Albert, M, Antel, J, Brück, W, Stadelmann, C. Extensive cortical remyelination in patients with chronic multiple sclerosis. Brain Pathol 2007; 17: 129–138.
Barnes, DE, Yaffe, K. The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurol 2011; 10: 819–828.
Bartzokis, G. Alzheimer’s disease as homeostatic responses to age-related myelin breakdown. Neurobiol Aging 2011; 32: 1341–1371.
Ben-Hur, T. Cell therapy for multiple sclerosis. Neurotherapeutics 2011; 8: 625–642.
Bettcher, BM, Yaffe, K, Boudreau, RM, et al. Declines in inflammation predict greater white matter microstructure in older adults. Neurobiol Aging 2015; 36: 948–954.
Braun, SM, Jessberger, S. Adult neurogenesis and its role in neuropsychiatric disease, brain repair and normal brain function. Neuropathol Appl Neurobiol 2014; 40: 3–12.
Breteler, MM. Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective. Neurobiol Aging 2000; 21: 153–160.
Bu, G. Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy. Nat Rev Neurosci 2009; 10: 333–344.
Bucks, RS, Olaithe, M, Eastwood, P. Neurocognitive function in obstructive sleep apnoea: a meta-review. Respirology 2013; 18: 61–70.
Castronovo, V, Scifo, P, Castellano, A, et al. White matter integrity in obstructive sleep apnea before and after treatment. Sleep 2014; 37: 1465–1475.
Chaddock-Heyman, L, Erickson, KI, Holtrop, JL, et al. Aerobic fitness is associated with greater white matter integrity in children. Front Hum Neurosci 2014; 8: 584.
Chang, A, Staugaitis, SM, Dutta, R, et al. Cortical remyelination: a new target for repair therapies in multiple sclerosis. Ann Neurol 2012; 72: 918–926.
Chen, J, Zuo, S, Wang, J, et al. Aspirin promotes oligodendrocyte precursor cell proliferation and differentiation after white matter lesion. Front Aging Neurosci 2014; 6: 7.
Chen, Y, Chen, K, Zhang, J, et al. Disrupted functional and structural networks in cognitively normal elderly subjects with the APOE ɛ4 allele. Neuropsychopharmacology 2015; 40: 1181–1191.
Cheng, CY, Tsai, CF, Wang, SJ, et al. Sleep disturbance correlates with white matter hyperintensity in patients with subcortical ischemic vascular dementia. J Geriatr Psychiatry Neurol 2013; 26: 158–164.
Chiang, GC, Zhan, W, Schuff, N, Weiner, MW. White matter alterations in cognitively normal apoE ε2 carriers: insight into Alzheimer resistance? AJNR 2012; 33: 1392–1397.
Dammann, O, Bueter, W, Leviton, A, et al. Neuregulin-1: a potential endogenous protector in perinatal brain white matter damage. Neonatology 2008; 93: 182–187.
Evin, G, Barakat, A, Masters, CL. BACE: therapeutic target and potential biomarker for Alzheimer’s disease. Int J Biochem Cell Biol 2010; 42: 1923–1926.
Filley, CM. Alzheimer’s Disease prevention: new optimism. Neurol Clin Pract 2015; 5: 193–200.
Folstein, MF, Folstein, SE, McHugh, PR. “Mini-Mental State”: a practical method of grading the cognitive state of patients for the clinician. J Psychiat Res 1975; 12: 189–198.
Forette, F, Seux, ML, Staessen, JA, et al. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med 2002; 162: 2046–2052.
Franklin, RJ, Ffrench-Constant, C. Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 2008; 9: 839–855.
Franklin, RJ, Goldman, SA. Glia disease and repair-remyelination. Cold Spring Harb Perspect Biol 2015; 2015; 7 (7). pii: a020594.
Goldman, SA, Schanz, S, Windrem, MS. Stem cell–based strategies for treating pediatric disorders of myelin. Hum Mol Genet 2008; 17: 876–883.
Gons, RA, Tuladhar, AM, de Laat, KF, et al. Physical activity is related to the structural integrity of cerebral white matter. Neurology 2013; 81: 971–976.
Hu, X, Hicks, CW, He, W, et al. Bace1 modulates myelination in the central and peripheral nervous system. Nat Neurosci 2006; 9: 1520–1525.
Huang, JK, Jarjour, AA, Nait Oumesmar, B, et al. Retinoid X receptor gamma signaling accelerates CNS remyelination. Nat Neurosci 2011; 14: 45–53.
Johnson, NF, Kim, C, Clasey, JL, et al. Cardiorespiratory fitness is positively correlated with cerebral white matter integrity in healthy seniors. Neuroimage 2012; 59: 1514–1523.
Karussis, D, Karageorgiou, C, Vaknin-Dembinsky, C, et al. Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch Neurol 2010; 67: 1187–1194.
Keough, MB, Yong, VW. Remyelination therapy for multiple sclerosis. Neurotherapeutics 2013; 10: 44–54.
Kim, H, Yun, CH, Thomas, RJ, et al. Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population. Sleep 2013; 36: 709–715B.
Lassmann, H, Brück, W, Lucchinetti, C, Rodriguez, M. Remyelination in multiple sclerosis. Mult Scler 1997; 3: 133–136.
Leung, TW, Wang, L, Soo, YO, et al. Evolution of intracranial atherosclerotic disease under modern medical therapy. Ann Neurol 2015; 77: 478–486.
