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Avian influenza: our current understanding

  • David L. Suarez (a1)
  • DOI:
  • Published online: 01 July 2010

Avian influenza (AI) virus is one of the most important diseases of the poultry industry around the world. The virus has a broad host range in birds and mammals, although the natural reservoir is wild birds where it typically causes an asymptomatic to mild infection. The virus in poultry can cause a range of clinical diseases and is defined either as low pathogenic AI (LPAI) or highly pathogenic AI (HPAI) depending on the type of disease it causes in chickens. Viruses that replicate primarily on mucosal surfaces and cause mild disease with low mortality are termed LPAI. Viruses that replicate on mucosal surfaces and systemically and cause severe disease with a mortality rate of 75% or greater in experimentally infected chickens are referred to as HPAI. A virus that is highly pathogenic in chickens may infect but result in a completely different disease and replication pattern in other host species. Outbreaks of HPAI have been relatively uncommon around the world in the last 50 years and have had limited spread within a country or region with one major exception, Asian lineage H5N1 that was first identified in 1996. This lineage of virus has spread to over 60 countries and has become endemic in poultry in at least four countries. AI virus also represents a public health threat, with some infected humans having severe disease and with a high case fatality rate. AI remains a difficult disease to control because of the highly infectious nature of the virus and the interface of domestic and wild animals. A better understanding of the disease and its transmission is important for control.

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DJ Alexander (2007). Summary of avian influenza activity in Europe, Asia, Africa, and Australasia, 2002–2006. Avian Diseases 51 (suppl. 1): 161166.

WB Becker (1966). The isolation and classification of Tern virus: influenza A-Tern South Africa 1961. Journal of Hygiene (London) 64: 309320.

JD Brown , G Goekjian , R Poulson , S Valeika and DE Stallknecht (2009a). Avian influenza virus in water: infectivity is dependent on pH, salinity and temperature. Veterinary Microbiology 136: 2026.

JD Brown , DE Stallknecht , JR Beck , DL Suarez and DE Swayne (2006). Susceptibility of North American ducks and gulls to H5N1 highly pathogenic avian influenza viruses. Emerging Infectious Diseases 12: 16631670.

JD Brown , DE Stallknecht , RD Berghaus and DE Swayne (2009b). Infectious and lethal doses of H5N1 highly pathogenic avian influenza virus for house sparrows (Passer domesticus) and rock pigeons (Columbia livia). Journal of Veterinary Diagnostic Investigation 21: 437445.

JD Brown , DE Stallknecht and DE Swayne (2008). Experimental infection of swans and geese with highly pathogenic avian influenza virus (H5N1) of Asian lineage. Emerging Infectious Diseases 14: 136142.

JD Brown , DE Stallknecht , S Valeika and DE Swayne (2007). Susceptibility of wood ducks to H5N1 highly pathogenic avian influenza virus. Journal of Wildlife Diseases 43: 660667.

LL Bulaga , L Garber , DA Senne , TJ Myers , R Good , S Wainwright , S Trock and DL Suarez (2003). Epidemiologic and surveillance studies on avian influenza in live-bird markets in New York and New Jersey, 2001. Avian Diseases 47 (suppl. 3): 9961001.

I Capua and F Mutinelli (2001). Mortality in Muscovy ducks (Cairina moschata) and domestic geese (Anser anser var. domestica) associated with natural infection with a highly pathogenic avian influenza virus of H7N1 subtype. Avian Pathology 30: 179183.

AN Cauthen , DE Swayne , S Schultz-Cherry , ML Perdue and DL Suarez (2000). Continued circulation in China of highly pathogenic avian influenza viruses encoding the hemagglutinin gene associated with the 1997 H5N1 outbreak in poultry and humans. Journal of Virology 74: 65926599.

H Chen , G Deng , Z Li , G Tian , Y Li , P Jiao , L Zhang , Z Liu , RG Webster and K Yu (2004). The evolution of H5N1 influenza viruses in ducks in southern China. Proceedings of the National Academy of Sciences, USA 101: 1045210457.

H Chen , Y Li , Z Li , J Shi , K Shinya , G Deng , Q Qi , G Tian , S Fan , H Zhao , Y Sun and Y Kawaoka (2006a). Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. Journal of Virology 80: 59765983.

H Chen , Y Matsuoka , D Swayne , Q Chen , NJ Cox , BR Murphy and K Subbarao (2003). Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza virus vaccine candidate. Vaccine 21: 44304436.

