Skip to main content
×
×
Home
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 2
  • Cited by
    This (lowercase (translateProductType product.productType)) has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Botică, Dan Aurelian 2017. Business Ethics and Leadership from an Eastern European, Transdisciplinary Context. p. 87.

    Buss, Robert R. Sun, Woong and Oppenheim, Ronald W. 2006. ADAPTIVE ROLES OF PROGRAMMED CELL DEATH DURING NERVOUS SYSTEM DEVELOPMENT. Annual Review of Neuroscience, Vol. 29, Issue. 1, p. 1.


    ×
  • Print publication year: 2006
  • Online publication date: March 2012

16 - Neuronal death and rescue: neurotrophic factors and anti-apoptotic mechanisms

from Section B1 - Neural repair
Summary
Developmental cell death is an integral part of the many adaptive strategies employed during ontogeny for generating the mature nervous system. There is increasing evidence that some of the mechanisms that regulate the death and survival of developing neurons and that of mature neurons following injury or in neurologic disease are similar. This chapter discusses several hypotheses of the etiology of amyotrophic lateral sclerosis (ALS). Neuronal cell death observed in brains of Huntington's disease (HD) patients, mutant Htt-expressing transgenic mice or neurotoxin-treated rats occurs through apoptosis. Recent studies reveal continuity in the molecular mechanisms by which apoptosis occurs in the various animal models of Parkinson's disease (PD). The chapter describes the cellular and molecular events of spinal cord injury (SCI) and suggests potential strategies for therapeutic rescue. Anti-apoptotic agents, including neurotrophic factors (NTFs), are necessary but not exclusive components of any effective therapy for neurodegenerative disease and neuronal injury.
Recommend this book

Email your librarian or administrator to recommend adding this book to your organisation's collection.

Textbook of Neural Repair and Rehabilitation
  • Online ISBN: 9780511545061
  • Book DOI: https://doi.org/10.1017/CBO9780511545061
Please enter your name
Please enter a valid email address
Who would you like to send this to *
×