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Sleep disturbance in mild cognitive impairment: differential effects of current and remitted depression

  • Sharon L. Naismith (a1), Naomi L. Rogers (a2), Simon J. G. Lewis (a1), Keri Diamond (a1), Zoë Terpening (a1), Louisa Norrie (a1) and Ian B. Hickie (a1)...
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Naismith SL, Rogers NL, Lewis SJG, Diamond K, Terpening Z, Norrie L, Hickie IB. Sleep disturbance in mild cognitive impairment: differential effects of current and remitted depression.

Objective: Although patients with mild cognitive impairment (MCI) commonly report sleep disturbance, the extent to which depressive symptoms contribute to this relationship is unclear. This study sought to delineate the contribution of current and remitted major depression (MD) to sleep disturbance in MCI.

Methods: Seventy-seven patients meeting criteria for MCI (mean age = 66.6 ± 8.8 years) were grouped according to those with no history of depression (MCI, n = 33), those meeting criteria for current MD [mild cognitive impairment and meeting criteria for current major depression (DEP-C), n = 14] and those with remitted MD [mild cognitive impairment and remitted major depression (DEP-R), n = 30]. Additionally, 17 healthy controls (CON) participated. Sleep was patient-rated using the Pittsburgh Sleep Quality Index and included assessment of sleep quality, duration, efficiency, disturbances, medications, sleep onset latency and daytime dysfunction. Depression severity was clinician-rated using the Hamilton Depression Rating Scale.

Results: Overall sleep disturbance was significantly greater in the DEP-C and DEP-R groups in comparison to the CON and MCI groups (p < 0.001). Only 12% of CON reported sleep disturbance, compared to 30% of MCI, 63% of DEP-R and 86% of DEP-C. Sub-scale analysis showed that the sleep disturbance in depressive groups was most evident across the domains of sleep quality, sleep efficiency, sleep latency and daytime dysfunction.

Conclusion: Sleep disturbance in MCI is strongly associated with a current or past diagnosis of MD. The finding that sleep complaints are still prominent in those with remitted depression, suggests that ‘trait' markers exist that may reflect underlying neurobiological changes within the sleep–wake system.