H Chen , GJ Smith , KS Li , J Wang , XH Fan , JM Rayner , D Vijaykrishna , JX Zhang , LJ Zhang , CT Guo , CL Cheung , KM Xu , L Duan , K Huang , K Qin , YH Leung , WL Wu , HR Lu , Y Chen , NS Xia , TS Naipospos , KY Yuen , SS Hassan , S Bahri , TD Nguyen , RG Webster , JS Peiris and Y Guan (2006b). Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proceedings of the National Academy of Sciences, USA 103: 28452850.

H Chen , GJ Smith , SY Zhang , K Qin , J Wang , KS Li , RG Webster , JS Peiris and Y Guan (2005). Avian flu: H5N1 virus outbreak in migratory waterfowl. Nature 436: 191192.

YK Choi , SH Seo , JA Kim , RJ Webby and RG Webster (2005). Avian influenza viruses in Korean live poultry markets and their pathogenic potential. Virology 332: 529537.

PM Colman (1989). Neuraminidase enzyme and antigen. In: RM Krug (ed.) The Influenza Viruses. New York: Plenum Press, pp. 175218.

TP Costa , JD Brown , EW Howerth and DE Stallknecht (2010). The effect of age on avian influenza viral shedding in Mallards (Anas platyrhynchos). Avian Diseases 54: 581585.

R Deibel , DE Emord , W Dukelow , VS Hinshaw and JM Wood (1985). Influenza viruses and paramyxoviruses in ducks in the Atlantic flyway, 1977–1983, including an H5N2 isolate related to the virulent chicken virus. Avian Diseases 29: 970985.

TH Fang , YY Lien , MC Cheng and HJ Tsai (2006). Resistance of immune-suppressed pigeons to subtypes H5N2 and H6N1 low pathogenic avian influenza virus. Avian Diseases 50: 269272.

CJ Feare (2010). Role of wild birds in the spread of highly pathogenic avian influenza virus H5N1 and implications for global surveillance. Avian Diseases 54: 201212.

M Gilbert , X Xiao , J Domenech , J Lubroth , V Martin and J Slingenbergh (2006). Anatidae migration in the western Palearctic and spread of highly pathogenic avian influenza H5NI virus. Emerging Infectious Diseases 12: 16501656.

Y Guan , JS Peiris , AS Lipatov , TM Ellis , KC Dyrting , S Krauss , LJ Zhang , RG Webster and KF Shortridge (2002a). Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong, SAR. Proceedings of the National Academy of Science, USA 99: 89508955.

Y Guan , M Peiris , KF Kong , KC Dyrting , TM Ellis , T Sit , LJ Zhang and KF Shortridge (2002b). H5N1 influenza viruses isolated from geese in Southeastern China: evidence for genetic reassortment and interspecies transmission to ducks. Virology 292: 1623.

Y Guan , LL Poon , CY Cheung , TM Ellis , W Lim , AS Lipatov , KH Chan , KM Sturm-Ramirez , CL Cheung , YH Leung , KY Yuen , RG Webster and JS Peiris (2004). H5N1 influenza: a protean pandemic threat. Proceedings of the National Academy of Sciences, USA 101: 81568161.

Y Guan , KF Shortridge , S Krauss and RG Webster (1999). Molecular characterization of H9N2 influenza viruses: were they the donors of the ‘internal’ genes of H5N1 viruses in Hong Kong? Proceedings of the National Academy of Sciences, USA 96: 93639637.

DA Halvorson (2008). Control of low pathogenicity avian influenza. In: DE Swayne (ed) Avian Influenza. Ames, IA: Blackwell Publishing, pp. 513536.

BA Hanson , MP Luttrell , VH Goekjian , L Niles , DE Swayne , DA Senne and DE Stallknecht (2008). Is the occurrence of avian influenza virus in Charadriiformes species and location dependent? Journal of Wildlife Diseases 44: 351361.

TC Harder , J Teuffert , E Starick , J Gethmann , C Grund , S Fereidouni , M Durban , KH Bogner , A Neubauer-Juric , R Repper , A Hlinak , A Engelhardt , A Nöckler , K Smietanka , Z Minta , M Kramer , A Globig , TC Mettenleiter , FJ Conraths and M Beer (2009). Highly pathogenic avian influenza virus (H5N1) in frozen duck carcasses, Germany, 2007. Emerging Infectious Diseases 15: 272279.

