Hostname: page-component-7c8c6479df-5xszh Total loading time: 0 Render date: 2024-03-28T03:27:05.427Z Has data issue: false hasContentIssue false

Late gestation diet supplementation of resin acid-enriched composition increases sow colostrum immunoglobulin G content, piglet colostrum intake and improve sow gut microbiota

Published online by Cambridge University Press:  27 December 2018

S. Hasan*
Affiliation:
Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, 00014 Helsinki, Finland
S. Saha
Affiliation:
Department of Agricultural Sciences, University of Helsinki, 00014 Helsinki, Finland
S. Junnikkala
Affiliation:
Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, 00014 Helsinki, Finland
T. Orro
Affiliation:
Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Kreutzwaldi 62, 51006, Tartu, Estonia
O. Peltoniemi
Affiliation:
Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, 00014 Helsinki, Finland
C. Oliviero
Affiliation:
Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, 00014 Helsinki, Finland
Get access

Abstract

Resin acid-enriched composition (RAC) mainly containing tall oil fatty acid with an active component of resin acid (RA) can improve the microbial population in the digestive system, change the microbial fermentation, and improve the feed conversion ratio. We investigated the effects of dietary supplementation of RAC on sow colostrum yield (CY), colostrum composition and gut microbiota. Tall oil fatty acid and RA are commonly termed RAC and CLA, pinolenic, abietic, dehydrobiotic acids are characteristic components of RAC. The experiment was conducted in three trials in three respective herds. Sows were fed with a control diet and the same diet supplemented with 5 g RAC/day per sow during the last week of gestation. The 16S ribosomal RNA gene sequencing technique was used to assess sows’ faecal microbiota populations at farrowing. Colostrum nutritional composition, acute phase proteins (APPs) and immunoglobulin (Ig) content were also assessed. Individual piglets were weighed at birth and 24 h after the birth of first piglets in order to calculate CY and later at 3 to 4 weeks to calculate average daily gain. The RAC-fed sows had significantly higher IgG levels (P<0.05) in all three herds but treatment did not influence colostrum IgA and IgM concentration. There were no significant differences in colostrum protein, lactose and fat content in sows of the two diet groups (P>0.05), but those fed RAC had higher levels of colostrum serum amyloid A. Colostrum yield was significantly higher in RAC-fed sows in herds 2 and 3 with heavier piglets between 3 and 4 weeks of age (P<0.05), but not in herd 1 (P>0.05). Resin acid-enriched composition supplementation significantly increased some beneficial and fermentative bacteria (Romboutsia and Clostridium sensu stricto) than the control diet (P<0.01) while some opportunistic pathogens (Barnesiella, Sporobacter, Intestinimonas and Campylobacter), including Proteobacteria, were suppressed. Therefore, RAC added to the sow diet at late pregnancy increases colostrum IgG, colostrum availability for neonate piglets, and seems to promote better maternal intestinal microbial sources.

