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Antimicrobial resistance in companion animals

  • J. Scott Weese (a1)

Antimicrobial resistance (AMR) is an emerging problem in companion animals, because of difficult-to-treat infections, possible pressure to use antimicrobials that are important in human medicine, and potential zoonotic transmission. The extent and importance of AMR in companion animals are poorly understood, in part because of limited surveillance; however, it is clear that resistance is problematic in many pathogens and commensals, including staphylococci, enterococci, Escherichia coli and Salmonella.

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Amavisit, P, Markham, PF, Lightfoot, D, Whithear, KG and Browning, GF (2001). Molecular epidemiology of Salmonella Heidelberg in an equine hospital. Veterinary Microbiology 80: 8598.
Authier, S, Paquette, D, Labrecque, O and Messier, S (2006). Comparison of susceptibility to antimicrobials of bacterial isolates from companion animals in a veterinary diagnostic laboratory in Canada between 2 time points 10 years apart. Canadian Veterinary Journal 47: 774778.
Bagcigil, F, Moodley, A, Baptiste, K, Jensen, V and Guardabassi, L (2007). Occurrence, species distribution, antimicrobial resistance and clonality of methicillin- and erythromycin-resistant staphylococci in the nasal cavity of domestic animals. Veterinary Microbiology 121: 307315.
Baptiste, K, Williams, K, Willams, N, Wattret, A, Clegg, P, Dawson, S, Corkill, J, O'Neill, T and Hart, C (2005). Methicillin-resistant staphylococci in companion animals. Emerging Infectious Diseases 11: 19421944.
Boerlin, P, Eugster, S, Gaschen, F, Straub, R and Schawalder, P (2001). Transmission of opportunistic pathogens in a veterinary teaching hospital. Veterinary Microbiology 82: 347359.
Bonomo, R and Szabo, D (2006). Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. Clinical Infectious Diseases 43 (Suppl. 2): S49S56.
Carattoli, A, Lovari, S, Franco, A, Cordaro, G, Di Matteo, P and Battisti, A (2005). Extended-spectrum beta-lactamases in Escherichia coli isolated from dogs and cats in Rome, Italy, from 2001 to 2003. Antimicrobial Agents and Chemotherapy 49: 833835.
Cherry, B, Burns, A, Johnson, GS, Pfeiffer, H, Dumas, N, Barrett, D, Mcdonough, PL and Eidson, M (2004). Salmonella Typhimurium outbreak associated with veterinary clinic. Emerging Infectious Diseases 10: 22492251.
Clark, C, Greenwood, S, Boison, JO, Chirino-Trejo, M and Dowling, PM (2008). Bacterial isolates from equine infections in western Canada (1998–2003). Canadian Veterinary Journal 49: 153160.
Costa, D, Poeta, P, Sáenz, Y, Coelho, AC, Matos, M, Vinué, L, Rodrigues, J and Torres, C (2008). Prevalence of antimicrobial resistance and resistance genes in faecal Escherichia coli isolates recovered from healthy pets. Veterinary Microbiology 127: 97105.
Damborg, P, Sørensen, AH and Guardabassi, L (2008). Monitoring of antimicrobial resistance in healthy dogs: first report of canine ampicillin-resistant Enterococcus faecium clonal complex 17. Veterinary Microbiology 132: 190196.
De Graef, EM, Decostere, A, Devriese, LA and Haesebrouck, F (2004). Antibiotic resistance among fecal indicator bacteria from healthy individually owned and kennel dogs. Microbial Drug Resistance 10: 6569.
De Niederhäusern, S, Sabia, C, Messi, P, Guerrieri, E, Manicardi, G and Bondi, M (2007). VanA-type vancomycin-resistant enterococci in equine and swine rectal swabs and in human clinical samples. Current Microbiology 55: 240246.
Deplano, A, Denis, O, Poirel, L, Hocquet, D, Nonhoff, C, Byl, B, Nordmann, P, Vincent, J and Struelens, M (2005). Molecular characterization of an epidemic clone of panantibiotic-resistant Pseudomonas aeruginosa. Journal of Clinical Microbiology 43: 11981204.
Devriese, L, Ieven, M, Goossens, H, Vandamme, P, Pot, B, Hommez, J and Haesebrouck, F (1996). Presence of vancomycin-resistant enterococci in farm and pet animals. Antimicrobial Agents and Chemotherapy 40: 22852287.
Dolejska, M, Duskova, E, Machova, G, Kohoutova, L and Cizek, A (2008) Detection of EBSL-producing Escherichia coli in horses, personnel and the environment within a veterinary teaching hospital. ASM Conference on Antimicrobial Resistance in Zoonotic and Foodborne Pathogens. Copenhagen, Denmark.
