul. 2012; 5: 155–62.Google Scholar
Cavaliere, C, Aiello, M, Di Perri, C, et al. Functional connectivity substrates for tDCS response in minimally conscious state patients. Front Cell Neurosci. 2016; 10: 257.Google Scholar
Lei, J, Wang, L, Gao, G, et al. Right median nerve electrical stimulation for acute traumatic coma patients. J. Neurotrauma 2015; 32: 1584–9.Google Scholar
Peeters, M, Page, G, Maloteaux, JM, et al. Hypersensitivity of dopamine transmission in the rat striatum after treatment with the NMDA receptor antagonist amantadine. Brain Res. 2002; 949: 3241.Google Scholar
Giacino, JT, Whyte, J, Bagiella, E, et al. Placebo-controlled trial of amantadine for severe traumatic brain injury. N. Engl. J. Med. 2012; 366: 819–26.Google Scholar
Gosseries, O, Charland-Verville, V, Thonnard, M, et al. Amantadine, apomorphine and zolpidem in the treatment of disorders of consciousness. Curr. Pharm. Des. 2014; 20: 4167–84.Google Scholar
Kovacic, P, Somanathan, R. Zolpidem, a clinical hypnotic that affects electronic transfer, alters synaptic activity through potential GABA receptors in the nervous system without significant free radical generation. Oxid. Med. Cell. Longev. 2009; 2: 52–7.Google Scholar
Schiff, ND. Recovery of consciousness after brain injury: A mesocircuit hypothesis. Trends in Neurosciences 2010; 33: 19.Google Scholar
Chatelle, C, Thibaut, A, Gosseries, O, et al. Changes in cerebral metabolism in patients with a minimally conscious state responding to zolpidem. Front. Hum. Neurosci. 2014; 8: 917.CrossRefGoogle ScholarPubMed
Whyte, J, Rajan, R, Rosenbaum, A, et al. Zolpidem and restoration of consciousness. Am. J. Phys. Med. Rehabil. 2014; 93: 101–13.Google Scholar
Thonnard, M, Gosseries, O, Demertzi, A, et al. Effect of zolpidem in chronic disorders of consciousness: A prospective open-label study. Funct. Neurol. 2013; 28: 259–64.Google Scholar
Margetis, K, Korfias, SI, Gatzonis, S, et al. Intrathecal baclofen associated with improvement of consciousness disorders in spasticity patients. Neuromodulation 2014; 17: 699704: discussion 704.CrossRefGoogle ScholarPubMed
Al-Khodairy, AT, Wicky, G, Nicolo, D, et al. Influence of intrathecal baclofen on the level of consciousness and mental functions after extremely severe traumatic brain injury: Brief report. Brain Injury 2015; 29: 527–32.CrossRefGoogle ScholarPubMed
Battleday, RM, Brem, AK, Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review. Eur. Neuropsychopharmacol. 2015; 25: 1865–81.Google Scholar
Dhamapurkar, SK, Wilson, BA, Rose, A, et al. Does modafinil improve the level of consciousness for people with a prolonged disorder of consciousness? A retrospective pilot study. Disabil. Rehabil. 2016; 17.Google Scholar
Yamamoto, T, Katayama, Y, Obuchi, T, et al. Deep brain stimulation and spinal cord stimulation for vegetative state and minimally conscious state. World Neurosurg. 2013; 80: S30 e19.Google Scholar
Schiff, ND, Giacino, JT, Kalmar, K, et al. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 2007; 448: 600–3.Google Scholar
Magrassi, L, Maggioni, G, Pistarini, C, et al. Results of a prospective study (CATS) on the effects of thalamic stimulation in minimally conscious and vegetative state patients. J. Neurosurg. 2016; 125: 972–81.Google Scholar
Giacino, J, Fins, JJ, Machado, A, et al. Central thalamic deep brain stimulation to promote recovery from chronic posttraumatic minimally conscious state: Challenges and opportunities. Neuromodulation 2012; 15: 339–49.Google Scholar

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