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Chapter 7 - Neurodegenerative Chemosensory Disorders

Published online by Cambridge University Press:  17 January 2018

Christopher H. Hawkes
Affiliation:
Barts and the London School of Medicine and Surgery
Richard L. Doty
Affiliation:
University of Pennsylvania
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Print publication year: 2018

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References

Abele, M., Riet, A., Hummel, T., Klockgether, T., Wullner, U. 2003.Olfactory dysfunction in cerebellar ataxia and multiple system atrophy. Journal of Neurology 250, 14531455.CrossRefGoogle ScholarPubMed
Adler, C.H., Caviness, J.N., Sabbagh, M.N., et al. 2005. Olfactory testing in Parkinson’s disease and other movement disorders: Correlation with Parkinsonian severity. Movement Disorders 20(Supplement 10), Abs: 231.Google Scholar
Aggarwal, N.T., Bienias, J.L., Bennett, D.A., et al. 2006. The relation of cigarette smoking to incident Alzheimer’s disease in a biracial urban community population. Neuroepidemiology 26(3), 140146.CrossRefGoogle Scholar
Ahlskog, J.E., Waring, S.C., Petersen, R.C., et al. 1998. Olfactory dysfunction in Guamanian ALS, parkinsonism, and dementia. Neurology 51, 16721677.CrossRefGoogle ScholarPubMed
Alcalay, R.N., Siderowf, A., Ottman, R., et al. 2011. Olfaction in Parkin heterozygotes and compound heterozygotes: The CORE-PD study. Neurology 76, 319326.CrossRefGoogle ScholarPubMed
Altinayar, S., Oner, S., Can, S., Kizilay, A., Sarac, K., 2014. Olfactory disfunction and its relation olfactor bulbus volume in Parkinson’s disease. European Review for Medical and Pharmacological Sciences 18(23), 36593664.Google Scholar
Altschuler, E., 1996. Gastric Helicobacter pylori infection as a cause of idiopathic Parkinson disease and non-arteric anterior optic ischemic neuropathy. Medical Hypotheses 47(5), 413414.CrossRefGoogle ScholarPubMed
Ansari, K.A., Johnson, A., 1975. Olfactory function in patients with Parkinson’s disease. Journal of Chronic Diseases 28, 493497.CrossRefGoogle ScholarPubMed
Antunes, M., Bowler, R.M., Doty, R.L., 2007. San Francisco/Oakland Bay Bridge Welder Study: Olfactory function. Neurology 69, 12781284.CrossRefGoogle ScholarPubMed
Armstrong, C., Harrison, W.T., 1935. Prevention of intranasally-inoculated poliomyelitis of monkeys by instillation of alum into the nostrils. Public Health Reports 50, 725730.CrossRefGoogle Scholar
Arriagada, P.V., Louis, D.N., Hedley-Whyte, E.T., Hyman, B.T., 1991. Neurofibrillary tangles and olfactory dysgenesis. Lancet 337, 559.CrossRefGoogle ScholarPubMed
Ascherio, A., Chen, H., Weisskopf, M.G., et al. 2006. Pesticide exposure and risk for Parkinson’s disease. Annals of Neurology 60, 197203.CrossRefGoogle ScholarPubMed
Attems, J., Lintner, F., Jellinger, K.A., 2005. Olfactory involvement in aging and Alzheimer’s disease: an autopsy study. Journal of Alzheimer’s Disease 7(2), 149157.CrossRefGoogle ScholarPubMed
Bacon, A.W., Bondi, M.W., Salmon, D.P., Murphy, C., 1998. Very early changes in olfactory functioning due to Alzheimer’s disease and the role of apolipoprotein E in olfaction. Annals of the New York Academy of Sciences 855, 723731.CrossRefGoogle ScholarPubMed
Bahar-Fuchs, A., Moss, S., Rose, C., Savage, G., 2010. Olfactory performance in AD, aMCI, and healthy aging: A unirhinal approach. Chemical Senses 35, 855862.CrossRefGoogle ScholarPubMed
Bak, T.H., Chandran, S., 2011. What wires together dies together: Verbs, actions and neurodegeneration in motor neuron disease. Cortex 48, 936944.CrossRefGoogle ScholarPubMed
Baker, K.B., Montgomery, E.B. Jr, 2001. Performance on the PD test battery by relatives of patients with progressive supranuclear palsy. Neurology 56, 2530.CrossRefGoogle ScholarPubMed
Bakija-Konsuo, A., Mulic, R., Boraska, V., et al. 2011. Leprosy epidemics during history increased protective allele frequency of PARK2/PACRG genes in the population of the Mljet Island, Croatia. European Journal of Medical Genetics 54, e548e552.Google ScholarPubMed
Ball, M.J., Nuttall, K., 1980. Neurofibrillary tangles granulovacuolar degeneration and neuron loss in Down’s syndrome: Quantitative comparison with Alzheimer’s dementia. Annals of Neurology 7, 462465.CrossRefGoogle Scholar
Ballard, C., Ziabreva, I., Perry, R., et al. 2006. Differences in neuropathologic characteristics across the Lewy body dementia spectrum. Neurology 67, 19311934.CrossRefGoogle ScholarPubMed
Bannier, S., Berdague, J.L., Rieu, I., et al. 2012. Prevalence and phenomenology of olfactory hallucinations in Parkinson’s disease. Journal of Neurology, Neurosurgery, & Psychiatry 83, 10191021.CrossRefGoogle ScholarPubMed
Barnett, E.M., Cassell, M.D., Perlman, S., 1993. Two neurotropic viruses, herpes simplex virus type 1 and mouse hepatitis virus, spread along different neural pathways from the main olfactory bulb. Neuroscience 57, 10071025.CrossRefGoogle ScholarPubMed
Barrios, F.A., Gonzalez, L., Favila, R., et al. 2007. Olfaction and neurodegeneration in HD. Neuroreport 18, 7376.CrossRefGoogle ScholarPubMed
Bar-Sela, S., Reingold, S., Richter, E.D., 2001. Amyotrophic lateral sclerosis in a battery-factory worker exposed to cadmium. International Journal of Occupational and Environmental Health 7, 109.CrossRefGoogle Scholar
Barz, S., Hummel, T., Pauli, E., et al. 1997. Chemosensory event-related potentials in response to trigeminal and olfactory stimulation in idiopathic Parkinson’s disease. Neurology 49, 14241431.CrossRefGoogle ScholarPubMed
Beach, T.G., White, C.L. 3rd, Hladik, C.L., et al. 2009. Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders. Acta Neuropathologica 117(2), 169174.CrossRefGoogle ScholarPubMed
Beavan, M., McNeill, A., Proukakis, C., et al. 2015. Evolution of prodromal clinical markers of Parkinson disease in a GBA mutation-positive cohort. JAMA Neurology 72, 201208.CrossRefGoogle Scholar
Bedard, A., Parent, A., 2004. Evidence of newly generated neurons in the human olfactory bulb. Developmental Brain Research 151, 159168.CrossRefGoogle ScholarPubMed
Belluscio, L., Gold, G.H., Nemes, A., Axel, R., 1998. Mice deficient in G(olf) are anosmic. Neuron 20, 6981.CrossRefGoogle Scholar
Belzunegui, S., Sebastian, W.S., Garrido-Gil, P., 2007. The number of dopaminergic cells is increased in the olfactory bulb of monkeys chronically exposed to MPTP. Synapse 61, 10061012.CrossRefGoogle ScholarPubMed
Berendse, H.W., Roos, D.S., Raijmakers, P., Doty, R.L., 2011. Motor and non-motor correlates of olfactory dysfunction in Parkinson’s disease. Journal of the Neurological Sciences 310, 2124.CrossRefGoogle ScholarPubMed
Berger, P.C., Vogel, F.S., 1973. The development of the pathologic changes of Alzheimer’s disease and senile dementia in patients with Down’s syndrome. American Journal of Pathology 73, 457476.Google Scholar
Bessen, R.A., Shearin, H., Martinka, S., et al. 2010. Prion shedding from olfactory neurons into nasal secretions. PLoS Pathogens 6, e1000837.CrossRefGoogle ScholarPubMed
Bessen, R.A., Wilham, J.M., Lowe, D., Watschke, C.P., Shearin, H., Martinka, S., Caughey, B., Wiley, J.A., 2011. Accelerated shedding of prions following damage to the olfactory epithelium. Journal of Virology 86(3), 17771788.CrossRefGoogle Scholar
Betarbet, R., Sherer, T.B., MacKenzie, G., et al. 2000. Chronic systemic pesticide exposure reproduces features of Parkinson’s disease. Nature Neuroscience 3, 13011306.CrossRefGoogle ScholarPubMed
Boesveldt, S., Verbaan, D., Knol, D.L., et al. 2008. A comparative study of odor identification and odor discrimination deficits in Parkinson’s disease. Movement Disorders 23, 19841990.CrossRefGoogle ScholarPubMed
Boeve, B.F., Silber, M.H., Parisi, J.E., et al. 2003. Synucleinopathy pathology and REM sleep behavior disorder plus dementia or parkinsonism. Neurology 61, 4045.CrossRefGoogle ScholarPubMed
Bogerts, B., Hantsch, J., Herzer, M., 1983. A Morphometric Study of the Dopamine-Containing Cell Groups in the Mesencephalon of Normals, Parkinson Patients, and Schizophrenics. Biological Psychiatry 18, 951969.Google ScholarPubMed
Bohnen, N.I., Gedela, S., Herath, P., Constantine, G.M., Moore, R.Y., 2008. Selective hyposmia in Parkinson disease: association with hippocampal dopamine activity. Neuroscience Letters 447, 1216.CrossRefGoogle ScholarPubMed
Bohnen, N.I., Gedela, S., Kuwabara, H., et al. 2007. Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson’s disease. Journal of Neurology 254, 8490.CrossRefGoogle ScholarPubMed
Bohnen, N.I., Muller, M.L., Kotagal, V., et al. 2010. Olfactory dysfunction, central cholinergic integrity and cognitive impairment in Parkinson’s disease. Brain 133, 17471754.CrossRefGoogle ScholarPubMed
Bond, J.A., 1986. Bioactivation and biotransformation of xenobiotics in rat nasal tissue. In: Toxicology of the Nasal Passages. Ed. Barrow, C.S.. Washington DC: Hemisphere Publishing Corporation pp. 249261.Google Scholar
Bostantjopoulou, S., Katsarou, Z., Papadimitriou, A., et al. 2001. Clinical features of parkinsonian patients with the alpha-synuclein (G209A) mutation. Movement Disorders 16, 10071013.CrossRefGoogle ScholarPubMed
Bovi, T., Antonini, A., Ottaviani, S., et al. 2010. The status of olfactory function and the striatal dopaminergic system in drug-induced parkinsonism. Journal of Neurology 257, 18821889.CrossRefGoogle ScholarPubMed
Bower, J.H., Maraganore, D.M., Peterson, B.J., Ahlskog, J.E., Rocca, W.A., 2006. Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: a case-control study. Neurology 67, 494496.CrossRefGoogle ScholarPubMed
Braak, H., Braak, E., 1991. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologica 82(4), 239259.CrossRefGoogle ScholarPubMed
Braak, H., Braak, E., 1998. Evolution of neuronal changes in the course of Alzheimer’s disease. Journal of Neural Transmission 53, 127140.CrossRefGoogle ScholarPubMed
Braak, H., de Vos, R.A., Bohl, J., Del Tredici, K., 2006. Gastric α-synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson’s disease-related brain pathology. Neuroscience Letters 396(1), 6772.CrossRefGoogle ScholarPubMed
Braak, H., Del Tredici, K., 2011. The pathological process underlying Alzheimer’s disease in individuals under thirty. Acta Neuropathologica 121, 171181.CrossRefGoogle ScholarPubMed
Braak, H., Del Tredici, K., Rub, U., et al. 2003a. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiology of Aging 24, 197–211.CrossRefGoogle ScholarPubMed
Braak, H., Rub, U., Gai, W.P., Del Tredici, K. 2003b. Idiopathic Parkinson’s disease: Possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. Journal of Neural Transmission 110, 517536.CrossRefGoogle ScholarPubMed
Braak, H., Thal, D.R., Ghebremedhin, E., Del, T.K., 2011. Stages of the pathologic process in Alzheimer disease: Age categories from 1 to 100 years. Journal of Neuropathology and Experimental Neurology 70, 960969.CrossRefGoogle ScholarPubMed
Braga-Neto, P., Felicio, A.C., Pedroso, J.L., et al. 2011. Clinical correlates of olfactory dysfunction in spinocerebellar ataxia type 3. Parkinsonism & Related Disorders 17, 353356.CrossRefGoogle ScholarPubMed
Branco Germiniani, F., Cavalcante, T., Moro, A., et al. 2014. Evaluation of olfactory function in Friedreich’s ataxia: A case-control study. European Journal of Neurology 21, 175175.Google Scholar
Brittebo, E.B., Eriksson, V.F., Bakke, J., Brandt, I., 1991. Toxicity of 2 6-dichlorothiobenzamide (Chlorthiamid) and 2 6-dichlorobenzamide in the olfactory nasal mucosa of mice. Fundamental and Applied Toxicology 17, 92102.CrossRefGoogle Scholar
