Skip to main content Accessibility help
×
Hostname: page-component-8448b6f56d-42gr6 Total loading time: 0 Render date: 2024-04-16T16:11:58.626Z Has data issue: false hasContentIssue false

6 - Cognitive Functioning in Older Adults with Schizophrenia

from Section 2 - Biological, Neurocognitive, and Medical Aspects

Published online by Cambridge University Press:  15 March 2019

Carl I. Cohen
Affiliation:
SUNY Downstate Medical Center
Paul D. Meesters
Affiliation:
Friesland Mental Health Services
Get access

Summary

The number of older adults living with schizophrenia is increasing and includes those who have had the illness since an early age and those who developed it later in life. Cognitive dysfunction is a core dimension of schizophrenia. Current literature suggests that older adults with schizophrenia who have been chronically institutionalized experience accelerated cognitive decline. In contrast, those living in the community seem to experience a relatively stable course of cognition. However, given that most of the community-based studies were short in duration or small in size, a more heterogeneous and fluctuating course of cognition consistent with a dynamic clinical course late in life cannot be ruled out. To date there is no evidence to support cognitive enhancement intervention, pharmacological or not. There is, however, evidence to support the use of psychosocial interventions to enhance functional abilities directly. Thus, larger and longer studies that could characterize the heterogeneity in cognitive trajectories are needed. They will also identify the factors that moderate these trajectories and could be targeted using cognitive enhancement interventions.
Type
Chapter
Information
Schizophrenia and Psychoses in Later Life
New Perspectives on Treatment, Research, and Policy
, pp. 69 - 78
Publisher: Cambridge University Press
Print publication year: 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Cohen, C.I., Outcome of schizophrenia into later life: an overview. Gerontologist, 1990. 30(6): 790–7.CrossRefGoogle ScholarPubMed
Cohen, C.I., Directions for research and policy on schizophrenia and older adults: Summary of the GAP Committee report. Psychiatric Services, 2000. 51(3): 299302.CrossRefGoogle ScholarPubMed
Gurland, B.J. and Cross, P.S., Epidemiology of psycho-pathology in old-age: some implications for clinical services. Psychiatric Clinics of North America, 1982. 5(1): 1182.CrossRefGoogle Scholar
Palmer, B.W., Heaton, R.K., Paulsen, J.S., et al., Is it possible to be schizophrenic yet neuropsychologically normal? Neuropsychology, 1997. 11(3): 437–46.CrossRefGoogle ScholarPubMed
Kahn, R.S. and Keefe, R.S.E., Schizophrenia is a cognitive illness: time for a change in focus. JAMA Psychiatry, 2013. 70(10): 1107–12.CrossRefGoogle ScholarPubMed
Cuffel, B.J., Jeste, D.V., Halpain, M., et al., Treatment costs and use of community mental health services for schizophrenia by age cohorts. American Journal of Psychiatry, 1996. 153(7): 870–6.Google ScholarPubMed
Karim, S., Overshott, R., and Burns, A., Older people with chronic schizophrenia. Aging and Mental Health, 2005. 9(4): 315324.CrossRefGoogle ScholarPubMed
Green, M.F. and Harvey, P.D., Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? Schizophrenia Bulletin, 2000. 26(1): 119–36.CrossRefGoogle ScholarPubMed
Kalache, S.M., Mulsant, B.H., Davies, S.J.C., et al., The impact of aging, cognition, and symptoms on functional competence in individuals with schizophrenia across the lifespan. Schizophrenia Bulletin, 2015. 41(2): 374–81.CrossRefGoogle ScholarPubMed
Tsoutsoulas, C., Mulsant, B.H., Kalache, S.M., et al., The influence of medical burden severity and cognition on functional competence in older community-dwelling individuals with schizophrenia. Schizophrenia Research, 2016. 170(2-3): 330–5.CrossRefGoogle ScholarPubMed
Roth, M., The natural history of mental disorder in old age. Journal of Mental Science, 1955. 101(423): 281301.CrossRefGoogle ScholarPubMed
