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Genetic variation and responses to vaccines

Published online by Cambridge University Press:  28 February 2007

Elizabeth J. Glass
Elizabeth J. Glass*
Affiliation:
Roslin Institute, Roslin, Midlothian EH25 9PS, UK
*
E-mail: Liz.glass@bbsrc.ac.uk
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Abstract

Disease is a major source of economic loss to the livestock industry. Understanding the role of genetic factors in immune responsiveness and disease resistance should provide new approaches to the control of disease through development of safe synthetic subunit vaccines and breeding for disease resistance. The major histocompatibility complex (MHC) has been an important candidate locus for immune responsiveness studies. However, it is clear that other loci play an important role. Identifying these and quantifying the relative importance of MHC and non-MHC genes should result in new insights into host–pathogen interactions, and information that can be exploited by vaccine designers. The rapidly increasing information available about the bovine genome and the identification of polymorphisms in immune-related genes will offer potential candidates that control immune responses to vaccines. The bovine MHC, BoLA, encodes two distinct isotypes of class II molecules, DR and DQ, and in about half the common haplotypes the DQ genes are duplicated and expressed. DQ molecules are composed of two polymorphic chains whereas DR consists of one polymorphic and one non-polymorphic chain. Although, it is clear that MHC polymorphism is related to immune responsiveness, it is less clear how different allelic and locus products influence the outcome of an immune response in terms of generating protective immunity in outbred animals. A peptide derived from foot-and-mouth disease virus (FMDV) was used as a probe for BoLA class II function. Both DR and DQ are involved in antigen presentation. In an analysis of T-cell clones specific for the peptide, distinct biases to particular restriction elements were observed. In addition inter-haplotype pairings of DQA and DQB molecules produced functional molecules, which greatly increases the numbers of possible restriction elements, compared with the number of genes, particularly in cattle with duplicated DQ genes. In a vaccine trial with several peptides derived from FMDV, BoLA class II DRB3 polymorphisms were correlated with both protection and non-protection. Although variation in immune responsiveness to the FMDV peptide between different individuals is partly explainable by BoLA class II alleles, other genetic factors play an important role. In a quantitative trait locus project, employing a second-generation cross between Charolais and Holstein cattle, significant sire and breed effects were also observed in T-cell, cytokine and antibody responses to the FMDV peptide. These results suggest that both MHC and non-MHC genes play a role in regulating bovine immune traits of relevance to vaccine design. Identifying these genes and quantifying their relative contributions is the subject of further studies.

Keywords

vaccinesimmune responsegenetic variationMHC genesnon-MHC genes
Type
Research Article
Information
Animal Health Research Reviews , Volume 5 , Issue 2 , December 2004 , pp. 197 - 208
Copyright
Copyright © CAB International 2004

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References

Adams, LG and Templeton, JW (1998). Genetic resistance to bacterial diseases in animals. Revue Scientifique et Technique de l'Office International Des Epizooties 17: 200–219.CrossRefGoogle Scholar
Agaba, M, Kemp, SJ, Barendse, W and Teale, AJ (1996). Polymorphism at the bovine tumor necrosis factor alpha locus and assignment to BTA 23. Mammalian Genome 7: 186–7.CrossRefGoogle ScholarPubMed
Alexandersen, S, Zhang, ZD and Donaldson, AI (2002). Aspects of the persistence of foot-and-mouth disease virus in animals—the carrier problem. Microbes and Infection 4: 1099–1110.CrossRefGoogle ScholarPubMed