Brodoehl, S., Klingner, C., Volk, G.F., et al. 2012. Decreased olfactory bulb volume in idiopathic Parkinson’s disease detected by 3.0-Tesla magnetic resonance imaging. Movement Disorders 27, 10191025.CrossRefGoogle Scholar
Broggio, E., Pluchon, C., Ingrand, P., Gil, R., 2001. Taste impairment in Alzheimer’s disease. Revue Neurologique 157(4), 409413.Google ScholarPubMed
Brousseau, K., Brainerd, H.G., Mongolism: A Study of the Physical and Mental Characteristics of Mongolian Imbeciles. Baltimore: Williams and Wilkins. 1928.CrossRefGoogle Scholar
Busenbark, K.L., Huber, S.J., Greer, G., Pahwa, R., Koller, W.C., 1992. Olfactory function in essential tremor. Neurology 42, 16311632.CrossRefGoogle ScholarPubMed
Buxton, P.H., Hayward, M., 1967. Polyneuritis cranialis associated with industrial trichloroethylene exposure. Journal of Neurology, Neurosurgery, & Psychiatry 30, 511518.CrossRefGoogle Scholar
Bylsma, F.W., Moberg, P.J., Doty, R.L., Brandt, J., 1997. Odour identification in Huntington’s disease patients and their offspring with and without the genetic mutation for HD. Journal of Neuropsychology and Clinical Neuroscience 9, 598600Google Scholar
Calderón-Garcidueñas, L., Reed, W., Maronpot, R.R., et al. 2004. Brain inflammation and Alzheimer’s-like pathology in individuals exposed to severe air pollution. Toxicologic Pathology 32(6), 650658.CrossRefGoogle ScholarPubMed
Calderón-Garcidueñas, L., Franco-Lira, M., Henríquez-Roldán, C., et al. 2010. Urban air pollution: Influences on olfactory function and pathology in exposed children and young adults. Experimental and Toxicologic Pathology 62(1), 91102.CrossRefGoogle ScholarPubMed
Charles, P.C., Walters, E., Margolis, F., Johnston, R.E., 1995. Mechanism of neuroinvasion of Venezuelan equine encephalitis virus in the mouse. Virology 208, 662671.CrossRefGoogle ScholarPubMed
Chen, M.A., Lander, T.R., Murphy, C., 2006. Nasal health in Down syndrome: A cross-sectional study. Otolaryngology – Head and Neck Surgery 134, 741745.CrossRefGoogle ScholarPubMed
Chen, S., Tan, H.Y., Wu, Z.H., et al. 2014. Imaging of olfactory bulb and gray matter volumes in brain areas associated with olfactory function in patients with Parkinson’s disease and multiple system atrophy. European Journal of Radiology 83, 564570.CrossRefGoogle ScholarPubMed
Connelly, T., Farmer, J., Lunch, D., Doty, R.L., 2003. Olfactory dysfunction in degenerative ataxias. Journal of Neurology, Neurosurgery, & Psychiatry 74(10), 14351437.CrossRefGoogle ScholarPubMed
Constantinidis, J., de Ajuriaguerra, J., 1970. Syndrome familial avec tremblement parkin-sonien et anosmie et sa thérapeutique par la L-dopa associée à un inhibiteur de la decarboxylase. Thérapeutique (Semaine des Hôpitaux), 46, 263269.Google Scholar
Crino, P.B., Martin, J.A., Hill, W.D., et al. 1995. Beta-amyloid peptide and amyloid precursor proteins in olfactory mucosa of patients with Alzheimer’s disease Parkinson’s disease and Down syndrome. Annals of Otology, Rhinology, and Laryngology 104, 655661.CrossRefGoogle ScholarPubMed
Dahl, A.R., 1986. Possible consequences of cytochrome P-450 dependent monooxygenases in nasal tissues. In: Toxicology of the Nasal Passages. Ed. Barrow, C.S. Hemisphere Publishing Corporation. Washington D.C.; 263273.Google Scholar
Dahl, A.R., 1988. The effect of cytochrome P-450-dependent metabolism and other enzyme activities in olfaction. In: Molecular Neurobiology of the Olfactory System. Eds. Margolis, F.L., Getchell, T.V. Plenum press. New York; 5170.CrossRefGoogle Scholar
Daniel, S.E., Hawkes, C.H., 1992. Preliminary diagnosis of Parkinson’s disease by olfactory bulb pathology [letter]. Lancet 340, 186.CrossRefGoogle ScholarPubMed
Daum, R.F., Sekinger, B., Kobal, G., Lang, C.J., (2000) Riechprufung mit “sniffin’ sticks” zur klinischen Diagnostik des Morbus Parkinson. Nervenarzt 71, 643650.CrossRefGoogle Scholar
Deeb, J., Shah, M., Muhammed, N., et al. 2010. A basic smeel test is as sensitive as a dopamine transporter scan: Comparison of olfaction, taste and DaTSCAN in the diagnosis of Parkinson’s disease. QJM 103, 941952.CrossRefGoogle Scholar
Del Tredici, K., Hawkes, C.H., Ghebremedhin, E., Braak, H., 2010. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease. Acta Neuropathologica 119, 703713.CrossRefGoogle ScholarPubMed
Devanand, D.P., Liu, X., Tabert, M.H., et al. 2008. Combining early markers strongly predicts conversion from mild cognitive impairment to Alzheimer’s disease. Biological Psychiatry 64(10), 871879.CrossRefGoogle ScholarPubMed
Devanand, D.P., Michaels-Marston, K.S., Liu, X., et al. 2000. Olfactory deficits in patients with mild cognitive impairment predict Alzheimer’s disease at follow-up. American Journal of Psychiatry 157, 13991405.CrossRefGoogle ScholarPubMed
Diaz-Maroto, M.C., Perez-Coello, M.S., Cabezudo, M.D., 2002. Headspace solid-phase microextraction analysis of volatile components of spices. Chromatographia, 55, 723728.CrossRefGoogle Scholar
Ding Xie, F., 2015, Olfactory mucosa: Composition, enzymatic localization, and metabolism. In Doty, R.L., (Ed.), Handbook of Olfaction and Gustation. Hoboken: John Wiley & Sons, pp. 6391.CrossRefGoogle Scholar
Djaldetti, R., Nageris, B.I., Lorberboym, M., et al. 2008 [(123)I]-FP-CIT SPECT and olfaction test in patients with combined postural and rest tremor. Journal of Neural Transmission 115: 469472.CrossRefGoogle Scholar
Doty, R.L., 1991, Olfactory dysfunction in neurodegenerative disorders. In: Getchell, T.V., Doty, R.L., Bartoshuk, L.M., Snow, J.B. Jr Smell and Taste in Health and Disease. New York: Raven Press, pp. 735752.Google Scholar
Doty, R.L., 2001, Olfaction. Annual Review of Psychology 52, 423452.CrossRefGoogle ScholarPubMed
Doty, R.L., 2008. The olfactory vector hypothesis of neurodegenerative disease: Is it viable? Annals of Neurology 63, 715.CrossRefGoogle ScholarPubMed
Doty, R.L., 2015a. Neurotoxic exposure and impairment of the chemical senses of taste and smell. Handbook of Clinical Neurology 131, 299324.CrossRefGoogle ScholarPubMed
Doty, R.L., 2015b (Ed.), Handbook of Olfaction and Gustation. Hoboken: John Wiley & Sons.CrossRefGoogle Scholar
Doty, R.L., 2017. Olfactory dysfunction in neurological diseases: Is there a common pathological substrate? Lancet Neurology 16, 478488.CrossRefGoogle Scholar
Doty, R.L., Bayona, E.A., Leon-Ariza, D.S., et al. 2014. The lateralized smell test for detecting Alzheimer’s disease: Failure to replicate. Journal of the Neurological Sciences 340, 170173.CrossRefGoogle ScholarPubMed
Doty, R.L., Bromley, S.M., Moberg, P.J., Hummel, T., 1997. Laterality in human nasal chemoreception. Chapter 14. In: Christman, S. (Ed.), Cerebral Asymmetries in Sensory and Perceptual Processing. Elsevier, pp. 497542.CrossRefGoogle Scholar
Doty, R.L., Deems, D.A., Stellar, S., 1988. Olfactory dysfunction in parkinsonism: A general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology, 38, 12371244.CrossRefGoogle ScholarPubMed
Doty, R.L., Golbe, L.I., McKeown, D.A., et al. 1993. Olfactory testing differentiates between progressive supranuclear palsy and idiopathic Parkinson’s disease. Neurology, 43, 962965.CrossRefGoogle ScholarPubMed
Doty, R.L., Hawkes, C.H., Good, K.P., Duda, J.E., 2015. Odor perception and neuropathology in neurodegenerative diseases and schizophrenia. In: Doty, R.L. (Ed.), Handbook of Olfaction and Gustation. 3rd edition. Hoboken, NJ: John Wiley & Sons, pp. 403451.CrossRefGoogle Scholar
Doty, R.L., Nsoesie, M.T., Chung, I., et al. 2015. Taste function in early stage treated and untreated Parkinson’s disease. Journal of Neurology 262, 547557.CrossRefGoogle ScholarPubMed
Doty, R.L., Perl, D.P., Steele, J.C., et al. 1991a. Odor identification deficit of the parkinsonism-dementia complex of Guam: Equivalence to that of Alzheimer’s and idiopathic Parkinson’s disease. Neurology 41, 7780.CrossRefGoogle ScholarPubMed
Doty, R.L., Reyes, P.F., Gregor, T., 1987, Presence of both odor identification and detection deficits in Alzheimer’s disease. Brain Research Bulletin 18, 597600.CrossRefGoogle ScholarPubMed
Doty, R.L., Riklan, M., Deems, D.A., Reynolds, C., Stellar, S., 1989. The olfactory and cognitive deficits of Parkinson’s disease: Evidence for independence. Annals of Neurology 25, 166171.CrossRefGoogle ScholarPubMed
Doty, R.L., Shaman, P., Applebaum, S.L., et al. 1984. Smell identification ability: Changes with age. Science 226, 14411443.CrossRefGoogle ScholarPubMed
Doty, R.L., Stern, M.B., Pfeiffer, C., Gollomp, S.M., Hurtig, H.I., 1992a. Bilateral olfactory dysfunction in early stage treated and untreated idiopathic Parkinson’s disease. Journal of Neurology, Neurosurgery, & Psychiatry 55, 138142.CrossRefGoogle ScholarPubMed
Doty, R.L., Singh, A., Tetrud, J., Langston, J.W., 1992b. Lack of major olfactory dysfunction in MPTP-induced parkinsonism. Annals of Neurology 32, 97100.CrossRefGoogle ScholarPubMed
Doty, R.L., Tourbier, I., Ng, V., et al. 2015. Influences of hormone replacement therapy on olfactory and cognitive function in postmenopausal women. Neurobiology of Aging 36(6), 20532059.CrossRefGoogle ScholarPubMed
Double, K.L., Rowe, D.B., Hayes, M., et al. 2003. Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identification test. Archives of Neurology 60, 545549.CrossRefGoogle ScholarPubMed
Driver-Dunckley, E., Adler, C.H., Hentz, J.G., et al. 2014. Olfactory dysfunction in incidental Lewy body disease and Parkinson’s disease. Parkinsonism & Related Disorders 20, 12601262.CrossRefGoogle ScholarPubMed
Duda, J.E., Noorigian, J.V., Petrovitch, H., White, L.R., Ross, W.R., 2007. Pattern of Lewy body progression suggested Braak staging system is supported by analysis of a population based cohort of patients. Movement Disorders 22: Suppl 16, LB5 (late breaking abstract).Google Scholar
Duda, J.E., Shah, U., Arnold, S.E., Lee, V.M., Trojanowski, J.Q., 1999. The expression of alpha- beta- and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases. Experimental Neurology 160: 515522.CrossRefGoogle ScholarPubMed
Duff, K., McCaffrey, R.J., Solomon, G.S., 2002. The Pocket Smell Test: Successfully discriminating probable Alzheimer’s dementia from vascular dementia and major depression. Journal of Neuropsychiatry and Clinical Neurosciences, 14(2), 197201.CrossRefGoogle ScholarPubMed
Dunn, L.M., 1981. Peabody Picture Vocabulary Test-Revised Manual for Forms L and M. American Guidance Service: Circle Pines, MN.Google Scholar
Dziewulska, D., Doi, H., Fasano, A., et al. 2013. Olfactory impairment and pathology in neurodegenerative disorders with brain iron accumulation. Acta Neuropathologica 126, 151153.CrossRefGoogle ScholarPubMed
Eggers, C., Schmidt, A., Hagenah, J., et al. 2010. Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit. Neurology 74, 17981805.CrossRefGoogle ScholarPubMed
Elbaz, A., Levecque, C., Clavel, J., et al. 2004. CYP2D6 polymorphism pesticide exposure and Parkinson’s disease. Annals of Neurology 55(3), 430434.CrossRefGoogle ScholarPubMed
Elian, M., 1991. Olfactory impairment in motor neuron disease: a pilot study. Journal of Neurology, Neurosurgery, & Psychiatry 54, 927–8CrossRefGoogle ScholarPubMed
Esiri, M.M., 1991. Pathology of the olfactory and taste systems. In: Getchell, T.V., Doty, R.L., Bartoshuk, L.M., Snow, J.B. Jr Smell and Taste in Health and Disease. N.Y.: Raven Press, pp. 683701.Google Scholar