M Hatta , Y Hatta , JH Kim , S Watanabe , K Shinya , T Nguyen , PS Lien , QM Le and Y Kawaoka (2007). Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS Pathogens 3: 13741379.

NJ Hill , JY Takekawa , CJ Cardona , JT Ackerman , AK Schultz , KA Spragens and WM Boyce (2010). Waterfowl ecology and avian influenza in California: do host traits inform us about viral occurrence? Avian Diseases 54: 426432.

VS Hinshaw , RG Webster and B Turner (1979). Water-bone transmission of influenza A viruses? Intervirology 11: 6668.

E Hoffmann , J Stech , I Leneva , S Krauss , C Scholtissek , PS Chin , M Peiris , KF Shortridge and RG Webster (2000). Characterization of the influenza A virus gene pool in avian species in southern China: was H6N1 a derivative or a precursor of H5N1? Journal of Virology 74: 63096315.

Y Kawaoka , TM Chambers , WL Sladen and RG Webster (1988). Is the gene pool of influenza viruses in shorebirds and gulls different from that in wild ducks? Virology 163: 247250.

EH Lau , YH Leung , LJ Zhang , BJ Cowling , SP Mak , Y Guan , GM Leung and JS Peiris (2007). Effect of interventions on influenza A (H9N2) isolation in Hong Kong's live poultry markets, 1999–2005. Emerging Infectious Diseases 13: 13401347.

CW Lee and DL Suarez (2005). Avian influenza virus: prospects for prevention and control by vaccination. Animal Health Research Reviews 6: 115.

CW Lee , DE Swayne , JA Linares , DA Senne and DL Suarez (2005). H5N2 avian influenza outbreak in Texas in 2004: the first highly pathogenic strain in the United States in 20 years? Journal of Virology 79: 1141211421.

KS Li , Y Guan , GJ Smith , KM Xu , L Duan , AP Rahardjo , P Puthavathana , C Buranathai , TD Nguyen , AT Estoepangestie , A Chaisingh , P Auewarakul , HT Long , NT Hanh , RJ Webby , LL Poon , H Chen , KF Shortridge , KY Yuen , RG Webster and JS Peiris (2004). Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 430: 209213.

J Liu , H Xiao , F Lei , Q Zhu , K Qin , XW Zhang , XL Zhang , D Zhao , G Wang , Y Feng , J Ma , W Liu , J Wang and GF Gao (2005). Highly pathogenic H5N1 influenza virus infection in migratory birds. Science 309: 1206.

M Liu , S He , D Walker , N Zhou , DR Perez , B Mo , F Li , X Huang , RG Webster and RJ Webby (2003). The influenza virus gene pool in a poultry market in South central china. Virology 305: 267275.

Y Liu , J Zhou , H Yang , W Yao , W Bu , B Yang , W Song , Y Meng , J Lin , C Han , J Zhu , Z Ma , J Zhao and X Wang (2007). Susceptibility and transmissibility of pigeons to Asian lineage highly pathogenic avian influenza virus subtype H5N1. Avian Pathology 36: 461465.

JX Long , DX Peng , YL Liu , YT Wu and XF Liu (2008). Virulence of H5N1 avian influenza virus enhanced by a 15-nucleotide deletion in the viral nonstructural gene. Virus Genes 36: 471478.

DK Lvov , MY Shchelkanov , AG Prilipov , NA Vlasov , IT Fedyakina , PG Deryabin , SV Alkhovsky , TV Grebennikova , AD Zaberezhny and DL Suarez (2010). Evolution of HPAI H5N1 Virus in Natural Ecosystems of Northern Eurasia (2005–2008). Avian Diseases 54: 483495.

P Massin , S van der Werf and N Naffakh (2001). Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses. Journal of Virology 75: 53985404.

A McLeod (2008). The economics of avian influenza. In: DE Swayne (ed) Avian Influenza. Ames, IA, Blackwell Publishing, pp. 537560.

LJ Mitnaul , MN Matrosovich , MR Castrucci , AB Tuzikov , NV Bovin , D Kobasa and Y Kawaoka (2000). Balanced hemagglutinin and neuraminidase activities are critical for efficient replication of influenza A virus. Journal of Virology 74: 60156020.

S Munier , T Larcher , F Cormier-Aline , D Soubieux , B Su , L Guigand , B Labrosse , Y Cherel , P Quéré , D Marc and N Naffakh (2010). A genetically engineered waterfowl influenza virus with a deletion in the stalk of the neuraminidase has increased virulence for chickens. Journal of Virology 84: 940952.

