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Clinical implications of neuropsychiatric systemic lupus erythematosus

  • Anselm Mak, Roger Chun Man Ho and Chak Sing Lau
Summary

Systemic lupus erythematosus (SLE) is a disorder which can affect the central nervous system and result in a broad range of psychiatric syndromes such as psychosis, mood disorders, acute confusion and cognitive dysfunction. Despite the robust nomenclature of neuropsychiatric SLE (NPSLE), psychiatric syndromes in patients are often non-specific and may be secondary to concurrent non-SLE-related conditions and complications of medical therapies. Although the exact immunopathological mechanism for psychiatric presentation remains elusive, prompt exclusion of other factors contributing to the psychiatric symptoms coupled with effective assessment strategies and management with immunosuppression and psychiatric therapy are imperative. Psychiatrists and rheumatologists must work in close liaison to identify, treat and prognosticate patients with psychiatric syndromes in order to improve their quality of life, vocational aptitude and, ultimately, survival.

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Copyright
Corresponding author
Dr Roger Chun Man Ho, Department of Psychological Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 110974. Email: pcmrhcm@nus.edu.sg
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Declaration of Interest

None.

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References
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BJPsych Advances
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  • EISSN: 1472-1481
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Clinical implications of neuropsychiatric systemic lupus erythematosus

  • Anselm Mak, Roger Chun Man Ho and Chak Sing Lau
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