Evidente, V.G., Esteban, R.P., Hernandez, J.L., et al. 2004. Smell testing is abnormal in “lubag” or X-linked dystonia-parkinsonism: A pilot study. Parkinsonism & Related Disorders 10, 407410.CrossRefGoogle ScholarPubMed
Faber, H.K., Silverberg, R.J., 1946. A neuropathological study of acute human polio-myelitis with special reference to the inidtial lesio and various potential portals of entry. Journal of Experimental Medicine 83, 329353.CrossRefGoogle Scholar
Fearnley, J.M., Lees, A.J., 1991. Ageing and Parkinson’s disease: substantia nigra regional selectivity. Brain 114, 22832301.CrossRefGoogle ScholarPubMed
Fernandez-Ruiz, J., Diaz, R., Hall-Haro, C., et al. 2003. Olfactory dysfunction in hereditary ataxia and basal ganglia disorders. Neuroreport 14(10), 13391341.Google ScholarPubMed
Ferraris, A., Ialongo, T., Passali, G.C., et al. 2009. Olfactory dysfunction in Parkinsonism caused by PINK1 mutations. Movement Disorders 24(16), 23502357.CrossRefGoogle ScholarPubMed
Ferreira, J.J., Guedes, L.C., Rosa, M.M., et al. 2007. High prevalence of LRRK2 mutations in familial and sporadic Parkinson’s disease in Portugal. Movement Disorders, 22, 11941201.CrossRefGoogle ScholarPubMed
Ferreyra-Moyano, H., Barragan, E., 1989. The olfactory system and Alzheimer’s disease. International Journal of Neuroscience 49, 157197.CrossRefGoogle ScholarPubMed
Fleming, S.M., Tetreault, N.A., Mulligan, C.K., et al. 2008. Olfactory deficits in mice overexpressing human wildtype alpha-synuclein. European Journal of Neuroscience 28, 247256.CrossRefGoogle ScholarPubMed
Flexner, S., Clark, P.F., 1912. A note on the mode of infection in epidemic poliomyelitis. Proceedings of the Society for Experimental Biology & Medicine 10, 12.CrossRefGoogle Scholar
Flexner, S., Lewis, P.A., 1910. Experimental epidemic poliomyelitis in monkeys. Journal of Experimental Medicine 12, 227255.CrossRefGoogle ScholarPubMed
Funabe, S., Takao, M., Saito, Y., et al. 2013. Neuropathologic analysis of Lewy-related alpha-synucleinopathy in olfactory mucosa. Neuropathology 33, 4758.CrossRefGoogle ScholarPubMed
Gadoth, N., Mass, E., Gordon, C.R., Steiner, J.E., 1997. Taste and smell in familial dysautonomia. Developmental Medicine and Child Neurology 39, 393397.Google ScholarPubMed
Galvin, J.E., Pollack, J., Morris, J.C., 2006. Clinical phenotype of Parkinson disease dementia. Neurology 67, 16051611.CrossRefGoogle ScholarPubMed
Gardiner, J., Barton, D., Vanslambrouck, J.M., et al. 2008. Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases. Neuroscientist 14, 240250.CrossRefGoogle ScholarPubMed
Garland, E.M., Raj, S.R., Peltier, A.C., Robertson, D., Biaggioni, I., 2011. A cross-sectional study contrasting olfactory function in autonomic disorders. Neurology 76, 456460.CrossRefGoogle ScholarPubMed
Genter, M.B., Krishan, M., Preditor, R.D., 2015. The olfactory system as a route of delivery for agents to the brain and circulation. In: Doty, R.L. (Ed.), Handbook of Olfaction and Gustation. 3rd edition. Hoboken, NJ: John Wiley & Sons, pp. 453484.CrossRefGoogle Scholar
Geser, F., Wenning, G.K., Poewe, W., McKeith, I., 2005. How to diagnose dementia with Lewy bodies: state of the art. Movement Disorders 20 Suppl 12, S1120.CrossRefGoogle ScholarPubMed
Ghadami, M., Majidzadeh, A., Morovvati, S., et al. 2004. Isolated congenital anosmia with morphologically normal olfactory bulb in two Iranian families: A new clinical entity? American Journal of Medical Genetics Part A 127A, 307309.CrossRefGoogle ScholarPubMed
Gilbert, P.E., Murphy, C., 2004. The effect of the ApoE epsilon4 allele on recognition memory for olfactory and visual stimuli in patients with pathologically confirmed Alzheimer’s disease, probable Alzheimer’s disease, and healthy elderly controls. Journal of Clinical Experimental Neuropsychology 26, 779794.CrossRefGoogle ScholarPubMed
Gillner, M., Brittebo, E.B., Brandt, I., Soderkvist Appelgren, L-E., Gustafsson, J-A., 1987. Uptake and specific binding of 2 3 7 8-tetrachlorodibenzo-p-dioxin in the olfactory mucosa of mice and rats. Cancer Research 47, 41504159.Google ScholarPubMed
Glasl, L., Kloos, K., Giesert, F., et al. 2012. Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb. Experimental Neurology 235, 214227.CrossRefGoogle ScholarPubMed
Glass, P.G., Lees, A.J., Mathias, C., Mason, L., Best, C., Williams, D.R., Katzenschlager, R., Silveira‐Moriyama, L., et al. 2011. Olfaction in pathologically proven patients with multiple system atrophy. Movement Disorders 27(2), 327328.CrossRefGoogle ScholarPubMed
Goetz, C.G., Stebbins, G.T., Ouyang, B., 2011. Visual plus nonvisual hallucinations in Parkinson’s disease: Development and evolution over 10 years. Movement Disorders 26, 21962200.CrossRefGoogle ScholarPubMed
Goetz, C.G., Vogel, C., Tanner, C.M., Stebbins, G.T., 1998. Early dopaminergic drug-induced hallucinations in parkinsonian patients. Neurology 51, 811814.CrossRefGoogle ScholarPubMed
Goker-Alpan, O., Lopez, G., Vithayathil, J., et al. 2008. The spectrum of parkinsonian manifestations associated with glucocerebrosidase mutations. Archives of Neurology 65, 13531357.CrossRefGoogle ScholarPubMed
Goldstein, D.S., Sewell, L., 2009. Olfactory dysfunction in pure autonomic failure: Implications for the pathogenesis of Lewy body diseases. Parkinsonism & Related Disorders 15(7), 516520.CrossRefGoogle ScholarPubMed
Goldstein, D.S., Holmes, C., Bentho, O., et al. 2008. Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy. Parkinsonism & Related Disorders 14, 600607.CrossRefGoogle ScholarPubMed
Gottofrey, J., Tjalve, H., 1991. Axonal transport of cadmium in the olfactory nerve of the pike. Pharmacology & Toxicology 69, 242252.CrossRefGoogle ScholarPubMed
Graves, A.B., Bowen, J.D., Rajaram, L., et al. 1999. Impaired olfaction as a marker for cognitive decline: Interaction with apolipoprotein E epsilon4 status. Neurology 53, 14801487.CrossRefGoogle ScholarPubMed
Gray, A.J., Staples, V., Murren, K., Dhariwal, A., Bentham, P., 2001. Olfactory identification is impaired in clinic-based patients with vascular dementia and senile dementia of Alzheimer type. International Journal of Geriatric Psychiatry 16(5), 513517.CrossRefGoogle ScholarPubMed
Gray, J.M., Young, A.W., Barker, W.A., Curtis, A., Gibson, D., 1997. Impaired recognition of disgust in Huntington’s disease gene carriers. Brain 120(Pt 11), 20292038.CrossRefGoogle ScholarPubMed
Gresham, L.S., Molgaard, C.A., Smith, R.A., 1993. Induction of cytochrome P-450 enzymes via tobacco smoke: A potential mechanism for developing resistance to environmental toxins as related to parkinsonism and other neurologic diseases. Neuroepidemiology 12(2), 114116.CrossRefGoogle Scholar
Haehner, A., Hummel, T., Hummel, C., et al. 2007. Olfactory loss may be a first sign of idiopathic Parkinson’s disease. Movement Disorders 22, 839842.CrossRefGoogle ScholarPubMed
Hague, K., Lento, P., Morgello, S., Caro, S., Kaufmann, H., 1997. The distribution of Lewy bodies in pure autonomic failure: autopsy findings and review of the literature. Acta Neuropathol 94, 192196.CrossRefGoogle ScholarPubMed
Halliday, G., Del Tredici, K., Braak, H., 2006. Critical appraisal of the Braak staging of brain pathology related to sporadic Parkinson’s disease. Journal of Neural Transmission Suppl 70, 99103.Google Scholar
Halliday, G.M., Barker, R.A., Rowe, D.B., 2011. Non-dopamine Lesions in Parkinson’s Disease. Oxford: Oxford University Press.Google Scholar
Hamilton, J.M., Murphy, C., Paulsen, J.S., 1999. Odour detection learning and memory in Huntington’s disease. Journal of the International Neuropsychological Society 5, 609615.CrossRefGoogle ScholarPubMed
Hamir, A.N., Kunkle, R.A., Richt, J.A., Miller, J.M., Greenlee, J.J., 2008. Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep. Veterinary Pathology 45, 711.CrossRefGoogle ScholarPubMed
Handley, O.J., Morrison, C.M., Miles, C., Bayer, A.J., 2006. ApoE gene and familial risk of Alzheimer’s disease as predictors of odour identification in older adults. Neurobiology of Aging 27, 14251430.CrossRefGoogle ScholarPubMed
Hardy, J., 2005. Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: “Permissive templating” as a general mechanism underlying neurodegeneration. Biochemical Society Transactions 33, 578581.CrossRefGoogle ScholarPubMed
Hawkes, C.H., Shephard, B.C., 1992. Olfactory impairment in Parkinson’s disease: Evidence of dysfunction measured by olfactory event-related potentials and smell identification tests. Annals of Neurology 32, 248 (abstract).Google Scholar
Hawkes, C.H., Shephard, B.C., 1993, Selective anosmia in Parkinson’s disease? Lancet Neurology 341, 435436.CrossRefGoogle ScholarPubMed
Hawkes, C.H., Shephard, B.C., 1998. Olfactory evoked responses and identification tests in neurological disease. Annals of New York Academy of Science 855, 608615.CrossRefGoogle ScholarPubMed
Hawkes, C., Shah, M., Fogo, A., 2005. Smell identification declines from age 36 years and mainly affects pleasant odours. Movement Disorders 20 (Suppl. 10) S48. P160 (abstract).Google Scholar
Hawkes, C.H., Del Tredici, K, Braak, H., 2007. Parkinson’s disease: A dual-hit hypothesis. Neuropathology and Applied Neurobiology 33(6), 599614.CrossRefGoogle ScholarPubMed
Hawkes, C.H., 2008a. Parkinson’s disease and aging: same or different process? Movement Disorders 23(1), 4753.CrossRefGoogle ScholarPubMed
Hawkes, C.H., 2008b. The prodromal phase of sporadic Parkinson’s disease: Does it exist and if so how long is it? Movement Disorders 23, 17991807.CrossRefGoogle Scholar
Hawkes, C.H., Del Tredici, K., Braak, H., 2010. A timeline for Parkinson’s disease. Parkinsonism & Related Disorders 16, 7984.CrossRefGoogle ScholarPubMed
Hawkes, C.H., Shephard, B.C., Daniel, SE. (1997). Olfactory dysfunction in Parkinson’s disease. Journal of Neurology, Neurosurgery, & Psychiatry 62, 436436.CrossRefGoogle ScholarPubMed
Hayes, C.J., Stevenson, R.J., Coltheart, M., 2007. Disgust and Huntington’s disease. Neuropsychologia 45, 11351151.CrossRefGoogle ScholarPubMed
Hemdal, P., Corwin, J., Oster, H., 1993. Olfactory identification deficits in Down’s syndrome and idiopathic mental retardation. Neuropsychologia 31, 977984.CrossRefGoogle ScholarPubMed
Hensiek, A.E., Bhatia, K., Hawkes, C.H., 2000. Olfactory function in drug induced parkinsonism. Journal of Neurology 247(3), 303.Google Scholar
Hentschel, K., Baba, Y., Williams, L.N., et al. 2005. Olfaction in familial parkinsonism (FP). Movement Disorders 20, P175, S52S52.Google Scholar
Hext, P.M., Lock, E.A., 1992. The accumulation and metabolism of 3-trifluoromethylpyridine by rat olfactory and hepatic tissues. Toxicology 72, 6175.CrossRefGoogle ScholarPubMed
Höglinger, G.U., Alvarez-Fischer, D., Arias-Carrión, O., et al. 2015. A new dopaminergic nigro-olfactory projection. Acta neuropathologica 130(3), 333348.CrossRefGoogle ScholarPubMed
Holter, S.M., Stromberg, M., Kovalenko, M., et al. 2013. A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington’s disease CAG knock-in mice. PLoS One 8, e80923.CrossRefGoogle ScholarPubMed
Hozumi, S., Nakagawasai, O., Tan-No, K., Niijima, F., Yamadera, F., Murata, A., Arai, Y., Yasuhara, H., Tadano, T., 2003. Characteristics of changes in cholinergic function and impairment of learning and memory-related behavior induced by olfactory bulbectomy. Behavioural Brain Research 138(1), 915.CrossRefGoogle ScholarPubMed
