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Actinobacillus pleuropneumoniae vaccines: from bacterins to new insights into vaccination strategies

Published online by Cambridge University Press:  17 March 2008

Mahendrasingh Ramjeet ,
Vincent Deslandes ,
Julien Gouré  and
Mario Jacques
Mahendrasingh Ramjeet
Affiliation:
Groupe de recherche sur les maladies infectieuses du porc, Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, Saint-Hyacinthe, QC, J2S 7C6, Canada
Vincent Deslandes
Affiliation:
Groupe de recherche sur les maladies infectieuses du porc, Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, Saint-Hyacinthe, QC, J2S 7C6, Canada
Julien Gouré
Affiliation:
Groupe de recherche sur les maladies infectieuses du porc, Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, Saint-Hyacinthe, QC, J2S 7C6, Canada
Mario Jacques*
Affiliation:
Groupe de recherche sur les maladies infectieuses du porc, Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, Saint-Hyacinthe, QC, J2S 7C6, Canada
*
*Corresponding author. E-mail: mario.jacques@umontreal.ca
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Abstract

With the growing emergence of antibiotic resistance and rising consumer demands concerning food safety, vaccination to prevent bacterial infections is of increasing relevance. Actinobacillus pleuropneumoniae is the etiological agent of porcine pleuropneumonia, a respiratory disease leading to severe economic losses in the swine industry. Despite all the research and trials that were performed with A. pleuropneumoniae vaccination in the past, a safe vaccine that offers complete protection against all serotypes has yet not reached the market. However, recent advances made in the identification of new potential vaccine candidates and in the targeting of specific immune responses, give encouraging vaccination perspectives. Here, we review past and current knowledge on A. pleuropneumoniae vaccines as well as the newly available genomic tools and vaccination strategies that could be useful in the design of an efficient vaccine against A. pleuropneumoniae infection.

Keywords

Actinobacillus pleuropneumoniaevaccinepigsbacterinssubunitlive attenuated
Type
Review Article
Information
Animal Health Research Reviews , Volume 9 , Issue 1 , June 2008 , pp. 25 - 45
Copyright
Copyright © Cambridge University Press 2008

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