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Chapter 10 - Polycystic ovarian syndrome

from Section 3: - Difficulties and complication of ovarian stimulation

Published online by Cambridge University Press:  05 August 2011

By
C. Coughlan  and
W. Ledger
Edited by
Mohamed Aboulghar  and
Botros Rizk
Mohamed Aboulghar
Affiliation:
Cairo University and the IVF-ET Center
Botros Rizk
Affiliation:
University of South Alabama
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Summary

Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrinopathies, affecting 5-10% of women of reproductive age. PCOS is one of the commonest causes of anovulatory infertility. The characteristic clinical features of PCOS include menstrual irregularity such as oligomenorrhoea and signs of hyperandrogenaemia including hirsutism, acne, and/or obesity. A recent study observed a significant and progressive correlation between body mass index (BMI) and both blood pressure and clinical features in women with PCOS. Clomifene citrate has been the standard treatment for induction of ovulation in women with anovulatory infertility for many years. The beneficial endocrinologic and morphologic effects of laparoscopic ovarian diathermy appear to be sustained for up to 9 years in most patients with PCOS. In vitro maturation (IVM) protocols are now a valuable alternative to conventional in vitro fertilization (IVF) as a strategy to prevent ovarian hyperstimulation syndrome (OHSS).

Keywords

gonadotropinsin vitro fertilizationintrauterine inseminationmultiple pregnanciesovulation oocytesmultifollicular growthmild ovarian hyperstimulationluteal support
Type
Chapter
Information
Ovarian Stimulation , pp. 87 - 102
Publisher: Cambridge University Press
Print publication year: 2010

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