Huart, C., Rombaux, P., Gérard, T., Hanseeuw, B., Lhommel, R., Quenon, L., Ivanoiu, A., Mouraux, A., 2015. Unirhinal olfactory testing for the diagnostic workup of mild cognitive impairment. Journal of Alzheimer’s Disease 47(1), 253270.CrossRefGoogle ScholarPubMed
Hughes, A.J., Daniel, S.E., Lees, A.J. 2001. Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease. Neurology 57(8), 14971499.CrossRefGoogle ScholarPubMed
Huisman, E., Uylings, H.B, Hoogland, P.V., 2004. A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson’s disease. Movement Disorders 19, 687692.CrossRefGoogle ScholarPubMed
Huisman, E., Uylings, HB., Hoogland, PV., 2008. Gender-related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson’s disease patients. Movement Disorders 23, 14071413.CrossRefGoogle ScholarPubMed
Iijima, M., Osawa, M., Momose, M., et al. 2010. Cardiac sympathetic degeneration correlates with olfactory function in Parkinson’s disease. Movement Disorders 25(9), 11431149.CrossRefGoogle ScholarPubMed
Imamura, K., Matumoto, S., Mabuchi, N., et al. 2009. Relationship between the regional cerebral blood flow and the cognitive function and anosmia in patients with Parkinson disease and Alzheimer disease. Brain Nerve 61(6), 683690.Google ScholarPubMed
Iranzo, A., Molinuevo, J.L., Santamaria, J., et al. 2006. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: A descriptive study. Lancet Neurology 5, 572577.CrossRefGoogle ScholarPubMed
Iscan, M., Reuhl, K., Weiss, B., Maines, M.D., 1990. Regional and subcellular distribution of cytochrome P-450-dependent drug metabolism in monkey brain: The olfactory bulb and the mitrochondrial fraction have high levels of activity. Biochemical and Biophysical Research Communications 169, 858863.CrossRefGoogle Scholar
Jellinger, K.A. 2009. Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders. Acta Neuropathologica 117(2), 215–6CrossRefGoogle ScholarPubMed
Jennings, D., Siderowf, A., Stern, M., et al. 2014. Imaging prodromal Parkinson disease: the Parkinson Associated Risk Syndrome Study. Neurology 83, 17391746.CrossRefGoogle ScholarPubMed
Johansen, K.K., White, L.R., Farrer, M.J., Aasly, J.O., 2011. Subclinical signs in LRRK2 mutation carriers. Parkinsonism & Related Disorders 17, 528532.CrossRefGoogle ScholarPubMed
Juncos, J.L., Lazarus, J.T., Rohr, J., et al. 2012. Olfactory dysfunction in fragile X tremor ataxia syndrome. Movement Disorders 27, 15561559.CrossRefGoogle ScholarPubMed
Kalaitzakis, M.E., Graeber, M.B., Gentleman, S.M., Pearce, R.K., 2008. The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson’s disease: A critical analysis of alpha-synuclein staging. Neuropathology and Applied Neurobiology 34, 284295.CrossRefGoogle Scholar
Kalmey, J.K., Thewissen, J.G., Dluzen, DE. 1998. Age-related size reduction of foramina in the cribriform plate. Anatomical Record 251(3), 326329.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Kandasamy, M., Rosskopf, M., Wagner, K., et al. 2015. Reduction in subventricular zone-derived olfactory bulb neurogenesis in a rat model of Huntington’s disease is accompanied by striatal invasion of neuroblasts. PLoS One 10, e0116069.CrossRefGoogle Scholar
Kashihara, K., Hanaoka, A., Imamura, T., 2011. Frequency and characteristics of taste impairment in patients with Parkinson’s disease: Results of a clinical interview. Internal Medicine 50(20), 23112315.CrossRefGoogle ScholarPubMed
Kareken, D.A., Doty, R.L., Moberg, P.J., et al. 2001. Olfactory-evoked regional cerebral blood flow in Alzheimer’s disease. Neuropsychology 15(1), 1829.CrossRefGoogle ScholarPubMed
Katzman, R., 1986. Alzheimer’s disease. New England Journal of Medicine 314, 964973.CrossRefGoogle ScholarPubMed
Katzman, R., 1986. Differential diagnosis of dementing illnesses. Neurologic Clinics 4, 329340.CrossRefGoogle ScholarPubMed
Kaufmann, H., Nahm, K., Purohit, D., Wolfe, D., 2004. Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies. Neurology 63, 10931095.CrossRefGoogle ScholarPubMed
Kertelge, L., Bruggemann, N., Schmidt, A., et al. 2010. Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson’s disease. Movement Disorders 25, 26652669.CrossRefGoogle ScholarPubMed
Khan, N.L., Katzenschlager, R., Watt, H., et al. 2004. Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease. Neurology 62, 12241226.CrossRefGoogle ScholarPubMed
Killgore, W.D.S., McBride, S.H., 2006. Odour identification accuracy declines following 24 h of sleep deprivation. J Sleep Res 15, 111116.CrossRefGoogle Scholar
Kim, H.J., Jeon, B.S., Lee, J.Y., et al. 2011. Taste function in patients with Parkinson disease. Journal of Neurology 258, 10761079.CrossRefGoogle ScholarPubMed
Kishikawa, M., Iseki, M., Sakae, M., Kawaguchi, S., Fujii, H., 1994. Early diagnosis of Alzheimer’s? Nature 369(6479), 365366.CrossRefGoogle ScholarPubMed
Klein, C., Schneider, S.A., Lang, A.E., 2009. Hereditary parkinsonism: Parkinson disease look-alikes–an algorithm for clinicians to “PARK” genes and beyond. Movement Disorders 24(14), 20422058.CrossRefGoogle ScholarPubMed
Klimek, L., 1998. Sense of smell in allergic rhinitis. Pneumologie 52, 196202.Google ScholarPubMed
Knupfer, L., Spiegel, R., 1986. Differences in olfactory test performance between normal aged, Alzheimer and vascular type dementia individuals. International Journal of Geriatric Psychiatry 1(1), 314.CrossRefGoogle Scholar
Kobal, G., Plattig, K.H., 1978. [Objective olfactometry: Methodological annotations for recording olfactory EEG-responses from the awake human]. EEG EMG Z eitschrift Fur Elektroenzephalographie, Elektromyographie Und Verwandte Gebiete 9, 135145.Google ScholarPubMed
Koss, E., Weiffenbach, J.M., Haxby, J.V., Friedland, R.P., 1988. Olfactory detection and identification performance are dissociated in early Alzheimer’s disease. Neurology 38(8), 12281228.CrossRefGoogle ScholarPubMed
Kovacs, T., Papp, M.I., Cairns, N.J., Khan, M.N., Lantos, P.L. 2003. Olfactory bulb in multiple system atrophy. Movement Disorders 18, 938942.CrossRefGoogle ScholarPubMed
Kovacs, G.G., Trabattoni, G., Hainfellner, J.A., et al. 2002. Mutations of the prion protein gene phenotypic spectrum. Journal of Neurology 249, 15671582.Google ScholarPubMed
Kovács, T., 2013. The olfactory system in Alzheimer’s disease: Pathology, pathophysiology and pathway for therapy. Translational Neuroscience 4(1), 3445.CrossRefGoogle Scholar
Kovacs, T., Cairns, N.J., Lantos, P.L., 2001. Olfactory centres in Alzheimer’s disease: Olfactory bulb is involved in early Braak’s stages. Neuroreport 12, 285288.CrossRefGoogle ScholarPubMed
Krismer, F., Wenning, G.K., Li, Y., Poewe, W., Stefanova, N. 2013. Intact olfaction in a mouse model of multiple system atrophy. PLoS One, 8, e64625.CrossRefGoogle Scholar
Krüger, R., Müller, T., Riess, O., 2000. Involvement of α-synuclein in Parkinson’s disease and other neurodegenerative disorders. Journal of Neural Transmission 107(1), 3140.Google ScholarPubMed
Krüger, S., Haehner, A., Thiem, C., Hummel, T. 2008. Neuroleptic-induced parkinsonism is associated with olfactory dysfunction. Journal of Neurology 255(10), 15741579.CrossRefGoogle ScholarPubMed
Kumar, K.R., Weissbach, A., Heldmann, M., et al. 2012. Frequency of the D620 N mutation in VPS35 in Parkinson disease. Archives of Neurology 69, 13601364.CrossRefGoogle Scholar
Kurtenbach, S., Wewering, S., Hatt, H., Neuhaus, E.M., Lubbert, H. 2013., Olfaction in three genetic and two MPTP-induced Parkinson’s disease mouse models. PLoS One 8, e77509.CrossRefGoogle ScholarPubMed
Landis, B.N., Burkhard, P.R., 2008. Phantosmias and Parkinson disease. Archives of Neurology 65, 12371239.CrossRefGoogle ScholarPubMed
Lang, C.J., Leuschner, T., Ulrich, K. et al. 2006. Taste in dementing diseases and parkinsonism. Journal of the Neurological Sciences 248, 177184.CrossRefGoogle ScholarPubMed
Lang, C., Schwandner, K., Hecht, M., 2011. Do patients with motor neuron disease suffer from disorders of taste or smell? Amyotrophic Lateral Sclerosis 12, 368371.CrossRefGoogle ScholarPubMed
Larson, J., Kim, D., Patel, R.C., Floreani, C., 2008. Olfactory discrimination learning in mice lacking the fragile X mental retardation protein. Neurobiology of Learning and Memory 90, 90102.CrossRefGoogle ScholarPubMed
Le Pichon, C.E., Valley, M.T., Polymenidou, M., et al. 2009. Olfactory behavior and physiology are disrupted in prion protein knockout mice. Nature Neuroscience 12, 6069.CrossRefGoogle ScholarPubMed
Lee, D.H., Oh, J.S., Ham, J.H., et al. 2015. Is normosmic Parkinson disease a unique clinical phenotype? Neurology 85(15), 12701275.CrossRefGoogle ScholarPubMed
Lee, L.V., Munoz, E.L., Tan, K.T., Reyes, M.T., 2001. Sex linked recessive dystonia parkinsonism of Panay, Philippines (XDP). Molecular Pathology 54, 362368.Google ScholarPubMed
Lee, P.H., Yeo, S.H., Yong, S.W., Kim, Y.J., 2007. Odour identification test and its relation to cardiac 123I-metaiodobenzylguanidine in patients with drug induced parkinsonism. Journal of Neurology, Neurosurgery, & Psychiatry 78, 12501252.CrossRefGoogle ScholarPubMed
Lehman, C.D., Bartoshuk, L.M., Catalanotto, F.C., Kveton, J.F., Lowlicht, R.A., 1995. Effect of anesthesia of the chorda tympani nerve on taste perception in humans. Physiology & Behavior 57(5), 943–51.CrossRefGoogle ScholarPubMed
Lelan, F., Boyer, C., Thinard, R., et al. 2011. Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease. Journal of Parkinson’s Disease 987084.Google Scholar
Lesage, S., Anheim, M., Condroyer, C., et al 1995. French Parkinson’s Disease Genetics Study Group. Large-scale screening of the Gaucher’s disease-related glucocerebrosidase gene in Europeans with Parkinson’s disease. Human Molecular Genetics 2011; 20(1), 202–10.Google Scholar
Lesage, S., Durr, A., Brice, A., 2007. LRRK2: A link between familial and sporadic Parkinson’s disease? Pathologie Biologie (Paris), 55, 107110.CrossRefGoogle ScholarPubMed
Li, A.A., Mink, P.J., McIntosh, L.J., Teta, M.J., Finley, B., 2005. Evaluation of epidemiologic and animal data associating pesticides with Parkinson’s disease. Occupational and Environmental Medicine 47(10), 10591087.CrossRefGoogle ScholarPubMed
Liberini, P., Parola, S., Spano, P.F., Antonini, L., 2000. Olfaction in Parkinson’s disease: Methods of assessment and clinical relevance. Journal of Neurology 247, 8896CrossRefGoogle ScholarPubMed
Liou, H.H., Tsai, M.C., Chen, C.J., et al. 1997. Environmental risk factors and Parkinson’s disease: a case-control study in Taiwan. Neurology 48(6), 15831588.CrossRefGoogle ScholarPubMed
Lohmann, E., Leclere, L., De Anna, F., et al. 2009. French Parkinson’s Disease Genetics Study Group. A clinical, neuropsychological and olfactory evaluation of a large family with LRRK2 mutations. Parkinsonism & Related Disorders 15(4), 273276.CrossRefGoogle Scholar
Louis, E.D., Bromley, S.M., Jurewicz, E.C., Watner, D., 2002. Olfactory dysfunction in essential tremor: A deficit unrelated to disease duration or severity. Neurology, 59(10), 16311633.CrossRefGoogle ScholarPubMed
Louis, E.D., Jurewicz, E.C., 2003. Olfaction in essential tremor patients with and without isolated rest tremor. Movement Disorders 18(11), 13871389.CrossRefGoogle ScholarPubMed
Louis, E.D., Rios, E., Pellegrino, K.M., et al. 2008. Higher blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations correlate with lower olfactory scores in essential tremor. Neurotoxicology 29, 460465.CrossRefGoogle ScholarPubMed
Louis, E.D., Vonsattel, J.P., Honig, L.S., et al. 2006. Neuropathologic findings in essential tremor. Neurology 66(11), 17561759.CrossRefGoogle ScholarPubMed