Amadori, M, Archetti, IL, Verardi, R and Berneri, C (1992). Isolation of mononuclear cytotoxic cells from cattle vaccinated against foot-and-mouth disease. Archives of Virology 122: 293–306.CrossRefGoogle ScholarPubMed
Ambrose, NC, Lloyd, D and Maillard, JC (1999). Immune responses to Dermatophilus congolensis infections. Parasitology Today 15: 295–300.CrossRefGoogle ScholarPubMed
Anon (2000). Outbreak of classical swine fever in Suffolk. Veterinary Record 147: 175–175.Google Scholar
Ashwell, MS and van Tassell, CP (1999). Detection of putative loci affecting milk, health, and type traits in a US Holstein population using 70 microsatellite markers in a genome scan. Journal of Dairy Science 82: 2407–2502.CrossRefGoogle Scholar
Aujame, L, Burdin, N and Vicari, M (2002). How microarrays can improve our understanding of immune responses and vaccine development. Annals of the New York Academy of Sciences 975: 1–23.CrossRefGoogle ScholarPubMed
Ballingall, KT, Luyai, A and McKeever, DJ (1997). Analysis of genetic diversity at the DQA loci in African cattle: evidence for a BoLA DQA3 locus. Immunogenetics 46: 237–244.CrossRefGoogle ScholarPubMed
Ballingall, KT, MacHugh, ND, Taracha, ELN, Mertens, B and McKeever, DJ (2001). Transcription of the unique ruminant class II major histocompatibility complex-DYA and DIB genes in dendritic cells. European Journal of Immunology 31: 82–86.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
Band, MR, Larson, JH, Redeiz, M, Green, CA, Heyen, DW, Donovan, J, Windish, R, Steining, C, Mahyuddin, P, Womack, JE and Lewin, HA (2000). An ordered map of the cattle and human genomes. Genome Research 10: 1359–1368.CrossRefGoogle ScholarPubMed
Band, MR, Olmstead, C, Everts, RE, Liu, ZL and Lewin, HA (2002). A 3800 gene microarray for cattle functional genomics: comparison of gene expression in spleen, placenta, and brain. Animal Biotechnology 13: 163–72.CrossRefGoogle ScholarPubMed
Barendse, W, Vaiman, D, Kemp, S, Sugimoto, Y, Armitage, S, Williams, Jet al. (1997). A medium density genetic linkage map of the bovine genome. Mammalian Genome 8: 21–28.CrossRefGoogle ScholarPubMed
Behnke, JM, Iraqi, F, Menge, D, Baker, RL, Gibson, J and Wakelin, D (2003). Chasing the genes that control resistance to gastrointestinal nematodes. Journal of Helminthology 77: 99–109.CrossRefGoogle ScholarPubMed
Bishop, SC and Stear, MJ (2003). Modeling of host genetics and resistance to infectious diseases: understanding and controlling nematode infections. Veterinary Parasitology 115: 147–166.CrossRefGoogle ScholarPubMed
Boichard, D, Grohs, C, Bourgeois, F, Cerqueira, F, Faugeras, R, Neau, A, Rupp, R, Amigues, Y, Boscher, MY and Levezie, H (2003). Detection of genes influencing economic traits in three French dairy cattle breeds. Genetics Selection Evolution 35: 77–101.CrossRefGoogle ScholarPubMed
Borrow, P and Shaw, GM (1998). Cytotoxic T-lymphocyte escape viral variants: how important are they in viral evasion of immune clearance in vivo? Immunological Reviews 164: 37–51.CrossRefGoogle ScholarPubMed
Brown, WC (2001). Molecular approaches to elucidating innate and acquired immune responses to Babesia bovis, a protozoan parasite that causes persistent infection. Veterinary Parasitology 101: 233–248.CrossRefGoogle ScholarPubMed
Brunner, RM, Sanftleben, H, Goldammer, T, Kuhn, C, Weikard, R, Kata, SR, Womack, JE and Schwerin, M (2003). The telomeric region of BTA18 containing a potential QTL region for health in cattle exhibits high similarity to the HSA19q region in humans. Genomics 81: 270–278.CrossRefGoogle Scholar
Casati, MZ, Longeri, M, Polli, M, Ceriotti, G and Poli, G (1995). BoLA class II polymorphism and immune response to Mycobacterium bovis antigens in vitro. Journal of Animal Breeding and Genetics 112: 391–400.CrossRefGoogle Scholar
Childerstone, AJ, Cedillo-Baron, L, Foster-Cuevas, M and Parkhouse, RME (1999). Demonstration of bovine CD8 + T-cell responses to foot and mouth disease virus. Journal of General Virology 80: 663–669.CrossRefGoogle ScholarPubMed
Collen, T (1994). Foot-and-mouth disease virus (aphthovirus): viral T cell epitopes. In: Morrison, I, Godderis, BML, editors. Cell Mediated Immunity in Ruminants. CRC Press. Boca Raton, pp. 173–197Google Scholar