Levine, JM, Reynolds, R, Fawcett, JW. The oligodendrocyte precursor cell in health and disease. Trends Neurosci 2001; 24: 39–47.
Lundgaard, I, Luzhynskaya, A, Stockley, JH, et al. Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes. PLoS Biol 2013; 11: e1001743.
Lunn, JS, Sakowski, SA, Hur, J, Feldman, EL. Stem cell technology for neurodegenerative diseases. Ann Neurol 2011; 70: 353–361.
Maki, T, Liang, AC, Miyamoto, N, et al. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases. Front Cell Neurosci 2013; 7: 275.
Matthews, FE, Arthur, A, Barnes, LE, et al. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II. Lancet 2013; 382: 1405–1412.
McKee, AC, Cantu, RC, Nowinski, CJ, et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 2009; 68: 709–735.
Mei, L, Nave, KA. Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron 2014; 83: 27–49.
Mi, S, Pepinsky, RB, Cadavid, D. Blocking LINGO-1 as a therapy to promote CNS repair: from concept to the clinic. CNS Drugs 2013; 27: 493–503.
Ming, GL, Song, H. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 2011; 70: 687–702.
Mitew, S, Hay, CM, Peckham, H, et al. Mechanisms regulating the development of oligodendrocytes and central nervous system myelin. Neuroscience 2014; 276: 29–47.
Morandi, A, Rogers, BP, Gunther, ML, et al. The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study. Crit Care Med 2012; 40: 2182–2189.
Ngandu, T, Lehtisalo, J, Solomon, A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 2015; 385: 2255–2263.
Pandharipande, PP, Girard, TD, Jackson, JC, et al. Long-term cognitive impairment after critical illness. N Engl J Med 2013; 369: 1306–1316.
Peters, A. The effects of normal aging on myelinated nerve fibers in monkey central nervous system. Front Neuroanat 2009; 3: 11.
Peters, A, Sethares, C. Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey. J Comp Neurol 2002; 442: 277–291.
Prins, ND, Scheltens, P. White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol 2015; 11: 157–165.
Qiu, C, Kivipelto, M, von Strauss, E. Epidemiology of Alzheimer’s disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 2009; 11: 111–128.
Qiu, C, von Strauss, E, Bäckman, L, et al. Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden. Neurology 2013; 80: 1888–1894.
Ready, RE, Baran, B, Chaudhry, M, et al. Apolipoprotein E-e4, processing speed, and white matter volume in a genetically enriched sample of midlife adults Am J Alzheimers Dis Other Demen 2011; 26: 463–468.
Rocca, WA, Petersen, RC, Knopman, DS, et al. Trends in the incidence and prevalence of Alzheimer’s disease, dementia, and cognitive impairment in the United States. Alzheimers Dement 2011; 7: 80–93.
Ryan, L, Walther, K, Bendlin, BB, et al. Age-related differences in white matter integrity and cognitive function are related to APOE status. Neuroimage 2011; 54: 1565–1577.
Salat, DH. Imaging small vessel–associated white matter changes in aging. Neuroscience 2014; 276: 174–186.
Shi, H, Hu, X, Leak, RK, Shi, Y, et al. Demyelination as a rational therapeutic target for ischemic or traumatic brain injury. Exp Neurol 2015 Mar 24. [Epub ahead of print]
Spira, AP, Gamaldo, AA, An, Y, et al. Self-reported sleep and β-amyloid deposition in community-dwelling older adults. JAMA Neurol 2013; 70: 1537–1543.
Valenzuela, M, Esler, M, Ritchie, K, Brodaty, H. Antihypertensives for combating dementia? A perspective on candidate molecular mechanisms and population-based prevention. Transl Psychiatry 2012; 2: e107.
Vanderver, A, Tonduti, D, Schiffmann, R, et al. Leukodystrophy overview. In: Pagon, RA, Adam, MP, Ardinger, HH, Wallace, SE, Amemiya, A, Bean, LJH, Bird, TD, Dolan, CR, Fong, CT, Smith, RJH, Stephens, K, eds. GeneReviews® [Internet]. Seattle: University of Washington, Seattle; 1993–2015. 2014 Feb 6.
Verhaaren, BF, Vernooij, MW, de Boer, R, et al. High blood pressure and cerebral white matter lesion progression in the general population. Hypertension 2013; 61: 1354–1359.
Voss, MW, Heo, S, Prakash, RS, et al. The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: results of a one-year exercise intervention. Hum Brain Mapp 2013; 34: 2972–2985.
Wang, R, Fratiglioni, L, Laukka, EJ, et al. Effects of vascular risk factors and APOE ε4 on white matter integrity and cognitive decline. Neurology 2015; 84: 1128–1135.
Xie, L, Kang, H, Xu, Q, et al. Sleep drives metabolite clearance from the adult brain. Science 2013; 342: 373–377.
Xiong, Y, Mahmood, A, Chopp, M. Angiogenesis, neurogenesis and brain recovery of function following injury. Curr Opin Investig Drugs 2010; 11: 298–308.
Yaffe, K. Metabolic syndrome and cognitive disorders: is the sum greater than its parts? Alzheimer Dis Assoc Disord 2007; 21: 167–171.
Zhang, R, Chopp, M, Zhang, ZG. Oligodendrogenesis after cerebral ischemia. Front Cell Neurosci 2013; 7: 201.