Ensink, JM, Bosch, G and Van Duijkeren, E (2005). Clinical efficacy of prophylactic administration of trimethoprim/sulfadiazine in a Streptococcus equi subsp. zooepidemicus infection model in ponies. Journal of Veterinary Pharmacology and Therapeutics 28: 4549.
Faires, M and Weese, JS (2008) Prevalence of inducible clindamycin resistant Staphylococcus aureus isolates from dogs and cats. ASM Conference on Antimicrobial Resistance in Zoonotic and Foodborne Pathogens. Copenhagen, Denmark.
Feary, DJ, Hyatt, D, Traub-Dargatz, J, Roach, S, Jones, RL, Wu, CC and Morley, PS (2005). Investigation of falsely reported resistance of Streptococcus equi subsp. zooepidemicus isolates from horses to trimethoprim-sulfamethoxazole. J Vet Diagn Invest 17: 483486.
Fournier, P, Vallenet, D, Barbe, V, Audic, S, Ogata, H, Poirel, L, Richet, H, Robert, C, Mangenot, S, Abergel, C, Nordmann, P, Weissenbach, J, Raoult, D and Claverie, J (2006). Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet 2: e7.
Francey, T, Gaschen, F, Nicolet, J and Burnens, AP (2000). The role of Acinetobacter baumannii as a nosocomial pathogen for dogs and cats in an intensive care unit. Journal of Veterinary Internal Medicine 14: 177183.
Frontoso, R, De Carlo, E, Pasolini, MP, Van Der Meulen, K, Pagnini, U, Iovane, G and De Martino, L (2008). Retrospective study of bacterial isolates and their antimicrobial susceptibilities in equine uteri during fertility problems. Research in Veterinary Science 84: 16.
Frye, JG and Fedorka-Cray, PJ (2007). Prevalence, distribution and characterisation of ceftiofur resistance in Salmonella enterica isolated from animals in the USA from 1999 to 2003. International Journal of Antimicrobial Agents 30: 134142.
Gray, JT, Hungerford, LL, Fedorka-Cray, PJ and Headrick, ML (2004). Extended-spectrum-cephalosporin resistance in Salmonella enterica isolates of animal origin. Antimicrobial Agents and Chemotherapy 48: 31793181.
Hariharan, H, Mcphee, L, Heaney, S and Bryenton, J (1995). Antimicrobial drug susceptibility of clinical isolates of Pseudomonas aeruginosa. Canadian Veterinary Journal 36: 166168.
Hoekstra, K and Paulton, R (2002). Clinical prevalence and antimicrobial susceptibility of Staphylococcus aureus and Staph. intermedius in dogs. Journal of Applied Microbiology 93: 406413.
Ikeda, JS and Hirsh, DC (1985). Common plasmid encoding resistance to ampicillin, chloramphenicol, gentamicin, and trimethoprim-sulfadiazine in two serotypes of Salmonella isolated during an outbreak of equine salmonellosis. American Journal of Veterinary Research 46: 769773.
Ingrey, K, Ren, J and Prescott, J (2003). A fluoroquinolone induces a novel mitogen-encoding bacteriophage in Streptococcus canis. Infection and Immunity 71: 30283033.
Kadlec, K and Schwarz, S (2008). Analysis and distribution of class 1 and class 2 integrons and associated gene cassettes among Escherichia coli isolates from swine, horses, cats and dogs collected in the BfT-GermVet monitoring study. Journal of Antimicrobial Chemotherapy 62: 469473.
Keller, R and Hendrix, D (2005). Bacterial isolates and antimicrobial susceptibilities in equine bacterial ulcerative keratitis (1993–2004). Equine Veterinary Journal 37: 207211.
Kottler, S, Middleton, JR, Weese, JS and Cohn, L (2008) Prevalence of Staphylococcus aureus and MRSA carriage in three populations. 26th Annual Conference of the American College of Veterinary Internal Medicine, San Antonio, TX, USA.
Krcmery, V and Kalavsky, E (2007). Multidrug-resistant Acinetobacter baumannii. Emerging Infectious Diseases 13: 943944.
Li, XZ, Mehrotra, M, Ghimire, S and Adewoye, L (2007). beta-Lactam resistance and beta-lactamases in bacteria of animal origin. Veterinary Microbiology 121: 197214.
Lüthje, P and Schwarz, S (2007). Molecular basis of resistance to macrolides and lincosamides among staphylococci and streptococci from various animal sources collected in the resistance monitoring program BfT-GermVet. International Journal of Antimicrobial Agents 29: 528535.
