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Section 5 - Thromboembolism and Anticoagulation

Published online by Cambridge University Press:  01 February 2018

Sue Pavord
Affiliation:
University of Oxford
Beverley Hunt
Affiliation:
King's College London
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Publisher: Cambridge University Press
Print publication year: 2018

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References

References

Bates, SM, Ginsberg, JS. How we manage venous thromboembolism during pregnancy. Blood 2002; 100: 34703478.CrossRefGoogle ScholarPubMed
Bates, SM, Greer, IA, Pabinger, I et al. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 844S886S.CrossRefGoogle ScholarPubMed
Sultan, AA Grainge, M West, J et al. Impact of risk factors on the timing of first postpartum venous thromboembolism: a population-based cohort study from England. Blood 2014; 124(18): 28722880.CrossRefGoogle ScholarPubMed
Kamel, H, Navi, BB, Sriram, N, et al. Risk of a thrombotic event after the 6-week postpartum period. New England Journal of Medicine 2014; 370: 13071315.Google Scholar
Knight, M, Kenyon, S, Brocklehurst, P et al. on behalf of MBRRACE-UK. Saving Lives, Improving Mothers’ Care – Lessons learned to inform future maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2009–12. Oxford: National Perinatal Epidemiology Unit, University of Oxford; 2014.Google Scholar
Lewis, G, ed. The Confidential Enquiry into Maternal and Child Health – Saving Mothers’ Lives: Reviewing Maternal Deaths to Make Motherhood Safer 2003–2005. The seventh report on Confidential Enquiries into Maternal Deaths in the United Kingdom. London: CEMACH; 2007.Google Scholar
Royal College of Obstetricians and Gynecologists (RCOG). Thromboembolic Disease in Pregnancy and the Puerperium: Acute Management. Green-Top Guideline No. 37b. London: Royal College of Obstetricians and Gynecologists; 2015 (https://www.rcog.org.uk/ globalassets/ documents/guidelines/ gtg-37b.pdf).Google Scholar
British Thoracic Society Standards of Care Committee Pulmonary Embolism Guideline Development Group. British Thoracic Society guidelines for the management of suspected acute pulmonary embolism. Thorax 2003; 58: 470484.CrossRefGoogle Scholar
Scarsbrook, AF, Evans, AL, Owen, AR, Gleeson, FV. Diagnosis of suspected venous thromboembolic disease in pregnancy. Clinical Radiology 2006; 61: 112.Google Scholar
Royal College of Obstetricians and Gynecologists (RCOG). Reducing the Risk of Thrombosis and Embolism During Pregnancy and the Puerperium. Green-Top Guideline No. 37a. London: Royal College of Obstetricians and Gynecologists; 2015 (https://www.rcog.org.uk/globalassets/documents/guidelines/gtg-37a.pdf).Google Scholar
Jacobsen, AF, Skjeldestad, FE, Sandset, PM. Ante- and postnatal risk factors of venous thrombosis: a hospital-based case-control study. Journal of Thrombosis and Hemostasis 2008; 6: 905912.Google Scholar
Lindqvist, P, Dahlbäck, B, Marŝál, K. Thrombotic risk during pregnancy: a population study. Obstetrics and Gynecology 1999; 94: 595599.Google ScholarPubMed
James, AH, Jamison, MG, Brancazio, LR, Myers, ER. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. American Journal of Obstetrics and Gynecology 2006; 194: 13111315.CrossRefGoogle ScholarPubMed
Knight, M on behalf of UKOSS. Antenatal pulmonary embolism: risk factors, management and outcomes. BJOG: An International Journal of Obstetrics and Gynecology 2008; 115: 453461.CrossRefGoogle ScholarPubMed
Greer, IA. Pregnancy complicated by venous thrombosis. New England Journal of Medicine 2015; 73: 540547.CrossRefGoogle Scholar
Dentali, F, Douketis, JD, Gianni, M et al. Meta-analysis: anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients. Annals of Internal Medicine 2007; 146(4): 278288.CrossRefGoogle ScholarPubMed
Cutts, BA, Dasgupta, D, Hunt, BJ. New directions in the diagnosis and treatment of pulmonary embolism in pregnancy. American Journal of Obstetrics and Gynecology 2013; 208(2): 102108.Google Scholar
Cutts, BA, Tran, HA, Merriman, E et al. The utility of the Wells clinical prediction model and ventilation-perfusion scanning for pulmonary embolism diagnosis in pregnancy. Blood Coagulation and Fibrinolysis 2014; 25(4): 375378.CrossRefGoogle ScholarPubMed
Cook, JV, Kyriou, J. Radiation from CT and perfusion scanning in pregnancy. BMJ 2005; 331: 350.CrossRefGoogle ScholarPubMed