Type
Research Article
Copyright
© The Animal Consortium 2018 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bontempo, V, Sciannimanico, D, Pastorelli, G, Rossi, R, Rosi, F and Corino, C 2004. Dietary conjugated linoleic acid positively affects immunologic variables in lactating sows and piglets. The Journal of Nutrition 134, 817824.Google Scholar
Calder, PC 1996. Immunomodulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids. Proceedings of the Nutrition Society 55, 737774.Google Scholar
Coffman, RL, Ohara, J, Bond, MW, Carty, J, Zlotnik, A and Paul, WE 1986. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. The Journal of Immunology 136, 45384541.Google Scholar
Cole, JR, Wang, Q, Fish, JA, Chai, B, McGarrell, DM, Sun, Y, Brown, CT, Porras-Alfaro, A, Kuske, CR and Tiedje, JM 2013. Ribosomal Database Project: data and tools for high throughput rRNA analysis. Nucleic Acids Research 42, D642.Google Scholar
Corino, C, Pastorelli, G, Rosi, F, Bontempo, V and Rossi, R 2009. Effect of dietary conjugated linoleic acid supplementation in sows on performance and immunoglobulin concentration in piglets. Journal of Animal Science 87, 22992305.Google Scholar
Decaluwé, R, Maes, D, Wuyts, B, Cools, A, Piepers, S and Janssens, GPJ 2014. Piglets’ colostrum intake associates with daily weight gain and survival until weaning. Livestock Science 162, 185192.Google Scholar
Devillers, N, Farmer, C, Le Dividich, J and Prunier, A 2007. Variability of colostrum yield and colostrum intake in pigs. Animal 1, 10331041.Google Scholar
Devillers, N, Van Milgen, J, Prunier, A and Le Dividich, J 2004. Estimation of colostrum intake in the neonatal pig. Animal Science 78, 305313.Google Scholar
Dorman, H and Deans, SG 2000. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. Journal of Applied Microbiology 88, 308316.Google Scholar
Edgar, RC 2013. UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nature Methods 10, 9961008.Google Scholar
Hasan, S, Junnikkala, S, Peltoniemi, O, Paulin, L, Lyyski, A, Vorenmaa, J and Oliviero, C 2018. Dietary supplementation with yeast hydrolysate in pregnancy influences colostrum yield and gut microbiota of sows and piglets after birth. PLoS One 13, e0197586.Google Scholar
Hasan, S, Junnikkala, S, Valros, A, Peltoniemi, O and Oliviero, C 2016. Validation of Brix refractometer to estimate colostrum immunoglobulin G content and composition in the sow. Animal 10, 17281733.Google Scholar
Kang, M, Hirai, S, Goto, T, Kuroyanagi, K, Lee, J, Uemura, T, Ezaki, Y, Takahashi, N and Kawada, T 2008. Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. Biochemical and Biophysical Research Communications 369, 333408.Google Scholar
Kettunen, H, van Eerden, E, Lipiński, K, Rinttilä, T, Valkonen, E and Vuorenmaa, J 2017. Dietary resin acid composition as a performance enhancer for broiler chickens. Journal of Applied Animal Nutrition 5, 1121.Google Scholar
Klobasa, F and Butler, JE 1987. Absolute and relative concentrations of immunoglobulins G, M, and A, and albumin in the lacteal secretion of sows of different lactation numbers. American Journal of Veterinary Research 48, 176182.Google Scholar
Larson, MA, Wei, SH, Weber, A, Mack, DR and McDonald, TL 2003. Human serum amyloid A3 peptide enhances intestinal MUC3 expression and inhibits EPEC adherence. Biochemical and Biophysical Research Communications 300, 531540.Google Scholar
Lopetuso, LR, Scaldaferri, F, Petito, V and Gasbarrini, A 2013. Commensal Clostridia: leading players in the maintenance of gut homeostasis. Gut Pathogens 5, 23.Google Scholar
Makimura, S and Suzuki, N 1982. Quantitative determination of bovine serum haptoglobin and its elevation in some inflammatory diseases. Nihon Juigaku Zasshi 44, 1521.Google Scholar
McDonald, TL, Larson, MA, Mack, D and Weber, A. 2001. Elevated extrahepatic expression and secretion of mammary-associated serum amyloid A 3 (M-SAA3) into colostrum. Veterinary Immunology and Immunopathology 83, 203311.Google Scholar
McDonald, TL, Weber, A and Smith, JW 1991. A monoclonal antibody sandwich immunoassay for serum amyloid A (SAA) protein. Journal of Immunological Methods 144, 149155.Google Scholar
Moya, SL, Boyle, LA, Lynch, PB and Arkins, S 2007. Age-related changes in pro-inflammatory cytokines, acute phase proteins and cortisol concentrations in neonatal piglets. Neonatology 91, 4448.Google Scholar
