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Prescribing psychotropic drugs for the elderly

  • Alistair Burns (a1) and Robert Baldwin (a2)

The pharmacological treatment of the elderly differs from that of younger patients, mainly because of altered pharmacokinetics and the higher proportion of patients with organic disorders. We deal here with dementia, delirium, affective disorder, late-life schizophrenia, sleep disturbance, and rapid tranquillisation.

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Abou-Saleh, M. T. & Coppen, A. (1983) The prognosis of depression in old age: the case for lithium therapy. British Journal of Psychiatry, 143, 527528.
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM-III-R). Washington, DC: APA.
Baldwin, R. C. & Jolley, D. J. (1986) The prognosis of depression in old age. British Journal of Psychiatry, 149, 574583.
Ball, C. J. (1992) The use of clozapine in older people. International Journal of Geriatric Psychiatry, 7, 689692.
Burns, A. (1992) Treatment by physical methods, medication. Current Opinion in Psychiatry, 5, 567570.
Burns, A. (1993) Treatment of non-cognitive features of dementia. In Treatment and Care in Old Age Psychiatry (eds Levy, R., Howard, R. & Burns, A.) pp. 3748. Petersfield: Wrightson Biomedical.
Evans, M. E. (1993) Depression in elderly physically ill inpatients, a 12 month prospective study. International Journal of Geriatric Psychiatry, 8, 587592.
Finch, E. J. L. & Katona, C. L. E. (1989) Lithium augmentation in the treatment of refractory depression in old age. International Journal of Geriatric Psychiatry, 4, 4146.
Flint, A. J. (1992) The optimum duration of antidepressant treatment in the elderly. International Journal of Geriatric Psychiatry, 7, 617619.
Howard, R. & Levy, R. (1992) Which factors affect treatment response in late paraphrenia. International Journal of Geriatric Psychiatry, 7, 667672.
Jacoby, R. (1991) Manic illness. In Psychiatry in the Elderly (eds Jacoby, R. & Oppenheimer, C.) pp. 720734. Oxford: Oxford University Press.
Katona, C. L. E. (1993) Optimising treatment for the elderly depressive, new antidepressants in the elderly. Journal of Psychopharmacology, 7 (suppl. 1), 131134.
Koenig, H. G., Goli, V., Shelp, F. et al (1989) Antidepressant use in elderly medical inpatients, lessons from an attempted clinical trial. Journal of General Internal Medicine, 4, 498505.
Levy, R. (1993) Is there life in the neuro-transmitter approach to the treatment of Alzheimer's disease? In Treatment and Care in Old Age Psychiatry (eds Levy, R., Howard, R. & Burns, A.) pp. 3946. Petersfield: Wrightson Biomedical.
McKeith, I., Perry, R., Fairbairn, A. et al (1992) Neuroleptic sensitivity with senile dementia of the Lewy body type. British Medical Journal, 305, 673678.
Meyer, J., Judd, B., Tawaklna, T. et al (1986) Improved cognition after control of risk factors for multi-infarct dementia. Journal of the American Medical Association, 265, 22032209.
Meyer, J., Rogers, R., McClintic, K. et al (1989) Randomised clinical trial of daily aspirin therapy and multi-infarct dementia. Journal of the American Geriatric Society, 37, 549555.
Morgan, D. G., May, P. C. & Fich, C. E. (1987) Dopamine and serotonin system in human and rodent brain, effects of age and neurodegenerative disease. Journal of the American Geriatric Society, 35, 334345.
NIH Consensus Development Panel on Depression in Late Life (1992) Diagnosis and treatment of depression in late life. Journal of the American Medical Association, 268, 10181024.
OADIG (1993) How long should the elderly take antidepressants? A double-blind placebo-controlled study of continuation/prophylaxis therapy with dothiepin. British Journal of Psychiatry, 162, 175182.
Post, F. (1966) Persistent Persecutory States of the Elderly. Oxford: Pergamon.
Postma, J. U. & Vranesic, D. (1985) Moclobemide in the treatment of depression in demented geriatric patients. Acta Therapeutica, 11, 14.
Reiffler, B. V., Teri, L., Raskind, M. et al (1989) Double-blind trial of imipramine in Alzheimer's disease patients with and without depression. American Journal of Psychiatry, 146, 4549.
Reynolds, C. F., Schneider, L. S., Lebowitz, B. D. et al (1993) Treatment of depression in the elderly, guidelines for primary care. In Diagnosis and Treatment of Depression in the Elderly, Proceedings of the NIH Consensus Development Panel Conference (eds Schneider, L. S., Reynolds, C. F., Lebowitz, B. & Friedhoff, A.) Washington, DC: APA.
SALT Collaborative Group (1991) Swedish Aspirin Low Dose Trial of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. Lancet, 338, 13451349.
Schneider, L., Pollock, D. & Lyness, S. (1990) A meta-analysis of controlled trials of neuroleptic treatment in dementia. Journal of the American Geriatric Society, 38, 553563
Schneider, L. & Sobin, P. (1994) Treatment for psychiatric symptoms and behavioural disturbances. In Dementia (eds Burns, A. & Levy, R.) London: Chapman and Hall.
Schwartz, M., Moquillansky, L., Lanyi, G. et al (1990) Sulpiride in tardive dyskinesia. Journal of Neurology, Neurosurgery and Psychiatry, 53, 800802.
Seth, R., Jennings, A. L., Bindman, J. et al (1992) Combination treatment with noradrenaline and serotonin reuptake inhibitors in resistant depression. British Journal of Psychiatry, 161, 562565.
Shulman, K., Tohen, M. & Satlin, A. (1992) The significance of mania in old age. Reviews in Clinical Gerontology, 2, 3943.
Song, F., Freemantle, N., Sheldon, T. A. et al (1993) Selective serotonin reuptake inhibitors, a meta-analysis of efficacy and acceptability. British Medical Journal, 306, 683687.
Van Marwijk, H. W. J., Beeker, F. M., Nolan, W. A. et al (1990) Lithium augmentation in geriatric depression. Journal of Affective Disorders, 20, 217223.
Whalley, J. L. (1989) Drug treatments of dementia. British Journal of Psychiatry, 155, 595611.
World Health Organization (1990) Heads of centres collaborating in WHO co-ordinated studies in biological aspects of mental illness. Prophylactic use of anticholinergics in patients on long-term neuroleptic treatment, a consensus statement. British Journal of Psychiatry, 156, 412.
World Health Organization (1992) The ICD-10 Classification of Mental and Behavioural Disorders. Clinical Descriptions and Diagnostic Guidelines. Geneva: WHO.
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BJPsych Advances
  • ISSN: 1355-5146
  • EISSN: 1472-1481
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Prescribing psychotropic drugs for the elderly

  • Alistair Burns (a1) and Robert Baldwin (a2)
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