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Mismatch in cerebral blood flow and glucose metabolism after the forced swim stress in rats

Published online by Cambridge University Press:  20 June 2016

Yosuke Kameno ,
Katsuaki Suzuki ,
Shu Takagai ,
Keiko Iwata ,
Hideo Matsuzaki ,
Kenji Takahashi ,
Tomoyasu Wakuda ,
Yasuhide Iwata ,
Yasuhiro Magata  and
Norio Mori
Yosuke Kameno
Affiliation:
Department of Psychiatry, Hamamatsu University School of Medicine, Japan
Katsuaki Suzuki*
Affiliation:
Department of Psychiatry, Hamamatsu University School of Medicine, Japan
Shu Takagai
Affiliation:
Research Center for Child Mental Development, Hamamatsu University School of Medicine, Japan
Keiko Iwata
Affiliation:
Research Center for Child Mental Development, University of Fukui, Japan
Hideo Matsuzaki
Affiliation:
Research Center for Child Mental Development, University of Fukui, Japan
Kenji Takahashi
Affiliation:
Research Center for Child Mental Development, Hamamatsu University School of Medicine, Japan
Tomoyasu Wakuda
Affiliation:
Department of Psychiatry, Hamamatsu University School of Medicine, Japan
Yasuhide Iwata
Affiliation:
Department of Psychiatry, Hamamatsu University School of Medicine, Japan
Yasuhiro Magata
Affiliation:
Medical Photonics Research Center, Hamamatsu University School of Medicine, Japan
Norio Mori
Affiliation:
Department of Psychiatry, Hamamatsu University School of Medicine, Japan Research Center for Child Mental Development, Hamamatsu University School of Medicine, Japan
*
Corresponding author: Dr. Katsuaki Suzuki, Department of Psychiatry, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan. Tel: +81 53 435 2295; Fax: +81 53 435 3621; E-mail: k-suzuki@hama-med.ac.jp
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Abstract

Objective

Neuroimaging studies of depression considered as a stress-related disorder have shown uncoupling in regional cerebral blood flow (rCBF) and regional cerebral metabolic rate for glucose (rCMRglc). We hypothesised that the mismatch change of rCBF and rCMRglc could be a stress-related phenomenon.

Methods

We exposed male rats to 15-min period of forced swim (FS), followed by the measurement of rCBF using N-isopropyl-4-[123I] iodoamphetamine (123I-IMP) and rCMRglc using 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG).

Results

The uptake rate of 18F-FDG in the FS group showed a significant decrease in the prefrontal cortex (0.86±0.20%ID/g, p<0.01) and thalamus (0.77±0.17%ID/g, p<0.05) and tended to be lower in the hippocampus (0.58±0.13%ID/g) and cerebellum (0.59±0.13%ID/g) without overt alteration in the uptake rate of 123I-IMP.

Conclusions

The FS stress can cause mismatch change of rCBF and rCMRglc, which reflect a stress-related phenomenon.

Keywords

depressionforced swim stressratregional cerebral blood flowregional cerebral metabolic rate for glucose
Type
Short Communication
Information
Acta Neuropsychiatrica , Volume 28 , Issue 6 , December 2016 , pp. 352 - 356
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Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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