Collen, T, Carr, V, Parsons, K, Charleston, B and Morrison, WI (2002). Analysis of the repertoire of cattle CD4(+) T cells reactive with bovine viral diarrhoea virus. Veterinary Immunology and Immunopathology 87: 235–238.CrossRefGoogle ScholarPubMed
Court, RA, Sitte, K, Opdebeeck, JP and East, IJ (1998). Mapping the T cell epitopes of the Babesia bovis antigen 12D3: implications for vaccine design. Parasite Immunology 20: 1–8.CrossRefGoogle Scholar
Coussens, PM and Nobis, W (2002). Bioinformatics and high throughput approach to create genomic resources for the study of bovine immunobiology. Veterinary Immunology and Immunopathology 86: 229–244.CrossRefGoogle Scholar
Dalton, JP and Mulcahy, G (2001). Parasite vaccines—a reality? Veterinary Parasitology 98: 149–167.CrossRefGoogle ScholarPubMed
De Groot, AS, Bosma, A, Chinai, N, Frost, J, Jesdale, BM, Gonzalez, MA, Martin, W and Saint-Aubin, C (2001). From genome to vaccine: in silico predictions, ex vivo verification. Vaccine 19: 4385–4395.CrossRefGoogle ScholarPubMed
De Groot, AS, Nene, V, Hegde, NR, Srikumaran, S, Rayner, J and Martin, W (2003). T cell epitope identification for bovine vaccines: an epitope mapping method for BoLA A-11. International Journal of Parasitology 33: 641–53.CrossRefGoogle ScholarPubMed
Demotz, S, Moulon, C, Roggero, MA, Fasel, N, Masina, S (2001). Native-like, long synthetic peptides as components of sub-unit vaccines: practical and theoretical considerations for their use in humans. Molecular Immunology 38: 415–22.CrossRefGoogle ScholarPubMed
De Silvestri, A, Pasi, A, Martinetti, M, Belloni, C, Tinelli, C, Rondini, G, Salvaneschi, L and Cuccia, M (2001). Family study of non-responsiveness to hepatitis B vaccine confirms the importance of HLA class III C4A locus. Genes and Immunity 2: 367–372.CrossRefGoogle ScholarPubMed
Detilleux, JC (2002). Genetic factors affecting susceptibility of dairy cows to udder pathogens. Veterinary Immunology and Immunopathology 88: 103–110.CrossRefGoogle ScholarPubMed
DiMarchi, R, Brooke, G, Gale, C, Cracknell, V, Doel, T and Mowat, N (1986). Protection of cattle against foot-and-mouth disease by a synthetic peptide. Science 232: 639–641.CrossRefGoogle ScholarPubMed
Ellis, SA and Ballinghall, KT (1999). Cattle MHC: evolution in action? Immunological Reviews 167: 159–168.CrossRefGoogle Scholar
Fleischer, P, Metzner, M, Beyerbach, M, Hoedemaker, M and Klee, W (2001). The relationship between milk yield and the incidence of some diseases of dairy cows. Journal of Dairy Science 84: 2025–2035.CrossRefGoogle ScholarPubMed
Fogg, MH, Parsons, KR, Thomas, LH and Taylor, G (2001). Identification of CD4 + T cell epitopes on the fusion (F) and attachment (G) proteins of bovine respiratory syncytial virus (BRSV). Vaccine 19: 3226–3240.CrossRefGoogle ScholarPubMed
Foster, CB and Chanock, SJ (2000). Mining variations in genes of innate and phagocytic immunity: current status and future prospects. Current Opinion in Haematology 7: 9–15.CrossRefGoogle ScholarPubMed
Frisch, JE, O'Neill, CJ and Kelly, MJ (2000). Using genetics to control cattle parasites—the Rockhampton experience. International Journal of Parasitology 30: 253–264.CrossRefGoogle ScholarPubMed
Gaddum, RM, Cook, RS, Furze, JM, Ellis, SA and Taylor, G (2003). Recognition of bovine respiratory syncytial virus proteins by bovine CD8 + T lymphocytes Immunology 108: 220–229.CrossRefGoogle ScholarPubMed
García-Briones, M, Russell, GC, Oliver, RA, Tami, C, Taboga, O, Carrillo, E, Palma, EL, Sobrino, F and Glass, EJ (2000). Association of bovine DRB3 alleles with immune response to FMDV peptides and protection against viral challenge. Vaccine 19: 1167–1171.CrossRefGoogle ScholarPubMed
Gasbarre, LC, Leighton, EA and Sonstegard, T (2001). Role of the bovine immune system and genome in resistance to gastrointestinal nematodes. Veterinary Parasitology 98: 51–64.CrossRefGoogle ScholarPubMed
