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Introduction: the basic neurology of sleep

from SECTION 1 - NORMAL SLEEP

Published online by Cambridge University Press:  08 August 2009

By
Harold R. Smith
Edited by
Harold R. Smith ,
Cynthia L. Comella  and
Birgit Högl
Harold R. Smith
Affiliation:
University of California, USA
Harold R. Smith
Affiliation:
University of California, Irvine
Cynthia L. Comella
Affiliation:
Rush University Medical Center, Chicago
Birgit Högl
Affiliation:
Inssbruck Medical University
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Summary

Overview

Sleep is not an inactive state.

Dating back to early modern classifications of sleep based on electrophysiological measurements, the inherent activities of various neural substrates in sleep have been readily recognized.

Normal sleep has been classified as having two characteristic divisions: non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. These sleep states are defined by neurophysiological parameters of electroencephalogram (EEG), electrooculogram (EOG), and surface electromyogram (EMG), as detailed by Dr. Billiard in the following chapter. These characteristics clearly distinguish the NREM and REM sleep states from the wakefulness state.

Behaviorally, sleep is a reversible state characterized by perceptual disengagement and apparent unresponsiveness to the environment with closed eyes, reduced movements, and recumbency. Early behaviorally based studies revealed that even in those with unequivocal electrophysiologic correlates of being asleep, arousal to one's own name and responsiveness to other auditory stimuli persist.

Additionally, the understanding that continues to evolve of the neurophysiology and neurochemistry of normal sleep suggests that many of the neurologic substrates involved are by no means passive, but rather very active in sleep. An example is the increase in cerebral blood flow that occurs in normal sleep. Both animal and human studies have shown that cerebral blood flow in NREM sleep may increase up to 25% greater than in wakefulness, and up to 80% greater in REM sleep. These changes in cerebral blood flow, at least in part, correlate with concomitant increased brain oxygen metabolism in sleep.

Type
Chapter
Information
Sleep Medicine , pp. 1 - 8
Publisher: Cambridge University Press
Print publication year: 2008