K Nakamura , T Imada , K Imai , Y Yamamoto , N Tanimura , M Yamada , M Mase , K Tsukamoto and S Yamaguchi (2008). Pathology of specific-pathogen-free chickens inoculated with H5N1 avian influenza viruses isolated in Japan in 2004. Avian Diseases 52: 813.

DC Nguyen , TM Uyeki , S Jadhao , T Maines , M Shaw , Y Matsuoka , C Smith , T Rowe , X Lu , H Hall , X Xu , A Balish , A Klimov , TM Tumpey , DE Swayne , LP Huynh , HK Nghiem , HH Nguyen , LT Hoang , NJ Cox and JM Katz (2005). Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi, Vietnam, in 2001. Journal of Virology 79: 42014212.

T Nguyen , CT Davis , W Stembridge , B Shu , A Balish , K Inui , HT Do , HT Ngo , XF Wan , M McCarron , SE Lindstrom , NJ Cox , CV Nguyen , AI Klimov and RO Donis (2009). Characterization of a highly pathogenic avian influenza H5N1 virus sublineage in poultry seized at ports of entry into Vietnam. Virology 387: 250256.

M Okamatsu , T Saito , Y Yamamoto , M Mase , S Tsuduku , K Nakamura , K Tsukamoto and S Yamaguchi (2007). Low pathogenicity H5N2 avian influenza outbreak in Japan during the 2005–2006. Veterinary Microbiology 124: 3546.

M Pantin-Jackwood , JL Wasilenko , E Spackman , DL Suarez and DE Swayne (2010). Susceptibility of turkeys to pandemic-H1N1 virus by reproductive tract insemination. Virology Journal 7: 27.

MJ Pantin-Jackwood and DE Swayne (2007). Pathobiology of Asian highly pathogenic avian influenza H5N1 virus infections in ducks. Avian Diseases 51 (suppl. 1): 250259.

J Pasick , Y Berhane , T Hisanaga , H Kehler , K Hooper-McGrevy , K Handel , J Neufeld , C Argue and F Leighton (2010). Diagnostic test results and pathology associated with the 2007 Canadian H7N3 highly pathogenic avian influenza outbreak. Avian Diseases 54: 213219.

AM Pelzel , BJ McCluskey and AE Scott (2006). Review of the highly pathogenic avian influenza outbreak in Texas, 2004. Journal of the American Veterinary Medical Association 228: 18691875.

ML Perdue (2008). Molecular determinants of pathogencity for avian influenza viruses. In: DE Swayne (ed.) Avian Influenza. Ames, IA: Blackwell Publishing, pp. 2341.

DR Perez , W Lim , JP Seiler , G Yi , M Peiris , KF Shortridge and RG Webster (2003a). Role of quail in the interspecies transmission of H9 influenza A viruses: molecular changes on HA that correspond to adaptation from ducks to chickens. Journal of Virology 77: 31483156.

DR Perez , RJ Webby , E Hoffmann and RG Webster (2003b). Land-based birds as potential disseminators of avian mammalian reassortant influenza A viruses. Avian Diseases 47 (suppl. 3): 11141117.

LE Perkins and DE Swayne (2001). Pathobiology of A/chicken/Hong Kong/220/97 (H5N1) avian influenza virus in seven gallinaceous species. Veterinary Pathology 38: 149164.

LE Perkins and DE Swayne (2002). Pathogenicity of a Hong Kong-origin H5N1 highly pathogenic avian influenza virus for emus, geese, ducks, and pigeons. Avian Diseases 46: 5363.

J Pfeiffer , M Pantin-Jackwood , TL To , T Nguyen and DL Suarez (2009). Phylogenetic and biological characterization of highly pathogenic H5N1 avian influenza viruses (Vietnam 2005) in chickens and ducks. Virus Research 142: 108120.

SPS Pillai , M Pantin-Jackwood , HM Yassine , YM Saif , and CW Lee (2010). The high susceptibility of Turkeys to influenza viruses of different origins implies their importance as potential intermediate hosts. Avian Diseases 54: 522526.

M Pittman and A Laddomada (2008). Legislation for the control of avian influenza in the European Union. Zoonoses and Public Health 55: 2936.

G Ramirez-Nieto , HL Shivaprasad , C-H Kim , HS Lillehoj , H Song , IG Osorio , and DR Perez (2010). Adaptation of a mallard H5N2 low pathogenic influenza virus in chickens with prior history of infection with infectious bursal disease virus. Avian Diseases 54: 513521.