Holden, N.L., Late paraphrenia or the paraphrenias: a descriptive study with a 10-year follow-up. British Journal of Psychiatry, 1987. 150: 635–9.CrossRefGoogle ScholarPubMed
Folstein, M.F., Folstein, S.E., and McHugh, P.R., Mini-Mental State: practical method for grading cognitive state of patients for clinicians. Journal of Psychiatric Research, 1975. 12(3): 189–98.Google Scholar
Harvey, P.D., White, L., Parella, M., et al., The longitudinal stability of cognitive impairment in schizophrenia: Mini-Mental State scores at one- and two-year follow-ups in geriatric inpatients. British Journal of Psychiatry, 1995. 166: 630–3.CrossRefGoogle Scholar
Harvey, P.D., Lombardi, J., Leibman, M., et al., Cognitive impairment and negative symptoms in geriatric chronic schizophrenic patients: a follow-up study. Schizophrenia Research, 1996. 22(3): 223–31.CrossRefGoogle ScholarPubMed
Harvey, P.D., Lombardi, J., Leibman, M., , et al., Performance of chronic schizophrenic patients on cognitive neuropsychological measures sensitive to dementia. International Journal of Geriatric Psychiatry, 1996. 11(7): 621–7.3.0.CO;2-V>CrossRefGoogle Scholar
Harvey, P.D., Silverman, J.M., Mohs, R.C., et al., Cognitive decline in late-life schizophrenia: a longitudinal study of geriatric chronically hospitalized patients. Biological Psychiatry, 1999. 45(1): 3240.CrossRefGoogle ScholarPubMed
Waddington, J.L. and Youssef, H.A., Cognitive dysfunction in chronic schizophrenia followed prospectively over 10 years and its longitudinal relationship to the emergence of tardive dyskinesia. Psychological Medicine, 1996. 26(4): 681–8.CrossRefGoogle Scholar
McGurk, S.R., Moriarty, P.J., Harvey, P.D., et al., The longitudinal relationship of clinical symptoms, cognitive functioning, and adaptive life in geriatric schizophrenia. Schizophrenia Research, 2000. 42(1): 4755.CrossRefGoogle ScholarPubMed
Friedman, J.I., Harvey, P.D., Coleman, T., et al., Six-year follow-up study of cognitive and functional status across the lifespan in schizophrenia: a comparison with Alzheimer's disease and normal aging. American Journal of Psychiatry, 2001. 158(9): 1441–8.CrossRefGoogle ScholarPubMed
McClure, M.M., Barch, D.M., Flory, J.D., et al., Context-procesing deficits in schizotypal personality disorder. Journal of Abnormal Psychology, 2004. 113(4): 556–8.Google Scholar
Heaton, R.K., Gladsjo, J.A., Palmer, B.W., et al., Stability and course of neuropsychological deficits in schizophrenia. Archives of General Psychiatry, 2001. 58(1): 2432.CrossRefGoogle ScholarPubMed
Savla, G.N., Moore, D.J., Roesch, S.C., et al., An evaluation of longitudinal neurocognitive performance among middle-aged and older schizophrenia patients: use of mixed-model analyses. Schizophrenia Research, 2006. 83(2-3): 215–23.Google Scholar
Palmer, B.W., Bondi, M.W., Twamley, E.W., et al., Are late-onset schizophrenia spectrum disorders neurodegenerative conditions? Annual rates of change on two dementia measures. Journal of Neuropsychiatry and Clinical Neurosciences, 2003. 15(1): 4552.CrossRefGoogle ScholarPubMed
Laks, J., Fontenelle, L.F., Chalita, A., and Mendlowicz, M.V., Absence of dementia in late-onset schizophrenia: a one year follow-up of a Brazilian case series. Arquivos de Neuro-Psiquiatria, 2006. 64(4): 946–9.CrossRefGoogle ScholarPubMed
Brodaty, H., Sachdev, P., Koschera, A., et al., Long-term outcome of late-onset schizophrenia: 5-year follow-up study. British Journal of Psychiatry, 2003. 183: 213–19.CrossRefGoogle ScholarPubMed
Loewenstein, D.A., Czaja, S.J., Bowie, C.R., and Harvey, P.D., Age-associated differences in cognitive performance in older patients with schizophrenia: a comparison with healthy older adults. American Journal of Geriatric Psychiatry, 2012. 20(1): 2940.CrossRefGoogle ScholarPubMed
Stern, Y., What is cognitive reserve? Theory and research application of the reserve concept. Journal of the International Neuropsychological Society, 2002. 8(3): 448–60.CrossRefGoogle ScholarPubMed
