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Conjugated linoleic acid

  • Patrick R. O'Quinn (a1), James L. Nelssen (a1), Robert D. Goodband (a1) and Michael D. Tokach (a1)
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*Email: Goodband@ksu.edu
References
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AAFCO (1985). Official Publication, Association of American Feed Control Officials, Inc., Atlanta, GA.
AOAC (1995). Official Methods of Analysis. 16th ed. Arlington, VA: Association of Official Analytical Chemists.
AOCS (1994). Official Methods and Recommended Practices of the American Oil Chemists’ Society. 4th ed. Champaign, IL: American Oil Chemists’ Society.
Bassaganya, J, Bregendahl, K and Zimmerman, DR (1999). Growth performance, whole body composition, plasma urea nitrogen and serum alpha-1-acylglycoprotein in weanling pigs fed CLA [abstract]. Journal of Animal Science 77 (Supplement 1): 256.
Bauman, D and Griinari, JM (1999). Biosynthesis of CLA and its incorporation into meat and milk of ruminants [abstract]. Journal of Animal Science 77 (Supplement 1): 1.
Baumgard, L, Corl, B, Dwyer, D, Saebo, A and Bauman, DE (1999). Identification of the CLA isomer responsible for milk fat depression [abstract]. Journal of Animal Science 77 (Supplement 1): 2.
Belury, MA and Kempa-Steczko, A (1997). Conjugated linoleic acid modulates hepatic lipid composition in mice. Lipids 32: 199204.
Belury, MA, Nickel, KP, Bird, CE and Wu, Y (1996) Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion. Nutrition and Cancer 26: 149157.
Belury, MA, Moya-Camarena, SY, Liu, K and Vanden Heuvel, JP (1997). Dietary conjugated linoleic acid induces peroxisome-specific enzyme accumulation and ornithine decarboxylase activity in mouse liver. Journal of Nutritional Biochemistry 8: 579584.
Bjorntorp, P (1991). Metabolic implications of body fat distribution. Diabetes Care 14: 11321143.
Cesano, A, Visonneau, S, Scimeca, JA, Kritchevsky, D and Santoli, D (1998). Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. Anticancer Research 18: 833838.
Chew, BP, Wong, TS, Schultz, TD and Magnuson, NS (1997). Effects of conjugated dienoic derivatives of linoleic acid and β-carotene in modulating lymphocyte and macrophage function. Anticancer Research 17: 10991106.
Chin, SF, Storkson, JM, Liu, W and Pariza, MW (1991). Dietary sources of the anticarcinogen CLA (conjugated dienoic derivatives of linoleic acid). FASEB J 5: A1444.
Chin, SF, Storkson, JM, Albright, KJ, Cook, ME and Pariza, MW (1994). Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. Journal of Nutrition 124: 23442349.
Collier, A, Jackson, M, Dawkes, RM, Bell, D and Clarke, BF (1988). Reduced free radical activity detected by decreased diene conjugates in insulin-dependent diabetic patients. Diabetic Medicine 5: 747749.
Conner, AH and Rowe, JW (1975). Neutrals in southern pine tall oil. Journal of the American Oil Chemists’ Society 52: 334338.
Cook, ME and Pariza, M (1998). The role of conjugated linoleic acid (CLA) in health. International Dairy Journal 8: 459462.
Cook, ME, Miller, CC, Park, Y and Pariza, M (1993). Immune modulation by altered nutrient metabolism: nutritional control of immune-induced growth depression. Poultry Science 72: 13011305.
Cunningham, DC, Harrison, LY and Schultz, TD (1997). Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture. Anticancer Research 17: 197204.
Decker, EA (1995). The role of phenolics, conjugated linoleic acid, carnosine, and pyrroloquinoline quinone as nonessential dietary antioxidants. Nutrition Reviews 53: 4958.
Dugan, MER, Aalhus, JL, Schaefer, and Kramer, JKG (1997). The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs. Canadian Journal of Animal Science 77: 723725.
Dugan, MER, Aalhus, JL, Jeremiah, LE, Kramer, JKG and Schafer, AL (1999). The effects of feeding conjugated linoleic acid on subsequent pork quality. Canadian Journal of Animal Science 79: 4551.
Durgam, VR and Fernandes, G (1997) The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system. Cancer Letters 116: 121130.
Eggert, JM, Carroll, AL, Richert, BT, Gerrard, DE, Forrest, JC, Boker, BC, Wynveen, EJ, Hammelman, JE and Schinckel, AP (1999 a). Effects of conjugated linoleic acid (CLA) on the growth, carcass composition and pork quality of two genotypes of lean gilts [abstract]. Journal of Animal Science 77 (Supplement 1): 254.