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Corresponding author
Professor Sharon Naismith, Clinical Research Unit & Ageing Brain Centre, Brain & Mind Research Institute, 94 Mallett Street, Camperdown, NSW, Australia. Tel: +61 2 9351 0781; Fax: +61 2 9351 0855; E-mail: sharon.naismith@sydney.edu.au
References
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1Ohayon, MM, Vecchierini, M-F.Daytime sleepiness and cognitive impairment in the elderly population. Arch Intern Med 2002;162:201208.
2Kupfer, DJ, Reynolds, CF, Ulrich, RF, Shaw, DH, Coble, PA.EEG sleep, depression, and aging. Neurobiol Aging 1982;3:351360.
3Hickie, I, Scott, E.Late-onset depressive disorders: a preventable variant of cerebrovascular disease? Psychol Med 1998;28:10071013.
4Beaulieu-Bonneau, S, Hudon, C.Sleep disturbances in older adults with mild cognitive impairment. Intern Psychoger 2009;21:654666.
5Reynolds, CF, Kupfer, DJ, Taska, LS et al. EEG sleep in elderly depressed, demented, and healthy subjects. Biol Psychiatry 1985;20:431442.
6Cricco, M, Simonsick, EM, Foley, DJ.The impact of insomnia on cognitive functioning in older adults. J Am Geriatr Soc 2001;49:11851189.
7Mortimer, JA, Ebbitt, B, Jun, SP, Finch, MD.Predictors of cognitive and functional progression in patients with probable Alzheimer's disease. Neurology 1992;42:16891696.
8Naismith, SL, Lewis, SJG, Rogers, N. Sleep-Wake changes and cognition in neurodegenerative disease. In: Kerkhof, G, Van Dongen, H, eds. Human sleep and cognition part II: clinical and applied research, Progress in Brain Research, Vol. 190. New York, NY: Elsevier (in press).
9Cho, HJ, Lavretsky, H, Olmstead, R, Levin, MJ, Oxman, MN, Irwin, MR.Sleep disturbance and depression recurrence in community-dwelling older adults: a prospective study. Am J Psychiatry 2008;165:15431550.
10Naismith, SL, Norrie, L, Lewis, SJ, Rogers, NL, Scott, EM, Hickie, IB.Does sleep disturbance mediate neuropsychological functioning in older people with depression? J Affect Disord 2009;116:139143.
11Naismith, SL, Rogers, NL, Hickie, IB, Mackenzie, J, Norrie, LM, Lewis, SJ.Sleep well, think well: sleep-wake disturbance in mild cognitive impairment. J Geriatr Psychiatry Neurol 2010;23:123130.
12Duman, RS, Monteggia, LM.A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006;59:11161127.
13Naismith, SL, Hickie, IB, Turner, K et al. Neuropsychological performance in patients with depression is associated with clinical, etiological and genetic risk factors. J Clin Exp Neuropsychol 2003;25:866877.
14Stickgold, R.Sleep-dependent memory consolidation. Nature 2005;437:12721278.
15Steffens, DC, Otey, E, Alexopoulos, GS et al. Perspectives on depression, mild cognitive impairment, and cognitive decline. Arch Gen Psychiatry 2006;63:130138.
16Petersen, RC, Doody, R, Kurz, A et al. Current concepts in mild cognitive impairment. Arch Neurol 2001;58:19851992.
17Gauthier, S, Reisberg, B, Zaudig, M et al. Mild cognitive impairment. Lancet 2006;367:12621270.
18Petersen, RC, Morris, JC.Mild cognitive impairment as a clinical entity and treatment target. Arch Neurol 2005;62:11601163.
19DePaulo, JR, Folstein, MF.Psychiatric disturbances in neurological patients: detection, recognition, and hospital course. Ann Neurol 1978;4:225228.
20First, M, Gibbon, M, Spitzer, R, Williams, J, Benjamin, L.Structured clinical interview for DSM-IV Axis II personality disorders, (SCID-II). Washington, DC: American Psychiatric Press, Inc., 1997.
21Hamilton, M.A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:5661.
22Reisberg, B, Ferris, SH, de Leon, MJ et al. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 1982;139:11361139.
23Dubois, B, Feldman, HH, Jacova, C et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007;6:734746.
24Wechsler Test of Adult Reading. San Antonio, TX: Harcourt Assessment, 2001.
25Wechsler, DS.Wechsler Memory Scale, 3rd edn. San Antonio, TX: The Psychological Corporation, 1997.
26Spreen, O, Strauss, E.A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary, 2nd edn. New York: Oxford University Press, 1998.
27Buysse, DJ, Reynolds, CFr, Monk, TH, Berman, SR, Kupfer, DJ.The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193213.
28Thase, ME, Fasiczka, AL, Berman, SR, Simons, AD, Reynolds, CF.Electroencephalographic sleep profiles before and after cognitive behavior therapy of depression. Arch Gen Psychiatry 1998;55:138144.
29Hickie, I, Scott, E, Naismith, S et al. Late-onset depression: genetic, vascular and clinical contributions. Psychol Med 2001;13:14031412.
30Hobson, JA, Datta, S, Calvo, JM, Quattrochi, J.Acetylcholine as a brain state modulator: triggering and long-term regulation of REM sleep. Prog Brain Res 1993;98:389404.
31Gais, S, Born, J.Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation. Proc Natl Acad Sci USA 2004;101:21402144.
32Naismith, SL, Glozier, N, Burke, D, Carter, P, Scott, E, Hickie, I.Early intervention for cognitive decline: Is there a role for multiple medical or behavioural interventions?. Early Intervention Psychiatry 2009;3:1927.
33Mazzoni, G, Gori, S, Formicola, G et al. Word recall correlates with sleep cycles in elderly subjects. J Sleep Res 1999;8:185188.
34Arendt, J, Rajaratnam, SMW.Melatonin and its agonists: an update. Br J Psychiatry 2008;193:267269.
35Steffens, DC, McQuoid, DR, Potter, GG.Outcomes of older cognitively impaired individuals with current and past depression in the NCODE study. J Geriatr Psychiatry Neurol 2009;22:5261.
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Acta Neuropsychiatrica
  • ISSN: 0924-2708
  • EISSN: 1601-5215
  • URL: /core/journals/acta-neuropsychiatrica
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