Hurwitz, LM, Yoshizumi, TT, Goodman, PC et al. Radiation dose savings for adult pulmonary embolus 64-MDCT using bismuth breast shields, lower peak kilovoltage, and automatic tube current modulation. AJR American Journal of Roentgenology 2009; 192: 244253.CrossRefGoogle ScholarPubMed
The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology. Guidelines on the diagnosis and management of acute pulmonary embolism. European Heart Journal 2008; 29: 22762315.Google Scholar
Robertson, L, Wu, O, Langhorne, P, et al. Thrombophilia in pregnancy: a systematic review. British Journal of Haematology 2006; 132: 171196.Google Scholar
Greer, IA, Nelson-Piercy, C. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood 2005; 106: 401407.CrossRefGoogle ScholarPubMed
McColl, D, Ellison, J, Greer, IA, et al. Prevalence of the post thrombotic syndrome in young women with previous venous thromboembolism. British Journal of Haematology 2000; 108: 272274.Google Scholar
Kahn, SR, Shapiro, S, Wells, PS et al.; SOX Trial Investigators. Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial. Lancet 2014; 383(9920): 880888.CrossRefGoogle ScholarPubMed
Greer, I, Hunt, BJ. Low molecular weight heparin in pregnancy: current issues. British Journal of Haematology 2005; 128: 593560.CrossRefGoogle ScholarPubMed
Tang, AW, Greer, IA. A systematic review on the use of new anticoagulants in pregnancy. Obstetric Medicine 2013; 6: 6471.CrossRefGoogle ScholarPubMed
Colombier, S, Niclauss, L. Successful surgical pulmonary embolectomy for massive perinatal embolism after emergency cesarean section. Annals of Vascular Surgery 2015; 29(7): 1452.e14. doi: 10.1016/j.avsg.2015.04.066.CrossRefGoogle ScholarPubMed
Bataillard, A, Hebrard, A, Gaide-Chevronnay, L et al. Extracorporeal life support for massive pulmonary embolism during pregnancy. Perfusion 2015; 31(2): 169171.CrossRefGoogle ScholarPubMed

References

Royal College of Obstetricians and Gynecologists. Reducing the Risk of Thrombosis and Embolism during Pregnancy and Puerperium. Green-Top Guideline No. 37a. London: Royal College of Obstetricians and Gynecologists; 2015.Google Scholar
Lewis, G, ed. The Confidential Enquiry into Maternal and Child Health (CEMACH) – Saving Mothers’ Lives: Reviewing Maternal Deaths to Make Motherhood Safer – 2003–2005. The Seventh Report on Confidential Enquiries into Maternal Deaths in the United Kingdom. London: CEMACH; 2007.Google Scholar
Center for Maternal and Child Enquiries (CMACE). Saving Mothers’ Lives: Reviewing maternal deaths to make motherhood safer: 2006–08. The Eighth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG: An International Journal of Obstetrics and Gynecology 2011; 118 (Suppl 1): 1203.Google Scholar
MBRRACE. Saving Lives, Improving Mothers’ Care – Lessons learned to inform future maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2009–12. Oxford: National Perinatal Epidemiology Unit, University of Oxford; 2014.Google Scholar
Knight, M; UKOSS. Antenatal pulmonary embolism: risk factors, management and outcomes. BJOG: An International Journal of Obstetrics and Gynecology 2008; 115: 453461.Google Scholar
Royal College of Obstetricians and Gynecologists. Thromboprophylaxis during Pregnancy, Labor and After Normal Vaginal Delivery. Green-Top Guideline no. 37. London: Royal College of Obstetricians and Gynecologists; 2004.Google Scholar
Royal College of Obstetricians and Gynecologists. Reducing the risk of Thrombosis and Embolism during Pregnancy and Puerperium. Green-Top Guideline No. 37a. London: Royal College of Obstetricians and Gynecologists; 2009.Google Scholar
Heit, JA, Kobbervig, CE, James, AH et al. Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study. Annals of Internal Medicine 2005; 143: 697706.Google Scholar
Jacobsen, AF, Skjeldestad, FE, Sandset, PM. Ante- and postnatal risk factors of venous thrombosis: a hospital-based case–control study. Journal of Thrombosis and Hemostasis 2008; 6: 905912.CrossRefGoogle ScholarPubMed
James, AH. Prevention and management of venous thrombo-embolism in pregnancy. American Journal of Medicine 2007; 120: S2634.Google Scholar
Lindqvist, P, Dahlbäck, B, MarŜál, K. Thrombotic risk during pregnancy: a population study. BJOG: An International Journal of Obstetrics and Gynecology 1999; 94: 595599.Google ScholarPubMed
Kane, EV, Calderwood, C, Dobbie, R et al. A population-based study of venous thrombosis in pregnancy in Scotland 1980–2005. European Journal of Obstetrics & Gynecology and Reproductive Biology 2013; 169: 223229.CrossRefGoogle ScholarPubMed