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References

Adey, WR, Bors, E, Porter, RW. EEG sleep patterns after high cervical lesions in man. Arch Neurol 1968; 19:377–83.CrossRefGoogle ScholarPubMed
Basheer, R, Strecker, RF, Thakkar, MM, McCarley, RW. Adenosine and sleep–wake regulation. Prog Neurobiol 2004; 73:379–96.CrossRefGoogle ScholarPubMed
Batini, C, Moruzzi, G, Palestini, M, Rossi, GF, Zanchetti, A. Effects of complete pontine transections of the sleep–wakefulness rhythm: the midpontine pretrigeminal preparation. Arch Ital Biol 1959; 97:1–12.Google Scholar
Belsky, G, Henriksen, S, McGarr, K. Effects of anticholinesterase (DFP) on the sleep–wakefulness cycle of the cat. Psychophysiology 1968; 5:243.Google Scholar
Blanco-Centurion, C, Xu, M, Murillo-Rodriguez, E, et al. Adenosine and sleep homeostasis in the basal forebrain. J Neurosci 2006; 26:8092–100.CrossRefGoogle ScholarPubMed
Bremer, F. Cerveau “isolé” et physiologie du sommeil. C R Soc Biol (Paris) 1935; 118:1235–41.Google Scholar
Carlsson, A, Lindqvist, M, Magnusson, T. 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists. Nature 1957; 180:1200.CrossRefGoogle ScholarPubMed
Carskadon MA, Dement WC. Normal human sleep: an overview. In: Kryger, MH, Roth, T, Dement, WC, eds. Principles and Practice of Sleep Medicine, 2nd edn. Philadelphia, PA: Saunders, 1994: 16–25.Google Scholar
Celesia, GG, Jasper, HH. Acetylcholine released from the cerebral cortex in relation to state of activation. Neurology 1966; 16:1053–63.CrossRefGoogle Scholar
Datta, S, Mavanji, V, Patterson, EH, Ulloor, J. Regulation of rapid eye movement sleep in the freely moving rat: local microinjection of serotonin, norepinephrine, and adenosine into the brainstem. Sleep 2003; 26:513–20.CrossRefGoogle ScholarPubMed
Dement, W, Kleitman, N. Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming. Electroencephalogr Clin Neurophysiol 1957; 9:673–90.CrossRefGoogle ScholarPubMed
Dinner DS. Physiology of sleep. In: Levin, KH, Lüders, HO, eds. Comprehensive Clinical Neurophysiology. Philadelphia, PA: Saunders, 2000: 589–96.Google Scholar
Domino, EF, Yamamoto, K, Dren, AT. Role of cholinergic mechanisms in states of wakefulness and sleep. Prog Brain Res 1968; 28:113–33.CrossRefGoogle ScholarPubMed
Drucker-Colin, R, Pedraza, JGB. Kainic acid lesions of gigantocellular tegmental field (FTG) neurons do not abolish REM sleep. Brain Res 1983; 272:387–91.CrossRefGoogle Scholar
Fischer-Perroudon, C, Mouret, J, Jouvet, M. Sur un cas d'agrypnie (4 mois sans sommeil) au cours d'une maladie de Morvan: effet favorable du 5-hydroxytryptophane. Electroencephalogr Clin Neurophysiol 1974; 36:1–18.CrossRefGoogle Scholar
Freemon, FR, Salinas-Garcia, RF, Ward, JW. Sleep patterns in a patient with a brain stem infarction involving the raphe nucleus. Electroencephalogr Clin Neurophysiol 1974; 36:657–60.CrossRefGoogle Scholar
Friedman, L, Jones, BE. Computer graphics analysis of sleep–wakefulness state changes after pontine lesions. Brain Res Bull 1984; 13:53–68.CrossRefGoogle ScholarPubMed
Heller, HC. A global rather than local role for adenosine in sleep homeostasis. Sleep 2006; 29:1382–3.CrossRefGoogle ScholarPubMed
Hobson, JA, Alexander, J, Frederickson, CJ. The effect of lateral geniculate lesions on phasic electrical activity of the cortex during desynchronized sleep in the cat. Brain Res 1969; 14:607–21.CrossRefGoogle ScholarPubMed
Jones, BE. The respective involvement of noradrenaline and its delaminated metabolites in waking and paradoxical sleep: a neuropharmacological model. Brain Res 1972; 39:121–36.CrossRefGoogle Scholar
Jones, BE. Basic mechanisms of sleep–wake states. In: Kryger, MH, Roth, T, Dement, WC, eds. Principles and Practice of Sleep Medicine, 2nd edn. Philadelphia, PA: Saunders, 1994: 145–62.Google Scholar
