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Women's health, and particularly the impact of hormones, menopause and contraception on mental health, has long been poorly understood and under-addressed in clinical practice. This pioneering guide offers mental health professionals a vital resource to assess, formulate and manage the psychological effects of gynaecological hormonal conditions. Drawing on current evidence, UK clinical guidelines and powerful testimony from experts by experience, the book explores the scientific foundations of hormonal influences on mental well-being. It highlights areas where research is lacking and reflects the realities of working within NHS services. Designed for professionals supporting women with menstrual disorders, hormonal contraception use or peri-/post-menopausal symptoms, this guide equips readers to deliver informed, compassionate care. It also addresses healthcare inequalities, particularly for women with severe mental illness who face barriers to accessing physical health care. Practical, evidence-based and deeply insightful, this is an essential reference for anyone committed to improving clinical outcomes in women's mental health.
The principles of electromyography, including single-fibre electromyography and nerve conduction studies, are described simply, supported by clear diagrams and screenshots of high quality recordings. After a brief overview of anatomy, physiology, pathology and technical matters including electrodes, amplifiers and volume conduction, the way these principles aid the diagnosis of disorders of nerves, muscles and neuromuscular junctions is explained. The book concludes with the findings in common clinical conditions and explores the concept of normal vs abnormal values. This is an invaluable introductory text for trainees in clinical neurophysiology. Clinicians in specialties such as neurology, orthopaedic surgery, rheumatology, general medicine, physical medicine and rehabilitation will benefit from guidance on selecting patients for referral and assistance with the interpretation of the results. Based on the expertise of an author who has spent 25 years practising and teaching the subject, readers can be assured of a wealth of knowledge within these pages.
The endocrine and neuroendocrine system in pregnancy involves highly complex maternal, fetal and placental mechanisms, which are critical for the maintenance of pregnancy, the timing of parturition, for fetal growth and protection from adverse fetal programming. This timely book summarizes the different endocrine aspects related to pregnant women, describing how hormones regulate physiological homeostasis and influence the pathogenesis of disease. The first section of the book covers the role of specific hormones in detail, including oxytocin, hCG and estrogen. The second section discusses gestational disorders such as diabetes, hypertensive disorders and preeclampsia and how the involvement of hormones has clinical implications for management. Best practice for management of endocrine disorders, which can negatively impact pregnancy, such as thyroid disease and obesity, is also reviewed. This book is essential for clinicians and scientists looking to gain knowledge of the role of hormones in pregnancy and how they can best support patients.
Does eating more carbohydrates, or fats, cause one to put on more weight? Are ketone bodies toxins or vital products that keep us alive during starvation? Does the concept of 'fat-burning exercise' hold true? In this game-changing book, Keith Frayn, an international expert in human metabolism and nutrition, dispels common misconceptions about human metabolism, explaining in everyday language the important metabolic processes that underlie all aspects of our daily lives. Illustrated throughout with clear diagrams of metabolic processes, Frayn describes the communication systems that enable our different organs and tissues to cooperate, for instance in providing fuel to our muscles when we exercise, and in preserving our tissues during fasting. He explores the impressive adaptability of human metabolism and discusses the metabolic disorders that can arise when metabolism 'goes wrong'. For anyone sceptical of information about diet and lifestyle, this concise book guides the reader through what metabolism really involves.
Polycystic ovary syndrome (PCOS) is one of the most common reproductive health problems of women, causing irregular periods and potential infertility amongst other challenging symptoms. Effective treatment remains a significant challenge and is largely achieved through hormonal medication and lifestyle changes. This third edition covers the aetiology, pathology, impact on fertility and effective medical and surgical management. The content has been thoroughly revised in line with updated guidelines and research developments in the field. A new chapter on the patient's perspective has been included, bringing valuable insight into the lived experience of the condition. Mood disorders and the psychological aspects of PCOS are also covered for the first time. This is a key reference for all clinicians involved in the care of patients with PCOS, including gynaecologists, IVF specialists and reproductive endocrinologists.
Mental Health, Diabetes and Endocrinology examines the main areas of clinical overlap between endocrinology and mental health to address key clinical conundrums. Drawing on the most recent developments from literature and clinical practice, this book gives specific attention to the main areas where clinical conundrums and treatment challenges arise across endocrinology, psychiatry, psychology and primary care. Common challenges in this area include depression which can impact on the person's ability to self-care and to adhere to treatment with consequences for their morbidity and mortality; 'diabulaemia' associated with high mortality rates; obesity and associated mental disorders; cognitive impairment and mental capacity; anti-psychotic medications and their endocrine sequelae; and specific setting-related considerations. Mental Health, Diabetes and Endocrinology is a useful resource for the overlapping conditions across these specialities, and provides clinically-focussed evidence-based resources for all health care professionals who encounter these issues.
A practical approach to the field of androgen excess or deprivation in women's health. The content includes multiple viewpoints on the most common disorders in this class, such as polycystic ovary disease, hirsutism and menopausal issues. Each chapter provides a combination of long-lasting clinical principles in the diagnosis and management of these patients along with a state-of-the-art review. This text takes an innovative approach to uncommon conditions (such as congenital adrenal hyperplasia, transgender conditions). In addition to presenting clinical insights, and a review of the basic science underpinning these conditions, it focuses on key concepts that can be derived from these rare conditions to the entire field. This book is an essential addition to the library for any busy clinician who is looking for a practical reference guide but also for the sub-specialist who is looking for new and thought-provoking insights in this complex scientific area.