Mukhopadhya, I, Hansen, R, El-Omar, EM and Hold, GL 2012. IBD—what role do Proteobacteria play? Nature Reviews Gastroenterology and Hepatology 9, 219230.Google Scholar
Orro, T, Jacobsen, S, LePage, J, Niewold, T, Alasuutari, S and Soveri, T 2008. Temporal changes in serum concentrations of acute phase proteins in newborn dairy calves. The Veterinary Journal 176, 182187.Google Scholar
Park, JY, Lee, YK, Lee, D, Yoo, J, Shin, M, Yamabe, N, Kim, S, Lee, S, Kim, KH and Lee, H 2017. Abietic acid isolated from pine resin (Resina Pini) enhances angiogenesis in HUVECs and accelerates cutaneous wound healing in mice. Journal of Ethnopharmacology 203, 279287.Google Scholar
Pereira, PA, Aho, VT, Paulin, L, Pekkonen, E, Auvinen, P and Scheperjans, F 2017. Oral and nasal microbiota in Parkinson’s disease. Parkinsonism & Related disorders 38, 6167.Google Scholar
Quesnel, H 2011. Colostrum production by sows: variability of colostrum yield and immunoglobulin G concentrations. Animal 5, 15461553.Google Scholar
Rooke, JA and Bland, IM 2002. The acquisition of passive immunity in the new-born piglet. Livestock Production Science 78, 1323.Google Scholar
Salmon, H, Berri, M, Gerdts, V and Meurens, F 2009. Humoral and cellular factors of maternal immunity in swine. Developmental & Comparative Immunology 33, 384393.Google Scholar
Salyers, AA and Whitt, DD 2002. Bacterial pathogenesis: a molecular approach, 2nd edition. American Society for Microbiology Press, Washington, DC, USA.Google Scholar
Schloss, PD, Westcott, SL, Ryabin, T, Hall, JR, Hartmann, M, Hollister, EB, Lesniewski, RA, Oakley, BB, Parks, DH and Robinson, CJ 2009. Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities. Applied and Environmental Microbiology 75, 75377541.Google Scholar
Shin, N, Whon, TW and Bae, J 2015. Proteobacteria: microbial signature of dysbiosis in gut microbiota. Trends in Biotechnology 33, 496503.Google Scholar
Sorrells, AD, Eicher, SD, Harris, MJ, Pajor, EA and Richert, BT 2007. Pariparturient cortisol, acute phase cytokines, and acute phase protein profiles of gilts housed in groups or stalls during gestation. Journal of Animal Science 85, 17501757.Google Scholar
Takahashi, N, Kawada, T, Goto, T, Kim, C, Taimatsu, A, Egawa, K, Yamamoto, T, Jisaka, M, Nishimura, K and Yokota, K 2003. Abietic acid activates peroxisome proliferator‐activated receptor‐γ (PPARγ) in RAW264. 7 macrophages and 3T3‐L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism. FEBS Letters 550, 190204.Google Scholar
Vienola, K, Jurgens, G, Vuorenmaa, J and Apajalahti, J 2018. Tall oil fatty acid inclusion in the diet improves performance and increase ileal density of lactobacilli in broiler chickens. British Poultry Science 59, 349355.Google Scholar
Weijtens, M, Reinders, RD, Urlings, H and Van der Plas, J 1999. Campylobacter infections in fattening pigs; excretion pattern and genetic diversity. Journal of Applied Microbiology 86, 6370.Google Scholar
Wlodarska, M, Willing, BP, Bravo, DM and Finlay, BB 2015. Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection. Scientific Reports 5, 9253.Google Scholar
Yao, W, Li, J, Jun Wang, J, Zhou, W, Wang, Q, Zhu, R, Wang, F and Thacker, P 2012. Effects of dietary ratio of n-6 to n-3 polyunsaturated fatty acids on immunoglobulins, cytokines, fatty acid composition, and performance of lactating sows and suckling piglets. Journal of Animal Science and Biotechnology 3, 43.Google Scholar
Zakrzewski, M, Proietti, C, Ellis, JJ, Hasan, S, Brion, M, Berger, B and Krause, L 2016. Calypso: a user-friendly web-server for mining and visualizing microbiome–environment interactions. Bioinformatics 33, 782783.Google Scholar
Zhang, W, Zhu, Y, Zhou, D, Wu, Q, Song, D, Dicksved, J and Wang, J 2017. Oral administration of a select mixture of Bacillus probiotics affects the gut microbiota and goblet cell function following Escherichia coli challenge in newly weaned pigs of genotype MUC4 that are supposed to be enterotoxigenic E. coli F4ab/ac receptor negative. Applied and Environmental Microbiology 83, 2747.Google Scholar
Supplementary material: File

Hasan et al. supplementary material

Table S1

Download Hasan et al. supplementary material(File)
File 23.4 KB
Supplementary material: File

Hasan et al. supplementary material

Table S2

Download Hasan et al. supplementary material(File)
File 20 KB
Supplementary material: File

Hasan et al. supplementary material

Table S3

Download Hasan et al. supplementary material(File)
File 25.2 KB