Sultan, AA, West, J, Tata, LJ et al. Risk of first venous thromboembolism in and around pregnancy: a population-based cohort study. British Journal of Haematology 2012; 156: 366373.CrossRefGoogle ScholarPubMed
Pomp, ER, Lenselink, AM, Rosendaal, FR, Doggen, CJ. Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. Journal of Thrombosis and Haemostasis 2008; 6: 632637.CrossRefGoogle ScholarPubMed
Nelson, SM, Greer, IA. Thrombophilia and the risk for venous thromboembolism during pregnancy, delivery, and puerperium. Obstetric Gynecologic Clinics of North America 2006; 33: 413427.CrossRefGoogle ScholarPubMed
Bates, SM, Greer, IA, Middeldorp, S et al.; American College of Chest Physicians. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141 (2 Suppl): e691S736S.CrossRefGoogle ScholarPubMed
Jackson, E, Curtis, KM, Gaffield, ME. Risk of venous thromboembolism during the postpartum period: a systematic review. Obstetrics and Gynecology 2011; 117: 691703.CrossRefGoogle ScholarPubMed
National Institute for Health and Clinical Excellence. Venous Thromboembolism: Reducing the Risk. Reducing the risk of Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism) in Patients Admitted to Hospital. NICE Clinical Guideline 92. London: NICE; 2010.Google Scholar
Lindqvist, PG, Bremme, K, Hellgren, M. Swedish Society of Obstetrics and Gynecology (SFOG) Working Group on Hemostatic Disorders (Hem-ARG). Efficacy of obstetric thromboprophylaxis and long-term risk of recurrence of venous thromboembolism. Acta Obstetricia et Gynecologica Scandinavica 2011; 90: 648653.CrossRefGoogle Scholar
Hunt, BJ, Gattens, M, Khamashta, M, Nelson-Piercy, C, Almeida, A. Thromboprophylaxis with unmonitored intermediate-dose low molecular weight heparin in pregnancies with a previous arterial or venous thrombotic event. Blood Coagulation and Fibrinolysis 2003; 14: 735739.Google Scholar
Virchow, R. Thrombose und Embolie. Gefässentzündung und septische Infektion: Gesammelte Abhandlungen zur wissenschaftlichen Medicin [in German]. Frankfurt am Main: Von Meidinger & Sohn. 1856: 219732.Google Scholar
McColl, MD, Walker, ID, Greer, IA. The role of inherited thrombophilia in venous thromboembolism associated with pregnancy. British Journal of Obstetrics and Gynaecology 1999; 106: 756766.CrossRefGoogle ScholarPubMed
James, AH, Jamison, MG, Brancazio, LR, Myers, ER. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. American Journal of Obstetrics and Gynecology 2006; 194: 13111315.Google Scholar
Jamison, MG, Brancazio, LR, Myers, ER. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. American Journal of Obstetrics and Gynecology 2006; 194: 13111315.Google Scholar
Nelson-Piercy, C. Handbook of Obstetric Medicine, 5th edn. Florida: CRC Press, Taylor & Francis Group; 2015: 4960.Google Scholar
Larsen, TB, Sorensen, HT, Gislum, M, Johnsen, SP. Maternal smoking, obesity, and risk of venous thromboembolism during pregnancy and the puerperium: a population-based nested case-control study. Thrombosis Research 2007; 120: 505509.Google Scholar
Simpson, EL, Lawrenson, RA, Nightingale, AL, Farmer, RD. Venous thromboembolism in pregnancy and the puerperium: incidence and additional risk factors from a London perinatal database. BJOG: An International Journal of Obstetrics and Gynecology 2001; 108: 5660.Google ScholarPubMed
De Stefano, V, Martinelli, I, Rossi, E et al. The risk of recurrent venous thromboembolism in pregnancy and puerperium without antithrombotic prophylaxis. British Journal of Haematology 2006; 135: 386391.Google Scholar
Baglin, T, Gray, E, Greaves, M et al. British Committee for Standards in Hematology. Clinical guidelines for testing for heritable thrombophilia. British Journal of Haematology 2010; 149: 209220.CrossRefGoogle Scholar
Bramham, K, Retter, A, Robinson, SE. How I treat heterozygous hereditary antithrombin deficiency in pregnancy. Thrombosis and Haemostasis 2013; 110: 550559.Google Scholar
Rogenhofer, N, Bohlmann, MK, Beuter-Winkler, P et al. Prevention, management and extent of adverse pregnancy outcomes in women with hereditary antithrombin deficiency. Annals of Hematology 2014; 93: 385392.CrossRefGoogle ScholarPubMed
Liu, S, Rouleau, J, Joseph, KS et al. Maternal Health Study Group of the Canadian Perinatal Surveillance System. Epidemiology of pregnancy-associated venous thromboembolism: a population-based study in Canada. Journal of Obstetrics and Gynecology Canada 2009; 31: 611620.Google Scholar