Gasbarre, LC, Sonstegard, T, Van Tassell, CP and Padilha, T (2002). Detection of QTL affecting parasite resistance in a selected herd of Angus cattle. Proceedings of the 7th World Congress on Genetics Applied to Livestock Production(Montpelier, France). Communication 13–07Google Scholar
Geraghty, DE, Daza, R, Williams, LM, Vu, Q and Ishitani, A (2002). Genetics of the immune response: identifying immune variation within the MHC and throughout the genome. Immunological Reviews 190: 69–85.CrossRefGoogle ScholarPubMed
Gibbs, R, Weinstock, G, Kappes, S, Skow, L and Womack, J (2003). Bovine genomic sequencing initiative. Cattle-izing the human genome. http://www.genome.gov/Pages/Research/Sequencing/SeqProposals/BovineSEQ.pdfGoogle Scholar
Glass, EJ (2001). The balance between protective immunity and pathogenesis in tropical theileriosis: what we need to know to design effective vaccines for the future. Research in Veterinary Science 70: 71–75.CrossRefGoogle ScholarPubMed
Glass, EJ and Millar, P (1994). Induction of effective cross-reactive immunity by FMDV peptides is critically dependent upon specific MHC-peptide–T cell interactions. Immunology 82: 1–8.Google ScholarPubMed
Glass, EJ and Millar, P (1995). Bovine T cells preferentially recognise non viral spacer epitopes in putative FMDV vaccinal peptide. Vaccine 13 225–229.CrossRefGoogle Scholar
Glass, EJ, Oliver, RA, Collen, T, Doel, TR, DiMarchi, R and Spooner, RL (1991). MHC class II restricted recognition of FMDV peptides by bovine T cells. Immunology 74: 594–599.Google ScholarPubMed
Glass, EJ, Oliver, RA and Russell, GC (2000). Duplicated DQ-haplotypes increase the complexity of restriction element usage in cattle. Journal of Immunology 165: 134–138.CrossRefGoogle ScholarPubMed
Grosse, WM, Kappes, SM, Laegreid, WW, Keele, JW, Chitko-McKown, CG and Heaton, MP (1999). Single nucleotide polymorphism (SNP) discovery and linkage mapping of bovine cytokine genes. Mammalian Genome 10: 1062–1069.CrossRefGoogle ScholarPubMed
Haghparast, A, Wauben, MHM, Grosfeld-Stulemeyer, MC, van Kooten, P and Hensen, EJ (2000). Selection of T-cell epitopes from foot-and-mouth disease virus reflects the binding affinity to different cattle MHC class II molecules. Immunogenetics 51: 733–742.CrossRefGoogle ScholarPubMed
Hanotte, O, Ronin, Y, Agaba, M, Nilsson, P, Gelhaus, A, Horstmann, R, Sugimoto, Y, Kemp, S, Gibson, J, Korol, A, Soller, M and Teale, A (2003). Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle. Proceedings of the National Academy of Sciences of the United States of America 100: 7443–7448.CrossRefGoogle Scholar
Hansen, M, Lund, MS, Sorensen, MK and Christensen, LG (2002). Genetic parameters of dairy character, protein yield, clinical mastitis and other diseases in the Danish Holstein cattle. Journal of Dairy Science 85: 445–452.CrossRefGoogle ScholarPubMed
Heaton, MP, Grosse, WM, Kappes, SM, Keele, JW, Chitko-McKown, CG, Cundiff, LV, Braun, A, Little, DP and Laegreid, WW (2001a). Estimation of DNA sequence diversity in bovine cytokine genes. Mammalian Genome 12: 32–37.CrossRefGoogle ScholarPubMed
Heaton, MP, Chitko-McKown, CG, Grosse, WM, Keele, JW, Keen, JE and Laegreid, WW (2001b). Interleukin-8 haplotype structure from nucleotide sequence variation in commercial populations of US beef cattle. Mammalian Genome 12: 219–226.CrossRefGoogle ScholarPubMed
Hegde, NR and Srikumaran, S (2000). Reverse immunogenetic and polyepitopic approaches for the induction of cell-mediated immunity against bovine viral pathogens. Animal Health Research Reviews 1: 103–118.CrossRefGoogle ScholarPubMed
Hernandez, A, Karrow, N and Mallard, BA (2003). Evaluation of immune responses of cattle as a means to identify high or low responders and use of a human microarray to differentiate gene expression. Genetics Selection Evolution 35 S1: S67–S81.CrossRefGoogle ScholarPubMed
Hernandez-Sanchez, J, Waddington, D, Wiener, P, Haley, CS and Williams, JL (2002). Genome-wide search for markers associated with bovine spongiform encephalopathy. Mammalian Genome 13: 164–8.CrossRefGoogle ScholarPubMed
