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Lateralisation abnormalities in obsessive–compulsive disorder: a line bisection study

  • Naren Prahlada Rao (a1) (a2), Rashmi Arasappa (a1), Nalini Narayana Reddy (a1), Ganesan Venkatasubramanian (a1) and Janardhan Reddy Y.C. (a1)...
Abstract
Objective

Asymmetry in brain structure and function is implicated in the pathogenesis of psychiatric disorders. Although right hemisphere abnormality has been documented in obsessive–compulsive disorder (OCD), cerebral asymmetry is rarely examined. Therefore, in this study, we examined anomalous cerebral asymmetry in OCD patients using the line bisection task.

Methods

A total of 30 patients with OCD and 30 matched healthy controls were examined using a reliable and valid two-hand line bisection (LBS) task. The comparative profiles of LBS scores were analysed using analysis of covariance.

Results

Patients with OCD bisected significantly less number of lines to the left and had significant rightward deviation than controls, indicating right hemisphere dysfunction. The correlations observed in this study suggest that those with impaired laterality had more severe illness at baseline.

Conclusions

The findings of this study indicate abnormal cerebral lateralisation and right hemisphere dysfunction in OCD patients.

Copyright
© Scandinavian College of Neuropsychopharmacology 2015 
Corresponding author
Dr. Naren P Rao, Centre for Neuroscience, Indian Institute of Science, Bangalore, Karnataka, India. Tel: +91 802 293 2518; Fax: +91 802 360 3323; E-mail: docnaren@gmail.com
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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
  • URL: /core/journals/acta-neuropsychiatrica
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