National Collaborating Center for Women’s and Children’s Health. Antenatal Care: Routine Care for the Healthy Pregnant Woman. London: RCOG Press; 2008.Google Scholar
Royal College of Obstetricians and Gynecologists. Air Travel and Pregnancy. Scientific Impact Paper No. 1. London: RCOG; 2013.Google Scholar
Hezelgrave, NL, Whitty, CJ, Shennan, AH, Chappell, LC. Advising on travel during pregnancy. BMJ 2011; 342: d2506.CrossRefGoogle ScholarPubMed
Sultan, AA, Tata, LJ, West, J et al. Risk factors for first venous thromboembolism around pregnancy: a population-based cohort study from the United Kingdom. Blood 2013; 121: 39533961.Google Scholar
James, AH, Tapson, VF, Goldhaber, SZ. Thrombosis during pregnancy and the postpartum period. American Journal of Obstetrics and Gynecology 2005; 193: 216219.Google Scholar
Stone, S, Hunt, BJ, Khamashta, MA, Bewley, SJ, Nelson-Piercy, C. Primary antiphospholipid syndrome in pregnancy: an analysis of outcome in a cohort of 33 women treated with a rigorous protocol. Journal of Thrombosis and Haemostasis 2005; 3: 243245.CrossRefGoogle Scholar
Casele, H, Grobman, WA. Cost-effectiveness of thromboprophylaxis with intermittent pneumatic compression at Cesarean delivery. Obstetrics and Gynecology 2006; 108: 535540.CrossRefGoogle ScholarPubMed
Rogenhofer, N, Bohlmann, MK, Beuter-Winkler, P et al. Prevention, management and extent of adverse pregnancy outcomes in women with hereditary antithrombin deficiency. Annals of Hematology 2014; 93: 385392.CrossRefGoogle ScholarPubMed
Bates, SM, Greer, IA, Pabinger, I et al. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edn). Chest 2008; 133: 844S886S.CrossRefGoogle Scholar
Clark, NP, Delate, T, Witt, DM, Parker, S, McDuffie, R. A descriptive evaluation of unfractionated heparin use during pregnancy. Journal of Thrombosis and Thrombolysis 2009; 27: 267273.Google Scholar
Andersen, AS, Berthelsen, JG, Bergholt, T. Venous thrombo-embolism in pregnancy: prophylaxis and treatment with low molecular weight heparin. Acta Obstetricia et Gynecologica Scandinavica 2010; 89: 1521.CrossRefGoogle Scholar
Greer, IA, Nelson-Piercy, C. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood 2005; 106: 401407.Google Scholar
Lindhoff-Last, E, Bauersachs, R. Heparin-induced thrombocytopenia-alternative anticoagulation in pregnancy and lactation. Seminars in Thrombosis and Hemostasis 2002; 28: 439446.Google Scholar
Gerhardt, A, Zotz, RB, Stockschleder, M, Scharf, RE. Fondaparinux is an effective alternative anticoagulant in pregnant women with high risk of venous thromboembolism and intolerance to low-molecular-weight heparins and heparinoids. Thrombosis and Haemostasis 2007; 97: 496497.Google Scholar
Bomke, B, Hoffmann, T, Dücker, C, Scharf, RE. P01-09 Successful prevention or treatment of venous thromboembolism (VTE) with fondaparinux in pregnant women with allergic skin reactions to low-molecular-weight heparins (LMWHs) and danaparoid. Hämostaseologie 2010; 30 (Suppl): A35.Google Scholar
Lagrange, F, Vergnes, C, Brun, JL, et al. Absence of placental transfer of pentasaccharide (Fondaparinux, Arixtra®) in the dually perfused human cotyledon in vitro. Thrombosis and Haemostasis 2002; 87: 831835.Google Scholar
Holzgreve, W, Carey, JC, Hall, BD. Warfarin-induced fetal abnormalities. Lancet 1976; ii: 914–5.Google Scholar
Born, D, Martinez, EE, Almeida, PA et al. Risk of warfarin during pregnancy with mechanical valve prostheses. Obstetrics and Gynecology 2002; 99: 3540.Google Scholar
Sbarouni, E, Oakley, CM. Outcome of pregnancy in women with valve prostheses. British Heart Journal 1994; 71: 196201.Google Scholar
Born, D, Martinez, EE, Almeida, PA. Pregnancy in patients with prosthetic heart valves: the effects of anticoagulation on mother, fetus, and neonate. American Heart Journal 1992; 124: 413417.CrossRefGoogle ScholarPubMed

References

McLintock, C. Still casting its long shadow: rheumatic heart disease in Australia and New Zealand. International Medical Journal 2012; 42(9): 963966.CrossRefGoogle ScholarPubMed
Sadler, L, McCowan, L, White, H et al. Pregnancy outcomes and cardiac complications in women with mechanical, bioprosthetic and homograft valves. BJOG: An International Journal of Obstetrics and Gynecology 2000; 107(2): 245253.Google Scholar