Louis, E.D., Faust, P.L., Ma, K.J., et al. 2011. Torpedoes in the Cerebellar Vermis in Essential Tremor Cases vs. Controls. Cerebellum 10, 812819.CrossRefGoogle ScholarPubMed
Lovell, M.A., Jafek, B.W., Moran, D.T., Rowley, J.C., 1982. Biopsy of human olfactory mucosa: An instrument and a technique. Archives of Otolaryngology 247249.CrossRefGoogle Scholar
Lucassen, E.B., Sterling, N.W., Lee, E.Y., et al. 2014. History of smoking and olfaction in Parkinson’s disease. Movement Disorders 29(8), 10691074.CrossRefGoogle ScholarPubMed
Luzzi, S., Snowden, J.S., Neary, D., Coccia, M., Provinciali, L., Lambon Ralph, M.A., 2007. Distinct patterns of olfactory impairment in Alzheimer’s disease, semantic dementia, frontotemporal dementia, and corticobasal degeneration. Neuropsychologia 45(8), 18231831.CrossRefGoogle ScholarPubMed
Macknin, J.B., Higuchi, M., Lee, V.M.Y., Trojanowski, J.Q., Doty, R.L., 2004. Olfactory dysfunction occurs in transgenic mice overexpressing human τ protein. Brain Research 1000(1), 174178.CrossRefGoogle ScholarPubMed
Magerova, H., Vyhnalek, M., Laczo, J., et al. 2014. Odor Identification in Frontotemporal Lobar Degeneration Subtypes. American Journal of Alzheimer’s Disease and Other Dementias.CrossRefGoogle Scholar
Mann, D.M., 1988. Alzheimer’s disease and Down’s syndrome. Histopathology 13, 125137.CrossRefGoogle ScholarPubMed
Mann, D.M., 1989. The pathogenesis and progression of the pathological changes of Alzheimer’s disease. Annals of Medicine 21(2), 133136.CrossRefGoogle ScholarPubMed
Markesbery, W.R., Jicha, G.A., Liu, H., Schmitt, FA. 2009. Lewy body pathology in normal elderly subjects. Journal of Neuropathology and Experimental Neurology 68, 816822.CrossRefGoogle ScholarPubMed
Markopoulou, K., Larsen, K.W., Wszolek, E.K., et al. 1997. Olfactory dysfunction in familial parkinsonism. Neurology 49, 12621267.CrossRefGoogle ScholarPubMed
Marras, C., Goldman, S., Smith, A., et al. 2005. Smell identification ability in twin pairs discordant for Parkinson’s disease. Movement Disorders 20(6), 687693.CrossRefGoogle ScholarPubMed
Martel, G., Simon, A., Nocera, S., et al. 2015. Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice. Neurobiology of Aging 36(2), 10131028.CrossRefGoogle Scholar
Masucci, MG. 2004.Epstein-Barr virus oncogenesis and the ubiquitin-proteasome system. Oncogene 23, 21072115.CrossRefGoogle ScholarPubMed
McAuley, J.H., Gregory, S., 2012. Prevalence and clinical course of olfactory hallucinations in idiopathic Parkinson’s disease. Journal of Parkinson’s Disease 2, 199205.CrossRefGoogle ScholarPubMed
McKeith, I.G., 2006. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop. Journal of Alzheimer’s Disease 9 (3 Suppl), 417423.CrossRefGoogle Scholar
McKeown, D.A., Doty, R.L., Perl, D.P., Frye, R.E., Simms, I., Mester, A., 1996. Olfactory function in young adolescents with Down’s syndrome. Journal of Neurology, Neurosurgery, & Psychiatry 61, 412414.CrossRefGoogle ScholarPubMed
McLaughlin, N.C., Westervelt, H.J., 2008. Odor identification deficits in frontotemporal dementia: a preliminary study. Archives of Clinical Neuropsychology 23(1), 119123.CrossRefGoogle ScholarPubMed
McNeill, A., Duran, R., Proukakis, C., et al. 2012. Hyposmia and cognitive impairment in Gaucher disease patients and carriers. Movement Disorders 27, 526532.CrossRefGoogle ScholarPubMed
McShane, R.H., Nagy, Z., Esiri, M.M., et al. 2001. Anosmia in dementia is associated with Lewy bodies rather than Alzheimer’s pathology. Journal of Neurology, Neurosurgery, & Psychiatry 70, 739743.CrossRefGoogle ScholarPubMed
Mesholam, R.I., Moberg, P.J., Mahr, R.N., Doty, R.L., 1998. Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer’s and Parkinson’s diseases. Archives of Neurology 55, 8490.CrossRefGoogle ScholarPubMed
Meusel, T., Westermann, B., Fuhr, P., Hummel, T., Welge-Lussen, A., 2010. The course of olfactory deficits in patients with Parkinson’s disease–a study based on psychophysical and electrophysiological measures. Neuroscience Letters 486, 166170.CrossRefGoogle ScholarPubMed
Mirelman, A., Alcalay, R.N., Saunders-Pullman, R., et al. 2015. Nonmotor symptoms in healthy Ashkenazi Jewish carriers of the G2019S mutation in the LRRK2 gene. Movement Disorders 30, 981986.CrossRefGoogle ScholarPubMed
Mitchell, I.J., Heims, H., Neville, E.A., Rickards, H., 2005. Huntington’s disease patients show impaired perception of disgust in the gustatory and olfactory modalities. The Journal of Neuropsychiatry and Clinical Neurosciences 17, 119121.CrossRefGoogle ScholarPubMed
Miwa, T., Watanabe, A., Mitsumoto, Y., et al. 2004. Olfactory impairment and Parkinson’s disease-like symptoms observed in the common marmoset following administration of 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine. Acta Otolaryngologica Suppl. (553): 8084.CrossRefGoogle Scholar
Moberg, P.J., Doty, R.L., 1997. Olfactory function in Huntington’s disease patients and at-risk offspring. International Journal of Neuroscience; 89, 133139.CrossRefGoogle ScholarPubMed
Moberg, P.J., McGue, C., Kanes, S.J., et al. 2007. Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: Relationship to clinical symptomatology and psychophysical olfactory performance. Schizophrenia Research 90(1–3), 221228.CrossRefGoogle ScholarPubMed
Moberg, P.J., Pearlson, G.D., Speedie, L.J., et al. 1987. Olfactory recognition: differential impairments in early and late Huntington’s and Alzheimer’s disease. Journal of Clinical Experimental Neuropsychology 9, 650664.CrossRefGoogle Scholar
Moccia, M., Picillo, M., Erro, R., et al. 2014. How does smoking affect olfaction in Parkinson’s disease? Journal of the Neurological Sciences 340(1), 215217.CrossRefGoogle ScholarPubMed
Montgomery, E.B. Jr, Baker, K.B., Lyons, K., Koller, W.C., (1999) Abnormal performance on the PD test battery by asymptomatic first-degree relatives. Neurology 52, 757762.CrossRefGoogle ScholarPubMed
Montgomery, E.B. Jr., Koller, W.C., LaMantia, T.J., et al. (2000) Early detection of probable idiopathic Parkinson’s disease: I. Development of a diagnostic test battery. Movement Disorders, 15, 467473.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Morgan, C.D., Murphy, C., 2002. Olfactory event-related potentials in Alzheimer’s disease. Journal of the International Neuropsychological Society 8, 753763.CrossRefGoogle ScholarPubMed
Morley, J.F., Pawlowski, S.M., Kesari, A., et al. 2014. Motor and non-motor features of Parkinson’s disease that predict persistent drug-induced Parkinsonism. Parkinsonism & Related Disorders 20, 738742.CrossRefGoogle ScholarPubMed
Moscovich, M., Munhoz, R.P., Teive, H.A., et al. 2012. Olfactory impairment in familial ataxias. Journal of Neurology, Neurosurgery, & Psychiatry 83, 970974.CrossRefGoogle ScholarPubMed
Mueller, A., Reuner, U., Landis, B. et al. 2006. Extrapyramidal symptoms in Wilson’s disease are associated with olfactory dysfunction. Movement Disorders 21, 13111316.CrossRefGoogle ScholarPubMed
Muller, A., Mungersdorf, M., Reichmann, H., Strehle, G., Hummel, T., 2002. Olfactory function in Parkinsonian syndromes. Journal of Clinical Neuroscience 9, 521524.CrossRefGoogle ScholarPubMed
Mundiñano, I.C., Hernandez, M., Dicaudo, C., et al. 2013, Reduced cholinergic olfactory centrifugal inputs in patients with neurodegenerative disorders and MPTP-treated monkeys. Acta Neuropathologica 126, 411425.CrossRefGoogle ScholarPubMed
Mundinano, I.C., Caballero, M.C., Ordonez, C., et al. 2011. Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders. Acta Neuropathologica 122, 6174.CrossRefGoogle ScholarPubMed
Murphy, C., Gilmore, M.M., Seery, C.S., Salmon, D.P., Lasker, BR. (1990). Olfactory thresholds are associated with degree of dementia in Alzheimer’s disease. Neurobiology of Aging 11, 465469.CrossRefGoogle ScholarPubMed
Murphy, C., Jinich, S., 1996. Olfactory dysfunction in Down’s Syndrome. Neurobio Aging, 17, 631637.CrossRefGoogle ScholarPubMed
Murphy, C., Schubert, C.R., Cruickshanks, K.J., Klein, B.E., Klein, R., Nondahl, D.M., 2002. Prevalence of olfactory impairment in older adults. Jama, 288(18), 23072312.CrossRefGoogle ScholarPubMed
Najim al-Din, A.S., Wriekat, A., Mubaidin, A., Dasouki, M., Hiari, M., 1994. Pallido-pyramidal degeneration, supranuclear upgaze paresis and dementia: Kufor-Rakeb syndrome. Acta Neurologica Scandinavica 89, 347–52.Google ScholarPubMed
Navarro-Otano, J., Gaig, C., Muxi, A., et al. 2014. 123I-MIBG cardiac uptake, smell identification and 123I-FP-CIT SPECT in the differential diagnosis between vascular parkinsonism and Parkinson’s disease. Parkinsonism & Related Disorders 20, 192197.CrossRefGoogle ScholarPubMed
Nee, L.E., Scott, J., Polinsky, R.J., 1993. Olfactory dysfunction in the Shy-Drager syndrome. Clinical Autonomic Research 3, 281282.CrossRefGoogle ScholarPubMed
Nee, L.E., Lippa, C.F., 2001, Inherited Alzheimer’s disease PS-1 olfactory function: A 10-year follow-up study. American Journal of Alzheimer’s Disease & Other Dementias, 16, 8384.CrossRefGoogle ScholarPubMed
Neudorfer, O., Giladi, N., Elstein, D., et al. 1996. Occurrence of Parkinson’s syndrome in type I Gaucher disease. QJM 89, 691694.CrossRefGoogle ScholarPubMed
Neumann, J., Bras, J., Deas, E., et al. 2009. Glucocerebrosidase mutations in clinical and pathologically proven Parkinson’s disease. Brain 132, 17831794.CrossRefGoogle ScholarPubMed
Newman, R., Winans, S.S., 1980. An experimental study of the ventral striatum of the golden hamster. II Neuronal connections of the olfactory tubercle. Journal of Comparative Neurology 191, 193212.CrossRefGoogle ScholarPubMed
Nijjar, R.K., Murphy, C., 2002. Olfactory impairment increases as a function of age in persons with Down syndrome. Neurobiology of Aging 23(1), 6573.CrossRefGoogle ScholarPubMed
Nishioka, K., Ross, O.A., Ishii, K., et al. 2009. Expanding the clinical phenotype of SNCA duplication carriers. Movement Disorders 24, 18111819.CrossRefGoogle ScholarPubMed
Nordin, S., Almkvist, O., Berglund, B., Wahlund, L.O., 1997. Olfactory dysfunction for pyridine and dementia progression in Alzheimer disease. Archives of Neurology 54, 993998.CrossRefGoogle ScholarPubMed
Nordin, S., Paulsen, J.S., Murphy, C., 1995b. Sensory- and memory-mediated olfactory dysfunction in Huntington’s disease. Journal of the International Neuropsychological Society 1, 281290.CrossRefGoogle ScholarPubMed
Nores, J.M., Biacabe, B., Bonfils, P., 2000. [Olfactory disorders due to medications: analysis and review of the literature]. De Medecine Interne 21, 972977.Google ScholarPubMed
Nosrat, C.A., 1998. Neurotrophic factors in the tongue: expression patterns, biological activity, relation to innervation and studies of neurotrophin knockout mice. Annals of the New York Academy of Sciences 855, 2849.CrossRefGoogle ScholarPubMed
Noyce, A.J., Bestwick, J.P., Silveira-Moriyama, L., et al. 2014. PREDICT-PD: Identifying risk of Parkinson’s disease in the community: Methods and baseline results. Journal of Neurology, Neurosurgery, & Psychiatry 85, 3137.CrossRefGoogle ScholarPubMed
Noyce, A.J., Mencacci, N.E., Schrag, A., et al. 2015. Web-based assessment of Parkinson’s prodromal markers identifies GBA variants. Movement Disorders 30, 10021003.CrossRefGoogle ScholarPubMed
Noyce, A.J., R’Bibo, L., Peress, L., Bestwick, J.P., Adams‐Carr, K.L., Mencacci, N.E., Hawkes, C.H., Masters, J.M., Wood, N., Hardy, J., Giovannoni, G., 2017. PREDICT‐PD: An online approach to prospectively identify risk indicators of Parkinson’s disease. Movement Disorders 32(2), 219226.CrossRefGoogle ScholarPubMed
