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The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations

Published online by Cambridge University Press:  26 April 2001

P. A. UNDERHILL ,
G. PASSARINO ,
A. A. LIN ,
P. SHEN ,
M. MIRAZÓN LAHR ,
R. A. FOLEY ,
P. J. OEFNER  and
L. L. CAVALLI-SFORZA
P. A. UNDERHILL
Affiliation:
Department of Genetics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305–5120, USA
G. PASSARINO
Affiliation:
Department of Genetics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305–5120, USA Department of Cell Biology, Calabria University, Rende, Italy
A. A. LIN
Affiliation:
Department of Genetics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305–5120, USA
P. SHEN
Affiliation:
Stanford DNA Sequencing and Technology Center, 855 California Ave, Palo Alto, CA 94304, USA
M. MIRAZÓN LAHR
Affiliation:
Department of Biological Anthropology, University of Cambridge, Downing Street Cambridge CB2 3DZ, UK Departamento de Biologia, Inst. de Biociencas, Universidad de São Paulo, Rua do Matão, Travessa 14, No. 321, 05508–900 Cidade Universitária, São Paulo, Brasil
R. A. FOLEY
Affiliation:
Department of Biological Anthropology, University of Cambridge, Downing Street Cambridge CB2 3DZ, UK
P. J. OEFNER
Affiliation:
Stanford DNA Sequencing and Technology Center, 855 California Ave, Palo Alto, CA 94304, USA
L. L. CAVALLI-SFORZA
Affiliation:
Department of Genetics, Stanford University, 300 Pasteur Dr., Stanford, CA 94305–5120, USA
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Abstract

Although molecular genetic evidence continues to accumulate that is consistent with a recent common African ancestry of modern humans, its ability to illuminate regional histories remains incomplete. A set of unique event polymorphisms associated with the non-recombining portion of the Y-chromosome (NRY) addresses this issue by providing evidence concerning successful migrations originating from Africa, which can be interpreted as subsequent colonizations, differentiations and migrations overlaid upon previous population ranges. A total of 205 markers identified by denaturing high performance liquid chromatography (DHPLC), together with 13 taken from the literature, were used to construct a parsimonious genealogy. Ancestral allelic states were deduced from orthologous great ape sequences. A total of 131 unique haplotypes were defined which trace the microevolutionary trajectory of global modern human genetic diversification. The genealogy provides a detailed phylogeographic portrait of contemporary global population structure that is emblematic of human origins, divergence and population history that is consistent with climatic, paleoanthropological and other genetic knowledge.

Type
Research Article
Information
Annals of Human Genetics , Volume 65 , Issue 1 , January 2001 , pp. 43 - 62
Copyright
University College London 2001

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