Eggert, JM, Carroll, AL, Richert, BT, Gerrard, DE, Forrest, JC, Boker, BC, Wynveen, EJ, Hammelman, JE and Schinckel, AP (1999 b). Effects of high oil corn and duration of conjugated linoleic acid (CLA) supplementation on pig growth, pork quality and carcass composition [abstract]. Journal of Animal Science 77 (Supplement 1): 255.
Eggert, JM, Belury, MA, Kempa-Steczko, A, Schinckel, AP (1999 c). Effects of conjugated linoleic acid (CLA) on growth and composition of lean gilts [abstract]. Journal of Animal Science 77 (Supplement 1): 117.
Fogerty, AC, Ford, GL and Svoronos, D (1988). Octadeca-9, 11-dienoic acid in foodstuffs and in the lipids of human blood and breast milk. Nutrition Reports International 38: 937944.
Goodband, RD, Nelssen, JL, Hines, RH, Kropf, DH, Stoner, GR, Thaler, RC, Lewis, AJ and Schricker, BR (1993). Interrelationships between porcine somatotropin and dietary lysine on growth performance and carcass characteristics of finishing swine. Journal of Animal Science 71: 663672.
Ha, YL, Grimm, NK and Pariza, MW (1987). Anticarcinogens from fried ground beef: altered derivatives of linoleic acid. Carcinogenesis 8: 18811887.
Ha, YL, Grimm, NK and Pariza, MW (1989). Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. Journal of Agricultural and Food Chemistry 37: 7581.
Ha, YL, Storkson, J and Pariza, MW (1990). Inhibition of benzo(α)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. Cancer Research 50: 10971101.
Haumann, BF (1996). Conjugated linoleic acid offers research promise. INFORM 7: 152159.
Hayek, MG, Han, SN, Wu, D, Watkins, BA, Meydani, M, Dorsey, KL and Smith, DE (1999). Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCrlBR mice. Journal of Nutrition 129: 3238.
Hendra, TJ, Wickens, DG, Dormandy, TL and Yudkin, JS (1991). Platelet function and conjugated diene concentrations in diabetic and non-diabetic survivors of acute myocardial infarction. Cardiovascular Research 25: 676683.
Houseknecht, KL, Baile, CA, Matteri, RL and Spurlock, ME (1998 a). The biology of leptin: a review. Journal of Animal Science 76: 14051420.
Houseknecht, KL, Vanden Heuvel, JP, Moya-Camarena, SY, Portocarrero, CP, Peck, LW, Nickel, KP and Belury, MA (1998 b). Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fa/fa rat. Biochemical and Biophysical Research Communications 244: 678682.
Huang, Y, Luedecke, LO and Schultz, TD (1994). Effect of cheddar cheese consumption on plasma conjugated linoleic acid concentrations in men. Nutrition Research 14: 373386.
Huibers, DTA (1997) Tall oil. In: Kroschwitz, JI and Howe-Grant, M (eds), Encyclopedia of Chemical Technology, Vol. 23. 4th ed. New York: Wiley Interscience, pp. 616622.
Ip, C and Scimeca, JA (1997). Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. Nutrition and Cancer 27: 131135.
Ip, C, Carter, CA and Ip, MM (1985). Requirement of essential fatty acid for mammary tumorigenesis in the rat. Cancer Research 45: 19972001.
Ip, C, Chin, SF, Scimeca, JA and Pariza, MW (1991). Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Research 51: 61186124.
Ip, C, Lisk, DJ and Scimeca, JA (1994). Potential of food modification in cancer prevention. Cancer Research 54: 1957s-1959s.
Ip, C, Singh, M, Thompson, HJ and Scimeca, JA (1994). Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Research 54: 12121215.
Jones, PJH, Howell, T, MacDougall, DE, Feng, JY and Parsons, W (1998). Short-term administration of tall oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels. Metabolism 47: 751756.
Kramer, JKG, Fellner, V, Dugan, MER, Sauer, FD, Mossoba, MM and Yurawecz, MP (1997). Evaluating acid and base catalysts in the methylation of milk and rumen fatty acids with special emphasis on conjugated dienes and total trans fatty acids. Lipids 32: 12191228.
Kramer, JKG, Sehat, N, Dugan, MER, Mossoba, MM, Yurawecz, MP, Roach, AG, Eulitz, K, Aalhus, JL, Schafer, AL and Ku, Y (1998). Distributions of conjugated linoleic acid (CLA) isomers in tissue lipid classes of pigs fed a commercial CLA mixture determined by gas chromatography and silver-ion high-performance liquid chromatography. Lipids 33: 549558.
Kraupp, B, Huber, W and Herman, RS (1990). Liver growth and early cellular changes in response to peroxisome proliferation. Biochemical Society Transactions 18: 8992.