The concept of homeostasis, the maintenance of the internal physiological environment of an organism within tolerable limits, is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. With allostatic regulation by cephalic involvement, the body adapts to potentially diverse and dangerous situations through the activation of neural, hormonal, or immunological mechanisms. Allostasis explains how regulatory events maintain organismic viability, or not, in diverse contexts with varying set points of bodily needs and competing motivations. This 2005 book introduces the concept of allostasis and sets it alongside traditional views of homeostasis. It addresses basic regulatory systems and examines the behavior of bodily regulation under duress. The basic concepts of physiological homeostasis are integrated with disorders like depression, stress, anxiety and addiction. It will therefore appeal to graduate students, medical students and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.
Recent advances in non-invasive sampling techniques have led to an increase in the study of hormones and behaviour. Behaviour is complex but can be explained to a large degree by interactions between various psychological and physiological components, such as the interplay between hormonal and psychological systems. This new textbook from Nick Neave offers a detailed introduction to the fascinating science of behavioural endocrinology from a psychological perspective, examining the relationships between hormones and behaviour in both humans and animals. Neave explains the endocrine system and the ways in which hormones can influence brain structure and function, and presents a series of examples to demonstrate how hormones can influence specific behaviours, including sexual determination and differentiation, neurological differentiation, parental behaviours, aggressive behaviours and cognition. This introductory textbook will appeal to second and third year social science undergraduate students in psychology and biomedicine.
Osteoporosis is one of the leading causes of morbidity and mortality amongst the elderly. The rationale for The Osteoporosis Primer is to provide an introductory text that relates the clinical presentation of osteoporosis to its molecular biochemical basis. The text has been organised into four sections that deal with the molecular/cellular components of bone, the development of peak bone mass, the pathophysiology of aging bone and, finally, how all of these relate to the prevention, diagnosis and treatment of osteoporosis. The international team of authors includes many leading clinicians and scientists who have provided the reader with a concise, yet comprehensive, synopsis of bone development and skeletal homeostasis. This will be an essential introduction for individuals working on osteoporosis including students and doctors considering a career related to metabolic bone disease, physicians in general practice, geriatricians, rheumatologists, and endocrinologists.
This concise practical guide deals with the investigation, diagnosis and treatment of all the common metabolic bone diseases and disorders of calcium metabolism. All the most common diseases are covered including osteoporosis, osteomalacia, Paget's disease, hypercalcaemia and hypocalcaemia, and the volume concludes with a brief look at some of the rarer conditions which might occasionally be encountered. The book summarises briefly the most recent advances in the understanding of the aetiology of these diseases and provides useful and practical guidance on new and established treatment regimes. The volume will be a valuable source of guidance for the many physicians, based in hospitals and general practice, who encounter patients with these diseases. The volume will appeal broadly to consultants and senior registrars in general medicine, geriatric medicine, rheumatology and endocrinology, and to general practitioners.
Microalbuminuria, the abnormal urinary excretion of albumin, is recognised as an important independent marker of both renal and cardiovascular disease, particularly in diabetes mellitus. This volume is the only comprehensive and up-to-date review of the relevance of microalbuminuria to health and disease. It covers the pathophysiology and epidemiology of microalbuminuria, the methodology of laboratory assessment and a discussion of the non-specific nature of microalbuminuria in less well-recognised clinical situations. This is the first book to deal in detail with the treatment of microalbuminuria in diabetic and non-diabetic subjects. It will provide an essential source of reference and a guide to clinical practice for diabetologists, endocrinologists, cardiologists, renal physicians and clinical biochemists.
This revised edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the disorders that result from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject, and this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and its role in ageing and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. The volume is the most authoritative, comprehensive and detailed account available and will be an essential source of reference for all endocrinologists.
This book presents evidence that infection is cyclical with the seasons, and that this phenomenon is mirrored in cycles of immune function. The book identifies the mechanisms by which immune systems are bolstered to counteract seasonally-recurrent stressors, such as extreme temperature reductions and food shortages. Stress, infectious diseases, autoimmune diseases, and human cancers are examined, and the role of hormones such as melatonin and glucocorticoids is considered. The book begins with an overview of seasonality, biological rhythms and photoperiodism, and basic immunology, and then discusses seasonal fluctuations in disease prevalence, immune function, and energetics and endocrinology as they relate to immune function. The clinical significance of this issue is also addressed, as such seasonal changes may play an important role in the development and treatment of infections. This first monograph to examine seasonal immune function from an interdisciplinary perspective will serve practitioners as well as advanced undergraduates and graduate students in biology, immunology, human and veterinary medicine, neuroscience, endocrinology, and zoology.
This concise and practical book is designed for paediatricians and endocrinologists, trained or in training, who see children with endocrine problems. All the endocrine glands are covered, and the author has distilled his vast experience and expertise in this area to provide hard-hitting, practical advice on the diagnosis, management and treatment of the main endocrine disorders. It is not a heavily referenced tome but a monograph in the true sense of the word - a book in which an expert describes and discusses the area of his expertise for the benefit and interest of others. The volume is illustrated throughout and the text is also supplemented by many succinct and informative tables. The volume concludes with a short chapter on practical procedures, including endocrine tests, imaging, and drugs and doses.
This authoritative review volume provides a wide-ranging account of the immunological mechanisms that underlie many rheumatic diseases. Advances in our understanding of the immunopathology of diseases such as rheumatoid arthritis, ankylosing spondylitis and SLE, are paving the way for the development of effective and rational new therapies. This exciting prospect is an important stimulus for ground-breaking research into these diseases and the investigation of new therapeutic options. As the first book to focus exclusively on this burgeoning area of clinical research, this is an invaluable and contemporary account for all rheumatologists, clinical immunologists and those seeking to develop effective new therapies to combat rheumatic diseases.
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