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48 - Lymphatic filariasis and loa loa

from Section 8 - Helminth infections

Published online by Cambridge University Press:  05 March 2013

By
Camilla Rothe  and
Christopher J. M. Whitty
Edited by
David Mabey ,
Geoffrey Gill ,
Eldryd Parry ,
Martin W. Weber  and
Christopher J. M. Whitty
David Mabey
Affiliation:
London School of Hygiene and Tropical Medicine
Geoffrey Gill
Affiliation:
University of Liverpool
Eldryd Parry
Affiliation:
Tropical Health Education Trust
Martin W. Weber
Affiliation:
World Health Organization, Jakarta
Christopher J. M. Whitty
Affiliation:
London School of Hygiene and Tropical Medicine
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Summary

The problem in Africa

Lymphatic filariasis is a leading cause of permanent and long-term disability. It will continue to be a major problem in some areas of Africa for many years to come. The outlook for the control of lymphatic filariasis has, however, markedly improved recently. In the long term, filariasis is a potential candidate for elimination from Africa.

Loiasis exclusively occurs in Africa where millions of people are infected. In some endemic regions it is one of the commonest causes for medical consultations. Loiasis has recently gained attention due to severe complications observed in individuals co-infected with O. volvulus who were treated with antifiarial drugs.

Organism, life cycle and vector

Both lymphatic filariasis and loiasis are vector-borne infections caused by filarial nematodes.

In Africa lymphatic filariasis is almost exclusively caused by Wuchereria bancrofti. Microfilariae of W. bancrofti are ingested by female mosquitoes (Anopheles, Culex and Aedes spp.) during feeding. L.loa is transmitted by small blood-sucking Chrysops-flies, that live in or near forested and muddy areas.

Type
Chapter
Information
Principles of Medicine in Africa , pp. 453 - 456
Publisher: Cambridge University Press
Print publication year: 2013

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References

Boussinesq, M (2006). Loiasis. Ann Trop Med Parasitol; 100: 715–31.CrossRefGoogle ScholarPubMed
Bockarie, MJ, Pedersen, EM, White, GB, Michael, E (2009). Role of vector control in the global program to eliminate lymphatic filariasis. Annu Rev Entomol.; 54: 469–87.CrossRefGoogle ScholarPubMed
Critchley, J, Addiss, D, Ejere, H, Gamble, C, Garner, P, Gelband, H (2005). Albendazole for the control and elimination of lymphatic filariasis: systematic review.TMIH; 10: 118–25.Google ScholarPubMed
Dreyer, G, Noroes, J, Figueredo-Silva, J (2000). New insights into the natural history and pathology of bancroftian filariasis: implications for clinical management and filariasis control programmes. Trans Roy Soc Trop Med Hyg; 94: 594–6.CrossRefGoogle ScholarPubMed
Hoerauf, A (2008). Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis. Curr Opin Infect Dis; 21: 673–81.CrossRefGoogle ScholarPubMed
Mackenzie, CD, Lazarus, WM, Mwakitalu, ME et al. (2009). Lymphatic Filariasis: patients and the global elimination programme. Ann Trop Med Parasitol; 103: S41–51.CrossRefGoogle ScholarPubMed
Mand, S, Debrah, AY, Klarmann, U et al. (2010). The role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis. Acta Trop; 120: 523–32.Google Scholar
McMahon, JE, Marshall, TF, Vaughan, JP, Abaru, DE (1979a). Bancroftian filariasis: a comparison of microfilariae counting techniques using counting chamber, standard slide and membrane (nucleopore) filtration. Ann Trop Med Parasitol; 73: 457–64.CrossRefGoogle Scholar
McMahon, JE, Marshall, TF, Vaughan, JP, Kolstrup, N (1979b). Tanzania Filariasis Project: a provocative day test with diethylcarbamazine for the detection of microfilariae of nocturnally periodic Wuchereria bancrofti in the blood. Bull Wld Hlth Org; 57: 759–65.Google ScholarPubMed
Taylor, MJ, Makunde, WH, McGarry, HF et al. (2005). Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. The Lancet; 365: 2116–21.CrossRefGoogle ScholarPubMed
Taylor, MJ, Hoerauf, A, Bockarie, M (2010). Lymphatic Filariasis and onchocerciasis. The Lancet; 376: 1175–85.CrossRefGoogle ScholarPubMed
Touré, FS, Kassambara, L, Wiliams, T et al. (1998). Human occult loiasis: improvement in diagnostic sensitivity by the use of a nested polymerase chain reaction. Am J Trop Med Hyg; 59: 144–9.CrossRefGoogle ScholarPubMed

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