Skip to main content
×
×
Home
  • Print publication year: 2003
  • Online publication date: August 2009

16 - Withdrawal states and treatment of withdrawal

Summary

Withdrawal in perspective

Different needs of differing patients

Many patients who have sustained serious problems as a result of their drinking have not contracted the dependence syndrome and will experience no significant physiological disturbance on withdrawal. A further important group of patients will be showing dependence to slight or moderate degree, but will not suffer from withdrawal symptoms which are to any major extent debilitating. However, there are patients who will feel wretched on withdrawal, and a small group for whom withdrawal will precipitate life-threatening disturbance.

Given diversity in possible withdrawal experience, it makes no sense to approach the treatment of withdrawal in terms of a fixed regime for all-comers. A spectrum of likely withdrawal experiences suggests the need for a spectrum of treatment approaches as corollary. Many patients will need no medication at all to help them come off alcohol, and for many others withdrawal can be safely managed on an out-patient basis with minimum drug cover. In only the minority will withdrawal require admission to hospital, but for some of those patients the effective use of medication will be vital. The clinical significance of withdrawal is firstly, therefore, the demand it makes on the clinician to see the different needs of different patients and to manage minor withdrawal states without unnecessary fuss, while at the same time learning to recognize the necessity for very great care in treating the potentially dangerous situation. This chapter discusses treatment in terms of different regimes for different intensities of need.

Recommend this book

Email your librarian or administrator to recommend adding this book to your organisation's collection.

The Treatment of Drinking Problems
  • Online ISBN: 9780511543722
  • Book DOI: https://doi.org/10.1017/CBO9780511543722
Please enter your name
Please enter a valid email address
Who would you like to send this to *
×
References
Banger, M., Philipp, M., Herth, T., Hebenstreit, M. and Aldenhoff, J. (1992) Development of a rating scale for quantitative measurement of the alcohol withdrawal syndrome. European Archives of Psychiatry and Clinical Neuroscience 241, 241–6
Bearn, J., Gossop, M. and Strang, J. (1996) Randomised double-blind comparison of lofexidine and methadone in the in-patient treatment of opiate withdrawal. Drug and Alcohol Dependence 43, 87–91
Burin, M. R. M. J. and Cook, C. C. H. (2000) Alcohol withdrawal and hypokalaemia: a case report. Alcohol and Alcoholism 35, 188–9
Chick, J. (1989) Delirium tremens. British Medical Journal 298, 3–4
Collins, M. N., Burns, T., Berk, P. A. H. and Tubman, G. F. (1990) A structured programme for out-patient alcohol detoxification. British Journal of Psychiatry 156, 871–4
Cook, C. C. H., Hallwood, P. M. and Thomson, A. D. (1998) B vitamin deficiency and neuropsychiatric syndromes in alcohol misuse. Alcohol and Alcoholism 33, 317–36
Cook, C. C. H. and Thomson, A. D. (1997) B-complex vitamins in the prevention and treatment of Wernicke–Korsakoff syndrome. British Journal of Hospital Medicine 57, 461–5
Cushman, P. and Sowers, J. R. (1989) Alcohol withdrawal syndrome: clinical and hormonal responses to α2-adrenergic agonist treatment. Alcoholism: Clinical and Experimental Research 13, 361–3
Fish, D. N. (1991) Treatment of delirium in the critically ill patient. Clinical Pharmacology and Therapeutics 10, 456–66
Frank, L. and Pead, J. (1995) New Concepts in Drug Withdrawal. Monograph Series, No. 4. Melbourne: The University of Melbourne
Gross, M. M., Lewis, E. and Nagarajan, M. (1973) An improved quantitative system for assessing the acute alcoholic psychoses and related states (TSA and SSA). In Alcohol Intoxication and Withrawal: Experimental Studies, Vol. 35, ed. Gross, M. M. New York: Plenum Press, 365–76
Higgitt, A. C., Lader, M. H. and Fonagy, P. (1985) Clinical management of benzodiazepine dependence. British Medical Journal 291, 688–90
McInnes, G. (1987) Chlormethiazole and alcohol: a lethal cocktail. British Medical Journal 294, 592
O'Brien, P. (1995) Parenteral vitamin therapy in alcoholism. Psychiatric Bulletin 19, 788
Saitz, R., Mayo-Smith, M. F., Roberts, M. S., Redmond, H. A., Bernard, D. R. and Calkins, D. R. (1994) Individualized treatment for alcohol withdrawal. A randomized double-blind controlled trial. Journal of the American Medical Association 272, 519–23
Schweizer, E. and Rickels, K. (1998) Benzodiazepine dependence and withdrawal: a review of the syndrome and its clinical management. Acta Psychiatrica Scandinavica 98 (Suppl. 393), 95–101
Shaw, J. M., Kolesar, G. S., Sellers, E. M., Kaplan, H. L. and Sandor, P. (1981) Development of optimal treatment tactics for alcohol withdrawal. I. Assesment and effectiveness of supportive care. Journal of Clinical Psychopharmacology 1, 382–8
Sheridan, J., Cook, C. and Strang, J. (1999) Audit of the in-patient management of opioid withdrawal using lofexidine hydrochloride. Journal of Substance Use 4, 29–34
Stockwell, T., Bolt, L., Milner, I., Russell, G., Bolderston, H. and Pugh, P. (1991) Home detoxification from alcohol: its safety and efficacy in comparison with in-patient care. Alcohol and Alcoholism 26, 645–50
Sullivan, J. T., Sykora, K., Schneiderman, J., Naranjo, C. A. and Sellers, E. M. (1989) Assessment of alcohol withdrawal: the revised Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-Ar). British Journal of Addiction 84, 1353–7
Thomson, A. D., Baker, H. and Leevy, C. H. (1970) Patterns of 35S-thiamine hydrochloride absorption in the malnourished alcoholic patient. Journal of Laboratory and Clinical Medicine 76, 34–45
Turner, R. C., Lichstein, P. R., Peden, J. G., Busher, J. T. and Waivers, L. E. (1989) Alcohol withdrawal syndromes: a review of pathophysiology, clinical presentation, and treatment. Journal of General Internal Medicine 4, 432–44