Elkayam, U, Bitar, F. Valvular heart disease and pregnancy. Journal of the American College of Cardiology 2005; 46(3): 403410.Google Scholar
Eikelboom, JW, Connolly, SJ, Brueckmann, M et al. Dabigatran versus warfarin in patients with mechanical heart valves. New England Journal of Medicine 2013; 369(13): 1206–14.Google Scholar
European Society of Gynecology; Association for European Pediatric Cardiology; German Society for Gender Medicine; Regitz-Zagrosek, V, Blomstrom Lundqvist, C, Borghi, C et al. ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). European Heart Journal 2011; 32(24): 31473197.Google Scholar
Nishimura, RA, Otto, CM, Bonow, RO et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology 2014; 63(22): e57185.Google Scholar
Bates, SM, Greer, IA, Middeldorp, S et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012; 141(2 Suppl): e691S736S.Google Scholar
McLintock, C. Anticoagulant choices in pregnant women with mechanical heart valves: balancing maternal and fetal risks – the difference the dose makes. Thrombosis Research 2013; 131 (Suppl 1): S810.CrossRefGoogle ScholarPubMed
Schelleman, H, Limdi, NA, Kimmel, SE. Ethnic differences in warfarin maintenance dose requirement and its relationship with genetics. Pharmacogenomics 2008; 9(9): 13311346.Google Scholar
McLintock, C, McCowan, LM, North, RA. Maternal complications and pregnancy outcome in women with mechanical prosthetic heart valves treated with enoxaparin. BJOG: An International Journal of Obstetrics and Gynecology 2009; 116(12): 15851592.CrossRefGoogle ScholarPubMed
Mazibuko, B, Ramnarain, H, Moodley, J. An audit of pregnant women with prosthetic heart valves at a tertiary hospital in South Africa: a five-year experience. Cardiovascular Journal of Africa 2012; 23(4): 216221.CrossRefGoogle Scholar
Suri, V, Keepanasseril, A, Aggarwal, N et al. Mechanical valve prosthesis and anticoagulation regimens in pregnancy: a tertiary center experience. European Journal of Obstetrics & Gynecology and Reproductive Biology 2011; 159(2): 320323.Google Scholar
Becker, MH, Genieser, NB, Finegold, M, Miranda, D, Spackman, T. Chondrodysplasis punctata: is maternal warfarin therapy a factor? American Journal of Diseases of Childhood 1975; 129(3): 356359.CrossRefGoogle ScholarPubMed
Hall, JG, Pauli, RM, Wilson, KM. Maternal and fetal sequelae of anticoagulation during pregnancy. American Journal of Medicine 1980; 68(1): 122140.Google Scholar
Howe, AM, Lipson, AH, de Silva, M, Ouvrier, R, Webster, WS. Severe cervical dysplasia and nasal cartilage calcification following prenatal warfarin exposure. American Journal of Medical Genetics 1997; 71(4): 391396.Google Scholar
Howe, AM, Hawkins, JK, Webster, WS. The growth of the nasal septum in the 6–9 week period of foetal development – Warfarin embryopathy offers a new insight into prenatal facial development. Australian Dental Journal 2004; 49(4): 171176.CrossRefGoogle ScholarPubMed
Franco, B, Meroni, G, Parenti, G et al. A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy. Cell 1995; 81(1): 1525.CrossRefGoogle ScholarPubMed
van Driel, D, Wesseling, J, Sauer, PJ et al. Teratogen update: fetal effects after in utero exposure to coumarins: overview of cases, follow-up findings, and pathogenesis. Teratology 2002; 66(3): 127140.Google Scholar
McLintock, C. Thromboembolism in pregnancy: challenges and controversies in the prevention of pregnancy-associated venous thromboembolism and management of anticoagulation in women with mechanical prosthetic heart valves. Best Practice & Research Clinical Obstetrics & Gynaecology 2014; 28(4): 519536.CrossRefGoogle ScholarPubMed
Wong, V, Cheng, CH, Chan, KC. Fetal and neonatal outcome of exposure to anticoagulants during pregnancy. American Journal of Medical Genetics 1993; 45(1): 1721.Google Scholar
Van Driel, D, Wesseling, J, Rosendaal, FR et al. Growth until puberty after in utero exposure to coumarins. American Journal of Medical Genetics 2000; 95(5): 438443.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Greer, FR. Vitamin K the basics – what’s new? Early Human Development 2010; 86 (Suppl 1): 4347.CrossRefGoogle ScholarPubMed
Vitale, N, De Feo, M, Cotrufo, M. Anticoagulation for prosthetic heart valves during pregnancy: the importance of warfarin daily dose. European Journal of Cardiothoracic Surgery 2002; 22(4): 656; author reply 7.CrossRefGoogle ScholarPubMed
Cotrufo, M, De Feo, M, De Santo, LS et al. Risk of warfarin during pregnancy with mechanical valve prostheses. Obstetrics and Gynecology 2002; 99(1): 3540.Google ScholarPubMed