Heyen, DW, Weller, JI, Ron, M, Band, M, Beever, JE, Feldmesser, E, Da, Y, Wiggans, GR, VanRaden, PM and Lewin, HA (1999). A genome scan for QTL influencing milk production and health traits in dairy cattle. Physiological Genomics 1: 165–175.CrossRefGoogle ScholarPubMed
Hill, AVS (2001). The genomics and genetics of human infectious disease susceptibility. Annual Review of Genomics, and Human Genetics 2: 373–400.CrossRefGoogle ScholarPubMed
Hohler, T, Reuss, E, Evers, N, Dietrich, E, Rittner, C, Freitag, CM, Vollmar, J, Schneider, P and Fimmers, R (2002). Differential genetic determination of immune responsiveness to hepatitis B surface antigen and to hepatitis A virus: a vaccination study in twins. Lancet 360: 991–995.CrossRefGoogle ScholarPubMed
Holmskov, U, Jensenius, JC, Tornoe, I and Lovendahl, P (1998). The plasma levels of conglutinin are heritable in cattle and low levels predispose to infection. Immunology 93: 431–436.CrossRefGoogle ScholarPubMed
Jepson, A, Banya, W, Sisay-Joof, F, Hassan-King, M, Nunes, C, Bennett, S and Whittle, H (1997). Quantification of the relative contribution of major histocompatibility complex (MHC) and non-MHC genes to human immune responses to foreign antigens. Infection and Immunity 65: 872–876.CrossRefGoogle ScholarPubMed
Kappes, SM, Keele, JW, Stone, RT, Sonstegard, TS, Smith, TPL, McGraw, RA, Lopez-Corrales, NL and Beattie, CW (1997). A second-generation linkage map of the bovine genome. Genome Research 7: 235–249.CrossRefGoogle ScholarPubMed
Kelm, SC, Freeman, AE and Kehrli, ME (2001). Genetic control of disease resistance and immunoresponsiveness. Veterinary Clinics of North America—Food Animal Practice 17: 477–493.Google ScholarPubMed
Kitching, RP (2002). Identification of foot and mouth disease virus carrier and subclinically infected animals and differentiation from vaccinated animals. Revue Scientifique et Technique de l'Office International Des Epizooties 21: 531–538.CrossRefGoogle ScholarPubMed
Klungland, H, Sabry, A, Heringstad, B, Olsen, HG, Gomez-Raya, L, Vage, DI, Olsaker, I, Odegard, J, Klemetsdal, G, Schulman, N, Vilkki, J, Ruane, J, Aasland, M, Ronningen, K and Lien, S (2001). Quantitative trait loci affecting clinical mastitis and somatic cell count in dairy cattle. Mammalian Genome 12: 837–842.CrossRefGoogle ScholarPubMed
Knowles, NJ, Samuel, AR, Davies, PR, Kitching, RP and Donaldson, AI (2001). Outbreak of foot-and-mouth disease virus serotype O in the UK caused by a pandemic strain. Veterinary Record 148: 258–259.Google Scholar
Kuhn, C, Bennewitz, J, Reinsch, N, Xu, N, Thomsen, H, Looft, C, Brockmann, GA, Schwerin, M, Weimann, C, Hiendieder, S, Erhardt, G, Medjugorac, I, Forster, M, Brenig, B, Reinhardt, F, Reents, R, Russ, I, Averdunk, G, Blumel, J and Kalm, E (2003). Quantitative trait loci mapping of functional traits in the German Holstein cattle population. Journal of Dairy Science 86: 360–368.CrossRefGoogle ScholarPubMed
Lagonigro, R, Wiener, P, Pilla, F, Woolliams, JA and Williams, J (2003). A new mutation in the coding region of the bovine leptin gene associated with feed intake. Animal Genetics 34: 371–4.CrossRefGoogle ScholarPubMed
Lander, ES, Linton, LM, Birren, B, Nusbaum, C, Zody, MC, Baldwin, Jet al. (2001). Initial sequencing and analysis of the human genome. Nature 409: 860–921.Google ScholarPubMed
Lewin, HA, Russell, GC and Glass, EJ (1999). Comparative organization and function of the major histocompatibility complex of domesticated cattle. Immunological Reviews 167: 145–158.CrossRefGoogle ScholarPubMed
McGuire, K, Makins, G and Glass, EJ (2002). Multi-component analysis of bovine macrophages from breeds differing in resistance to disease. Immunology 107 (Supplement 1): 99.Google Scholar
McKeever, DJ, Taracha, ELN, Morrison, WI, Musoke, AJ and Morzaria, SP (1999). Protective immune mechanisms against Theileria parva: evolution of vaccine development strategies. Parasitology Today 15: 263–267.CrossRefGoogle ScholarPubMed
Maillard, J-C, Berthier, D, Chantal, I, Thevenon, S, Sidibe, I, Stachurski, F, Delemsaga, D, Razafindraibe, H and Elsen, J-M (2003). Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis. Genetics Selection Evolution 35 S1: S193–S200.CrossRefGoogle ScholarPubMed