Harvey, P.D., Loewenstein, D.A., and Czaja, S.J., Hospitalization and psychosis: Influences on the course of cognition and everyday functioning in people with schizophrenia. Neurobiology of Disease, 2013. 53: 1825.CrossRefGoogle ScholarPubMed
Thompson, W.K., Savla, G.N., Vahia, I.V., et al., Characterizing trajectories of cognitive functioning in older adults with schizophrenia: does method matter? Schizophrenia Research, 2013. 143(1): 90–6.CrossRefGoogle ScholarPubMed
Cohen, C.I. and Murante, T., A prospective analysis of the role of cognition in three models of aging and schizophrenia. Schizophrenia Research, 2018. 196: 22–8.CrossRefGoogle ScholarPubMed
Ribe, A.R., Laursen, T.M., Charles, M., et al., Long-term risk of dementia in persons with schizophrenia. JAMA Psychiatry, 2015. 72(11): 1095–101.CrossRefGoogle ScholarPubMed
Mattis, S., Dementia Rating Scale. 1973, Odessa, FL: Psychological Assessment Resources, Inc.Google Scholar
Randolph, C., Tierney, M.C., Mohr, E., and Chase, T.N., The repeatable battery for the assessment of neuropsychological status (RBANS): preliminary clinical validity. Journal of Clinical and Experimental Neuropsychology, 1998. 20(3): 310–19.CrossRefGoogle ScholarPubMed
Almeida, O.P., Howard, R.J., Levy, R., et al., Cognitive features of psychotic states arising in late-life (late paraphrenia). Psychological Medicine, 1995. 25(4): 685–98.Google ScholarPubMed
Davidson, M., Harvey, P., Welsh, K.A., et al., Cognitive functioning in late-life schizophrenia: a comparison of elderly schizophrenic patients and patients with Alzheimer's disease. American Journal of Psychiatry, 1996. 153(10): 1274–9.Google ScholarPubMed
Harvey, P.D., Jacobsen, H., Mancini, D., et al., Clinical, cognitive and functional characteristics of long-stay patients with schizophrenia: a comparison of VA and state hospital patients. Schizophrenia Research, 2000. 43(1): 39.CrossRefGoogle ScholarPubMed
Jeste, D.V., Harris, M.J., Krull, A., et al., Clinical and neuropsychological characteristics of patients with late-onset schizophrenia. American Journal of Psychiatry, 1995. 152(5): 722–30.Google ScholarPubMed
McBride, T., Moberg, P.J., Arnold, S.E., et al., Neuropsychological functioning in elderly patients with schizophrenia and Alzheimer's disease. Schizophrenia Research, 2002. 55(3): 217–27.CrossRefGoogle ScholarPubMed
Miller, B.L., Lesser, I.M., Boone, K.B., et al., Brain-lesions and cognitive function in late-life psychosis. British Journal of Psychiatry, 1991. 158: 7682.CrossRefGoogle ScholarPubMed
Moore, D.J., Palmer, B.W., and Jeste, D.V., Use of the Mini-Mental State Exam in middle-aged and older outpatients with schizophrenia: cognitive impairment and its associations. American Journal of Geriatric Psychiatry, 2004. 12(4): 412–19.Google ScholarPubMed
Patterson, T.L., Klapow, J.C., Eastham, J.H., et al., Correlates of functional status in older patients with schizophrenia. Psychiatry Research, 1998. 80(1): 4152.CrossRefGoogle ScholarPubMed
Sachdev, P., Brodaty, H., Rose, N., and Cathcart, S., Schizophrenia with onset after age 50 years 2: Neurological, neuropsychological and MRI investigation. British Journal of Psychiatry, 1999. 175: 416–21.CrossRefGoogle ScholarPubMed
Sachdev, P., Brodaty, H., Cheang, D., and Cathcart, S., Hippocampus and amygdala volumes in elderly schizophrenic patients as assessed by magnetic resonance imaging. Psychiatry and Clinical Neurosciences, 2000. 54(1): 105–12.CrossRefGoogle ScholarPubMed
Rajji, T.K., Voineskos, A.N., Butters, M.A., et al., Cognitive performance of individuals with schizophrenia across seven decades: a study using the MATRICS Consensus Cognitive Battery. American Journal of Geriatric Psychiatry, 2013. 21(2): 108–18.CrossRefGoogle ScholarPubMed
Bankole, A.O., Cohen, C.I., Vahia, I., et al., Factors affecting quality of life in a multiracial sample of older persons with schizophrenia. American Journal of Geriatric Psychiatry, 2007. 15(12): 1015–23.CrossRefGoogle Scholar
Cohen, C.I., Stastny, P., Perlick, D., Samuelly, I., and Horn, L., Cognitive deficits among aging schizophrenic-patients residing in the community. Hospital and Community Psychiatry, 1988. 39(5): 557–9.Google ScholarPubMed