Larsen, ST, Wiegand, BR, Parrish, FC Jr and Sparks, JC (1999) Effects of CLA supplementation on ham quality characteristics of crossbred growing–finishing barrows [abstract]. Journal of Animal Science 77 (Supplement 1): 92.
Lee, KN, Kritchevsky, D and Pariza, MW (1994). Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108: 1925.
Lee, KN, Storkson, JM and Pariza, MW (1995). Dietary conjugated linoleic acid changes fatty acid composition in different tissues by decreasing monounsaturated fatty acids. IFT Book of Abstracts 183.
Li, Y and Watkins, BA (1998). Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids. Lipids 33: 417425.
Lin, H, Boylston, TD, Chang, MJ, Luedecke, LO and Schultz, TD (1995). Survey of the conjugated linoleic acid contents of dairy products. Journal of Dairy Science 78: 23582365.
McGuire, MA and McGuire, MK (1999). Conjugated linoleic acid (CLA): a ruminant fatty acid with beneficial effects on human health [abstract]. Journal of Animal Science 77 (Supplement 1): 6.
Nicolosi, RJ, Rogers, EJ, Kritchevsky, D, Scimeca, JA and Huth, PJ (1997). Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery 22: 266277.
O'Quinn, PR, Koo, SI, Noh, SK, Nelsson, JL, Goodband, RD and Tokach, MD (1999 a). Effects of modified tall oil on body composition and serum and tissue levels of α-tocopherol, cholesterol, and phospholipids in ovariectomized rats [abstract]. Journal of Animal Science 77 (Supplement 1): 7.
O'Quinn, PR, Waylan, AT, Nelssen, JL, Goodband, RG, Unruh, JA, Woodworth, JC, Tokach, MD and Koo, SI (1999 b). The effects of modified tall oil and vitamin E on growth performance and carcass characteristics of finishing pigs [abstract]. Journal of Animal Science 77 (Supplement 1): 116.
O'Quinn, PR, Waylan, AT, Goodband, RG, Nelssen, JL, Unruh, JA, Woodworth, JC, Tokach, MD and Owen, KQ (1999 c). Effects of modified tall oil, chromium nicotinate, and L-carnitine on growth and carcass traits of finishing pigs [abstract]. Journal of Animal Science 77 (Supplement 1): 176.
O'Quinn, PR, Nelssen, JL, Unruh, JA, Goodband, RG, Woodworth, JC and Tokach, MD (2000 a). Effects of feeding modified tall oil and supplemental magnesium on growth performance, carcass characteristics, and meat quality of growing-finishing gilts [abstract]. Journal of Animal Science 78 (Supplement 1): 157.
O'Quinn, PR, Andrews, BS, Goodband, RD, Unruh, JA, Nelssen, JL, Woodworth, JC and Tokach, MD (2000 b). Effects of modified tall oil and creatine monohydrate on growth performance, carcass characteristics, and meat quality of growing–finishing pigs. Journal of Animal Science. In press.
O'Quinn, PR, Nelssen, JL, Goodband, RD, Unruh, JA, Woodworth, JC and Tokach, MD (2000 c). Effects of modified tall oil versus a commercial source of conjugated linoleic acid and increasing modified tall oil on growth performance and carcass characteristics of growing–finishing pigs. Journal of Animal Science. In press.
Pariza, M, Park, Y, Kim, S, Sugimoto, K, Aibright, K, Liu, W, Storkson, J and Cook, M (1997). Mechanism of body fat reduction by conjugated linoleic acid [abstract]. FASEB J 11: A139.
Park, Y, Albright, KJ, Liu, W, Cook, ME and Pariza, MW (1995). Dietary conjugated linoleic acid (CLA) reduces body fat content and isomers of CLA are incorporated into phospholipid fraction. IFT Book of Abstracts 183.
Park, Y, Albright, KJ, Liu, W, Storkson, JM, Cook, ME and Pariza, MW (1997). Effect of conjugated linoleic acid on body composition in mice. Lipids 32: 853858.
Park, Y, Albright, KJ, Storkson, JM, Cook, ME and Pariza, MW (1999 b). Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34: 243248.
Park, Y, Storkson, JM, Albright, KJ, Liu, W and Pariza, MW (1999 a). Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 34: 235241.
Parodi, PW (1994). Conjugated linoleic acid: an anticarcinogenic fatty acid present in milk fat. Australian Journal of Dairy Technology 49: 9397.
Pickup, JC and Crook, MA (1998). Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41: 12411248.
Reddy, JK (1990). Carcinogenicity of peroxisome proliferators: evaluation and mechanisms. Biochemical Society Transactions 18: 9294.