Meloen, RH, Langeveld, JPM, Schaaper, WMM and Slootstra, JW (2001). Synthetic peptide vaccines: Unexpected fulfillment of discarded hope? Biologicals 29: 233–236.CrossRefGoogle ScholarPubMed
Miltiadou, D, Law, AS and Russell, GC (2003). Establishment of a sequence-based typing (SBT) system for BoLA-DRB3 exon 2. Tissue Antigens 62: 55–65.CrossRefGoogle ScholarPubMed
Moreno, CR, Lantier, F, Berthon, P, Gautier-Bouchardon, AV, Boivin, R, Lantier, I, Brunel, J-C, Weisbecker, J-L, Francois, D, Bouix, J, Elsen, J-M (2003). Genetic parameters for resistance to the Salmonella abortusovis vaccinal strain Rv6 in sheep. Genetics Selection Evolution 35: 199–217.CrossRefGoogle Scholar
Mulcahy, G, Gale, C, Robertson, P, Iyisan, S, DiMarchi, RD and Doel, TR (1990). Isotype responses of infected, virus-vaccinated and peptide-vaccinated cattle to foot-and-mouth disease virus. Vaccine 8: 249–256.CrossRefGoogle ScholarPubMed
Newman, MJ, Traux, RE, French, DD, Dietrich, MA, Franke, D and Stear, MJ (1996). Evidence for genetic control of vaccine-induced antibody responses in cattle. Veterinary Immunology and Immunopathology 50: 43–54.CrossRefGoogle ScholarPubMed
Norimatsu, M, Harris, J, Chance, V, Dougan, G, Howard, CJ and Villarreal-Ramos, B (2003). Differential response of bovine monocyte-derived macrophages and dendritic cells to infection with Salmonella typhimurium in a low-dose model in vitro. Immunology 108: 55–61.CrossRefGoogle Scholar
Office International des Epizooties (1998). Genetic resistance to animal diseases. Revue Scientifique et Technique de l'Office International Des Epizooties 17: 1–392.Google Scholar
O'Neill, RG, Glass, EJ, Woolliams, JA, Williams, JL and Fitzpatrick, JL (2003). Vaccine induced IgG1 kinetics in a Holstein × Charolais composite backcross population: a phenotypic study. [abstract]. In: 3rd International Veterinary Vaccines and Diagnostics Conference, Guelph, Canada, July 2003.Google Scholar
Outteridge, PM (1993). High and low responsiveness to vaccines in farm-animals. Immunology and Cell Biology 71: 355–366.CrossRefGoogle ScholarPubMed
Paliakasis, K, Routsias, J, Petratos, K, Ouzounis, C, Kokkinidis, M and Papadopoulos, GK (1996). Novel structural features of the human histocompatibility molecules HLA-DQ as revealed by modeling based on the published structure of the related molecule HLA-DR. Journal of Structural Biology 117:145–163.CrossRefGoogle ScholarPubMed
Preston, P, Hall, R, Glass, E, Campbell, J, Darghouth, M, Ahmed, J, Shiels, B, Spooner, R, Jongejan, F and Brown, D (1999). Theileria annulata: innate and adaptive immune responses cooperate in protective immunity. Parasitology Today 15: 268–274.CrossRefGoogle Scholar
Raadsma, HW, McEwan, JC, Stear, MJ and Crawford, AM (1999). Genetic characterisation of protective vaccine responses in sheep using multi-valent Dichelobacter nodosus vaccines. Veterinary Immunology and Immunopathology 72: 219–229.CrossRefGoogle ScholarPubMed
Raddrizzani, L, Sturniolo, T, Guenot, J, Bono, E, Gallazzi, F, Nagy, ZA, Sinigaglia, F and Hammer, J (1997). Different modes of peptide interaction enable HLA-DQ and HLA-DR molecules to bind diverse peptide repertoires. Journal of Immunology 159: 703–711.CrossRefGoogle ScholarPubMed
Royal Society (2002). Infectious diseases in livestock. http://www.royalsoc.ac.uk/inquiry/Google Scholar
Russell, GC, Oliver, RA, Craigmile, S, Nene, V and Glass, EJ (2002). Functional expression of a bovine major histocompatibility complex class I gene in transgenic mice. Veterinary Immunology and Immunopathology 87: 417–421.CrossRefGoogle ScholarPubMed
Schmidt, P, Kuhn, C, Maillard, JC, Pitra, C, Tiemann, U, Weikard, R and Schwerin, M (2002). A comprehensive survey for polymorphisms in the bovine IFN-gamma gene reveals a highly polymorphic intronic DNA sequence allowing improved genotyping of Bovinae. Journal of Interferon and Cytokine Research 22: 923–934.CrossRefGoogle ScholarPubMed
Sharif, S, Mallard, BA, Wilkie, BN, Sargeant, JM, Scott, HM, Dekkers, JC and Leslie, KE (1999). Associations of the bovine major histocompatibility complex DRB3 (BoLA-DRB3) with production traits in Canadian dairy cattle. Animal Genetics 30: 157–160.CrossRefGoogle ScholarPubMed