Soma-Pillay, P, Nene, Z, Mathivha, TM, Macdonald, AP. The effect of warfarin dosage on maternal and fetal outcomes in pregnant women with prosthetic heart valves. Obstetric Medicine 2011; 4: 2427.Google Scholar
van Hagen, IM, Roos-Hesselink, JW, Ruys, TP et al. Pregnancy in women with a mechanical heart valve: data of the European Society of Cardiology Registry of Pregnancy and Cardiac Disease (ROPAC). Circulation 2015; 132(2): 132142.Google Scholar
Lee, JH, Park, NH, Keum, DY, Choi, SY, Kwon, KY, Cho, CH. Low molecular weight heparin treatment in pregnant women with a mechanical heart valve prosthesis. Journal of Korean Medical Science 2007; 22(2): 258261.Google Scholar
De Santo, LS, Romano, G, Della Corte, A et al. Mechanical aortic valve replacement in young women planning on pregnancy: maternal and fetal outcomes under low oral anticoagulation, a pilot observational study on a comprehensive pre-operative counseling protocol. Journal of the American College of Cardiology 2012; 59(12): 11101115.CrossRefGoogle ScholarPubMed
Chan, WS, Anand, S, Ginsberg, JS. Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature. Archives of Internal Medicine 2000; 160(2): 191196.CrossRefGoogle Scholar
Arnaout, MS, Kazma, H, Khalil, A et al. Is there a safe anticoagulation protocol for pregnant women with prosthetic valves? Clinical and Experimental Obstetrics & Gynecology 1998; 25(3): 101104.Google Scholar
Basude, S, Hein, C, Curtis, SL, Clark, A, Trinder, J. Low-molecular-weight heparin or warfarin for anticoagulation in pregnant women with mechanical heart valves: what are the risks? A retrospective observational study. BJOG: An International Journal of Obstetrics and Gynecology 2012; 119(8): 10081013; discussion 12–3.Google Scholar
Meschengieser, SS, Fondevila, CG, Santarelli, MT, Lazzari, MA. Anticoagulation in pregnant women with mechanical heart valve prostheses. Heart 1999; 82(1): 2326.Google Scholar
Nassar, AH, Hobeika, EM, Abd Essamad, HM et al. Pregnancy outcome in women with prosthetic heart valves. American Journal of Obstetrics and Gynecology 2004; 191(3): 10091013.CrossRefGoogle ScholarPubMed
Kawamata, K, Neki, R, Yamanaka, K et al. Risks and pregnancy outcome in women with prosthetic mechanical heart valve replacement. Circulation Journal 2007; 71(2): 211213.CrossRefGoogle ScholarPubMed
McLintock, C. Anticoagulant therapy in pregnant women with mechanical prosthetic heart valves: no easy option. Thrombosis Research 2011; 127 (Suppl 3): S5660.Google Scholar
Oran, B, Lee-Parritz, A, Ansell, J. Low molecular weight heparin for the prophylaxis of thromboembolism in women with prosthetic mechanical heart valves during pregnancy. Thrombosis and Haemostasis 2004; 92(4): 747751.Google ScholarPubMed
Abildgaard, U, Sandset, PM, Hammerstrom, J, Gjestvang, FT, Tveit, A. Management of pregnant women with mechanical heart valve prosthesis: thromboprophylaxis with low molecular weight heparin. Thrombosis Research 2009; 124(3): 262267.Google Scholar
Chitsike, RS, Jacobson, BF, Manga, P et al. A prospective trial showing the safety of adjusted-dose enoxaparin for thromboprophylaxis of pregnant women with mechanical prosthetic heart valves. Clinical and Applied Thrombosis/Hemostasis 2011; 17(4): 313319.CrossRefGoogle Scholar
Goland, S, Schwartzenberg, S, Fan, J et al. Monitoring of anti-Xa in pregnant patients with mechanical prosthetic valves receiving low-molecular-weight heparin: peak or trough levels? Journal of Cardiovascular Pharmacology and Therapeutics 2014; 19(5): 451456.Google Scholar
Quinn, J, Von Klemperer, K, Brooks, R et al. Use of high intensity adjusted dose low molecular weight heparin in women with mechanical heart valves during pregnancy: a single-center experience. Hematologica 2009; 94(11): 16081612.Google Scholar
Yinon, Y, Siu, SC, Warshafsky, C et al. Use of low molecular weight heparin in pregnant women with mechanical heart valves. American Journal of Cardiology 2009; 104(9): 12591263.Google Scholar
Aventis Pharma. Heparin in pregnancy: cardiac valve thromboprophylaxis. Data on file; 1999.Google Scholar
Sanofi. Product monograph for Lovenox; 2015.Google Scholar
Gouin-Thibault, I, Pautas, E, Siguret, V. Safety profile of different low-molecular weight heparins used at therapeutic dose. Drug Safety 2005; 28(4): 333349.CrossRefGoogle ScholarPubMed