Jones, BE, Beaudet, A. Distribution of acetylcholine and catecholamine neurons in the cat brainstem: a choline acetyltransferase and tylosine hydroxylase immunohistochemical study. J Comp Neurol 1987; 261:15–32.CrossRefGoogle Scholar
Jones, BE, Cuello, AC. Afferents to the basal forebrain cholinergic cell area from pontomesencephalic catecholamine, serotonin, and acetylcholine neurons. Neuroscience 1989; 31:37–61.CrossRefGoogle ScholarPubMed
Jones, BE, Yang, TZ. The efferent projections from the reticular formation and the locus coeruleus studied by anterograde and retrograde axonal transport in the rat. J Comp Neurol 1985; 242:56–92.CrossRefGoogle ScholarPubMed
Jouvet, M. The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep–waking cycle. Ergeb Physiol 1972; 64:166–307.Google ScholarPubMed
Jouvet, M, Renault, J. Insomnie persistante après lesions des moyaux du raphe chez le chat. C R Soc Biol (Paris) 1966; 160:1461–5.Google Scholar
Lindsley, D, Bourden, J, Bagoun, H. Effects upon the EEG of acute injury to the brain stem activating system. Electroencephalogr Clin Neurophysiol 1949; 1:475–86.CrossRefGoogle Scholar
Madsen, PL, Schmidt, JF, Wildschiodtz, G, et al. Cerebral O2 metabolism and cerebral blood flow in humans during sleep and rapid-eye movement sleep. J Appl Physiol 1991; 70:2597–601.CrossRefGoogle ScholarPubMed
Magnes, J, Moruzzi, G, Pompeiano, O. Synchronization of the EEG produced by low frequency electrical stimulation of the region of the solitary tract. Arch Ital Biol 1961; 99:33–67.Google Scholar
Mangold, R, Sokoloff, K, Conner, E, et al. The effects of sleep and lack of sleep on the cerebral circulation and metabolism of normal young men. J Clinical Invest 1955; 34:1092–100.CrossRefGoogle ScholarPubMed
Markand, ON, Dyken, ML. Sleep abnormalities in patients with brain stem lesions. Neurology 1976; 26:769–76.CrossRefGoogle ScholarPubMed
Mauthner, L. Zur pathologie und physiologie des schlafes nebst bermerkungen ueber die “Nona.”Wein Klin Wochenschr 1890; 40: 961.Google Scholar
McGinty, D. Somnolence, recovery and hyposomnia following ventro-medial diencephalic lesions in the rat. Electroencephalogr Clin Neurophysiol 1969; 26:70–9.CrossRefGoogle ScholarPubMed
McGinty, D, Harper, RM. Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res 1976; 101:569–75.CrossRefGoogle ScholarPubMed
Mendelson WB. GABA-benzodiazepine receptor-chloride ionophore complex: implications for the pharmacology of sleep. In: Wauquier, A, Monti, JM, Gaillard, JM, Radulovacki, M, eds. Sleep: Neurotransmitters and Neuromodulators. New York, NY: Raven Press, 1985: 229 ff.Google Scholar
Mignot, E. A year in review: basic science, narcolepsy, and sleep in neurologic diseases. Sleep 2004; 27:1209–12.CrossRefGoogle ScholarPubMed
Monnier, M, Sauer, R, Hatt, AM. The activating effect of histamine on the central nervous system. Int Rev Neurobiol 1970; 12:265–305.CrossRefGoogle ScholarPubMed
Moruzzi, G. The sleep–waking cycle. Ergeb Physiol 1972; 64:1–165.Google ScholarPubMed
Moruzzi, G, Mogoun, H. Brainstem reticular formation and activation in the EEG. Electroencephalogr Clin Neurophysiol 1949; 1: 455–73.CrossRefGoogle ScholarPubMed
Nauta, W. Hypothalamic regulation of sleep in rats: experimental study. J Neurophysiol 1946; 9:285–316.CrossRefGoogle ScholarPubMed
Noor, Alam MD, Szymusiak, R, McGinty, D. Adenosinergic regulation of sleep: multiple sites of action in the brain. Sleep 2006; 29:1384–5.Google Scholar
Oswald, I, Taylor, AM, Treisman, M. Discriminative responses to stimulation during human sleep. Brain 1960; 83:440–53.CrossRefGoogle ScholarPubMed
Porkka-Heiskanen, T, Strecker, RE, Thakkar, M, et al. Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science 1997; 276:1265–8.CrossRefGoogle ScholarPubMed
Radulovacki M, Virus RM. Purine, 1-methylisoguanosine and pyrimidine compounds and sleep in rats. In: Wauquier, A, Monti, JM, Gaillard, JM, Radulovacki, M, eds. Sleep: Neurotransmitters and Neuromodulators. New York, NY: Raven Press, 1985: 221 ff.Google Scholar