Sharif, S, Mallard, BA and Sargeant, JM (2000). Presence of glutamine at position 74 of pocket 4 in the BoLA-DR antigen binding groove is associated with occurrence of clinical mastitis caused by Staphylococcus species. Veterinary Immunology and Immunopathology 76: 231–238.CrossRefGoogle ScholarPubMed
Sharif, S, Mallard, BA and Wilkie, BN (2003). Characterization of naturally processed and presented peptides associated with bovine major histocompatibility complex (BoLA) class II DR molecules. Animal Genetics 34: 116–123.CrossRefGoogle ScholarPubMed
Shuster, DE, Kehrli, ME, Ackermann, MR and Gilbert, RO (1992). Identification and prevalence of a genetic-defect that causes leukocyte adhesion deficiency in Holstein cattle. Proceedings of the National Academy of Sciences of the United States of America 89: 9225–9229.CrossRefGoogle ScholarPubMed
Singh, H and Raghava, GP (2001). ProPred: prediction of HLA-DR binding sites. Bioinformatics 17: 1236–1237.CrossRefGoogle ScholarPubMed
Singh, H and Raghava, GP (2003). ProPred1: prediction of promiscuous MHC class-I binding sites. Bioinformatics 19: 1009–1014.CrossRefGoogle ScholarPubMed
Sitte, K, Brinkworth, R, East, IJ and Jazwinska, EC (2002). A single amino acid deletion in the antigen binding site of BoLA-DRB3 is predicted to affect peptide binding. Veterinary Immunology and Immunopathology 85: 129–135.CrossRefGoogle ScholarPubMed
Smith, TP, Grosse, WM, Freking, BA, Roberts, AJ, Stone, RT, Casas, E, Wray, JE, White, J, Cho, J, Fahrenkrug, SC, Bennett, GL, Heaton, MP, Laegreid, WW, Rohrer, GA, Chitko-McKown, CG, Pertea, G, Holt, I, Karamycheva, S, Liang, F, Quackenbush, J and Keele, JW (2001). Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Genome Research 11: 626–630.CrossRefGoogle ScholarPubMed
Sobrino, F, Saiz, M, Jimenez-Clavero, MA, Nunez, JI, Rosas, MF, Baranowski, E and Ley, V (2001). Foot-and-mouth disease virus: a long known virus, but a current threat. Veterinary Research 32: 1–30.CrossRefGoogle ScholarPubMed
Sonstegard, TS, Capuco, AV, White, J, Van Tassell, CP, Connor, EE, Cho, J, Sultana, R, Shade, L, Wray, JE, Wells, KD and Quackenbush, J (2002). Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Mammalian Genome 13: 373–379.CrossRefGoogle ScholarPubMed
Spooner, RL, Oliver, RA, Sales, DI, McCoubrey, CM, Millar, P, Morgan, AG, Amorena, B, Bailey, E, Bernoco, D, Brandon, M, Bull, RW, Caldwell, J, Cwik, S, van Dam, RH, Dodd, J, Gahne, B, Grosclaude, F, Hall, JG, Hines, H, Leveziel, H, Newman, MJ, Stear, MJ, Stone, WH and Vaiman, M (1979). Analysis of alloantisera against bovine lymphocytes. Joint Report. Animal Blood Groups and Biochemical Genetics 10: 63–86.CrossRefGoogle ScholarPubMed
Sturniolo, T, Bono, E, Ding, J, Raddrizzani, L, Tuereci, O, Sahin, U, Braxenthaler, M, Gallazzi, F, Protti, MP, Sinigaglia, F and Hammer, J (1999). Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices. Nature Biotechnology 17: 555–561.CrossRefGoogle ScholarPubMed
Sutmoller, P, Barteling, SS, Olascoaga, RC and Sumption, KJ (2003). Control and eradication of foot-and-mouth disease. Virus Research 91: 101–144.CrossRefGoogle ScholarPubMed
Taboga, O, Tami, C, Carrillo, E, Núñez, JI, Rodríguez, A, Sáiz, JC, Blanco, E, Valero, ML, Roig, X, Camarero, JA, Andreu, D, Mateu, MG, Giralt, E, Domingo, E, Sobrino, F and Palma, EL (1997). A largescale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants. Journal of Virology 71: 2606–2614.CrossRefGoogle ScholarPubMed
Tan, PL, Jacobson, RM, Poland, GA, Jacobsen, SJ and Pankratz, VS (2001). Twin studies of immunogenicity—determining the genetic contribution to vaccine failure. Vaccine 19: 2434–2439.CrossRefGoogle ScholarPubMed
Teale, AJ (1999). Genetics of disease resistance. In: Fries, R and Ruvinsky, A, editors. The Genetics of Cattle Wallingford, UK: CAB International pp. 199–227Google Scholar
Van Eijk, MJT, Stewart-Haynes, JA and Lewin, HA (1992). Extensive polymorphism of the BoLA-DRB3 gene distinguished by PCR-RFLP. Animal Genetics 23: 483–496.CrossRefGoogle ScholarPubMed
