Skip to main content

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
Cancel
×
×
Home
  • Home
Article

Chromosomal Evidence of Donor Cells Proliferation following Bone Marrow Transplantation

  • G. Schwanitz (a1) (a2), G. Hartwich (a1) (a2) and J. Becker (a1) (a2)
Summary

After an intense cytostatic treatment of the patient F.N., whose bone marrow was completely infiltrated with lympho-sarcocytes, a bone marrow transplantation was made. The donor was the patient's sister. The difference in sex chromosomes made it possible to observe the fate of the transferred cells. Immediately after the treatment, till 6½ months later, cells with feminine caryotype were traceable in the patient's peripheral blood (up to 2%). This proves the proliferation of donor cells in the acceptor.

Copyright
COPYRIGHT: © The International Society for Twin Studies 1969
Corresponding author
Institut für Humangenetik und Anthropologie der Universität Erlangen-Nürnberg, Bismarckstrasse 26/11, 8520 Erlangen, Deutschland
Medizinische Klinik der Universität Erlangen-Nürnberg, Krankenhausstrasse 12, 8520 Erlangen, Deutschland
References
Hide All
Beilby, J. O. W., Cade, I. S., Jelliffe, A. M., Parkin, D. M., Stewart, J. W. (1960). Prolonged survival of a bone-marrow graft resulting in a blood-group chimera. Brit. Med. J., 1: 96.
Dunnigan, M. G., Brown, A. (1963). Autologous bone marrow and large doses of malignant disease. Report of a controlled trial. Lancet, 2: 477.
Gebhart, E. (1967). Untersuchungen über die cytogenetische Wirkung einiger Vaginalantikonzipienten und ihrer Hauptwirkstoffe. Diss. München.
Gebhart, E. (1969). Chromosomenaberrationen durch Myleran in menschlichen Leukocyten in vitro. Humangenetik, 7: 126.
Hampel, K. E. (1968). Über die Wirkung von Zytostatica auf die Chromosomen des Menschen. Int. J. Clin. Pharmacol., 14: 322.
Heller, P., Yakulis, V. (1958). Bone marrow transplants. Lancet, 1: 1131.
Kurnick, N. B. (1962). Autologous and isologous bone marrow therapy in man. Bone marrow therapy and protection in irradiated primates. Rijswijk, 289.
Moorhead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M., Hungerford, D. A. (1960). Chromosome preparations of leukocytes cultured from human peripheral blood. Exp. Cell. Res., 20: 613.
Schwanitz, G., Wolf, F., Koch, G. (1968). Aberraciones cromosomicas y alteraciones mitosicas después de tratamiento combinado con radioyodo y radiaciones Röntgen. Folia Clin. Int. (Barc.), 18: 3.
Witte, S. (1963). Die Knochenmarkstransfusion. Lehmanns Verlag, München.
Witte, S. (1968). Knochenmarkstransplantation. In Betke, K. und Tosberg, P.: Das Knochenmark. Lehmanns Verlag, München.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Acta geneticae medicae et gemellologiae: twin research
  • ISSN: 0001-5660
  • EISSN: 2059-6324
  • URL: /core/journals/amg-acta-geneticae-medicae-et-gemellologiae-twin-research
Please enter your name
Please enter a valid email address
Who would you like to send this to? *

CAPTCHA *

Skip to the audio challenge
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 2 *
Loading metrics...

Abstract views

Total abstract views: 54 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 12th June 2018. This data will be updated every 24 hours.

Cancel
Confirm
×