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Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle

  • Florian Daniel Zepf (a1) (a2), R.M. Stewart (a1), G. Guillemin (a3) and J.L. Ruas (a4)
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References
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1. Kiecolt-Glaser, JK, Derry, HM, Fagundes, CP et al. Inflammation: depression fans the flames and feasts on the heat. Am J Psychiatry 2015;172:10751091.
2. Wegner, M, Helmich, I, Machado, S, Nardi, AE, Arias-Carrion, O, Budde, H. Effects of exercise on anxiety and depression disorders: review of meta-analyses and neurobiological mechanisms. CNS Neurol Disord Drug Targets 2014;13:10021014.
3. Agudelo, LZ, Femenía, T, Orhan, F et al. Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell 2014;159:3345.
4. O’Mahony, SM, Clarke, G, Borre, YE, Dinan, TG, Cryan, JF. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res 2015;277:3248.
5. Zepf, FD, Stewart, RM. Inflammation, immunity and suicidality: a potential role for autoantibodies against neurotransmitters and antiphospholipid syndrome? Acta Psychiatr Scand 2015. doi:10.1111/acps.12508. [Epub ahead of print].
6. Rege, S, Mackworth-Young, C. Antiphospholipid antibodies as biomarkers in psychiatry: review of psychiatric manifestations in antiphospholipid syndrome. Transl Dev Psychiatry 2015;3:25452. http://dx.doi.org/10.3402/tdp.v3.25452.
7. Mackworth-Young, CG. Antiphospholipid syndrome: multiple mechanisms. Clin Exp Immunol 2004;136:393401.
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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
  • URL: /core/journals/acta-neuropsychiatrica
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