van Lierop, M-J C, Nilsson, PR, Wagenaar, JPA, van Noort, JM, Campbell, JDM, Glass, EJ, Joosten, I and Hensen, EJ (1995a). The influence of MHC polymorphism on the selection of T cell determinants of foot-and-mouth disease virus in cattle. Immunology 84: 79–85.Google ScholarPubMed
Van Lierop, MJC, Wagenaar, JPA, VanNoort, JM and Hensen, EJ (1995b). Sequences derived from the highly antigenic VP1 region-140 to region-160 of foot-and-mouth-disease virus do not prime for a bovine T-cell response against intact virus. Journal of Virology 69: 4511–4514.CrossRefGoogle Scholar
Vignal, A, Milan, D, SanCristobal, M and Eggen, A (2002). A review on SNP and other types of molecular markers and their use in animal genetics. Genetics Selection Evolution 34: 275–305.CrossRefGoogle ScholarPubMed
Vordermeier, M, Whelan, AO and Hewinson, RG (2003). Recognition of mycobacterial epitopes by T cells across mammalian species and use of a programme that predicts human HLA-DR binding peptides to predict bovine epitopes. Infection and Immunity 71: 1980–1987.CrossRefGoogle Scholar
Wagter, LC, Mallard, BA, Wilkie, BN, Leslie, KE, Boettcher, PJ and Dekkers, JC (2000). A quantitative approach to classifying Holstein cows based on antibody responsiveness and its relationship to peripartum mastitis occurrence. Journal of Dairy Science 83: 488–98.CrossRefGoogle ScholarPubMed
Wanner, JM, Rogers, GW, Kehrli, ME and Cooper, JB (1999). Clinical mastitis in primiparous Holsteins: comparisons of bovine leukocyte adhesion deficiency carriers and noncarriers. Journal of Dairy Science 82: 2517–2523.CrossRefGoogle ScholarPubMed
Watkins, CA, Gossner, A, Stevenson, K, Jones, DG, Sharp, JM and Hopkins, J (2002). Comparative expression profiling in the three defined forms of ovine paratuberculosis. In: Proceeding of the 7th International Colloquium on Paratuberculosis, pp. 35–38Google Scholar
Wilkie, BN and Mallard, BA (1999). Genetic effects on vaccination. Advances in Veterinary Medicine 41: 39–51.CrossRefGoogle ScholarPubMed
Williams, JL (2004). Livestock genomes (bvine genome). In: Meyers, RA editor. Encyclopaedia of Molecular Cell Biology and Molecular Medicine. Weinheim: Wiley-VCH.Google Scholar
Williams, JL, Eggen, A, Ferretti, L, Farr, C, Gautier, G, Amati, G, Ball, G, Caramori, T, Critcher, R, Costa, S, Hextall, P, Hills, D, Jeulin, A, Kiguwa, SL, Ross, O, Smith, AL, Saunier, KL, Urquhart, BGD and Waddington, D (2002). A bovine whole genome radiation hybrid panel and outline map. Mammalian Genome 13: 469–474.CrossRefGoogle ScholarPubMed
Woolhouse, MEJ (2003). Foot-and-mouth disease in the UK: What should we do next time? Journal of Applied Microbiology 94: 126S–130S.CrossRefGoogle ScholarPubMed
Xu, AL, Van Eijk, MJT, Park, C and Lewin, HA (1993). Polymorphism in BoLA-DRB3 exon-2 correlates with resistance to persistent lymphocytosis caused by bovine leukemia-virus. Journal of Immunology 151: 6977–6985.CrossRefGoogle ScholarPubMed
Yao, J, Burton, JL, Saama, P, Sipkovsky, SS and Coussens, PM (2001). Generation of EST and cDNA microarray resources for the study of bovine immunobiology. Acta Veterinaria Scandinavica 42: 391–405.Google Scholar
Young, FJ (2002). Innate and acquired immune responses in crossbred cattle. PhD thesis, University of Glasgow, UK.Google Scholar
Young, FJ, Logan, KL, Stear, MJ and Fitzpatrick, JL (2000). In vitro immunological responses of cattle to Staphylococcus aureus. Research in Veterinary Science 68 (Supplement A): 5.Google Scholar
Zanotti, M, Strillacci, MP, Polli, M, Archetti, IL and Longeri, M (2002). Nramp1 gene effect on bovine tuberculosis by microsatellite markers analysis. In: Proceedings of the 7th World Congress on Genetics Applied to Livestock Production(Montpelier, France). Communication 13–43Google Scholar
Zhang, ZD, Hutching, G, Kitching, P and Alexandersen, S (2002). The effects of gamma interferon on replication of foot-and-mouth disease virus in persistently infected bovine cells. Archives of Virology 147: 2157–2167.CrossRefGoogle ScholarPubMed