Oakley, B., Witt, M., 2004. Building sensory receptors on the tongue. Journal of Neurocytology 33, 631646.CrossRefGoogle ScholarPubMed
Okamoto, K., Hirai, S., Shoji, M., Takatama, M. 1990. Senile changes in the human olfactory bulbs. In Nagatsu, T (Ed), Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. NY: Plenum Press, pp. 349352.CrossRefGoogle Scholar
Oleson, S., Murphy, C., 2015. Olfactory Dysfunction in ApoE ɛ4/4 Homozygotes with Alzheimer’s Disease. Journal of Alzheimer’s Disease 46(3), 791803.CrossRefGoogle ScholarPubMed
Olichney, J.M., Murphy, C., Hofstetter, C.R., et al. 2005. Anosmia is very common in the Lewy body variant of Alzheimer’s disease. JM 76, 13421347.Google ScholarPubMed
Oliver, C., Holland, A.J., 1986. Down’s syndrome and Alzheimer’s disease: a review. Psychological Medicine 16, 307322.CrossRefGoogle ScholarPubMed
Omar, R., Mahoney, C.J., Buskley, A.H., Warren, J.D. 2013. Flavour identification in frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery, & Psychiatry 84(1), 8893.CrossRefGoogle ScholarPubMed
Ondo, W.G., Lai, D., 2005. Olfaction testing in patients with tremor-dominant PD: Is this a distinct condition? Movement Disorders 20: 471475.CrossRefGoogle Scholar
Oyanagi, K., The nature of the parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam and magnesium deficiency. Parkinsonism & Related Disorders 11 Suppl 1: S1723.CrossRefGoogle Scholar
Paisan-Ruiz, C., Li, A., Schneider, S.A., Holton, J.L., Johnson, R., Kidd, D., Chataway, J., Bhatia, K.P., Lees, A.J., Hardy, J, Revesz, T., 2010. Widespread Lewy body and tau accumulation in childhood and adult onset dystonia-parkinsonism cases with PLA2G6 mutations. Neurobiology of Aging 33(4), 814823.CrossRefGoogle ScholarPubMed
Papaioannou, N., Tooten, P.C., van Ederen, A.M., et al. 2001. Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques. Amyloid 8(1), 1121.CrossRefGoogle ScholarPubMed
Pardini, M., Huey, E.D., Cavanagh, A.L., Grafman, J., 2009. Olfactory function in corticobasal syndrome and frontotemporal dementia. Archives of Neurology 66, 9296.CrossRefGoogle ScholarPubMed
Park, J.S., Blair, N.F., Sue, C.M., 2015. The role of ATP13A2 in Parkinson’s disease: Clinical phenotypes and molecular mechanisms. Movement Disorders 30, 770779.CrossRefGoogle ScholarPubMed
Parkkinen, L., Kauppinen, T., Pirttilä, T., Autere, J.M., Alafuzoff, I. 2005. Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia. Annals of Neurology 57, 8291.CrossRefGoogle ScholarPubMed
Paschen, L., Schmidt, N., Wolff, S., et al. 2015. The olfactory bulb volume in patients with idiopathic Parkinson’s disease. European Journal of Neurology 22, 10681073.CrossRefGoogle ScholarPubMed
Paulsen, J.S., Langbehn, D.R., Stout, J.C., et al. 2008. Detection of Huntington’s disease decades before diagnosis: the Predict-HD study. Journal of Neurology, Neurosurgery, & Psychiatry 79, 874880.CrossRefGoogle ScholarPubMed
Pearce, R.K., Hawkes, C.H., Daniel, S.E., 1995. The anterior olfactory nucleus in Parkinson’s disease. Movement Disorders 10, 283287.CrossRefGoogle ScholarPubMed
Petzold, G.C., Einhaupl, K.M., Valdueza, J.M., 2003. Persistent bitter taste as an initial symptom of amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery, & Psychiatry 74, 687688.CrossRefGoogle ScholarPubMed
Pirogovsky, E., Gilbert, P.E., Jacobson, M., et al. 2007. Impairments in source memory for olfactory and visual stimuli in preclinical and clinical stages of Huntington’s disease. Journal of Clinical Experimental Neuropsychology 29, 395404.CrossRefGoogle ScholarPubMed
Pittock, S.J., Joyce, C., O’Keane, V., et al. 2000. Rapid-onset dystonia-parkinsonism: A clinical and genetic analysis of a new kindred. Neurology 55, 991995.CrossRefGoogle ScholarPubMed
Piwnica-Worms, K.E., Omar, R., Hailstone, J.C., Warren, J.D., 2010. Flavour processing in semantic dementia. Cortex 46, 761768.CrossRefGoogle ScholarPubMed
Poddighe, S., Bhat, K.M., Setzu, M.D., et al. 2013. Impaired sense of smell in a Drosophila Parkinson’s model. PLoS One 8, e73156.CrossRefGoogle Scholar
Politis, M., Wu, K., Molloy, S., et al. 2010. Parkinson’s disease symptoms: The patient’s perspective. Movement Disorders 25, 16461651.CrossRefGoogle ScholarPubMed
Ponsen, M.M., Stoffers, D., Booij, J., et al. 2004. Idiopathic hyposmia as a preclinical sign of Parkinson’s disease. Annals of Neurology 56, 173181.CrossRefGoogle ScholarPubMed
Postuma, R.B., Gagnon, J.F., Montplaisir, J., 2010. Clinical prediction of Parkinson’s disease: planning for the age of neuroprotection. Journal of Neurology, Neurosurgery, & Psychiatry 81, 10081013.CrossRefGoogle ScholarPubMed
Postuma, R.B., Gagnon, J.F., Vendette, M., Desjardins, C., Montplaisir, J.Y., 2011. Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder. Annals of Neurology 69, 811818.CrossRefGoogle ScholarPubMed
Postuma, R.B., Montplaisir, J., 2010. Transcranial ultrasound and olfaction in REM sleep behavior disorder: testing predictors of Parkinson’s disease. Sleep Med 11, 339340.CrossRefGoogle ScholarPubMed
Quagliato, L.B., Viana, M.A., Quagliato, E.M., Simis, S., 2009. Olfaction and essential tremor. Arquivos de Neuro-Psiquiatria 67(1), 2124.CrossRefGoogle ScholarPubMed
Quinn, N.P., Rossor, M.N., Marsden, C.D., 1987. Olfactory threshold in Parkinson’s disease. Journal of Neurology, Neurosurgery, & Psychiatry 50, 8889.CrossRefGoogle ScholarPubMed
Quinn, N.P., Rossor, M.N., Marsden, C.D., 1987. Olfactory threshold in Parkinson’s disease. Journal of Neurology, Neurosurgery, & Psychiatry 50, 8889.CrossRefGoogle ScholarPubMed
Rajput, A.H., Gibb, W.R., Zhong, X.H., et al. 1994. Dopa-responsive dystonia: Pathological and biochemical observations in a case. Annals of Neurology 35, 396402.CrossRefGoogle ScholarPubMed
Rebeck, G.W., Hyman, B.T., 1993. Neuroanatomical connections and specific regional vulnerability in Alzheimer’s disease. Neurobiology of Aging 14(1), 4547.CrossRefGoogle ScholarPubMed
Reuber, M., Al-Din, A.S., Baborie, A., Chakrabarty, A., 2001. New variant Creutzfeldt-Jakob disease presenting with loss of taste and smell. Journal of Neurology, Neurosurgery, & Psychiatry 71, 412413.CrossRefGoogle ScholarPubMed
Rial, D., Castro, A.A., Machado, N., et al. 2014. Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson’s disease. PLoS One 9, e114216.CrossRefGoogle ScholarPubMed
Ritz, B., Lee, P-C., Lassen, C.F., Arah, O.A., 2014. Parkinson disease and smoking revisited Ease of quitting is an early sign of the disease. Neurology, 83(16), 13961402.CrossRefGoogle ScholarPubMed
Roberts, R.O., Christianson, T.J., Kremers, W.K., et al. 2016, Association between olfactory dysfunction and amnestic mild cognitive impairment and Alzheimer disease dementia. JAMA Neurology 73, 93101.CrossRefGoogle ScholarPubMed
Roberts, E., 1986. Alzheimer’s disease may begin in the nose and may be caused by aluminosilicates. Neurobiology of Aging 7, 561567.CrossRefGoogle ScholarPubMed
Rosenberg, A., Gurevich, T., Mirelman, A., et al. 2011. Multivariate features associated with presence of “severe” mutations in the GBA gene in a cohort of asymptomatic first degree relatives of patient with Parkinson’s disease. Neurology IN41.003.Google Scholar
Ross, G.W., Abbott, R.D., Petrovitch, H., Tanner, C.M., White, L.R., 2012. Pre-motor features of Parkinson’s disease: The Honolulu-Asia Aging Study experience. Parkinsonism and Related Disorders 18, 199202.CrossRefGoogle ScholarPubMed
Ross, G.W., Petrovitch, H., Abbott, R.D., et al. 2004. Parkinsonian signs and substantia nigra neuron density in descendants elders without PD. Annals of Neurology 56, 532539.CrossRefGoogle Scholar
Ross, G.W., Abbott, R.D., Petrovitch, H., et al. 2006. Association of olfactory dysfunction with incidental Lewy bodies. Movement Disorders 21, 20622067.CrossRefGoogle ScholarPubMed
Ross, G.W., Petrovitch, H., Abbott, R.D., et al. 2008. Association of olfactory dysfunction with risk for future Parkinson’s disease. Annals of Neurology 63, 167173.CrossRefGoogle ScholarPubMed
Royall, D.R., Chiodo, L.K., Polk, M.S., Jaramillo, C.J., 2002. Severe dysosmia is specifically associated with Alzheimer-like memory deficits in nondemented elderly retirees. Neuroepidemiology 21(2), 6873.CrossRefGoogle ScholarPubMed
Rutty, C.J., 1996. The middle-class plaque: Epidmic polio and the Canadian State, 1936–1937. CBMH/BCHM 13, 277314.Google Scholar
Sabin, A.B., Olitsky, P.K., Cox, H.R., 1936. Protective action of certain chemicals against infection of monkeys with nasally instelled poliomyelitis virus. Journal of Experimental Medicine 63, 877892.CrossRefGoogle ScholarPubMed
Sabin, A.B., Ward, R., 1941. The natural history of human poliomyelitis. I. Distribution of virus in nervous and non-nervous tissues. Journal of Experimental Medicine., 73, 771793.CrossRefGoogle ScholarPubMed
Sagawa, M., Takao, M., Nogawa, S., et al. 2003. [Wilson’s disease associated with olfactory paranoid syndrome and idiopathic thrombocytopenic purpura]. No To Shinkei 55, 899902.Google ScholarPubMed
Sajjadian, A., Doty, R.L., Gutnick, D., Chirurgi, R.J., Sivak, M., Perl, D., 1994. Olfactory dysfunction in amyotrophic lateral sclerosis. Neurodegeneration 3, 153157.Google Scholar
Salerno-Kennedy, R., Cusack, S., Cashman, K.D., 2005. Olfactory function in people with genetic risk of dementia. Irish Journal of Medical Science Journal 174, 4650.Google ScholarPubMed
Salihoglu, M., Kendirli, M.T., Altundag, A., et al. 2014. The effect of obstructive sleep apnea on olfactory functions. Laryngoscope 124, 21902194.CrossRefGoogle ScholarPubMed
Samaranch, L., Lorenzo-Betancor, O., Arbelo, J.M., et al. 2010. PINK1-linked parkinsonism is associated with Lewy body pathology. Brain 133, 11281142.CrossRefGoogle ScholarPubMed
Sandyk, R., 1981. Olfactory hallucinations in Parkinson’s disease. South African Medical Journal 60, 950.Google ScholarPubMed
Satya-Murti, S., Crisostomo, E. (1988). Olfactory threshold in Friedreich’s ataxia. Muscle & nerve, 11(4), 406407.Google ScholarPubMed
Saunders-Pullman, R., Hagenah, J., Dhawan, V., et al. 2010. Gaucher disease ascertained through a Parkinson’s center: imaging and clinical characterization. Movement Disorders 25, 13641372.CrossRefGoogle ScholarPubMed
Saunders-Pullman, R., Mirelman, A., Wang, C., et al. 2014. Olfactory identification in LRRK2 G2019S mutation carriers: a relevant marker? Annals of Clinical and Translational Neurology 1, 670678.CrossRefGoogle ScholarPubMed
Saunders-Pullman, R., Stanley, K., Wang, C., et al. 2011. Olfactory dysfunction in LRRK2 G2019S mutation carriers. Neurology 77, 319324.CrossRefGoogle ScholarPubMed
Scherfler, C., Schocke, M.F., Seppi, K., et al. 2006. Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson’s disease. Brain 129, 538542.CrossRefGoogle ScholarPubMed
Schiffman, S.S., Clark, C.M., Warwick, Z.S., 1990. Gustatory and olfactory dysfunction in dementia: Not specific to Alzheimer’s disease. Neurobiology of Aging 11, 597600.CrossRefGoogle ScholarPubMed
Schiffman, S.S., Graham, B.G., Sattely-Miller, E.A., Zervakis, J., Welsh-Bohmer, K., 2002. Taste, smell and neuropsychological performance of individuals at familial risk for Alzheimer’s disease. Neurobiology of Aging 23, 397404.CrossRefGoogle ScholarPubMed
Schilit, N.A., Stackpole, E.E., , T.L., et al. 2015. Fragile X mental retardation protein regulates olfactory sensitivity but not odorant discrimination. Chemical Senses 40, 345350.CrossRefGoogle Scholar