Lyskova, P, Vydrzalova, M and Mazurova, J (2007). Identification and antimicrobial susceptibility of bacteria and yeasts isolated from healthy dogs and dogs with otitis externa. Journal of Veterinary Medicine A, Physiology, Pathology, Clinical Medicine 54: 559563.
Moore, CP, Collins, BK and Fales, WH (1995). Antibacterial susceptibility patterns for microbial isolates associated with infectious keratitis in horses: 63 cases (1986–1994). Journal of the American Veterinary Medical Association 207: 928933.
Morris, D, Mauldin, E, O'Shea, K, Shofer, F and Rankin, S (2006). Clinical, microbiological, and molecular characterization of methicillin-resistant Staphylococcus aureus infections of cats. American Journal of Veterinary Research 67: 14211425.
Naas, T, Kernbaum, S, Allali, S and Nordmann, P (2007). Multidrug-resistant Acinetobacter baumannii, Russia. Emerging Infectious Diseases 13: 669671.
O'Mahony, R, Abbott, Y, Leonard, F, Markey, B, Quinn, P, Pollock, P, Fanning, S and Rossney, A (2005). Methicillin-resistant Staphylococcus aureus (MRSA) isolated from animals and veterinary personnel in Ireland. Veterinary Microbiology 109: 285296.
Ossiprandi, M, Bottarelli, E, Cattabiani, F and Bianchi, E (2008). Susceptibility to vancomycin and other antibiotics of 165 Enterococcus strains isolated from dogs in Italy. Comparative Immunology Microbiology and Infectious Diseases 31: 19.
Pedersen, K, Pedersen, K, Jensen, H, Finster, K, Jensen, VF and Heuer, OE (2007). Occurrence of antimicrobial resistance in bacteria from diagnostic samples from dogs. Journal of Antimicrobial Chemotherapy 60: 775781.
Perez, F, Hujer, A, Hujer, K, Decker, B, Rather, P and Bonomo, R (2007). Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy 51: 34713484.
Poeta, P, Costa, D, Rodrigues, J and Torres, C (2006). Antimicrobial resistance and the mechanisms implicated in faecal enterococci from healthy humans, poultry and pets in Portugal. International Journal of Antimicrobial Agents 27: 131137.
Rankin, SC, Aceto, H, Cassidy, J, Holt, J, Young, S, Love, B, Tewari, D, Munro, DS and Benson, CE (2002). Molecular characterization of cephalosporin-resistant Salmonella enterica serotype Newport isolates from animals in Pennsylvania. Journal of Clinical Microbiology 40: 46794684.
Rantala, M, Lahti, E, Kuhalampi, J, Pesonen, S, Järvinen, A-K, Saijonmaa-Koulumies, L and Honkanen-Buzalski, T (2004). Antimicrobial resistance in Staphylococcus spp., Escherichia coli and Enterococcus spp. in dogs given antibiotics for chronic dermatological disorders, compared with non-treated control dogs. Acta Veterinaria Scandinavica 45: 3745.
Reid, G, Grim, S, Aldeza, C, Janda, W and Clark, N (2007). Rapid development of Acinetobacter baumannii resistance to tigecycline. Pharmacotherapy 27: 11981201.
Rice, EW, Boczek, LA, Johnson, CH and Messer, JW (2003). Detection of intrinsic vancomycin resistant enterococci in animal and human feces. Diagnostic Microbiology and Infectious Disease 46: 155158.
Rich, M, Deighton, L and Roberts, L (2005). Clindamycin-resistance in methicillin-resistant Staphylococcus aureus isolated from animals. Veterinary Microbiology 111: 237240.
Rich, M and Roberts, L (2006). MRSA in companion animals. Veterinary Record 159: 535536.
Rubin, J, Walker, R, Blickenstaff, K, Bodeis-Jones, S and Zhao, S (2008). Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections. Veterinary Microbiology, ePub ahead of print.
Sanchez, S, McCrackin Stevenson, MA, Hudson, CR, Maier, M, Buffington, T, Dam, Q and Maurer, JJ (2002). Characterization of multidrug-resistant Escherichia coli isolates associated with nosocomial infections in dogs. Journal of Clinical Microbiology 40: 35863595.
Sasaki, T, Kikuchi, K, Tanaka, Y, Takahashi, N, Kamata, S and Hiramatsu, K (2007). Methicillin-resistant Staphylococcus pseudintermedius in a veterinary teaching hospital. Journal of Clinical Microbiology 45: 11181125.
Schwarz, S, Kadlec, K and Strommenger, B (2007). Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius detected in the BfT-GermVet monitoring programme 2004–2006 in Germany. Journal of Antimicrobial Chemotherapy 61: 282285.
Schwarz, S, Roberts, MC, Werckenthin, C, Pang, Y and Lange, C (1998). Tetracycline resistance in Staphylococcus spp. from domestic animals. Veterinary Microbiology 63: 217227.