Evans, J.D., Negron, A.E., Palmer, B.W., et al., Cognitive deficits and psychopathology in institutionalized versus community-dwelling elderly schizophrenia patients. Journal of Geriatric Psychiatry and Neurology, 1999. 12(1): 1115.CrossRefGoogle ScholarPubMed
Palmer, B.W., Dunn, L.B., Appelbaum, P.S., and Jeste, D.V., Correlates of treatment-related decision-making capacity among middle-aged and older patients with schizophrenia. Archives of General Psychiatry, 2004. 61(3): 230–6.CrossRefGoogle ScholarPubMed
Zorrilla, L.T.E., Heaton, R.K., McAdams, L.A., et al., Cross-sectional study of older outpatients with schizophrenia and healthy comparison subjects: no differences in age-related cognitive decline. American Journal of Psychiatry, 2000. 157(8): 1324–6.Google Scholar
Jeste, D.V., Palmer, B.W., Appelbaum, P.S., et al., A new brief instrument for assessing decisional capacity for clinical research. Archives of General Psychiatry, 2007. 64(8): 966–74.CrossRefGoogle ScholarPubMed
Evans, J.D., Heaton, R.K., Paulsen, J.S., et al., The relationship of neuropsychological abilities to specific domains of functional capacity in older schizophrenia patients. Biological Psychiatry, 2003. 53(5): 422–30.CrossRefGoogle ScholarPubMed
Fucetola, R., Seidman, L.J., Kremen, W.S., et al., Age and neuropsychologic function in schizophrenia: a decline in executive abilities beyond that observed in healthy volunteers. Biological Psychiatry, 2000. 48(2): 137–46.CrossRefGoogle ScholarPubMed
Depp, C.A., Moore, D.J., Sitzer, D., et al., Neurocognitive impairment in middle-aged and older adults with bipolar disorder: comparison to schizophrenia and normal comparison subjects. Journal of Affective Disorders, 2007. 101(1–3): 201–9.CrossRefGoogle ScholarPubMed
Heaton, R., Paulsen, J.S., McAdams, L.A., et al., Neuropsychological deficits in schizophrenics: relationship to age, chronicity, and dementia. Archives of General Psychiatry, 1994. 51(6): 469–76.CrossRefGoogle ScholarPubMed
Kosmidis, M.H., Bozikas, V.P., Vlahou, C.H., et al., Verbal fluency in institutionalized patients with schizophrenia: age-related performance decline. Psychiatry Research, 2005. 134(3): 233–40.CrossRefGoogle ScholarPubMed
Moore, R., Blackwood, N., Corcoran, R., et al., Misunderstanding the intentions of others: an exploratory study of the cognitive etiology of persecutory delusions in very late-onset schizophrenia-like psychosis. American Journal of Geriatric Psychiatry, 2006. 14(5): 410–18.CrossRefGoogle ScholarPubMed
Dickinson, D., Ramsey, M.E., and Gold, J.M., Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. Archives of General Psychiatry, 2007. 64(5): 532–42.CrossRefGoogle ScholarPubMed
Ting, C., Rajji, T.K., Ismail, Z., et al., Differentiating the cognitive profile of schizophrenia from that of Alzheimer disease and depression in late life. PLOS One, 2010. 5(4): e10151.CrossRefGoogle ScholarPubMed
Green, M.F., What are the functional consequences of neurocognitive deficits in schizophrenia? American Journal of Psychiatry, 1996. 153(3): 321–30.Google ScholarPubMed
Lewandowski, K.E., Cohen, B.M., Keshavan, M.S., Sperry, S.H., and Ongür, D., Neuropsychological functioning predicts community outcomes in affective and non-affective psychoses: a 6-month follow-up. Schizophrenia Research, 2013. 148(1–3): 34–7.CrossRefGoogle ScholarPubMed
Tabares-Seisdedos, R., Balanzá-Martínez, V., Sánchez-Moreno, J., et al., Neurocognitive and clinical predictors of functional outcome in patients with schizophrenia and bipolar I disorder at one-year follow-up. Journal of Affective Disorders, 2008. 109(3): 286–99.CrossRefGoogle ScholarPubMed
Arts, B., Jabben, N., Krabbendam, L., and van Os, J., A 2-year naturalistic study on cognitive functioning in bipolar disorder. Acta Psychiatrica Scandinavica, 2011. 123(3): 190205.CrossRefGoogle Scholar