Elkayam, U, Goland, S. The search for a safe and effective anticoagulation regimen in pregnant women with mechanical prosthetic heart valves. Journal of the American College of Cardiology 2012; 59(12): 11161118.Google Scholar
Barbour, LA, Oja, JL, Schultz, LK. A prospective trial that demonstrates that dalteparin requirements increase in pregnancy to maintain therapeutic levels of anticoagulation. American Journal of Obstetrics and Gynecology 2004; 191(3): 10241029.CrossRefGoogle ScholarPubMed
Turpie, AG, Gent, M, Laupacis, A et al. A comparison of aspirin with placebo in patients treated with warfarin after heart-valve replacement New England Journal of Medicine 1993; 329(8): 524529.Google Scholar
Massonnet-Castel, S, Pelissier, E, Bara, L et al. Partial reversal of low molecular weight heparin (PK 10169) anti-Xa activity by protamine sulfate: in vitro and in vivo study during cardiac surgery with extracorporeal circulation. Hemostasis 1986; 16(2): 139146.Google Scholar
Tran, HA, Chunilal, SD, Harper, PL et al. An update of consensus guidelines for warfarin reversal. Medical Journal of Australia 2013; 198(4): 198199.Google Scholar
Casais, P, Rolandi, F. Prosthetic valve thrombosis in pregnancy: a promising treatment for a rare and mostly preventable complication. Circulation 2013; 128(5): 481482.Google Scholar
Orme, ML, Lewis, PJ, de Swiet, M et al. May mothers given warfarin breast-feed their infants? BMJ 1977; 1(6076): 15641565.CrossRefGoogle ScholarPubMed
Richter, C, Sitzmann, J, Lang, P et al. Excretion of low molecular weight heparin in human milk. British Journal of Clinical Pharmacology 2001; 52(6): 708710.Google Scholar
NZ Heart Foundation. New Zealand Guidelines for Rheumatic Fever: Diagnosis, management and secondary prevention of acute rheumatic fever and rheumatic heart disease; 2014 (Update). Heart Foundation of New Zealand.Google Scholar
Swan, L. Congenital heart disease in pregnancy. Best Practice & Research Clinical Obstetrics & Gynaecology 2014; 28(4): 495506.Google Scholar
UK National Institute for Health and Clinical Excellence (NICE). Prophylaxis Against Infective Endocarditis: Antimicrobial Prophylaxis Against Infective Endocarditis in Adults and Children Undergoing Interventional Procedures. London: NICE; 2008.Google Scholar

References

Cook, TM, Counsell, D, Wildsmith, JAW; on behalf of the Royal College of Anesthetists Third National Audit Project. Major complications of central neuraxial block: report on the Third National Audit Project of the Royal College of Anesthetists. British Journal of Anesthesia 2009; 102: 179190Google Scholar
Royal College of Obstetricians and Gynecologists. Thrombosis and Embolism during Pregnancy and the Puerperium: Reducing the Risk. Green-Top Guideline 37a. London: Royal College of Obstetricians and Gynecologists; 2015. https://www.rcog.org.uk/globalassets/documents/guidelines/gtg-37a.pdfGoogle Scholar
Knight, M et al. (eds.) on behalf of MBRRACE. Saving Lives, Improving Care. Oxford:NPEU, University of Oxford; 2015. https://www.npeu.ox.ac.uk/downloads/files/mbrrace-uk/reports/MBRRACE-UK%20Maternal%20Report%202015.pdfGoogle Scholar
CLASP (Collaborative Low dose Aspirin Study in Pregnancy) Collaborative Group. CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet 1994; 343: 619629.CrossRefGoogle Scholar
NICE. Hypertension in Pregnancy: diagnosis and management. Sections 1.1.1.2.1–2 NICE Guidelines CG107; 2010. https://www.nice.org.uk/guidance/cg107/chapter/guidanceGoogle Scholar
James, AH, Abel, DE, Braucazio, LR. Anticoagulants in pregnancy. Obstetrical and Gynecological Survey 2005; 61: 5961.Google Scholar
Wysowski, DK, Talarico, L, Bacsanyi, J, Botstein, P. Spinal and epidural hematoma and low molecular weight heparin. New England Journal of Medicine 1998; 338: 17741775.Google Scholar
Scottish Intercollegiate Guidelines Network. Section 7: Spinal and epidural blocks; Section 9: Pregnancy and puerperium. In Prophylaxis of Venous Thromboembolism. Publication No. 62. Edinburgh: SIGN; 2002: 2426; 3035.Google Scholar
Horlocker, TT, Wedel, DJ, Benzon, H et al. Regional anesthesia in the anticoagulated patient: Defining the risks (The Second ASRA Consensus Conference on Neuraxial Anesthesia and Anticoagulation). Regional Anesthesia and Pain Medicine 2003; 23: 172197.Google Scholar
Stafford-Smith, M. Impaired hemostasis and regional anesthesia. Canadian Journal of Anesthesia 1996; 43: R129R141.Google Scholar
