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A case-control study of interleukin-12 1188A/C polymorphism in obsessive-compulsive disorder in Chinese population

  • Shiguo Liu (a1) (a2) (a3), Yanhui Liu (a4), Yingying Yin (a4), Xinhua Zhang (a4) and Xu Ma (a5) (a6) (a7)
  • DOI:
  • Published online: 01 June 2014

Objective: Previous studies indicated that the levels of serum interleukin (IL)-12 at baseline were elevated in obsessive-compulsive disorder (OCD) patients compared with control subjects, suggesting that IL-12 maybe involved in the etiopathogenesis of OCD. Therefore, we study the relationship between 1188A/C polymorphism of IL-12(rs3212227) and OCD in Chinese Han population.

Methods: We genotyped 194 OCD patients and 322 healthy individuals by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), then analyzed the data using case-control association test.

Results: No significant differences were found in 1188A/C genotypic and allelic frequencies between OCD cases and controls (X2 = 2.12, df = 2, P = 0.35 by genotype; X2 = 0.005, df = 1, P = 0.94 by allele).

Conclusions: Our results suggested that there may be lack of an association between OCD and IL-12 1188A/C polymorphism in Chinese Han population.

Corresponding author
Xinhua Zhang, MD, Department of psychiatry, Medical College, Qingdao University, 16 Jiangsu Road, Qingdao 266003, China. Tel: +86 053282912012; Fax: +86 053282912016; E-mail:
Professor Xu Ma, Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081 China. Tel: +86 10 62176870; Fax: +86 10 62179151; E-mail:
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1.RC Kessler , P Berglund , O Demler , R Jin , KR Merikangas , EE. Walters Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005;62:593602.

2.J Bobes , MP Gonzalez , MT Bascaran , C Arango , PA Saiz , M. Bousono Quality of life and disability in patients with obsessive–compulsive disorder. Eur Psychiatry 2001;16:239245.

4.N Konuk , IO Tekin , U Ozturk Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder. Mediators Inflamm 2007;2007: 65704.

5.BH Rovin , L Lu , X. Zhang A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritis. Kidney Int 2002;62:261265.

6.C Gasche , P Grundtner , P Zwirn Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-α production. J Immunol 2003;170:55785582.

7.JF Leckman , L Katsovich , I Kawikova Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome. Biol Psychiatry 2005;57:667673.

8.AJ Church , RC Dale , F Cardoso CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome?. J Neuroimmunol 2003;136:149153.

9.G Morahan , D Huang , SI Ymer Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL-12B allele. Nat Genet 2001;27:218221.

10.D Denys , S Fluitman , A Kavelaars , K Heijnen , H. Westenberg Decreased TNF-a and NK activity in obsessive–compulsive disorder. Psychoneuroendocrinology 2004;29:945952.

11.D Huang , MR Cancilla , G. Morahan Complete primary structure, chromosomal localisation and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit. Genes Immun 2000;1:515520.

12.D Sieburth , EW Jabs , JA Warrington Assignment of genes encoding a unique cytokine (IL-12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics 1992;14:5962.

13.T van Veen , JB Crusius , HM Schrijver Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis. Ann Neurol 2001;50:275279.

14.D Seegers , A Zwiers , W Strober , AS Pena , G. Bouma A Taq1 polymorphism in the 3′UTR of the Il-12 p40 gene correlates with increased Il-12 secretion. Genes Immun 2002;3:419423.

15.PD Arnold , DR Rosenberg , E Mundo , S Tharmalingam , JL Kennedy , MA. Richter Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology (Berl) 2004;174:530538.

17.DJ. Stein Obsessive–compulsive disorder. Lancet 2002;360:397405.

19.P Monteleone , F Catapano , M Fabrazzo , A Tortorella , M. Maj Decreased blood levels of tumor necrosis factor-alpha in patients with obsessive-compulsive disorder. Neuropsychobiology 1998;37:182185.

20.LL Carpenter , GR Heninger , CJ McDougle , AR Tyrka , CN Epperson , LH. Price Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Psychiatry Res 2002;112:257262.

21.GG Kruager , RG Langley , C Leonardi A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis [J]. N Engl J Med 2007;356:580592.

22.C Rohowsky-koehan , D Molinaro , A. Choudhry Impaired interleukin-12 production in multiple sclerosis [J]. Mult Scler 1999;5:327334.

23.MF. Neurath IL-23:a master regulator in Crohn disease [J]. Nat Med 2007;13:2628.

24.S Kuroda , P. Puri Lack of association of IL8 gene polymorphisms with familial vesico-ureteral reflux. Pediatr Surg Int 2007;23:441445.

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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
  • URL: /core/journals/acta-neuropsychiatrica
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