Nemoto, T., Niimura, H., Ryu, Y., Sakuma, K., and Mizuno, M., Long-term course of cognitive function in chronically hospitalized patients with schizophrenia transitioning to community-based living. Schizophrenia Research, 2014. 155(1–3): 90–5.CrossRefGoogle ScholarPubMed
Kennedy, J., Jeste, D., Kaiser, C.J., et al., Olanzapine vs haloperidol in geriatric schizophrenia: analysis of data from a double-blind controlled trial. International Journal of Geriatric Psychiatry, 2003. 18(11): 1013–20.CrossRefGoogle ScholarPubMed
Harvey, P.D., Napolitano, J.A., Mao, L., and Gharabawi, G., Comparative effects of risperidone and olanzapine on cognition in elderly patients with schizophrenia or schizoaffective disorder. International Journal of Geriatric Psychiatry, 2003. 18(9): 820–8.CrossRefGoogle ScholarPubMed
Jeste, D.V., Barak, Y., Madhusoodanan, S., Grossman, F., and Gharabawi, G., International multisite double-blind trial of the atypical antipsychotics risperidone and olanzapine in 175 elderly patients with chronic schizophrenia. American Journal of Geriatric Psychiatry, 2003. 11(6): 638–47. [Erratum appears in American Journal of Geriatric Psychiatry, 2004. 12(1): 49].CrossRefGoogle ScholarPubMed
Kasckow, J., Lanouette, N., Patterson, T., et al., Treatment of subsyndromal depressive symptoms in middle-aged and older adults with schizophrenia: Effect on functioning. International Journal of Geriatric Psychiatry, 2010. 25(2): 183–90.CrossRefGoogle ScholarPubMed
Rajji, T.K., Mulsant, B.H., Nakajima, S., et al., Cognition and dopamine D-2 receptor availability in the striatum in older patients with schizophrenia. American Journal of Geriatric Psychiatry, 2017. 25(1): 110.CrossRefGoogle ScholarPubMed
Golas, A.C., Kalache, S.M., Tsoutsoulas, C., et al., Cognitive remediation for older community-dwelling individuals with schizophrenia: a pilot and feasibility study. International Journal of Geriatric Psychiatry, 2015. 30(11): 1129–34.CrossRefGoogle ScholarPubMed
McGurk, S.R. and Mueser, K.T., Response to cognitive rehabilitation in older versus younger persons with severe mental illness. American Journal of Psychiatric Rehabilitation, 2008. 11: 90105.CrossRefGoogle Scholar
Wykes, T., Reeder, C., Landau, S., et al., Does age matter? Effects of cognitive rehabilitation across the age span. Schizophrenia Research, 2009. 113(2–3): 252–8.CrossRefGoogle ScholarPubMed
Chan, C.L., Ngai, E.K., Leung, P.K., and Wong, S., Effect of the adapted virtual reality cognitive training program among Chinese older adults with chronic schizophrenia: a pilot study. International Journal of Geriatric Psychiatry, 2010. 25(6): 643–9.CrossRefGoogle ScholarPubMed
Kontis, D., Huddy, V., Reeder, C., Landau, S., and Wykes, T., Effects of age and cognitive reserve on cognitive remediation therapy outcome in patients with schizophrenia. American Journal of Geriatric Psychiatry, 2013. 21(3): 218–30.CrossRefGoogle ScholarPubMed
Granholm, E., McQuaid, J.R., McClure, F.S., et al., A randomized, controlled trial of cognitive behavioral social skills training for middle-aged and older outpatients with chronic schizophrenia. The American Journal of Psychiatry, 2005. 162(3): 520–9.CrossRefGoogle ScholarPubMed
Granholm, E., McQuaid, J.R., McClure, F.S., et al., Randomized controlled trial of cognitive behavioral social skills training for older people with schizophrenia: 12-month follow-up. Journal of Clinical Psychiatry, 2007. 68(5): 730–7.Google Scholar
Granholm, E., McQuaid, J.R., Link, P.C., et al., Neuropsychological predictors of functional outcome in cognitive behavioral social skills training for older people with schizophrenia. Schizophrenia Research, 2008. 100(1–3): 133143.CrossRefGoogle ScholarPubMed
Cohen, C.I. and Iqbal, M., Longitudinal study of remission among older adults with schizophrenia spectrum disorder. American Journal of Geriatric Psychiatry, 2014. 22(5): 450–8.CrossRefGoogle ScholarPubMed
Shmukler, A.B., Gurovich, I.Y., Agius, M., and Zaytseva, Y., Long-term trajectories of cognitive deficits in schizophrenia: a critical overview. European Psychiatry, 2015. 30(8): 1002–10.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×