DA Senne (2007). Avian influenza in North and South America, 2002–2005. Avian Diseases 51 (suppl. 1): 167173.

K Sharshov , N Silko , I Sousloparov , A Zaykovskaya , A Shestopalov and I Drozdov (2010). Avian influenza (H5N1) outbreak among wild birds, Russia, 2009. Emerging Infectious Diseases 16: 349351.

KF Shortridge , NN Zhou , Y Guan , P Gao , T Ito , Y Kawaoka , S Kodihalli , S Krauss , D Markwell , KG Murti , M Norwood , D Senne , L Sims , A Takada and RG Webster (1998). Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. Virology 252: 331342.

LD Sims , TM Ellis , KK Liu , K Dyrting , H Wong , M Peiris , Y Guan and KF Shortridge (2003). Avian influenza in Hong Kong 1997–2002. Avian Diseases 47 (suppl. 3): 832838.

V Sivanandan , DA Halvorson , E Laudert , DA Senne and MC Kumar (1991). Isolation of H13N2 influenza A virus from turkeys and surface water. Avian Diseases 35: 974977.

RD Slemons , DC Johnson , JS Osborn and F Hayes (1974). Type-A influenza viruses isolated from wild free-flying ducks in California. Avian Diseases 18: 119124.

RD Slemons , MC Shieldcastle , LD Heyman , KE Bednarik and DA Senne (1991). Type A influenza viruses in waterfowl in Ohio and implications for domestic turkeys. Avian Diseases 35: 165173.

EM Sorrell and DR Perez (2007). Adaptation of influenza A/Mallard/Potsdam/178-4/83 H2N2 virus in Japanese quail leads to infection and transmission in chickens. Avian Diseases 51 (suppl. 1): 264268.

E Spackman , KG McCracken , K Winker and DE Swayne (2006). H7N3 avian influenza virus found in a South American wild duck is related to the Chilean 2002 poultry outbreak, contains genes from equine and North American wild bird lineages, and is adapted to domestic turkeys. Journal of Virology 80: 77607764.

E Spackman , KG McCracken , K Winker and DE Swayne (2007a). An avian influenza virus from waterfowl in South America contains genes from North American avian and equine lineages. Avian Diseases 51 (suppl. 1): 273274.

E Spackman , DA Senne , S Davison and DL Suarez (2003). Sequence analysis of recent H7 avian influenza viruses associated with three different outbreaks in commercial poultry in the United States. Journal of Virology 77: 1339913402.

E Spackman , DE Swayne , DL Suarez , DA Senne , JC Pedersen , ML Killian , J Pasick , K Handel , SP Pillai , CW Lee , D Stallknecht , R Slemons , HS Ip and T Deliberto (2007b). Characterization of low pathogenicity H5N1 avian influenza viruses from North America. Journal of Virology 81: 1161211619.

DE Stallknecht and JD Brown (2008). Ecology of avian influenza in wild birds. In: DE Swayne (ed.) Avian Influenza. Ames, IA: Blackwell Publishing, pp. 4358.

KM Sturm-Ramirez , T Ellis , B Bousfield , L Bissett , K Dyrting , JE Rehg , L Poon , Y Guan , M Peiris and RG Webster (2004). Reemerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks. Journal of Virology 78: 48924901.

DL Suarez (2000). Evolution of avian influenza viruses. Veterinary Microbiology 74: 1527.

DL Suarez , DA Senne , J Banks , IH Brown , SC Essen , CW Lee , RJ Manvell , C Mathieu-Benson , V Moreno , JC Pedersen , B Panigrahy , H Rojas , E Spackman and DJ Alexander (2004). Recombination resulting in virulence shift in avian influenza outbreak, Chile. Emerging Infectious Diseases 10: 693699.

K Subbarao , H Chen , D Swayne , L Mingay , E Fodor , G Brownlee , X Xu , X Lu , J Katz , N Cox and Y Matsuoka (2003). Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics. Virology 305: 192200.

K Subbarao , A Klimov , J Katz , H Regnery , W Lim , H Hall , M Perdue , D Swayne , C Bender , J Huang , M Hemphill , T Rowe , M Shaw , X Xu , K Fukuda and N Cox (1998). Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279: 393396.

Y Suzuki (2005). Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses. Biological and Pharmacological Bulletin 28: 399408.

