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Genetic diversity of Anaplasma species major surface proteins and implications for anaplasmosis serodiagnosis and vaccine development

  • José de la Fuente (a1) (a2), Ala Lew (a3), Hans Lutz (a4), Marina L. Meli (a4), Regina Hofmann-Lehmann (a4), Varda Shkap (a5), Thea Molad (a5), Atilio J. Mangold (a6), Consuelo Almazán (a1), Victoria Naranjo (a2), Christian Gortázar (a2), Alessandra Torina (a7), Santo Caracappa (a7), Ana L. García-Pérez (a8), Marta Barral (a8), Beatriz Oporto (a8), Luigi Ceci (a9), Grazia Carelli (a9), Edmour F. Blouin (a1) and Katherine M. Kocan (a1)...
Abstract

The genus Anaplasma (Rickettsiales: Anaplasmataceae) includes several pathogens of veterinary and human medical importance. An understanding of the diversity of Anaplasma major surface proteins (MSPs), including those MSPs that modulate infection, development of persistent infections, and transmission of pathogens by ticks, is derived in part, by characterization and phylogenetic analyses of geographic strains. Information concerning the genetic diversity of Anaplasma spp. MSPs will likely influence the development of serodiagnostic assays and vaccine strategies for the control of anaplasmosis.

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Corresponding author
*Email: jose_delafuente@yahoo.com and djose@cvm.okstate.edu
References
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