Royal College of Obstetricians and Gynecologists. Thrombosis and Embolism during Pregnancy and the Puerperium: Acute Management. Green-Top Guideline 27b. London: Royal College of Obstetricians and Gynecologists; 2015. https://www.rcog.org.uk/globalassets/documents/guidelines/gtg-37b.pdfGoogle Scholar
Asghar, F, Bowman, P. A clinical approach to the management of thrombosis in obstetrics Part 2: diagnosis and management of venous thromboembolism. The Obstetrician and Gynecologist 2007; 9: 38.CrossRefGoogle Scholar
Gelson, E, Johnson, M, Gatzoulis, M, Uebing, A. Cardiac disease in pregnancy Part 2: acquired heart disease. The Obstetrician and Gynecologist 2007; 9: 8387.Google Scholar
Austin, SK, Lambert, J, Peebles, D, Cohen, H. Managing peri-delivery anticoagulation in women on therapeutic dose low molecular weight heparin: a role for unfractionated heparin? Journal of Thrombosis and Hemostasis 2007; 5 (Supp 1): P-S–622.Google Scholar
Akkad, A, Oppenheimer, C, Mushambi, M, Pavord, S. Intrapartum care for women on full anticoagulation. International Journal of Obstetric Anesthesia 2003; 12: 188192.Google Scholar
Loo, CC, Dahlgren, G, Irestedt, L. Neurological complications of obstetric regional analgesia. International Journal of Obstetric Anesthesia 2000; 9: 99124.CrossRefGoogle Scholar
Bates, SM, Greer, IA, Pabinger, I, Sofer, S, Hirsh, J. Venous Thromboembolism, Thrombophilias, Anti-thrombotic therapy and Pregnancy. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 844S886S.Google Scholar
Harrop-Griffiths, et al. on behalf of the Association of Anesthetists of Great Britain and Ireland, Obstetric Anesthetists’ Association and Regional Anesthesia UK. Regional anesthesia and patients with abnormalities of coagulation. Anesthesia 2013; 68: 966972.Google Scholar
Leonhardt, G, Gaul, C, Nietsch, HH et al. Thrombolytic therapy in pregnancy. Journal of Thrombosis and Thrombolysis 2006; 21: 271276.CrossRefGoogle ScholarPubMed
Ekbatani, A, Asaro, LR, Malinow, AM. Anticoagulation with argatroban in a parturient with heparin-induced thrombocytopenia. International Journal of Obstetric Anesthesia 2010; 19: 8287.Google Scholar
Young, SK, Al-Mondhiry, HA, Vaida, SJ, Ambrose, A, Botti, JJ. Successful use of argatroban during the third trimester of pregnancy: case report and review of the literature. Pharmacotherapy 2008; 28: 15311536.Google Scholar
Tanimura, K, Ebina, Y, Sonoyama, A, et al. Argatroban therapy for heparin-induced thrombocytopenia during pregnancy in a woman with hereditary antithrombin deficiency. Journal of Obstetrics and Gynaecology Research 2012; 38: 749752.Google Scholar
Huhle, G, Geberth, M, Hoffmann, U, Heene, DL, Harenberg, J. Management of heparin-associated thrombocytopenia in pregnancy with subcutaneous r-hirudin. Gynecologic and Obstetric Investigation 2000; 49: 6769.Google Scholar
Tang, AW, Greer, I. A systematic review on the use of new anticoagulants in pregnancy. Obstetric Medicine 2013; 6: 6471.Google Scholar
Ciurzyński, M, Jankowski, K, Pietrzak, B et al. Use of fondaparinux in a pregnant woman with pulmonary embolism and heparin-induced thrombocytopenia. Medical Science Monitor 2011; 17: CS5659.Google Scholar
Duhl, AJ, Paidas, MJ, Ural, SH et al. Pregnancy and Thrombosis Working Group. Antithrombotic therapy and pregnancy: consensus report and recommendations for prevention and treatment of venous thromboembolism and adverse pregnancy outcomes. American Journal of Obstetrics and Gynecology 2007; 197: 457.e1–21.CrossRefGoogle Scholar
Cohen, H, Arachchillage, DR, Middeldorp, S, Beyer-Westendorf, J, Abdul-Kadir, R. Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH. Journal of Thrombosis and Haemostasis 2016. doi: 10.1111/jth.13366Google Scholar
Macafee, B, Campbell, JP, Ashpole, K, et al. Reference ranges for thromboelastography (TEG®) and traditional coagulation tests in term parturients undergoing cesarean section. Anesthesia 2012: 67: 741747.Google Scholar
Armstrong, S, Fernando, R, Ashpole, K, Simons, R, Columb, M. Assessment of coagulation in the obstetric population using ROTEM® thromboelastometry. International Journal of Obstetric Anesthesia 2011; 20: 293298.Google Scholar
Beilin, Y, Arnold, I, Hossain, S. Evaluation of the platelet function analyser (PFA-100®) vs. the thromboelastogram (TEG) in the parturient. International Journal of Obstetric Anesthesia 2006; 15(1): 712.Google Scholar

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