Schlitt, M., Chronister, R.B., Whitley, R.J., 1991. Pathogenesis and pathophysiology of viral infections of the central nervous system. In Scheld, W.M., Whitley, R.J., Durack, D.T. (Eds.), Infections of the Central Nervous System. Raven Press, pp. 718.Google Scholar
Schubert, C.R., Carmichael, L.L., Murphy, C., Klein, B.E., Klein, R., Cruickshanks, K.J., 2008. Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults. Journal of the American Geriatrics Society 56(8), 15171521.CrossRefGoogle Scholar
Schultz, E.W., Gebhardt, L.R., 1936. Prevention of intranasally inoculated poliomyelitis in monkeys by previous intranasal irrigation with chemical agents. Proceedings of the Society for Experimental Biology and Medicine 34, 133135.CrossRefGoogle Scholar
Schultz, E.W., Gebhardt, L.R., 1937. Zinc sulfate prophylaxis in poliomyelitis. Journal of the American Podiatric Medical Association 108, 21822184.CrossRefGoogle Scholar
Schwartz, B.S., Doty, R.L., Monroe, C., Frye, R., Barker, S., 1989. Olfactory function in chemical workers exposed to acrylate and methacrylate vapors. American Journal of Public Health 79(5), 613618.CrossRefGoogle ScholarPubMed
Schwartz, B.S., Ford, D.P., Bolla, K.I., et al. 1990. Solvent-associated decrements in olfactory function in paint manufacturing workers. American Journal of Industrial Medicine 18(6), 697706.CrossRefGoogle ScholarPubMed
Semchuk, K.M., Love, E.J., Lee, R.G., Parkinson’s disease and exposure to agricultural work and pesticide chemicals. Neurology 42(7), 13281335.CrossRefGoogle Scholar
Serby, M., Mohan, C., Aryan, M., et al. 1996. Olfactory identification deficits in relatives of Alzheimer’s disease patients. Biological Psychiatry 39, 375377.CrossRefGoogle ScholarPubMed
Shackelford, J., Pagano, J.S., Targeting of host-cell ubiquitin pathways by viruses. Essays in Biochemistry 41, 139154CrossRefGoogle Scholar
Shah, M., Deeb, J., Fernando, M., et al. 2009. Abnormality of taste and smell in Parkinson’s disease. Parkinsonism & Related Disorders 15(3), 232237.CrossRefGoogle ScholarPubMed
Shah, M., Findley, L.J., Muhammed, N., Hawkes, C.H., 2005.Olfaction is normal in essential tremor and can be used to distinguish it from Parkinson’s disease. Movement Disorders 20, S10.Abs: 563.Google Scholar
Shah, M., Muhammed, N., Findley, L.J., Hawkes, C.H., 2007. Olfactory tests in the diagnosis of essential tremor. Journal of Neurology Neurosurgery and Psychiatry. In press.Google Scholar
Sharer, J.D., Leon-Sarmiento, F.E., Morley, J.F., Weintraub, D., Doty, R.L., 2015. Olfactory dysfunction in Parkinson’s disease: Positive effect of cigarette smoking. Movement Disorders 30, 859862.CrossRefGoogle ScholarPubMed
Sherer, T.B., Betarbet, R., Testa, C.M., et al. 2003. Mechanism of toxicity in rotenone models of Parkinson’s disease. Journal of Neuroscience 23, 1075610764.CrossRefGoogle ScholarPubMed
Shi, F., Liu, B., Zhou, Y., Yu, C., Jiang, T., 2009. Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer’s disease: Meta-analyses of MRI studies. Hippocampus 19, 10551064.CrossRefGoogle ScholarPubMed
Shimoji, A., Miyakawa, T., Watanabe, K., et al. 1987. Wilson’s disease with extensive degeneration of cerebral white matter and cortex. The Japanese Journal of Psychiatry and Neurology 41, 709717.Google ScholarPubMed
Shipley, M.T., 1985. Transport of molecules from nose to brain: Transneuronal anterograde and retrograde labelling in the rat olfactory system by wheatgerm agglutin-horseradish peroxidase applied to the nasal epithelium. Brain Research Bulletin 15, 129142.CrossRefGoogle Scholar
Siderowf, A., Jennings, D., Eberly, S., et al. 2012. Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome Study. Movement Disorders 27, 406412.CrossRefGoogle ScholarPubMed
Siderowf, A., Newberg, A., Chou, K.L., et al. 2005. [99mTc]TRODAT-1 SPECT imaging correlates with odor identification in early Parkinson disease. Neurology 64, 17161720.CrossRefGoogle ScholarPubMed
Sienkiewicz-Jarosz, H., Scinska, A., Kuran, W., Ryglewicz, D., Rogowski, A., Wrobel, E., Korkosz, A., Kukwa, A., Kostowski, W., Bienkowski, P., 2005. Taste responses in patients with Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry 76(1), 4046.CrossRefGoogle ScholarPubMed
Sienkiewicz-Jarosz, H., Scinska, A., Swiecicki, L., et al. 2013. Sweet liking in patients with Parkinson’s disease. Journal of the Neurological Sciences 329(1–2), 1722.CrossRefGoogle ScholarPubMed
Sierra, M., Sanchez-Juan, P., Martinez-Rodriguez, MI., et al. 2013. Olfaction and imaging biomarkers in premotor LRRK2 G2019S-associated Parkinson disease. Neurology 80, 621626.CrossRefGoogle ScholarPubMed
Silveira-Moriyama, L., Guedes, L.C., Kingsbury, A., et al. 2008. Hyposmia in G2019S LRRK2-related parkinsonism: clinical and pathologic data. Neurology 71(13), 10211026.CrossRefGoogle ScholarPubMed
Silveira-Moriyama, L., Holton, J.L., Kingsbury, A., et al. 2009. Regional differences in the severity of Lewy body pathology across the olfactory cortex. Neuroscience Letters 453, 7780.CrossRefGoogle ScholarPubMed
Silveira-Moriyama, L., Hughes, G., Church, A., et al. 2010. Hyposmia in progressive supranuclear palsy. Movement Disorders 25, 570577.CrossRefGoogle ScholarPubMed
Silveira-Moriyama, L., Mathias, C., Mason, L., et al. 2009, Hyposmia in pure autonomic failure. Neurology, 72, 16771681.CrossRefGoogle ScholarPubMed
Silveira-Moriyama, L., Munhoz, R.P., de, J.C., et al. 2010. Olfactory heterogeneity in LRRK2 related Parkinsonism. Movement Disorders 25, 28792883.CrossRefGoogle ScholarPubMed
Silveira-Moriyama, L., Munhoz, R.P., Carvalho, M.J., et al. 2010 Olfactory Loss in LRRK2 Related Parkinsonism. Neurology Suppl. Abstract P03.189Google Scholar
Silveira-Moriyama, L., Schwingenschuh, P., O’Donnell, A., et al. 2009. Olfaction in patients with suspected parkinsonism and scans without evidence of dopaminergic deficit (SWEDDs). Journal of Neurology, Neurosurgery, & Psychiatry 80(7), 744748.CrossRefGoogle ScholarPubMed
Silveira-Moriyama, L., Williams, D., Katzenschlager, R., Lees, A.J., 2005. Pizza, mint, and licorice: Smell testing in Parkinson’s disease in a UK population. Movement Disorders 20, S139.Google Scholar
Singleton, A., Gwinn-Hardy, K., Sharabi, Y., et al. 2004. Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication. Brain 127(Pt 4), 768772.CrossRefGoogle ScholarPubMed
Sliger, M., Lander, T., Murphy, C., 2004. Effects of the ApoE epsilon4 allele on olfactory function in Down syndrome. Journal of Alzheimer’s Disease 6(4), 397402.CrossRefGoogle ScholarPubMed
Smith, C.A.D, Gough, A.C., Leigh, P.N., Summers, , et al. 1992. Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson’ disease. Lancet 339, 13751377.CrossRefGoogle Scholar
Smith, D.H., Uryu, K., Saatman, K.E., Trojanowski, J.Q., McIntosh, T.K., 2003. Protein accumulation in traumatic brain injury. NeuroMolecular Medicine 4, 5972.CrossRefGoogle ScholarPubMed
Smutzer, G.S., Doty, R.L., Arnold, S.E., Trojanowski, J.Q., 2003. Olfactory system neuropathology in Alzheimer’s Disease. In Doty, R.L., (Ed.), Parkinson’s Disease and Schizophrenia. Chapter 24 in: Handbook of olfaction and gustation. Second edition. New York: Marcel Dekker.Google Scholar
Sobel, N., Thomason, M.E., Stappen, I., et al. 2001. An impairment in sniffing contributes to the olfactory impairment in Parkinson’s disease. Proceedings of the National Academy of Sciences of the United States of America 98, 41544159.CrossRefGoogle Scholar
Sommer, U., Hummel, T., Cormann, K., et al., 2004. Detection of presymptomatic Parkinson’s disease: combining smell tests, transcranial sonography and SPECT. Movement Disorders 19, 11961202.CrossRefGoogle ScholarPubMed
Spiegel, J., Hellwig, D., Mollers, M.O., et al. Transcranial sonography and [123I]FP-CIT SPECT disclose complementary aspects of Parkinson’s disease. Brain 129(Pt 5), 11881193.CrossRefGoogle Scholar
Stadlan, E., Duvoisen, R., Yahr, M., 1965. The pathology of Parkinsonism. Fifth International Congress of Neuropathologists, Zurich, Excerpta Medica., pp 569571.Google Scholar
Stamps, J.J., Bartoshuk, L.M., Heilman, K.M., 2013. A brief olfactory test for Alzheimer’s disease. Journal of the Neurological Sciences 333(1), 1924.CrossRefGoogle ScholarPubMed
Stamps, J.J., Doty, L., Wade, C.I., Heilman, K.M., 2016. The Left versus Right Nostril Odor Detection Test for Early Alzheimer’s Disease: Increased Sample Size, Changes with Progression of Alzheimer’s, and Performance with other Neurodegenerative Diseases. Abstract. Bonita Springs, FL: Association for Chemosensory Research.Google Scholar
Steinbach, S., Hundt, W., Vaitl, A., et al. 2010. Taste in mild cognitive impairment and Alzheimer’s disease. Journal of Neurology 257, 238246.CrossRefGoogle ScholarPubMed
Stern, M.B., Doty, R.L., Dotti, M., et al. 1994. Olfactory function in Parkinson’s disease subtypes. Neurology 44, 266268.CrossRefGoogle ScholarPubMed
Stiasny-Kolster, K., Doerr, Y., Moller, J.C., et al. 2005. Combination of “idiopathic” REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT. Brain 128, 126137.CrossRefGoogle ScholarPubMed
Strang, R.R., 1965. The association of gastro-duodenal ulceration and Parkinson’s disease. Medical Journal of Australia 52, 842843.CrossRefGoogle Scholar
Svensson, E., Horvath-Puho, E., Thomsen, R.W., et al. 2015. Vagotomy and Subsequent Risk of Parkinson’s Disease. Annals of Neurology 78, 10121013.CrossRefGoogle ScholarPubMed
Swan, G.E., Carmelli, D., 2002, Impaired olfaction predicts cognitive decline in nondemented older adults. Neuroepidemiology 21, 5867.CrossRefGoogle ScholarPubMed
Tabaton, M., Monaco, S., Cordone, M.P., et al. 2004. Prion deposition in olfactory biopsy of sporadic Creutzfeldt–Jakob disease. Annals of Neurology 55(2), 294296.CrossRefGoogle ScholarPubMed
Tabert, M.H., Liu, X., Doty, R.L., et al. 2005, A 10-item smell identification scale related to risk for Alzheimer’s disease. Annals of Neurology 58, 155160.CrossRefGoogle ScholarPubMed
Takeda, T., Iijima, M., Uchihara, T., et al. 2015. TDP-43 Pathology Progression Along the Olfactory Pathway as a Possible Substrate for Olfactory Impairment in Amyotrophic Lateral Sclerosis. Journal of Neuropathology and Experimental Neurology 74, 547556.CrossRefGoogle ScholarPubMed
Talamo, B.R., Rudel, R., Kosik, K.S., et al. 1989. Pathological changes in olfactory neurons in patients with Alzheimer’s disease. Nature 23, 337(6209), 736739.CrossRefGoogle ScholarPubMed
Tanner, C.M., Goldman, S.M., Aston, D.A., et al. 2002. Smoking and Parkinson’s disease in twins. Neurology 58(4), 581588.CrossRefGoogle ScholarPubMed
Thomann, P.A., Dos, S.V., Seidl, U., et al. 2009. MRI-derived atrophy of the olfactory bulb and tract in mild cognitive impairment and Alzheimer’s disease. Journal of Alzheimer’s Disease 17, 213221.CrossRefGoogle ScholarPubMed
Thomann, P.A., Dos, S.V., Toro, P., et al. 2009. Reduced olfactory bulb and tract volume in early Alzheimer’s disease–a MRI study. Neurobiology of Aging 30, 838841.CrossRefGoogle ScholarPubMed
Tijero, B., Gomez-Esteban, J.C., Llorens, V., et al. 2010. Cardiac sympathetic denervation precedes nigrostriatal loss in the E46 K mutation of the alpha-synuclein gene (SNCA). Clinical Autonomic Research 20, 267269.CrossRefGoogle Scholar
Tissingh, G., Berendse, H.W., Bergmans, P., et al. 2001. Loss of olfaction in de novo and treated Parkinson’s disease: Possible implications for early diagnosis. Movement Disorders 16(1), 4146.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Tjalve, H., Henriksson, J., 1999. Uptake of metals in the brain via olfactory pathways. Neurotoxicology 20, 181195.Google Scholar
