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Cognitive effects of acute tryptophan depletion in the healthy elderly

  • Janet Mace (a1), Richard Porter (a1), John O’Brien (a2) and Peter Gallagher (a3)
Abstract
<span class='bold'>Background:</span>

Studies investigating the cognitive effects of serotonin depletion, using the technique of acute tryptophan depletion (ATD) by dietary means, have generally suggested that ATD impairs delayed verbal recall and recognition. In two previous studies in the elderly, this result has not been replicated and ATD impaired working memory. These results may be susceptible to type II error but a similar testing schedule in the individual studies allows data to be pooled in a larger analysis.

<span class='bold'>Methods:</span>

Data from two separate double-blind placebo-controlled studies of the effects of ATD on cognitive function in the elderly were combined. In one study, a low dose and in the other a high dose of amino acids was used. In a repeated measures analysis of variance, the effects of ATD and the interaction of this with the other factors (age, gender and dose) on cognitive measures was examined.

<span class='bold'>Results:</span>

Data from 31 healthy subjects aged between 60 and 81 years were analysed. There were no main effects of ATD or consistent interactions between ATD and age, gender or dose. There were significant interactions between ATD, gender and dose. When tryptophan depleted, females having the higher dose drink had reduced scores on Digit span and immediate recall on the Rey Auditory Verbal Learning Test.

<span class='bold'>Conclusion:</span>

The enlarged data set did not confirm an overall effect of ATD on working memory or on delayed word recall but does suggest an effect of ATD on encoding or registration in the subgroup of females receiving a higher strength drink.

Copyright
Corresponding author
Richard Porter, Department of Psychological Medicine, University of Otago, PO Box 4345, Christchurch, New Zealand. Tel: +64 3 372 0400; Fax: +64 3 372 0407; E-mail: richard.porter@otago.ac.nz
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SN Young , FR Ervin , RO Pihl , P Finn . Biochemical aspects of tryptophan depletion in primates. Psychopharmacology 1989;98:508511.

S Nishizawa , C Benkelfat , SN Young et al. Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci U S A 1997;94:53085313.

RJ Porter , BS Lunn , J O’Brien . Effects of acute tryptophan depletion on cognitive function in Alzheimer’s disease and in the healthy elderly. Psychol Med 2003;33:4149.

RJ Porter , AJ Phipps , P Gallagher et al. Effects of acute tryptophan depletion on mood and cognitive function in older recovered depressed subjects. Am J Geriatr Psychiatry 2005;13:607615.

CR De Luca , SJ Wood , V Anderson et al. Normative data from the CANTAB. I: development of executive function over the lifespan. J Clin Exp Neuropsychol 2003;25:242254.

JA Schmitt , BL Jorissen , L Dye , CR Markus , NE Deutz , WJ Riedel . Memory function in women with premenstrual complaints and the effect of serotonergic stimulation by acute administration of an alpha-lactalbumin protein. J Psychopharmacol 2005;19:375384.

A Sambeth , A Blokland , CJ Harmer et al. Sex differences in the effect of acute tryptophan depletion on declarative episodic memory: a pooled analysis of nine studies. Neurosci Biobehav Rev 2007;31:516529.

RJ Porter , BS Lunn , LL Walker , JM Gray , CG Ballard , JT O’Brien . Cognitive deficit induced by acute tryptophan depletion in patients with Alzheimer’s disease. Am J Psychiatry 2000;157:638640.

SA Montgomery , M Asberg . A new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134:382389.

JA Yesavage , TL Brink , TL Rose et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 1982;17: 3749.

M Folstein , S Folstein , P Mchugh . “Mini mental state” a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189198.

SN Young , SE Smith , RO Pihl , FR Ervin . Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology 1985;87:173177.

EF Marshall , WN Kennedy , D Eccleston . Whole blood serotonin and plasma tryptophan using high-pressure liquid chromatography with electrochemical detection. Biochem Medi Metab Biol 1987;37:8186.

J Bryan , MA Luszcz , JR Crawford . Verbal knowledge and speed of information processing as mediators of age differences in verbal fluency performance among older adults. Psychol Aging 1997;12:473478.

Y Sakai , M Nishikawa , M Leyton , C Benkelfat , SN Young , M Diksic . Cortical trapping of alpha-[(11)C]methyl-l-tryptophan, an index of serotonin synthesis, is lower in females than males. Neuroimage 2006;33:815824.

L Traskman , M Asberg , L Bertilsson , L Sjostrand . Monoamine metabolites in CSF and suicidal behavior. Arch Gen Psychiatry 1981;38:631636.

JH Hughes , P Gallagher , ME Stewart , D Matthews , TP Kelly , AH Young . The effects of acute tryptophan depletion on neuropsychological function. Journal of Psychopharmacol 2003;17:300309.

KL Golightly , JA Lloyd , JE Hobson , P Gallagher , G Mercer , AH Young . Acute tryptophan depletion in schizophrenia. Psychol Med 2001;31:7584.

EA Evers , DE Tillie , FM Van Der Veen et al. Effects of a novel method of acute tryptophan depletion on plasma tryptophan and cognitive performance in healthy volunteers. Psychopharmacology 2005;178:9299.

B Scholtissen , FR Verhey , JJ Adam , J Prickaerts , AF Leentjens . Effects of acute tryptophan depletion on cognition, memory and motor performance in Parkinson’s disease. J Neurol Sci 2006;248:259265.

S Sobczak , A Honig , N Nicholson , W Riedel . Effects of acute tryptophan depletion on mood and cortisol release in first-degree relatives of type I and type II bipolar patients and healthy matched controls. Neuropsychopharmacology 2002;27:834842.

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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
  • URL: /core/journals/acta-neuropsychiatrica
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