DE Swayne (2008a). Epidemiology of avian influenza in agricultural and other man-made systems. In: DE Swayne (ed.) Avian Influenza. Ames, IA: Blackwell Publishing, pp. 5985.

DE Swayne (2008b). The global nature of avian influenza. In: DE Swayne (ed) Avian Influenza. Ames, IA: Blackwell Publishing, pp. 123143.

DE Swayne and JR Beck (2005). Experimental study to determine if low-pathogenicity and high-pathogenicity avian influenza viruses can be present in chicken breast and thigh meat following intranasal virus inoculation. Avian Diseases 49: 8185.

DE Swayne and DL Suarez (2005). U.S. Strategies for Controlling Avian Influenza in Agricultural Systems. Washington, DC: National Academies Press.

DE Swayne and RD Slemons (2008). Using mean infectious dose of high- and low-pathogenicity avian influenza viruses originating from wild duck and poultry as one measure of infectivity and adaptation to poultry. Avian Diseases 52: 455460.

DE Swayne , JR Beck , ML Perdue , M Brugh and RD Slemons (1996). Assessment of the ability of ratite-origin influenza viruses to infect and produce disease in rheas and chickens. Avian Diseases 40: 438447.

K Tsukamoto , T Imada , N Tanimura , M Okamatsu , M Mase , T Mizuhara , D Swayne and S Yamaguchi (2007). Impact of different husbandry conditions on contact and airborne transmission of H5N1 highly pathogenic avian influenza virus to chickens. Avian Diseases 51: 129132.

TM Tumpey , DR Kapczynski and DE Swayne (2004). Comparative susceptibility of chickens and turkeys to avian influenza A H7N2 virus infection and protective efficacy of a commercial avian influenza H7N2 virus vaccine. Avian Diseases 48: 167176.

TM Tumpey , DL Suarez , LE Perkins , DA Senne , JG Lee , YJ Lee , IP Mo , HW Sung and DE Swayne (2002). Characterization of a highly pathogenic H5N1 avian influenza A virus isolated from duck meat. Journal of Virology 76: 63446355.

JA van der Goot , MC de Jong , G Koch and M Van Boven (2003). Comparison of the transmission characteristics of low and high pathogenicity avian influenza A virus (H5N2). Epidemiology and Infection 131: 10031013.

JA van der Goot , G Koch , MC de Jong and M van Boven (2005). Quantification of the effect of vaccination on transmission of avian influenza (H7N7) in chickens. Proceedings of the National Academy of Sciences, USA 102: 1814118146.

RG Wallace and WM Fitch (2008). Influenza A H5N1 immigration is filtered out at some international borders. PLoS One 3: e1697.

H Wan and DR Perez (2006). Quail carry sialic acid receptors compatible with binding of avian and human influenza viruses. Virology 346: 278286.

J Wang , D Vijaykrishna , L Duan , J Bahl , JX Zhang , RG Webster , JS Peiris , H Chen , GJ Smith and Y Guan (2008). Identification of the progenitors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern China. Journal of Virology 82: 34053414.

RG Webster , Y Guan , M Peiris , D Walker , S Krauss , NN Zhou , EA Govorkova , TM Ellis , KC Dyrting , T Sit , DR Perez and KF Shortridge (2002). Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China. Journal of Virology 76: 118126.

O Werner , E Starick , J Teifke , R Klopfleisch , TY Prajitno , M Beer , B Hoffmann and TC Harder (2007). Minute excretion of highly pathogenic avian influenza virus A/chicken/Indonesia/2003 (H5N1) from experimentally infected domestic pigeons (Columbia livia) and lack of transmission to sentinel chickens. Journal of General Virology 88: 30893093.

World Health Organization Global Influenza Program Surveillance Network (2005). Evolution of H5N1 avian influenza viruses in Asia. Emerging Infectious Diseases 11: 15151521.

X Xu , K Subbarao , NJ Cox and Y Guo (1999). Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong. Virology 261: 1519.

KS Yee , TE Carpenter , TB Farver and CJ Cardona (2009). An evaluation of transmission routes for low pathogenicity avian influenza virus among chickens sold in live bird markets. Virology 394: 1927.

G Zhang , D Shoham , D Gilichinsky , S Davydov , JD Castello and SO Rogers (2006). Evidence of influenza a virus RNA in Siberian lake ice. Journal of Virology 80: 1222912235.

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Animal Health Research Reviews
  • ISSN: 1466-2523
  • EISSN: 1475-2654
  • URL: /core/journals/animal-health-research-reviews
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