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Mismatch in cerebral blood flow and glucose metabolism after the forced swim stress in rats

  • Yosuke Kameno (a1), Katsuaki Suzuki (a1), Shu Takagai (a2), Keiko Iwata (a3), Hideo Matsuzaki (a3), Kenji Takahashi (a2), Tomoyasu Wakuda (a1), Yasuhide Iwata (a1), Yasuhiro Magata (a4) and Norio Mori (a1) (a2)...

Abstract

Objective

Neuroimaging studies of depression considered as a stress-related disorder have shown uncoupling in regional cerebral blood flow (rCBF) and regional cerebral metabolic rate for glucose (rCMRglc). We hypothesised that the mismatch change of rCBF and rCMRglc could be a stress-related phenomenon.

Methods

We exposed male rats to 15-min period of forced swim (FS), followed by the measurement of rCBF using N-isopropyl-4-[123I] iodoamphetamine (123I-IMP) and rCMRglc using 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG).

Results

The uptake rate of 18F-FDG in the FS group showed a significant decrease in the prefrontal cortex (0.86±0.20%ID/g, p<0.01) and thalamus (0.77±0.17%ID/g, p<0.05) and tended to be lower in the hippocampus (0.58±0.13%ID/g) and cerebellum (0.59±0.13%ID/g) without overt alteration in the uptake rate of 123I-IMP.

Conclusions

The FS stress can cause mismatch change of rCBF and rCMRglc, which reflect a stress-related phenomenon.

Copyright

Corresponding author

Corresponding author: Dr. Katsuaki Suzuki, Department of Psychiatry, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan. Tel: +81 53 435 2295; Fax: +81 53 435 3621; E-mail: k-suzuki@hama-med.ac.jp

References

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