Satory, DL and Smith, SB (1999). Conjugated linoleic acid inhibits proliferation but stimulates lipid filling of murine 3T3-L1 preadipocytes. Journal of Nutrition 129: 9297.
Schoonjans, K, Staels, B and Auwerx, J (1996). The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochimica et Biophysica Acta 1302: 93109.
Schut, HAJ, Cummings, DA, Smale, MHE, Joysula, S and Fiesen, M (1997). DNA adducts of heterocyclic amines: formation, removal and inhibition by dietary components. Mutation Research 376: 185194.
Sehat, N, Yurawecz, MP, Roach, JAG, Mossoba, MM, Kramer, JKG and Ku, Y (1998). Silver-ion high-performance liquid chromatographic separation and identification of conjugated linoleic acid isomers. Lipids 33: 217221.
Shantha, NC, Decker, EA, Hennig, B (1993). Comparison of methylation methods for the quantitation of conjugated linoleic acid isomers. Journal of the Association of Official Analytical Chemists International 76: 644649.
Singh, S, Gupta, J and Agrawal, CG (1992) Conjugated dienes in lipids of apolipoprotein B containing lipoproteins of normal and type 2 (non-insulin-dependent) diabetic patients. Indian Journal of Biochemistry and Biophysics 29: 282286.
Sisk, M, Azain, MJ and Hausman, DB (1998). Effect of conjugated linoleic acid on fat pad weights and cellularity in Sprague–Dawley and Zucker rats [abstract]. FASEB J 12: A536.
Sparks, JC, Wiegand, BR, Parrish, FC and Zimmerman, DR (1999). Effects of length of feeding conjugated linoleic acid (CLA) on growth and body composition of pigs [abstract]. Journal of Animal Science 77 (Supplement 1): 253.
Sugano, M, Tsujita, A, Yamasaki, M, Yamada, K, Ikeda, I and Kritchevsky, D (1997). Lymphatic recovery, tissue distribution, and metabolic effects of conjugated linoleic acid in rats. Journal of Nutritional Biochemistry 8: 3843.
Sugano, M, Tsujita, A, Yamasaki, M, Noguchi, M and Yamada, K (1998). Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats. Lipids 33: 521527.
Thiel, RL, Sparks, JC, Wiegand, BR, Parrish, FC Jr and Ewan, RC (1998). Conjugated linoleic acid improves performance and body composition in swine [abstract]. Journal of Animal Science 76 (Supplement 1): 127.
Thiel-Cooper, RL, Wiegand, BR, Parrish, FC Jr and Love, JA (1999) Effects of CLA supplementation on quality and sensory characteristics of pork [abstract]. Journal of Animal Science 77 (Supplement 1): 93.
Turek, JJ, Li, Y, Schoenlein, IA and Watkins, BA (1998). Modulation of macrophage cytokine production by conjugated linoleic acids is influenced by the dietary n-6:n-3 fatty acid ratio. Journal of Nutritional Biochemistry 9: 258266.
van den Berg, JJM, Cook, NE, Tribble, DL (1995). Reinvestigation of the antioxidant properties of conjugated linoleic acid. Lipids 30: 599605.
Waylan, AT (1999). The effects of dietary supplementation of modified tall oil, vitamin E, chromium nicotinate, and L-carnitine on pork quality, display color stability, and bacon characteristics. MS thesis, Kansas State University, Manhattan.
West, DB, Delany, JP, Camet, PM, Blohm, F, Truett, AA and Scimeca, J (1998). Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. American Journal of Physiology 275: R667-R672.
Wiegand, BR, Parrish, FC Jr and Sparks, JC (1999). Effects of CLA supplementation on pork quality characteristics in crossbred growing–finishing barrows [abstract]. Journal of Animal Science 77 (Supplement 1): 91.
Wolf, G (1996). Leptin: the weight-reducing plasma protein encoded by the obese gene. Nutrition Reviews 54: 9191.
Woodworth, JC, Goodband, RD, Unruh, JA, Nelssen, JL, Tokach, MD, Waylan, AT and O'Quinn, PR (1999). Interactive effects between fat source and modified tall oil on growth performance and carcass characteristics of finishing pigs [abstract]. Journal of Animal Science 77 (Supplement 1): 5.
Yurawecz, MP, Roach, JAG, Sehat, N, Mossoba, MM, Kramer, JKG, Fritsche, J, Steinhart, H and Ku,, Y (1998). A new conjugated linoleic acid isomer, 7 trans, 9 cis-octadecadienoic acid, in cow milk, cheese, beef and human milk and adipose tissue. Lipids 33: 803809.
Zhang, Y, Proenca, R, Maffei, M, Burone, M, Leopold, L and Friedman, JM (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425431.
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