Rechtschaffen, A, Kales, A. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Los Angeles, CA: UCLA Brain Information Service/Brain Research Institute, 1968.Google Scholar
Reivich, M, Issacs, G, Evarts, E, Kety, S. The effect of slow wave sleep and REM sleep on regional cerebral blood flow in cats. J Neurochem 1968; 15:301–6.CrossRefGoogle ScholarPubMed
Riou, F, Cespuglio, R, Jouvet, M. Endogenous peptides and sleep in the rat. I: Peptides decreasing paradoxical sleep. Neuropeptides 1982; 2:243–54.CrossRefGoogle Scholar
Sakai K. Some anatomical and physiological properties of pontomesencephalic tegmental neurons with special reference to the PGO waves and postural atonia during paradoxical sleep in the cat. In: Hobson, JA, Brazier, MA, eds. The Reticular Formation Revisited. New York, NY: Raven Press, 1980: 427–47.Google Scholar
Santiago, TV, Guerra, E, Neubauer, JA, Edelman, NH. Correlation between ventilation and brain blood flow during sleep. J Clin Invest 1984; 73:497–506.CrossRefGoogle ScholarPubMed
Sastre, J, Sakai, K, Jouvet, M. Persistence of paradoxical sleep after destruction of the pontine gigantocellular tegmental field with kainic acid in the cat. C R Acad Sci (Paris) 1979; 289:959–64.Google ScholarPubMed
Siegel JM. Brainstem mechanisms generating REM sleep. In: Kryger, MH, Roth, T, Dement, WC, eds. Principles and Practice of Sleep Medicine, 2nd edn. Philadelphia, PA: Saunders, 1994: 125–44.Google Scholar
Siegel, JM, Tomaszewski, KS, Nienhuis, R. Behavioral organization of reticular formation: studies in the unrestrained cat, II. Cells related to facial movements. J Neurophysiol 1983; 50:717–23.CrossRefGoogle ScholarPubMed
Siegel, JM, Nienhuis, R, Tomaszewski, KS. REM sleep signs rostral to chronic transections at the pontomedullary junction. Neurosci Lett 1984; 45:241–6.CrossRefGoogle ScholarPubMed
Simon-Arceo, K, Ramirez-Salado, I, Calvo, JM. Long-lasting enhancement of rapid eye movement sleep and pontogeniculooccipital waves by vasoactive intestinal peptide microinjection into the amygdala temporal lobe. Sleep 2003; 26:259–64.CrossRefGoogle ScholarPubMed
Smith HR. Stimulant-dependent sleep disorder. In: Gilman S, ed. MedLink Neurology [online]. www.medlink.com. Accessed December, 2007.
Steriade M. Brain electrical activity and sensory processing during waking and sleep states. In: Kryger, MH, Roth, T, Dement, WC, eds. Principles and Practice of Sleep Medicine, 2nd edn. Philadelphia, PA: Saunders, 1994: 105–24.Google Scholar
Steriade, M, Hobson, JA. Neuronal activity during the sleep–waking cycle. Prog Neurobiol 1976; 6:155–376.CrossRefGoogle ScholarPubMed
Sterman, MB, Clemente, CD. Forebrain inhibitory mechanisms: cortical synchronization induced by basal forebrain stimulation. Exp Neurol 1962; 6:91–102.CrossRefGoogle ScholarPubMed
Sterman, MB, Clemente, CD. Forebrain inhibitory mechanisms: sleep patterns induced by basal forebrain stimulation in the behaving cat. Exp Neurol 1962; 6:103–17.CrossRefGoogle ScholarPubMed
Townsend, RE, Prinz, PN, Obrist, WD. Human cerebral blood flow during sleep and waking. J Appl Physiol 1973; 35:620–5.CrossRefGoogle ScholarPubMed
Villablanca, J. The electrocorticogram in the chronic cerveau isolé cat. Electroencephalogr Clin Neurophysiol 1965; 19: 576–86.CrossRefGoogle ScholarPubMed
Economo, C. Encephalitis Lethargica: Its Sequelae and Treatment. London: Oxford University Press, 1931.Google Scholar
Williams, HL, Hammack, JT, Daly, RL, Dement, WC, Lubin, A. Responses to auditory stimulation, sleep loss and the EEG stages of sleep. Electroencephalogr Clin Neurophysiol 1964; 16:269–79.CrossRefGoogle Scholar
Zepelin, H, Rechtschaffen, A. Mammalian sleep, longevity and energy metabolism. Brain Behav Evol 1974; 10:425–70.CrossRefGoogle ScholarPubMed

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