Starcic, M, Johnson, J, Stell, A, Van Der Goot, J, Hendriks, H, Van Vorstenbosch, C, Van Dijk, L and Gaastra, W (2002). Haemolytic Escherichia coli isolated from dogs with diarrhea have characteristics of both uropathogenic and necrotoxigenic strains. Veterinary Microbiology 85: 361377.
Teshager, T, Domínguez, L, Moreno, MA, Saénz, Y, Torres, C and Cardeñosa, S (2000). Isolation of an SHV-12 beta-lactamase-producing Escherichia coli strain from a dog with recurrent urinary tract infections. Antimicrobial Agents and Chemotherapy 44: 34833484.
Tillotson, K, Savage, CJ, Salman, MD, Gentry-Weeks, CR, Rice, D, Fedorka-Cray, PJ, Hendrickson, DA, Jones, RL, Nelson, W and Traub-Dargatz, JL (1997). Outbreak of Salmonella infantis infection in a large animal veterinary teaching hospital. Journal of the American Veterinary Medical Association 211: 15541557.
Van Belkun, A, Van Den Braak, N, Thomassen, R, Verbrugh, H and Endtz, H (1996). Vancomycin-resistant enterococci in cats and dogs. Lancet 348: 10381039.
Vo, A, Van Duijkeren, E, Fluit, A and Gaastra, W (2007a). Characteristics of extended-spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates from horses. Veterinary Microbiology 124: 248255.
Vo, AT, Van Duijkeren, E, Fluit, AC and Gaastra, W (2007b). A novel Salmonella genomic island 1 and rare integron types in Salmonella Typhimurium isolates from horses in The Netherlands. Journal of Antimicrobial Chemotherapy 59: 594599.
Wagenvoort, JH, Burgers, DM, Wagenvoort, TH and Burgers, E (2003). Absence of vancomycin-resistant enterococci (VRE) in companion dogs in the conurbation of Parkstad Limburg, The Netherlands. Journal of Antimicrobial Chemotherapy 52: 532.
Ward, MP, Brady, TH, Couëtil, LL, Liljebjelke, K, Maurer, JJ and Wu, CC (2005). Investigation and control of an outbreak of salmonellosis caused by multidrug-resistant Salmonella typhimurium in a population of hospitalized horses. Veterinary Microbiology 107: 233240.
Weese, JS, Baird, J, Poppe, C and Archambault, M (2001). Emergence of Salmonella typhimurium definitive type 104 (DT104) as an important cause of salmonellosis in horses in Ontario. Canadian Veterinary Journal 42: 788792.
Weese, JS, Archambault, M, Willey, B, Hearn, P, Kreiswirth, B, Said-Salim, B, Mcgeer, A, Likhoshvay, Y, Prescott, J and Low, D (2005a). Methicillin-resistant Staphylococcus aureus in horses and horse personnel, 2000–2002. Emerging Infectious Diseases 11: 430435.
Weese, JS, Rousseau, J, Traub-Dargatz, J, Willey, B, Mcgeer, A and Low, D (2005b). Community-associated methicillin-resistant Staphylococcus aureus in horses and humans who work with horses. Journal of the American Veterinary Medical Association 226: 580583.
Weese, JS, Baptiste, KE, Baverud, V and Toutain, P-E (2008) Guidelines for antimicrobial use in horses. In: Guardabassi, L, Jensen, LB and Kruse, H (eds) Guide to Antimicrobial Use in Animals. 1st edn.Ames, IA: Blackwell Publishing Ltd.
Wildermuth, BE, Griffin, CE, Rosenkrantz, WS and Boord, MJ (2007). Susceptibility of Pseudomonas isolates from the ears and skin of dogs to enrofloxacin, marbofloxacin, and ciprofloxacin. Journal of the American Animal Hospital Association 43: 337341.
Wright, JG, Tengelsen, LA, Smith, KE, Bender, JB, Frank, RK, Grendon, JH, Rice, DH, Thiessen, AM, Gilbertson, CJ, Sivapalasingam, S, Barrett, TJ, Besser, TE, Hancock, DD and Angulo, FJ (2005). Multidrug-resistant Salmonella Typhimurium in four animal facilities. Emerging Infectious Diseases 11: 12351241.
Zhao, S, Mcdermott, PF, White, DG, Qaiyumi, S, Friedman, SL, Abbott, JW, Glenn, A, Ayers, SL, Post, KW, Fales, WH, Wilson, RB, Reggiardo, C and Walker, RD (2007). Characterization of multidrug resistant Salmonella recovered from diseased animals. Veterinary Microbiology 123: 122132.
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Animal Health Research Reviews
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