Tjalve, H., Henriksson, J., Tallkvist, J., Larsson, B.S., Lindquist, N.G., 1996. Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmacology & Toxicology 79, 347356.CrossRefGoogle ScholarPubMed
Tomlinson, A.H., Esiri, M.M., 1983. Herpes Simplex encephalitis: Immuno-histological demonstration of spread of virus via olfactory pathways in mice. Journal of Neurological Science 60, 473484.CrossRefGoogle Scholar
Toomey, J.A., 1935. Intranasal or gastrointestinal portal of entry in poliomyelitis. Science 82(2122), 200201.CrossRefGoogle ScholarPubMed
Toomey, J.A., 1936. The gastrointestinal portal of entry in poliomyelitis. Jorunal of Pediatrics 8, 664675.CrossRefGoogle Scholar
Travers, J.B., Akey, L.R., Chen, S.C., Rosen, S., Paulson, G., Travers, S.P., 1993. Taste preferences in Parkinson’s disease patients. Chemical Senses 18, 4755CrossRefGoogle Scholar
Trojanowski, J.Q., Newman, P.D., Hill, W.D., Lee, V.M., 1991. Human olfactory epithelium in normal aging, Alzheimer’s disease, and other neurodegenerative disorders. Journal of Comparative Neurology., 310, 365376.CrossRefGoogle ScholarPubMed
Tsuboi, Y., Wszolek, Z.K., Graff-Radford, N.R., Cookson, N., Dickson, D.W., 2003. Tau pathology in the olfactory bulb correlates with Braak stage, Lewy body pathology and apolipoprotein epsilon4. Neuropathology & Applied Neurobiology, 29, 503510.CrossRefGoogle ScholarPubMed
Tyas, S.L., Manfreda, J., Strain, L.A., Montgomery, P.R., 2001. Risk factors for Alzheimer’s disease: A population-based, longitudinal study in Manitoba, Canada. International Journal of Epidemiology, 30(3), 590597.CrossRefGoogle ScholarPubMed
Tysnes, O.B., Kenborg, L., Herlofson, K., et al. 2015. Does vagotomy reduce the risk of Parkinson’s disease? Annals Neurology 78, 10111012.Google Scholar
Tzen, K.Y., Lu, C.S., Yen, T.C., Wey, S.P., Ting, G., 2001. Differential diagnosis of Parkinson’s disease and vascular parkinsonism by (99 m)Tc-TRODAT-1. Journal of Nuclear Medicine 42(3), 408413.Google Scholar
Ubeda-Bañon, I., Saiz-Sanchez, D., de la Rosa-Prieto, C., et al. 2010a. Alpha-Synucleinopathy in the human olfactory system in Parkinson’s disease: Involvement of calcium-binding protein- and substance P-positive cells. Acta Neuropathologica 119, 723735.CrossRefGoogle ScholarPubMed
Ubeda-Banon, I., Saiz-Sanchez, D., de la Rosa-Prieto, C., et al. 2010b. Staging of alpha-synuclein in the olfactory bulb in a model of Parkinson’s disease: cell types involved. Movement Disorders 25, 17011707.CrossRefGoogle Scholar
Ubeda-Banon, I., Saiz-Sanchez, D., de la Rosa-Prieto, C., Martinez-Marcos, A., 2012. alpha-Synuclein in the olfactory system of a mouse model of Parkinson’s disease: Correlation with olfactory projections. Brain Structure and Function 217, 447458.CrossRefGoogle ScholarPubMed
Uchida, K., Kihara, N., Hashimoto, K., et al. 2003. Age-related histological changes in the canine substantia nigra. Journal of Veterinary Medical Science 65(2), 179185.CrossRefGoogle ScholarPubMed
Uchiyama, T., Fukutake, T., Arai, K., Nakagawa, K., Hattori, T., 2001. Machado-Joseph disease associated with an absence of fungiform papillae on the tongue. Neurology 56, 558560.CrossRefGoogle ScholarPubMed
van der Goes van Naters, W., Carlson, J.R., 2006. Insects as chemosensors of humans and crops. Nature 444(7117), 302307.CrossRefGoogle ScholarPubMed
Veeriah, S., Taylor, B.S., Meng, S., et al. 2010. Somatic mutations of the Parkinson’s disease-associated gene PARK2 in glioblastoma and other human malignancies. Nature Genetics 42, 7782.CrossRefGoogle ScholarPubMed
Velayudhan, L., Lovestone, S., 2009. Smell identification test as a treatment response marker in patients with Alzheimer disease receiving donepezil. Journal of Clinical Psychopharmacology 29, 387390.CrossRefGoogle ScholarPubMed
Velázquez-Pérez, L., Fernandez-Ruiz, J., Díaz, R., et al. 2006. Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases Journal of Neurology 253(9), 11651169.CrossRefGoogle Scholar
Vemula, S.R., Puschmann, A., Xiao, J., et al. 2013. Role of Galpha(olf) in familial and sporadic adult-onset primary dystonia. Human Molecular Genetics 22, 25102519.CrossRefGoogle ScholarPubMed
Verbaan, D., Boesveldt, S., van Rooden, S.M., et al. 2008. Is olfactory impairment in Parkinson’s disease related to phenotypic or genotypic characteristics? Neurology 71, 18771882.CrossRefGoogle ScholarPubMed
Vogt, B.A., Van Hoesen, G.W., Vogt, L.J., 1990. Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer’s disease. Acta Neuropathologica 80(6), 581589CrossRefGoogle ScholarPubMed
Vucic, S., Tian, D., Chong, P.S., et al. 2006. Facial onset sensory and motor neuronopathy (FOSMN syndrome): a novel syndrome in neurology. Brain 129(Pt 12), 33843390.CrossRefGoogle ScholarPubMed
Wakabayashi, K., Takahashi, H., Ohama, E., Ikuta, F., 1990. Parkinson’s disease: An immunohistochemical study of Lewy body-containing neurons in the enteric nervous system. Acta Neuropathologica 79, 581583.CrossRefGoogle ScholarPubMed
Wakabayashi, K., Takahashi, H., 1997. Neuropathology of autonomic nervous system in Parkinson’s disease. European Neurology 38, Suppl 2, 27.CrossRefGoogle ScholarPubMed
Waldton, S., 1974. Clinical observations of impaired cranial nerve function in senile dementia. Acta Psychiatrica Scandinavica 50, 539547.CrossRefGoogle ScholarPubMed
Warner, M.D., Peabody, C.A., Berger, P.A., 1988. Olfactory deficits in Down’s syndrome. Biological Psychiatry, 23, 836839.CrossRefGoogle ScholarPubMed
Waters, C.H., Faust, P.L., Powers, J., et al. 1993. Neuropathology of lubag (x-linked dystonia parkinsonism). Movement Disorders 8, 387390.CrossRefGoogle ScholarPubMed
Wenning, G.K., Shephard, B., Hawkes, C.H., et al. 1995. Olfactory function in typical parkinsonian syndromes. Acta-Neurologica Scandinavica 91, 247250.CrossRefGoogle Scholar
Wesson, D.W., Levy, E., Nixon, R.A., Wilson, D.A., 2010. Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer’s disease mouse model. Journal of Neuroscience 30, 505514.CrossRefGoogle Scholar
Westervelt, H.J., Carvalho, J., Duff, K., 2007. Presentation of Alzheimer’s disease in patients with and without olfactory deficits. Archives of Clinical Neuropsychology 22, 117122.CrossRefGoogle ScholarPubMed
Wetter, S., Murphy, C., 2001. Apolipoprotein E epsilon4 positive individuals demonstrate delayed olfactory event-related potentials. Neurobiology of Aging 22, 439447.CrossRefGoogle ScholarPubMed
Wetter, S., Peavy, G., Jacobson, M., et al. 2005. Olfactory and auditory event-related potentials in Huntington’s disease. Neuropsychology 19(4), 428436.CrossRefGoogle ScholarPubMed
Wetter, S., Murphy, C., 1999. Individuals with Down’s syndrome demonstrate abnormal olfactory event-related potentials. Clinical Neurophysiology, 110, 15631569.CrossRefGoogle ScholarPubMed
Wider, C., Skipper, L., Solida, A., et al. 2008. Autosomal dominant dopa-responsive parkinsonism in a multigenerational Swiss family. Parkinsonism & Related Disorders 14, 465470.CrossRefGoogle Scholar
Williams, S.S., Williams, J., Combrinck, , M., et al. 2009. Olfactory impairment is more marked in patients with mild dementia with Lewy bodies than those with mild Alzheimer’s disease. Journal of Neurology, Neurosurgery, & Psychiatry 80(6), 667670.CrossRefGoogle Scholar
Williams, D.R., de Silva, R., Paviour, D.C., et al. 2005. Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson’s syndrome and PSP-parkinsonism. Brain 128, 12471258.CrossRefGoogle ScholarPubMed
Wilson, R.S., Arnold, S.E.,Schneider, , J.A.,Tang, , Y., Bennett, D.A., 2007a. The relationship between cerebral Alzheimer’s disease pathology and odour identification in old age. Journal of Neurology, Neurosurgery, and Psychiatry 78, 3035.CrossRefGoogle ScholarPubMed
Wilson, R.S., Schneider, J.A., Arnold, S.E., et al. 2007b. Olfactory identification and incidence of mild cognitive impairment in older age. Archives of General Psychiatry 64, 802808.CrossRefGoogle ScholarPubMed
Wilson, R.S., Arnold, S.E., Schneider, J.A., et al. 2009. Olfactory impairment in presymptomatic Alzheimer’s disease. Annals of the New York Academy of Sciences 1170, 730735.CrossRefGoogle ScholarPubMed
Wilson, R.S., Yu, L., Schneider, J.A., et al. 2011. Lewy bodies and olfactory dysfunction in old age. Chemical Senses 36, 367373.CrossRefGoogle ScholarPubMed
Wisniewski, K.E., Wisniewski, H.M., Wen, G.Y., 1985. Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome. Annals of Neurology 17, 278282.CrossRefGoogle ScholarPubMed
Witoonpanich, P., Cash, D.M., Shakespeare, T.J., et al. 2013. Olfactory impairment in posterior cortical atrophy. Journal of Neurology, Neurosurgery, & Psychiatry 84, 588590.CrossRefGoogle ScholarPubMed
Witt, M., Bormann, K., Gudziol, V., et al. 2009. Biopsies of olfactory epithelium in patients with Parkinson’s disease. Movement Disorders 24, 906914.CrossRefGoogle ScholarPubMed
Wood, N.I., Goodman, A.O., van der Burg, J.M., et al. 2008. Increased thirst and drinking in Huntington’s disease and the R6/2 mouse. Brain Research Bulletin 76, 7079.CrossRefGoogle ScholarPubMed
Wu, N., Rao, X., Gao, Y., Wang, J., Xu, F., 2013. Amyloid-beta deposition and olfactory dysfunction in an Alzheimer’s disease model. Journal of Alzheimer’s Disease 37, 699712.CrossRefGoogle Scholar
Yahr, M.D., Orosz, D., Purohit, D.P., 2003. Co-occurrence of essential tremor and Parkinson’s disease: Clinical study of a large kindred with autopsy findings. Parkinsonism & Related Disorders 9(4), 225231.CrossRefGoogle ScholarPubMed
Yamada, M., Onodera, M., Mizuno, Y., Mochizuki, H., 2004. Neurogenesis in olfactory bulb identified by retroviral labeling in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated adult mice. Neuroscience 124(1), 173181.CrossRefGoogle ScholarPubMed
Yamagishi, M., Ishizuka, Y., Seki, K., 1994. Pathology of olfactory mucosa in patients with Alzheimer’s disease. Annals of Otology, Rhinology, and Laryngology 103, 421427.CrossRefGoogle ScholarPubMed
Yousem, D.M., Oguz, K.K., Li, C., 2001. Imaging of the olfactory system. Seminars in Ultrasound, CT and MRI 22, 456472.CrossRefGoogle ScholarPubMed
Zanusso, G., Ferrari, S., Benedetti, D., et al. 2009. Different prion conformers target the olfactory pathway in sporadic Creutzfeldt-Jakob disease. Annals of the New York Academy of Sciences 1170, 637643.CrossRefGoogle ScholarPubMed
Zanusso, G., Ferrari, S., Cardone, F., et al. 2003. Detection of pathologic prion protein in the olfactory epithelium in sporadic Creutzfeldt-Jakob disease. The New England Journal of Medicine 348, 711719.CrossRefGoogle ScholarPubMed
Ziegler-Graham, K., Brookmeyer, R., Johnson, E., Arrighi, H.M., 2008. Worldwide variation in the doubling time of Alzheimer’s disease incidence rates. Alzheimer’s & Dementia 4(5), 316323.CrossRefGoogle ScholarPubMed
Zijlmans, J.C., Thijssen, H.O., Vogels, O.J., et al. 1995. MRI in patients with suspected vascular parkinsonism. Neurology 45(12), 21832188.CrossRefGoogle ScholarPubMed
Ziso, B., Williams, T.L., Walters, R.J., et al. 2015. Facial onset sensory and motor neuronopathy: Further evidence for aTDP-43 proteinopathy. Case Reports in Neurology 7, 95100.CrossRefGoogle ScholarPubMed
Zucco, G.M., Negrin, N.S., 1994. Olfactory deficits in Down subjects: A link with Alzheimer’s disease. Perceptual and Motor Skills 78(2), 627631.CrossRefGoogle Scholar

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