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Investigation of serum levels of sortilin in response to antidepressant treatment

Published online by Cambridge University Press:  08 May 2017

Henriette Nørmølle Buttenschøn ,
Marit Nielsen ,
Simon Glerup  and
Ole Mors
Henriette Nørmølle Buttenschøn*
Affiliation:
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Risskov, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark
Marit Nielsen
Affiliation:
Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Risskov, Denmark
Simon Glerup
Affiliation:
The Lundbeck Foundation Research Center, MIND, Aarhus University, Aarhus, Denmark
Ole Mors
Affiliation:
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark
*
*Henriette N. Buttenschøn, Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Risskov, Denmark. Tel: +45 7847 1163; Fax: +45 7847 1108; E-mail: hnbt@clin.au.dk
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Abstract

Background

The identification of biomarkers for depression is of great clinical relevance as the diagnosis is currently subjective. Recent research points towards sortilin as a potential biomarker for depression, and the aim of the current study was to investigate the serum sortilin level in response to antidepressant treatment.

Methods

The study included 56 depressed individuals of which 41 responded to treatment. Depression scores and serum levels of sortilin were measured at baseline and after 12 weeks of antidepressant treatment. Statistical analyses were performed using Stata 13.

Results

The depression score and response to treatment were not predicted by the sortilin level. Likewise, we observed no significant change in serum sortilin levels following 12 weeks of antidepressant treatment. Furthermore, no association between the serum sortilin level and depression score was observed.

Conclusion

The results do not point towards sortilin as a state-dependent biomarker.

Keywords

antidepressant treatmentbiomarkerdepressionsortilin
Type
Short Communication
Information
Acta Neuropsychiatrica , Volume 30 , Issue 2 , April 2018 , pp. 111 - 116
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Copyright
© Scandinavian College of Neuropsychopharmacology 2017 

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